Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function
Abstract
Fatty acids derived from adipose tissue lipolysis, intramyocellular triacylglycerol lipolysis, or de novo lipogenesis serve a variety of functions in skeletal muscle. The two major fates of fatty acids are mitochondrial oxidation to provide energy for the myocyte and storage within a variety of lipids, where they are stored primarily in discrete lipid droplets or serve as important structural components of membranes. In this review, we provide a brief overview of skeletal muscle fatty acid metabolism and highlight recent notable advances in the field. We then 1) discuss how lipids are stored in and mobilized from various subcellular locations to provide adaptive or maladaptive signals in the myocyte and 2) outline how lipid metabolites or metabolic byproducts derived from the actions of triacylglycerol metabolism or β-oxidation act as positive and negative regulators of insulin action. We have placed an emphasis on recent developments in the lipid biology field with respect to understanding skeletal muscle physiology and discuss unanswered questions and technical limitations for assessing lipid signaling in skeletal muscle.
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Accumulation of fatty acids, ceramides, and diacylglycerol in the cytosol is linked to insulin resistance through inhibition of insulin signaling.
“an accumulation of these fatty acids and ceramides and diacylglycerol in the cytosolic compartment are linked to insulin resistance via an inhibition of the insulin signaling cascade (36,37).”
From Simvastatin Effects on Skeletal Muscle (2013) · cites this paper as [37]
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Finucane, M. M., Stevens, G. A., Cowan, M. J., Danaei, G., Lin, J. K., Paciorek, C. J., Singh, G. M., Gutierrez, H. R., Lu, Y., Bahalim, A. N., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62037-5 · Cited by 4,050 · see citing works
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245 · see citing works
Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase
Zimmermann, R., Bogner‐Strauß, J. G., Haemmerle, G., Schoiswohl, G., Birner‐Gruenberger, R., Riederer, M., Lass, A., Neuberger, G., Eisenhaber, F., Hermetter, A., et al. (2004) · Science · doi:10.1126/science.1100747 · Cited by 2,121 · see citing works
Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.013 · Cited by 1,990 · see citing works
Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561 · see citing works
Mechanism of free fatty acid-induced insulin resistance in humans.
Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539 · see citing works
Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390 · see citing works
Kishimoto, A., Takai, Y., Terutoshi, M. O. R. I., Kikkawa, U., & Nishizuka, Y. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85886-6 · Cited by 1,303 · see citing works
Krssak, M., Falk Petersen, K., Dresner, A., DiPietro, L., Vogel, S. M., Rothman, D. L., Shulman, G. I., & Roden, M. (1999) · Diabetologia · doi:10.1007/s001250051123 · Cited by 1,264 · see citing works
Anderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37048 · Cited by 1,253 · see citing works
Holland, W. L., Brozinick, J. T., Wang, L.-P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.002 · Cited by 1,232 · see citing works
Goodpaster, B. H. (2001) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.12.5755 · Cited by 1,194 · see citing works
Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179 · see citing works
Skeletal muscle triglyceride levels are inversely related to insulin action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179 · see citing works
Hannun, Y. A., Loomis, C. R., Merrill, A. H., & Bell, R. M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67133-9 · Cited by 1,156 · see citing works
Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling
Fang, Y., Vilella-Bach, M., Bachmann, R., Flanigan, A., & Chen, J. (2001) · Science · doi:10.1126/science.1066015 · Cited by 1,055 · see citing works
Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2
Abu-Elheiga, L., Matzuk, M. M., Abo-Hashema, K. A. H., & Wakil, S. J. (2001) · Science · doi:10.1126/science.1056843 · Cited by 903 · see citing works
