Cited by 123Diabetes, Cardiovascular Risks, and LipoproteinsMetabolism, Diabetes, and CancerAdipose Tissue and Metabolism

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Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus.

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Vaag, A, Skött, P, Damsbo, P, Gall, M A, Richter, E A, Beck-Nielsen, H·1991·Journal of Clinical Investigation

DOI 10.1172/jci115432

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Abstract

Increased nonesterified fatty acid (NEFA) levels may be important in causing insulin resistance in skeletal muscles in patients with non-insulin-dependent diabetes mellitus (NIDDM). The acute effect of the antilipolytic nicotinic acid analogue Acipimox (2 X 250 mg) on basal and insulin-stimulated (3 h, 40 mU/m2 per min) glucose metabolism was therefore studied in 12 patients with NIDDM. Whole-body glucose metabolism was assessed using [3-3H]glucose and indirect calorimetry. Biopsies were taken from the vastus lateralis muscle during basal and insulin-stimulated steady-state periods. Acipimox reduced NEFA in the basal state and during insulin stimulation. Lipid oxidation was inhibited by Acipimox in all patients in the basal state (20 +/- 2 vs. 33 +/- 3 mg/m2 per min, P less than 0.01) and during insulin infusion (8 +/- 2 vs. 17 +/- 2 mg/m2 per min, P less than 0.01). Acipimox increased the insulin-stimulated glucose disposal rate (369 +/- 49 vs. 262 +/- 31 mg/m2 per min, P less than 0.01), whereas the glucose disposal rate was unaffected by Acipimox in the basal state. Acipimox increased glucose oxidation in the basal state (76 +/- 4 vs. 50 +/- 4 mg/m2 per min, P less than 0.01). During insulin infusion Acipimox increased both glucose oxidation (121 +/- 7 vs. 95 +/- 4 mg/m2 per min, P less than 0.01) and nonoxidative glucose disposal (248 +/- 47 vs. 167 +/- 29 mg/m2 per min, P less than 0.01). Acipimox enhanced basal and insulin-stimulated muscle fractional glycogen synthase activities (32 +/- 2 vs. 25 +/- 3%, P less than 0.05, and 50 +/- 5 vs. 41 +/- 4%, P less than 0.05). Activities of muscle pyruvate dehydrogenase and phosphofructokinase were unaffected by Acipimox. In conclusion, Acipimox acutely improved insulin action in patients with NIDDM by increasing both glucose oxidation and nonoxidative glucose disposal. This supports the hypothesis that elevated NEFA concentrations may be important for the insulin resistance in NIDDM. The mechanism responsible for the increased insulin-stimulated nonoxidative glucose disposal may be a stimulatory effect of Acipimox on glycogen synthase activity in skeletal muscles.

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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
A Flexible System of Enzymatic Analysis
Lowry, O. H., & Passonneau, J. V. (1972) · Elsevier eBooks · doi:10.1016/b978-0-12-457950-7.x5001-3 · Cited by 4,050
Calculation of substrate oxidation rates in vivo from gaseous exchange.
Frayn, K. N. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.55.2.628 · Cited by 2,365
The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization
DeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., & Felber, J. P. (1981) · Diabetes · doi:10.2337/diab.30.12.1000 · Cited by 1,770
INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT*
Steele, R. D. (1959) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1959.tb44923.x · Cited by 1,680
The theoretical bases of indirect calorimetry: A review
Ferrannini, E. (1988) · Metabolism · doi:10.1016/0026-0495(88)90110-2 · Cited by 1,604
A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose
Thomas, J. A., Schlender, K. K., & Larner, J. (1968) · Analytical Biochemistry · doi:10.1016/0003-2697(68)90127-9 · Cited by 1,198
Effect of fatty acids on glucose production and utilization in man.
Ferrannini, E., Barrett, E. J., Bevilacqua, S., & DeFronzo, R. A. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111133 · Cited by 1,050

Show all 64 references

Research works printed but not linked: 1

Passonneau, J. V. 1974. L-(+)-lactate: fluorometric method. In Methods ofEnzymatic Analysis. Volume 3. H. V. Bergmeyer, editor. Academic Press, Inc. New York. 1468-1472.

