Cited by 142Lipid metabolism and biosynthesisAdipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function

Watt, Matthew J., Hoy, Andrew J.·2012·American Journal of Physiology-Endocrinology and Metabolism

Abstract

Fatty acids derived from adipose tissue lipolysis, intramyocellular triacylglycerol lipolysis, or de novo lipogenesis serve a variety of functions in skeletal muscle. The two major fates of fatty acids are mitochondrial oxidation to provide energy for the myocyte and storage within a variety of lipids, where they are stored primarily in discrete lipid droplets or serve as important structural components of membranes. In this review, we provide a brief overview of skeletal muscle fatty acid metabolism and highlight recent notable advances in the field. We then 1) discuss how lipids are stored in and mobilized from various subcellular locations to provide adaptive or maladaptive signals in the myocyte and 2) outline how lipid metabolites or metabolic byproducts derived from the actions of triacylglycerol metabolism or β-oxidation act as positive and negative regulators of insulin action. We have placed an emphasis on recent developments in the lipid biology field with respect to understanding skeletal muscle physiology and discuss unanswered questions and technical limitations for assessing lipid signaling in skeletal muscle.

Integrity signals

Registry

Crossref · 10.1152/ajpendo.00561.2011

Cites

211 of 211 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Accumulation of fatty acids, ceramides, and diacylglycerol in the cytosol is linked to insulin resistance through inhibition of insulin signaling.

    “an accumulation of these fatty acids and ceramides and diacylglycerol in the cytosolic compartment are linked to insulin resistance via an inhibition of the insulin signaling cascade (36,37).”

    From Simvastatin Effects on Skeletal Muscle (2013) · cites this paper as [37]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Watt, M. J., & Hoy, A. J.
Affiliations
Monash University (AU)
Corresponding author
Watt, Matthew J.
Venue
American Journal of Physiology-Endocrinology and Metabolism
Published
2012-06-01
Volume
302
Issue
11
Pages
E1315-E1328
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
OpenAlex
W2033804400
Cited by
142
References
208
Citations by year
2026: 5 · 2025: 13 · 2024: 15 · 2023: 7 · 2022: 9 · 2021: 13 · 2020: 11 · 2019: 15 · 2018: 7 · 2017: 3 · 2016: 6 · 2015: 11 · 2014: 9 · 2013: 11 · 2012: 7
FWCI
0.88
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
skeletal muscle lipid metabolism, fatty acid metabolism, lipolysis, de novo lipogenesis, lipid droplets, mitochondrial fatty acid oxidation, fatty acid beta-oxidation, lipid signaling, insulin action, adipose tissue lipolysis, membrane lipids
MeSH terms
Adaptation, Physiological, Animals, Fatty Acids, Humans, Insulin Resistance, Lipids, Triglycerides, Signal Transduction, Muscle, Skeletal, Muscle Fibers, Skeletal, Lipid Metabolism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review