Lass, A., Zimmermann, R., Haemmerle, G., Riederer, M., Schoiswohl, G., Schweiger, M., Kienesberger, P. C., Bogner‐Strauß, J. G., Gorkiewicz, G., & Zechner, R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.03.005 · Cited by 884 · see citing works
Perseghin, G., Scifo, P., De Cobelli, F., Pagliato, E., Battezzati, A., Arcelloni, C., Vanzulli, A., Testolin, G., Pozza, G., Del Maschio, A., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.8.1600 · Cited by 877 · see citing works
Greenberg, A. S., Egan, J. J., Wek, S. A., Garty, N. B., Blanchette‐Mackie, E. J., & Londos, C. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99168-4 · Cited by 831 · see citing works
Jenkins, C. M., Mancuso, D. J., Yan, W., Sims, H. F., Gibson, B., & Gross, R. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407841200 · Cited by 778 · see citing works
Holland, W. L., Bikman, B. T., Wang, L.-P., Yuguang, G., Sargent, K. M., Bulchand, S., Knotts, T. A., Shui, G., Clegg, D. J., Wenk, M. R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43378 · Cited by 705 · see citing works
Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans
Adams, J. M., Pratipanawatr, T., Berria, R., Wang, E. L., DeFronzo, R. A., Sullards, M. C., & Mandarino, L. J. (2004) · Diabetes · doi:10.2337/diabetes.53.1.25 · Cited by 670 · see citing works
Haus, J. M., Kashyap, S. R., Kasumov, T., Zhang, R., Kelly, K. R., DeFronzo, R. A., & Kirwan, J. P. (2008) · Diabetes · doi:10.2337/db08-1228 · Cited by 665 · see citing works
Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans
Baron, A., Brechtel, G., Wallace, P., & Edelman, S. V. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.255.6.e769 · Cited by 645 · see citing works
Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores
Lass, A., Zimmermann, R., Oberer, M., & Zechner, R. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.10.004 · Cited by 641 · see citing works
Haemmerle, G., Zimmermann, R., Hayn, M., Theussl, C., Waeg, G., Wagner, E., Sattler, W., Magin, T. M., Wagner, E. F., & Zechner, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110355200 · Cited by 613 · see citing works
Villena, J. A., Roy, S., Sarkadi‐Nagy, E., Kim, K., & Sul, H. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403855200 · Cited by 606 · see citing works
The role of mitochondria in insulin resistance and type 2 diabetes mellitus
Szendroedi, J., Phielix, E., & Roden, M. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.138 · Cited by 600 · see citing works
Schmitz-Peiffer, C., Craig, D. L., & Biden, T. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.24202 · Cited by 592 · see citing works
Holland, W. L., & Summers, S. A. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0025 · Cited by 585 · see citing works
Mihaylova, M. M., Vasquez, D. S., Ravnskjær, K., Denechaud, P., Yu, R. T., Alvarez, J. G. A., Downes, M., Evans, R. M., Montminy, M., & Shaw, R. J. (2011) · Cell · doi:10.1016/j.cell.2011.03.043 · Cited by 554 · see citing works
Enhanced insulin sensitivity in mice lacking ganglioside GM3
Yamashita, T., Hashiramoto, A., Haluzik, M., Mizukami, H., Beck, S., Norton, A., Kono, M., Tsuji, S., Daniotti, J. L., Werth, N., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0635898100 · Cited by 531 · see citing works
Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype
Ahmadian, M., Abbott, M. J., Tang, T., Hudak, C. S. S., Kim, Y., Bruss, M. D., Hellerstein, M. K., Lee, H., Samuel, V. T., Shulman, G. I., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.002 · Cited by 526 · see citing works
PKC-θ knockout mice are protected from fat-induced insulin resistance
Kim, J. K., Fillmore, J. J., Sunshine, M. J., Albrecht, B., Higashimori, T., Kim, D.-W., Liu, Z.-X., Soos, T. J., Cline, G. W., O’Brien, W. R., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422230 · Cited by 500 · see citing works
Sullivan, J. E., Brocklehurst, K. J., Marley, A. E., Carey, F., Carling, D., & Beri, R. K. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01006-4 · Cited by 488 · see citing works
Yang, X., Lü, X., Lombès, M., Rha, G. B., Chi, Y., Guerin, T. M., Smart, E. J., & Liu, J. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.003 · Cited by 482 · see citing works