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Effect of decreasing plasma free fatty acids by acipimox on hepatic glucose metabolism in normal rats
Lee, K., Park, J. Y., Kim, C. H., Hong, S. K., Suh, K. I., Park, K. S., & Park, S. W. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90123-7 · Cited by 27
Inhibition of Lipolysis Stimulates Whole Body Glucose Production and Disposal in Normal Postabsorptive Subjects1
Féry, F., Plat, L., Balériaux, M. L., & Balasse, E. O. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.3.3821 · Cited by 27
Acipimox increases glucose disposal in normal man independent of changes in plasma nonesterified fatty acid concentration and whole-body lipid oxidation rate
Fulcher, G. R., Walker, M., Farrer, M., Johnson, A.-L., & Alberti, K. G. M. M. (1993) · Metabolism · doi:10.1016/0026-0495(93)90079-4 · Cited by 27
Effect of lipid oxidation on glucose utilization in humans
Jéquier, E. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.3.527s · Cited by 25
Skeletal muscle lipotoxicity in insulin resistance and type 2 diabetes
Brøns, C., & Vaag, A. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.177758 · Cited by 25
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Suppression of nocturnal fatty acid concentrations by bedtime carbohydrate supplement in type 2 diabetes: effects on insulin sensitivity, lipids, and glycemic control
Axelsen, M., Lönnroth, P., Lenner, R. A., Taskinen, M., & Smith, U. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.5.1108 · Cited by 24
Hepatic glucose production: therapeutic target in type 2 diabetes?
Stæhr, P., Nielsen, O. H., & Beck‐Nielsen, H. (2002) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2002.00177.x · Cited by 25
Self-citation
1 New Hypoglycaemic Agents
Hulin, B. (1994) · Progress in medicinal chemistry · doi:10.1016/s0079-6468(08)70018-3 · Cited by 23
Peripheral and hepatic insulin sensitivity in non-insulin-dependent diabetes mellitus: Effect of nonesterified fatty acids
Walker, M., Agius, L., Ørskov, H., & Alberti, K. G. M. M. (1993) · Metabolism · doi:10.1016/0026-0495(93)90219-e · Cited by 23
Kinetics and utilization of lipid sources during acute exercise and acipimox
Nellemann, B., Søndergaard, E., Jensen, J., Pedersen, S. B., Jessen, N., Jørgensen, J. O. L., & Nielsen, S. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00043.2014 · Cited by 19
Nutrient effects: post-absorptive interactions
Jéquier, E. (1995) · Proceedings of The Nutrition Society · doi:10.1079/pns19950052 · Cited by 19
The nicotinic acid analogue acipimox increases plasma leptin and decreases free fatty acids in type 2 diabetic patients
Worm, D., Vinten, J., Vaag, A. A., Henriksen, J. E., & Beck‐Nielsen, H. (2000) · European Journal of Endocrinology · doi:10.1530/eje.0.1430389 · Cited by 19
Self-citation
Thermic and metabolic responses to oral glucose in obese subjects with non-insulin-dependent diabetes mellitus treated with insulin or a very-low-energy diet
Gougeon, R. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.1.78 · Cited by 19
Long-term effects of a sustained-release preparation of acipimox on dyslipidemia and glucose metabolism in non—insulin-dependent diabetes mellitus
Davoren, P. M., Kelly, W., Gries, F. A., Hübinger, A., Whately‐Smith, C., & Alberti, K. G. M. M. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90252-9 · Cited by 17
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Campelj, D. G., & Philp, A. (2022) · Sports Medicine · doi:10.1007/s40279-022-01772-2 · Cited by 20
Effects of Benfluorex on Fatty Acid and Glucose Metabolism in Isolated Rat Hepatocytes
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Impact of moderate exercise on fatty acid oxidation in pancreatic β-cells and skeletal muscle
Langlois, A., Forterre, A. V., Pinget, M., & Bouzakri, K. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01551-2 · Cited by 18
Acute inhibition of lipolysis does not affect postprandial suppression of endogenous glucose production
