The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Marked synergism between tumor necrosis factor-alpha and interferon-gamma in regulation of keratinocyte-derived adhesion molecules and chemotactic factors.
Open accessAbstract
T lymphocytes and mononuclear cells preferentially accumulate in the epidermis in inflammatory skin disease. To determine the role of keratinocytes in both the chemotaxis and adhesion of these cells to the epidermis, cultured keratinocytes were incubated with IFN-gamma and tumor necrosis factor-alpha (TNF-alpha), and mRNA detected and quantitated for IL-8, monocyte chemotaxis and activating factor, and intercellular adhesion molecule-1. Whereas induction of these mRNAs was either absent, or relatively weak and transient, to either IFN-gamma or TNF-alpha alone, when administered in combination there was a dramatic increase and persistence in the induction of all three genes. Pretreatment of the keratinocytes with cycloheximide failed to eliminate transcription, implying that all three are primary response genes. Transforming growth factor-beta, which modulates other keratinocyte functions (not related to adhesion or chemotaxis of inflammatory cells) failed to induce any of the genes. These novel findings potentially explain the selective recruitment of T cells and monocytes observed in inflammatory skin disease, because IFN-gamma and TNF-alpha can co-ordinately regulate keratinocyte-derived chemoattractants and adhesion molecule production.
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Cites
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The Neutrophil-Activating Protein (NAP-1) Is Also Chemotactic for T Lymphocytes
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Matsushima, K., Larsen, C. G., DuBois, G. C., & Oppenheim, J. J. (1989) · The Journal of experimental medicine · doi:10.1084/jem.169.4.1485 · Cited by 756
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Human monocyte chemoattractant protein-1 (MCP-1)
Leonard, E. J., & Yoshimura, T. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90035-8 · Cited by 663
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Induction and detection of a human endothelial activation antigen in vivo.
Cotran, R. S., Gimbrone, M. A., Bevilacqua, M. P., Mendrick, D. L., & Pober, J. S. (1986) · The Journal of experimental medicine · doi:10.1084/jem.164.2.661 · Cited by 372
The Regulation of Lymphocyte Traffic
Butcher, E. C. (1986) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-642-71272-2_3 · Cited by 276
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Cited by
Austin, L. M., Ozawa, M., Kikuchi, T., Walters, I. B., & Krueger, J. G. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00749.x · Cited by 485
Ohmori, Y., Schreiber, R. D., & Hamilton, T. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.23.14899 · Cited by 413
Kannaiyan, R., Shanmugam, M. K., & Sethi, G. (2011) · Cancer Letters · doi:10.1016/j.canlet.2010.10.025 · Cited by 346
The Cytokine Network in Psoriasis
Nickoloff, B. J. (1991) · Archives of Dermatology · doi:10.1001/archderm.127.6.871 · Cited by 344
Self-citationAlbanesi, C., Cavani, A., & Girolomoni, G. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.1.494 · Cited by 307
Metadata
- Authors
- Barker, J. N., Sarma, V, Mitra, R. S., Dixit, V. M., & Nickoloff, B. J.
- Venue
- Journal of Clinical Investigation
- Published
- 1990-02-01
- Volume
- 85
- Issue
- 2
- Pages
- 605-608
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2029786286
- Cited by
- 261
- References
- 18
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Barker, J. N., Sarma, V, Mitra, R. S., Dixit, V. M., & Nickoloff, B. J. (1990). Marked synergism between tumor necrosis factor-alpha and interferon-gamma in regulation of keratinocyte-derived adhesion molecules and chemotactic factors. Journal of Clinical Investigation. https://doi.org/10.1172/jci114481
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