Koves, T. R., Li, P., An, J., Akimoto, T., Slentz, D., Ilkayeva, O., Dohm, G. L., Yan, Z., Newgard, C. B., & Muoio, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507621200 · Cited by 464 · see citing works
AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5
McGee, S. L., van Denderen, B. J. W., Howlett, K. F., Mollica, J., Schertzer, J. D., Kemp, B. E., & Hargreaves, M. (2008) · Diabetes · doi:10.2337/db07-0843 · Cited by 455 · see citing works
Two pathways for lysophosphatidic acid production
Aoki, J. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.06.005 · Cited by 451 · see citing works
Imaging of Lipid Biosynthesis: How a Neutral Lipid Enters Lipid Droplets
Kuerschner, L., Moessinger, C., & Thiele, C. (2008) · Traffic · doi:10.1111/j.1600-0854.2007.00689.x · Cited by 411 · see citing works
Regulation of Insulin Action by Ceramide
Stratford, S., Hoehn, K. L., Liu, F., & Summers, S. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406499200 · Cited by 410 · see citing works
Schenk, S., & Horowitz, J. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30566 · Cited by 407 · see citing works
Dietary fats and membrane function: implications for metabolism and disease
Hulbert, A. J., Turner, N. A., Storlien, L. H., & Else, P. L. (2005) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1017/s1464793104006578 · Cited by 406 · see citing works
Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance
Amati, F., Dubé, J. J., Alvarez-Carnero, E., Edreira, M. M., Chomentowski, P., Coen, P. M., Switzer, G. E., Bickel, P. E., Stefanovic-Racic, M., Toledo, F. G. S., et al. (2011) · Diabetes · doi:10.2337/db10-1221 · Cited by 395 · see citing works
Stone, S. J., Levin, M. C., Zhou, P., Han, J., Walther, T. C., & Farese, R. V. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805768200 · Cited by 390 · see citing works
Thermodynamics and Mechanics of Membrane Curvature Generation and Sensing by Proteins and Lipids
Baumgart, T., Capraro, B. R., Zhu, C., & Das, S. L. (2011) · Annual Review of Physical Chemistry · doi:10.1146/annurev.physchem.012809.103450 · Cited by 381 · see citing works
Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects
Reyna, S. M., Ghosh, S., Tantiwong, P., Meka, C. S. R., Eagan, P. A., Jenkinson, C. P., Cersósimo, E., DeFronzo, R. A., Coletta, D. K., Sriwijitkamol, A., et al. (2008) · Diabetes · doi:10.2337/db08-0038 · Cited by 381 · see citing works
Dubé, J. J., Amati, F., Stefanovic-Racic, M., Toledo, F. G. S., Sauers, S. E., & Goodpaster, B. H. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00769.2007 · Cited by 378 · see citing works
Ussher, J. R., Koves, T. R., Cadete, V. J. J., Zhang, L., Jaswal, J. S., Swyrd, S. J., Lopaschuk, D. G., Proctor, S. D., Keung, W., Muoio, D. M., et al. (2010) · Diabetes · doi:10.2337/db09-1293 · Cited by 363 · see citing works
Bruce, C. R., Hoy, A. J., Turner, N., Watt, M. J., Allen, T. L., Carpenter, K., Cooney, G. J., Febbraio, M. A., & Kraegen, E. W. (2009) · Diabetes · doi:10.2337/db08-1078 · Cited by 363 · see citing works
Self-citationAn update on sphingosine-1-phosphate and other sphingolipid mediators
Fyrst, H., & Saba, J. D. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.392 · Cited by 344 · see citing works
Ye, J., Doyle, P. J., Iglesias, M. A., Watson, D. G., Cooney, G. J., & Kraegen, E. W. (2001) · Diabetes · doi:10.2337/diabetes.50.2.411 · Cited by 343 · see citing works
Lipid metabolic enzymes: emerging drug targets for the treatment of obesity
Shi, Y., & Burn, P. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1469 · Cited by 333 · see citing works
Choi, C. S., Savage, D. B., Abu-Elheiga, L., Liu, Z.-X., Kim, S., Kulkarni, A., Distefano, A., Hwang, Y.-J., Reznick, R. M., Codella, R., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706794104 · Cited by 325 · see citing works
OXPAT/PAT-1 Is a PPAR-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization
Wolins, N. E., Quaynor, B. K., Skinner, J. R., Tzekov, A., Croce, M. A., Gropler, M. C., Varma, V., Yao‐Borengasser, A., Rasouli, N., Kern, P. A., et al. (2006) · Diabetes · doi:10.2337/db06-0399 · Cited by 324 · see citing works
Glycerolipid Metabolism and Signaling in Health and Disease
Prentki, M., & Madiraju, S. R. M. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0007 · Cited by 322 · see citing works
