The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Monocyte-chemotactic activity of defensins from human neutrophils.
Open accessAbstract
We investigated the monocyte-chemotactic activity of fractionated extracts of human neutrophil granules. Monocyte-chemotactic activity was found predominantly in the defensin-containing fraction of the neutrophil granules. Purified preparations of each of the three human defensins (HNP-1, HNP-2, HNP-3) were then tested. HNP-1 demonstrated significant chemotactic activity for monocytes: Peak activity was seen at HNP-1 concentrations of 5 X 10(-9) M and was 49 +/- 20% (mean +/- SE, n = 9) of that elicited by 10(-8) M FMLP. HNP-2 (peak activity at 5 X 10(-9) M) was somewhat less active, yielding 19 +/- 10% (n = 11). HNP-3 failed to demonstrate chemotactic activity. Checkerboard analysis of monocyte response to HNP-1 and HNP-2 confirmed that their activity was chemotactic rather than chemokinetic. Neutrophils demonstrated a low level of response to defensins but this reaction was primarily chemokinetic. Defensins may play a role in the recruitment of monocytes by neutrophils into inflammatory sites.
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Cites
Clark, R. A., Wikner, N. E., Doherty, D. E., & Norris, D. A. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37900-6 · Cited by 152
Cited by
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
Self-citationNeutrophil granules and secretory vesicles in inflammation
Faurschou, M., & Borregaard, N. (2003) · Microbes and Infection · doi:10.1016/j.micinf.2003.09.008 · Cited by 1,162
Defensins: Antimicrobial and Cytotoxic Peptides of Mammalian Cells
Lehrer, R. I., Lichtenstein, A. K., & Ganz, T. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.000541 · Cited by 991
Self-citationMammalian defensins in immunity: more than just microbicidal
Yang, D., Biragyn, A., Kwak, L. W., & Oppenheim, J. J. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02246-9 · Cited by 696
Yang, D., Biragyn, A., Hoover, D. M., Lubkowski, J., & Oppenheim, J. J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104603 · Cited by 572
Metadata
- Authors
- Territo, M. C., Ganz, T., Selsted, M. E., & Lehrer, R.
- Venue
- Journal of Clinical Investigation
- Published
- 1989-12-01
- Volume
- 84
- Issue
- 6
- Pages
- 2017-2020
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2055856930
- Cited by
- 489
- References
- 1
- FWCI
- 6.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Territo, M. C., Ganz, T., Selsted, M. E., & Lehrer, R. (1989). Monocyte-chemotactic activity of defensins from human neutrophils. Journal of Clinical Investigation. https://doi.org/10.1172/jci114394
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
