The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Oxidant-induced DNA damage of target cells.
Open accessAbstract
In this study we examined the leukocytic oxidant species that induce oxidant damage of DNA in whole cells. H2O2 added extracellularly in micromolar concentrations (10-100 microM) induced DNA strand breaks in various target cells. The sensitivity of a specific target cell was inversely correlated to its catalase content and the rate of removal of H2O2 by the target cell. Oxidant species produced by xanthine oxidase/purine or phorbol myristate acetate-stimulated monocytes induced DNA breakage of target cells in proportion to the amount of H2O2 generated. These DNA strand breaks were prevented by extracellular catalase, but not by superoxide dismutase. Cytotoxic doses of HOCl, added to target cells, did not induce DNA strand breakage, and myeloperoxidase added extracellularly in the presence of an H2O2-generating system, prevented the formation of DNA strand breaks in proportion to its H2O2 degrading capacity. The studies also indicated that H2O2 formed hydroxyl radical (.OH) intracellularly, which appeared to be the most likely free radical responsible for DNA damage: .OH was detected in cells exposed to H2O2; the DNA base, deoxyguanosine, was hydroxylated in cells exposed to H2O2; and intracellular iron was essential for induction of DNA strand breaks.
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Griffith, O. W., & Meister, A. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35980-5 · Cited by 1,683
Albrich, J. M., McCarthy, C. A., & Hurst, J. K. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.1.210 · Cited by 442
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Metadata
- Authors
- Schraufstätter, I., Hyslop, P. A., Jackson, J. H., & Cochrane, C. G.
- Venue
- Journal of Clinical Investigation
- Published
- 1988-09-01
- Volume
- 82
- Issue
- 3
- Pages
- 1040-1050
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2164490838
- Cited by
- 373
- References
- 2
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