Dynamic Activity of Lipid Droplets: Protein Phosphorylation and GTP-Mediated Protein Translocation
Bartz, R., Zehmer, J. K., Zhu, M., Chen, Y., Serrero, G., Zhao, Y., & Liu, P. (2007) · Journal of Proteome Research · doi:10.1021/pr070158j · Cited by 316 · see citing works
Hornberger, T. A., Chu, W. K., Mak, Y. W., Hsiung, J. W., Huang, S. A., & Chien, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600678103 · Cited by 312 · see citing works
Regulation of sphingosine kinase and sphingolipid signaling
Pitson, S. M. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.08.001 · Cited by 307 · see citing works
Listenberger, L. L., Ostermeyer‐Fay, A. G., Goldberg, E. B., Brown, W. J., & Brown, D. A. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700359-jlr200 · Cited by 301 · see citing works
Pharmacological Inhibition of Glucosylceramide Synthase Enhances Insulin Sensitivity
Aerts, J. M. F. G., Ottenhoff, R., Powlson, A., Grefhorst, A., van Eijk, M., Dubbelhuis, P. F., Aten, J., Kuipers, F., Serlie, M. J. M., Wennekes, T., et al. (2007) · Diabetes · doi:10.2337/db06-1619 · Cited by 301 · see citing works
Yang, G., Badeanlou, L., Bielawski, J., Roberts, A. J., Hannun, Y. A., & Samad, F. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.91014.2008 · Cited by 295 · see citing works
Miyoshi, H., Perfield, J. W., Souza, S. C., Shen, W., Zhang, H., Stancheva, Z. S., Kraemer, F. B., Obin, M. S., & Greenberg, A. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605770200 · Cited by 293 · see citing works
Ceramide‐rich platforms in transmembrane signaling
Stancevic, B., & Kolesnick, R. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.02.026 · Cited by 291 · see citing works
Taschler, U., Radner, F. P. W., Heier, C., Schreiber, R., Schweiger, M., Schoiswohl, G., Preiss-Landl, K., Jaeger, D., Reiter, B., Köfeler, H. C., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.215434 · Cited by 284 · see citing works
Bergeron, R., Previs, S. F., Cline, G. W., Perret, P., Russell, R. R., Young, L. H., & Shulman, G. I. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1076 · Cited by 280 · see citing works
Wang, H., Bell, M., Sreenevasan, U., Hu, H., Liu, J., Dalen, K. T., Londos, C., Yamaguchi, T., Rizzo, M. A., Coleman, R., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.207779 · Cited by 279 · see citing works
Long-Chain Acyl-Coa Synthetases And Fatty Acid Channeling
Mashek, D. G., Li, L. O., & Coleman, R. (2007) · Future Lipidology · doi:10.2217/17460875.2.4.465 · Cited by 279 · see citing works
Seifert, E. L., Estey, C., Xuan, J. Y., & Harper, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.026203 · Cited by 278 · see citing works
Altered Adipose and Plasma Sphingolipid Metabolism in Obesity
Samad, F., Hester, K. D., Yang, G., Hannun, Y. A., & Bielawski, J. (2006) · Diabetes · doi:10.2337/db06-0330 · Cited by 276 · see citing works
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK
Watt, M. J., Dzamko, N. L., Thomas, W. G., Rose‐John, S., Ernst, M., Carling, D., Kemp, B. E., Febbraio, M. A., & Steinberg, G. R. (2006) · Nature Medicine · doi:10.1038/nm1383 · Cited by 275 · see citing works
1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo.
Turinsky, J., O'Sullivan, D. M., & Bayly, B. P. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44844-7 · Cited by 269 · see citing works
TIP47 functions in the biogenesis of lipid droplets
Bulankina, A. V., Deggerich, A., Wenzel, D., Mutenda, K. E., Wittmann, J., Rudolph, M. G., Burger, K. N. J., & Höning, S. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200812042 · Cited by 268 · see citing works
The Effect of Aging on Human Skeletal Muscle Mitochondrial and Intramyocellular Lipid Ultrastructure
Crane, J. D., Devries, M. C., Safdar, A., Hamadeh, M. J., & Tarnopolsky, M. A. (2010) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp179 · Cited by 262 · see citing works
Neschen, S., Morino, K., Hammond, L. E., Zhang, D., Liu, Z.-X., Romanelli, A. J., Cline, G. W., Pongratz, R. L., Zhang, X.-M., Choi, C. S., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.006 · Cited by 261 · see citing works
A Novel Function for Fatty Acid Translocase (FAT)/CD36
Campbell, S. E., Tandon, N. N., Woldegiorgis, G., Luiken, J. J. F. P., Glatz, J. F. C., & Bonen, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400566200 · Cited by 259 · see citing works
