The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry.
Open accessAbstract
To determine if levels of serum total homocysteine are elevated in patients with either cobalamin or folate deficiency, we utilized a new capillary gas chromatographic-mass spectrometric technique to measure total homocysteine in the serum of 78 patients with clinically confirmed cobalamin deficiency and 19 patients with clinically confirmed folate deficiency. Values ranged from 11 to 476 mumol/liter in the cobalamin-deficient patients and 77 of the 78 patients had values above the normal range of 7-22 mumol/liter as determined for 50 normal blood donors. In the cobalamin-deficient patients, serum total homocysteine was positively correlated with serum folate, mean corpuscular volume, serum lactate dehydrogenase, serum methylmalonic acid, and the degree of neurologic involvement, and inversely correlated with platelets and hematocrit. In the folate-deficient patients, values for serum total homocysteine ranged from 17 to 185 mumol/liter and 18 of the 19 patients had values above the normal range. Some patients with pernicious anemia who were intermittently treated with cyanocobalamin were found to have elevated serum levels of total homocysteine while they were free of hematologic and neurologic abnormalities. The measurement of serum total homocysteine will help define the incidence of cobalamin deficiency and folate deficiency in various patient populations.
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Cites
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Heterozygosity for Homocystinuria in Premature Peripheral and Cerebral Occlusive Arterial Disease
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Methionine metabolism in mammals. Distribution of homocysteine between competing pathways.
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Methionine metabolism in mammals. Adaptation to methionine excess.
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Stabler, S. P., Marcell, P. D., Podell, E. R., & Allen, R. H. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90026-1 · Cited by 289
Self-citationModerate homocysteinemia--a possible risk factor for arteriosclerotic cerebrovascular disease.
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PATHOGENESIS OF SUBACUTE COMBINED DEGENERATION: A RESULT OF METHYL GROUP DEFICIENCY
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Homocystinuria associated with decreased methylenetetrahydrofolate reductase activity
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Cited by
Homocysteine and Atherothrombosis
Welch, G. N., & Loscalzo, J. (1998) · New England Journal of Medicine · doi:10.1056/nejm199804093381507 · Cited by 1,997
Stabler, S. P. (2013) · New England Journal of Medicine · doi:10.1056/nejmcp1113996 · Cited by 1,224
Self-citationFacts and recommendations about total homocysteine determinations: an expert opinion
Refsum, H., Smith, A. D., Ueland, P. M., Nexo, E., Clarke, R., McPartlin, J., Johnston, C., Engbaek, F., Schneede, J., McPartlin, C., et al. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2003.021634 · Cited by 1,056
Green, R., Allen, L. H., Bjørke-Monsen, A.-L., Brito, A., Guéant, J.-L., Miller, J. W., Molloy, A. M., Nexo, E., Stabler, S., Toh, B.-H., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.40 · Cited by 970
Self-citationJacobsen, D. W., Gatautis, V. J., Green, R., Robinson, K., Savon, S. R., Secic, M., Ji, J., Otto, J. M., & Taylor, L. M. (1994) · Clinical Chemistry · doi:10.1093/clinchem/40.6.873 · Cited by 435
Metadata
- Authors
- Stabler, S. P., Marcell, P. D., Podell, E. R., Allen, R. H., Savage, D. G., & Lindenbaum, J.
- Venue
- Journal of Clinical Investigation
- Published
- 1988-02-01
- Volume
- 81
- Issue
- 2
- Pages
- 466-474
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2167908108
- Cited by
- 478
- References
- 26
- FWCI
- 11.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Stabler, S. P., Marcell, P. D., Podell, E. R., Allen, R. H., Savage, D. G., & Lindenbaum, J. (1988). Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry. Journal of Clinical Investigation. https://doi.org/10.1172/jci113343
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