Carey, P. E., Gerrard, J., Cline, G. W., Man, C. D., English, P. T., Firbank, M., Cobelli, C., & Taylor, R. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00195.2005 · Cited by 14
The Effect of Long-Term Pharmacological Antilipolysis on Substrate Metabolism in Growth Hormone (GH)-Substituted GH-Deficient Adults
Nielsen, S., Møller, N., Pedersen, S. B., Christiansen, J. S., & Jørgensen, J. O. L. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.7.8597 · Cited by 13
Nicotinic Acid and Derivatives
OLSSON, A. G. (1994) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-78426-2_13 · Cited by 12
Effect of acute acipimox administration on the rates of lipid and glycogen synthesis in cachectic tumor‐bearing rats
Obeid, O., & Emery, P. W. (1997) · Nutrition and Cancer · doi:10.1080/01635589709514559 · Cited by 12
Effects of blockade of fatty acid oxidation on whole body and tissue-specific glucose metabolism in rats
Jenkins, A. B., Storlien, L. H., Cooney, G. J., Denyer, G. S., Caterson, I. D., & Kraegen, E. W. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.4.e592 · Cited by 11
Low-carbohydrate diet does not affect intramyocellular lipid concentration or insulin sensitivity in lean, physically fit men when protein intake is elevated
Green, J. G., Johnson, N. A., Sachinwalla, T., Cunningham, C. W., Thompson, M. W., & Stannard, S. R. (2010) · Metabolism · doi:10.1016/j.metabol.2010.03.013 · Cited by 11
1 Insulin action, thermogenesis and obesity
Cooney, G. J., & Storlien, L. H. (1994) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(05)80283-6 · Cited by 10
Effects of Acipimox on the metabolism of free fatty acids and very low density lipoprotein triglyceride
Hannah, J. S., Bodkin, N. L., Paidi, M., Anh-Le, N., Howard, B. V., & HANSEN, B. C. (1995) · Acta Diabetologica · doi:10.1007/bf00576264 · Cited by 10
Regulation of skeletal muscle carbohydrate oxidation during steady-state contraction
Timmons, J. A., Poucher, S. M., Constantin‐Teodosiu, D., Macdonald, I. A., & Greenhaff, P. L. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.5.r1384 · Cited by 9
Tissue differences in the response of the pyruvate dehydrogenase complex to a glucose load during the development of obesity in gold-thioglucose-obese mice
Bryson, J. M., Cooney, G. J., Wensley, V. R., Phuyal, J. L., & Caterson, I. D. (1995) · Biochemical Journal · doi:10.1042/bj3050811 · Cited by 7
Regulation of Adipose Tissue Lipolysis, Importance for the Metabolic Syndrome
Arner, P. (1993) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2910-1_19 · Cited by 7

Authors: Vaag, A., Skött, P., Damsbo, P., Gall, M. A., Richter, E. A., & Beck-Nielsen, H.
Affiliations: Odense University Hospital (DK)
University of Copenhagen (DK)
ORCID: Vaag, A
Richter, E A
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1991-10-01
Volume: 88
Issue: 4
Pages: 1282-1290
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci115432
OpenAlex: W1987680714
Cited by: 123
References: 64
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 3
FWCI: 6.89
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: Diabetesforeningen
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: acipimox, type 2 diabetes, skeletal muscle glucose metabolism, insulin-stimulated glucose disposal, free fatty acids, lipolysis inhibition, lipid oxidation, glucose oxidation, glycogen synthase, insulin resistance, vastus lateralis, nonoxidative glucose disposal, pyruvate dehydrogenase, phosphofructokinase, glucose-6-phosphate
MeSH terms: Hypolipidemic Agents, Biological Transport, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Glucose, Glycogen Synthase, Humans, Lactates, Middle Aged, Muscles, Oxidation-Reduction, Pyrazines, Pyruvate Dehydrogenase Complex, Lactic Acid, Lipid Metabolism

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Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus.

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