Strączkowski, M., Kowalska, I., Nikołajuk, A., Dzienis-Straczkowska, S., Kinalska, I., Baranowski, M., Żendzian‐Piotrowska, M., Brzezinska, Z., & Górski, J. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1215 · Cited by 258 · see citing works
Lee, K., Kerner, J., & Hoppel, C. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.228692 · Cited by 254 · see citing works
Montell, E., Turini, M., Marotta, M., Roberts, M., Noé, V., Ciudad, C. J., Macé, K., & Gómez-Foix, A. M. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.2.e229 · Cited by 245 · see citing works
Kim, J. K., Gimeno, R. E., Higashimori, T., Kim, H., Choi, H., Punreddy, S., Mozell, R. L., Tan, G., Stricker‐Krongrad, A., Hirsch, D. J., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18917 · Cited by 244 · see citing works
Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue
Watt, M. J., Holmes, A. G., Pinnamaneni, S. K., GARNHAM, A. P., Steinberg, G. R., Kemp, B. E., & Febbraio, M. A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00361.2005 · Cited by 241 · see citing works
van Loon, L. J. C., Koopman, R., Manders, R., van der Weegen, W., van Kranenburg, G. P., & Keizer, H. A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00464.2003 · Cited by 239 · see citing works
Roepstorff, C., Thiele, M., Hillig, T., Pilegaard, H., Richter, E. A., Wojtaszewski, J. F. P., & Kiens, B. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.108720 · Cited by 238 · see citing works
Zhao, H., Przybylska, M., Wu, I., Zhang, J., Siegel, C., Komarnitsky, S., Yew, N. S., & Cheng, S. H. (2007) · Diabetes · doi:10.2337/db06-0719 · Cited by 238 · see citing works
LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues
Dalen, K. T., Dahl, T. B., Holter, E., Arntsen, B. M., Londos, C., Sztalryd, C., & Nebb, H. I. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.11.011 · Cited by 236 · see citing works
Adipocyte Protein S3-12 Coats Nascent Lipid Droplets
Wolins, N. E., Skinner, J. R., Schoenfish, M. J., Tzekov, A., Bensch, K. G., & Bickel, P. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304025200 · Cited by 235 · see citing works
Chibalin, A. V., Leng, Y., Vieira, E., Krook, A., Björnholm, M., Long, Y. C., Kotova, O., Zhong, Z., Sakane, F., Steiler, T., et al. (2008) · Cell · doi:10.1016/j.cell.2007.12.035 · Cited by 232 · see citing works
Coen, P. M., Dubé, J. J., Amati, F., Stefanović-Račić, M., Ferrell, R. E., Toledo, F. G. S., & Goodpaster, B. H. (2009) · Diabetes · doi:10.2337/db09-0988 · Cited by 229 · see citing works
O’Neil, T. K., Duffy, L. R., Frey, J. W., & Hornberger, T. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.173609 · Cited by 227 · see citing works
Fat content in individual muscle fibers of lean and obese subjects.
Malenfant, P., Joanisse, D., Thériault, R., Goodpaster, B., Kelley, D., & Simoneau, J.-A. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801733 · Cited by 227 · see citing works
Interactions of Perilipin-5 (Plin5) with Adipose Triglyceride Lipase
Granneman, J. G., Moore, H. P., Mottillo, E. P., Zhu, Z., & Zhou, L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.180711 · Cited by 222 · see citing works
Dalen, K. T., Schoonjans, K., Ulven, S. M., Weedon-Fekjær, M. S., Bentzen, T. G., Koutníková, H., Auwerx, J. H., & Nebb, H. I. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1243 · Cited by 212 · see citing works
Kim, J. K., Gimeno, R. E., Higashimori, T., Kim, H., Choi, H., Punreddy, S., Mozell, R. L., Tan, G., Stricker‐Krongrad, A., Hirsch, D. J., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200418917 · Cited by 212 · see citing works
Zhang, H., Wang, Y., Li, J., Yu, J., Pu, J., Li, L., Zhang, H., Zhang, S., Gong, P., Yang, F., et al. (2011) · Journal of Proteome Research · doi:10.1021/pr200553c · Cited by 211 · see citing works
JeBailey, L., Wanono, O., Niu, W., Roessler, J., Rudich, A., & Klip, A. (2007) · Diabetes · doi:10.2337/db06-0823 · Cited by 209 · see citing works
Ceramide and ceramide 1-phosphate in health and disease
Arana, L., Gangoiti, P., Ouro, A., Trueba, M., & Gómez‐Muñoz, A. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-15 · Cited by 205 · see citing works
Long-term synaptic changes induced in the cerebellar cortex by fear conditioning.
Sacchetti, B., Scelfo, B., Tempia, F., & Strata, P. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.012 · Cited by 201 · see citing works
Gaidhu, M. P., Fediuc, S., Anthony, N. M., So, M., Mirpourian, M., Perry, R. L. S., & Ceddia, R. B. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800480-jlr200 · Cited by 200 · see citing works
Nickerson, J. G., Alkhateeb, H. H., Benton, C. R., Lally, J., Nickerson, J., Han, X.-X., Wilson, M. H., Jain, S. S., Snook, L. A., Glatz, J. F. C., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.004788 · Cited by 197 · see citing works
Turró, S., Ingelmo‐Torres, M., Estanyol, J. M., Tebar, F., Fernandez-Rojo, M. A., Albor, C. V., Gaus, K., Grewal, T., Enrich, C., & Pol, A. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00465.x · Cited by 193 · see citing works
Mashek, D. G., Li, L. O., & Coleman, R. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600150-jlr200 · Cited by 192 · see citing works
Parizi, M., Howard, E. W., & Tomasek, J. J. (2000) · Experimental Cell Research · doi:10.1006/excr.1999.4754 · Cited by 188 · see citing works
Servetnick, D. A., Brasaemle, D., Gruia-Gray, J., Kimmel, A. R., Wolff, J., & Londos, C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16970 · Cited by 187 · see citing works
Functional differences in lipid metabolism in resting skeletal muscle of various fiber types
Dyck, D. J., Peters, S. J., Glatz, J. F. C., Górski, J., KEIZER, H. A., Kiens, B., Liu, S., Richter, E. A., Spriet, L. L., Vusse, G. J., et al. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.272.3.e340 · Cited by 186 · see citing works
Wang, H., Hu, L., Dalen, K. T., Dorward, H. M., Marcinkiewicz, A., Russell, D. L., Gong, D., Londos, C., Yamaguchi, T., Holm, C., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.006726 · Cited by 167 · see citing works
Pyruvate dehydrogenase activity and acetyl group accumulation during exercise after different diets
Putman, C. T., Spriet, L. L., Hultman, E., Lindinger, M. I., Lands, L. C., McKelvie, R. S., Cederblad, G., Jones, N. L., & Heigenhauser, G. J. F. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.5.e752 · Cited by 166 · see citing works
Regulation and function of triacylglycerol lipases in cellular metabolism
Watt, M. J., & Steinberg, G. R. (2008) · Biochemical Journal · doi:10.1042/bj20080305 · Cited by 165 · see citing works
Lipins: Multifunctional Lipid Metabolism Proteins
Csaki, L. S., & Reue, K. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104729 · Cited by 164 · see citing works
Perdomo, G., Commerford, S. R., Richard, A.-M. T., Adams, S. H., Corkey, B. E., O'Doherty, R. M., & Brown, N. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403566200 · Cited by 158 · see citing works
Effects of Weight Loss and Physical Activity on Muscle Lipid Content and Droplet Size
He, J., Goodpaster, B. H., & Kelley, D. E. (2004) · Obesity Research · doi:10.1038/oby.2004.92 · Cited by 154 · see citing works
Veverka, V., Crabbe, T., Bird, I., Lennie, G., Muskett, F. W., Taylor, R. J., & Carr, M. D. (2007) · Oncogene · doi:10.1038/sj.onc.1210693 · Cited by 154 · see citing works
Entry of muscle satellite cells into the cell cycle requires sphingolipid signaling
Nagata, Y., Partridge, T. A., Matsuda, R., & Zammit, P. S. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200605028 · Cited by 153 · see citing works
Anderson, E. J., Yamazaki, H., & Neufer, P. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706129200 · Cited by 151 · see citing works
McFie, P. J., Banman, S. L., Kary, S., & Stone, S. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.256008 · Cited by 149 · see citing works
Huijsman, E., van de Par, C., Economou, C., van der Poel, C., Lynch, G. S., Schoiswohl, G., Haemmerle, G., Zechner, R., & Watt, M. J. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00190.2009 · Cited by 145 · see citing works
Benton, C. R., Holloway, G. P., Han, X.-X., Yoshida, Y., Snook, L. A., Lally, J., Glatz, J. F. C., Luiken, J. J. F. P., Chabowski, A., & Bonen, A. (2010) · Diabetologia · doi:10.1007/s00125-010-1773-1 · Cited by 143 · see citing works
Joseph, C. K., Wright, S. D., BORNMANN, W. G., Randolph, J. T., Kumar, E. R., Bittman, R., Liu, J., & Kolesnick, R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32484-5 · Cited by 142 · see citing works
Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease
Gangoiti, P., Camacho, L., Arana, L., Ouro, A., Granado, M. H., Brizuela, L., Casas, J., Fabriàs, G., Abad, J. L., Delgado, A., et al. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.02.004 · Cited by 140 · see citing works
Network distribution of mitochondria and lipid droplets in human muscle fibres
Shaw, C. S., Jones, D. A., & Wagenmakers, A. J. M. (2007) · Histochemistry and Cell Biology · doi:10.1007/s00418-007-0349-8 · Cited by 140 · see citing works
Granneman, J. G., Moore, H. H., Mottillo, E. P., & Zhu, Z. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m808251200 · Cited by 139 · see citing works
Modulation of Pro-inflammatory Gene Expression by Nuclear Lysophosphatidic Acid Receptor Type-1
Gobeil, F., Bernier, S. G., Vazquez‐Tello, A., Brault, S., Beauchamp, M., Quiniou, C., Marrache, A. M., Checchin, D., Sennlaub, F., Hou, X., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212481200 · Cited by 137 · see citing works
Fischer, H., Ellström, P., Ekström, K., Gustafsson, L., Gustafsson, M. C. U., & Svanborg, C. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00867.x · Cited by 136 · see citing works
Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans
Badin, P.-M., Louche, K., Mairal, A., Liebisch, G., Schmitz, G., Rustan, A. C., Smith, S. R., Langin, D., & Moro, C. (2011) · Diabetes · doi:10.2337/db10-1364 · Cited by 132 · see citing works
Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells
Sebastián, D., Guitart, M., Garcia‐Martínez, C., Mauvezin, C., Orellana‐Gavaldà, J. M., Serra, D., Gómèz‐Foix, A. M., Hegardt, F. G., & Asins, G. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800535-jlr200 · Cited by 131 · see citing works
Pigment Epithelium–Derived Factor Regulates Lipid Metabolism via Adipose Triglyceride Lipase
Borg, M. L., Andrews, Z. B., Duh, E. J., Zechner, R., Meikle, P. J., & Watt, M. J. (2011) · Diabetes · doi:10.2337/db10-0845 · Cited by 128 · see citing works
Vaag, A., Skött, P., Damsbo, P., Gall, M. A., Richter, E. A., & Beck-Nielsen, H. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115432 · Cited by 123 · see citing works
Roepstorff, C., Donsmark, M., Thiele, M., Vistisen, B., Stewart, G., Vissing, K., Schjerling, P., Hardie, D. G., Galbo, H., & Kiens, B. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00097.2006 · Cited by 118 · see citing works
Turban, S., & Hajduch, É. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.12.022 · Cited by 116 · see citing works
Sphingosine 1‐phosphate regulates myogenic differentiation: a major role for S1P 2 receptor
Donati, C., Meacci, E., Nuti, F., Becciolini, L., Farnararo, M., & Bruni, P. (2004) · The FASEB Journal · doi:10.1096/fj.04-1780fje · Cited by 115 · see citing works
Blouin, C. M., Prado, C., Takane, K. K., Lasnier, F., Garcı́a-Ocaña, A., Ferré, P., Dugail, I., & Hajduch, É. (2009) · Diabetes · doi:10.2337/db09-0897 · Cited by 115 · see citing works
LIPID SYNTHESIS, INTRACELLULAR TRANSPORT, AND STORAGE
Stein, O., & Stein, Y. (1968) · The Journal of Cell Biology · doi:10.1083/jcb.36.1.63 · Cited by 114 · see citing works
Summermatter, S., Baum, O., Santos, G., Hoppeler, H. H., & Handschin, C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.145995 · Cited by 114 · see citing works
Egan, J. J., Greenberg, A. S., Chang, M. K., & Londos, C. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30578-1 · Cited by 113 · see citing works
Huang, H., Kasumov, T., Gatmaitan, P., Heneghan, H., Kashyap, S. R., Schauer, P. R., Brethauer, S. A., & Kirwan, J. P. (2011) · Obesity · doi:10.1038/oby.2011.107 · Cited by 113 · see citing works
Inhibition of ADRP prevents diet-induced insulin resistance
Varela, G. M., Antwi, D. A., Dhir, R. N., Yin, X., Singhal, N. S., Graham, M. J., Crooke, R. M., & Ahima, R. S. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90204.2008 · Cited by 111 · see citing works
The effects of sphingosine on sarcoplasmic reticulum membrane calcium release.
Sabbadini, R. A., Betto, R., Teresi, A., Fachechi-Cassano, G., & Salviati, G. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49559-8 · Cited by 110 · see citing works
Kinetics of intramuscular triglyceride fatty acids in exercising humans
Guo, Z., Burguera, B., & Jensen, M. D. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.5.2057 · Cited by 110 · see citing works
Boon, H., Bosselaar, M., Praet, S., Blaak, E. E., Saris, W. H. M., Wagenmakers, A. J. M., McGee, S. L., Tack, C. J., Smits, P., Hargreaves, M., et al. (2008) · Diabetologia · doi:10.1007/s00125-008-1108-7 · Cited by 108 · see citing works
Formigli, L., Sassoli, C., Squecco, R., Bini, F., Martinesi, M., Chellini, F., Luciani, G., Sbrana, F., Zecchi‐Orlandini, S., Francini, F., et al. (2009) · Journal of Cell Science · doi:10.1242/jcs.035402 · Cited by 108 · see citing works
Fatty acids as substrates for heart and skeletal muscle.
Zierler, K. L. (1976) · Circulation Research · doi:10.1161/01.res.38.6.459 · Cited by 108 · see citing works
Sathyanarayana, P., Barthwal, M. K., Kundu, C. N., Lane, M. E., Bergmann, A., Tzivion, G., & Rana, A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00734-7 · Cited by 107 · see citing works
Sphingolipid Metabolism, Oxidant Signaling, and Contractile Function of Skeletal Muscle
Nikolova‐Karakashian, M., & Reid, M. B. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3940 · Cited by 106 · see citing works
Prats, C., Donsmark, M., Qvortrup, K., Londos, C., Sztalryd, C., Holm, C., Galbo, H., & Ploug, T. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600247-jlr200 · Cited by 105 · see citing works
Minnaard, R., Schrauwen, P., Schaart, G., Jörgensen, J. A., Lenaers, E., Mensink, M., & Hesselink, M. K. C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0352 · Cited by 104 · see citing works
Dyck, D. J., Steinberg, G. R., & Bonen, A. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.3.e600 · Cited by 104 · see citing works
Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance
Röhl, M., Pasparakis, M., Baudler, S., Baumgartl, J., Gautam, D., Huth, M., Lorenzi, R. D., Krone, W., Rajewsky, K., & Brüning, J. C. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18712 · Cited by 103 · see citing works
Smith, B. K., Jain, S., Rimbaud, S., Dam, A. D., Quadrilatero, J., Ventura‐Clapier, R., Bonen, A., & Holloway, G. P. (2011) · Biochemical Journal · doi:10.1042/bj20101861 · Cited by 102 · see citing works
Luquet, S. H., López‐Soriano, J., Holst, D., Gaudel, C., Jehl-Piétri, C., Fredenrich, A., & Grimaldi, P. A. (2004) · Biochimie · doi:10.1016/j.biochi.2004.09.024 · Cited by 97 · see citing works
Watson, M., Coghlan, M. P., & Hundal, H. S. (2008) · Biochemical Journal · doi:10.1042/bj20081149 · Cited by 93 · see citing works
Kanaley, J. A., Shadid, S., Sheehan, M. T., Guo, Z., & Jensen, M. D. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.180695 · Cited by 92 · see citing works
Muscle contraction increases palmitate esterification and oxidation and triacylglycerol oxidation
Dyck, D. J., & Bonen, A. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.5.e888 · Cited by 89 · see citing works
Regulation of Visceral and Subcutaneous Adipocyte Lipolysis by Acute AICAR‐induced AMPK Activation
Anthony, N. M., Gaidhu, M. P., & Ceddia, R. B. (2009) · Obesity · doi:10.1038/oby.2008.645 · Cited by 89 · see citing works
Bell, J. A., Reed, M. A., Consitt, L. A., Martin, O. J., Haynie, K. R., Hulver, M. W., Muoio, D. M., & Dohm, G. L. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1596 · Cited by 87 · see citing works
Hu, W. M., Bielawski, J., Samad, F., Merrill, A. H., & Cowart, L. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800635-jlr200 · Cited by 87 · see citing works
Watt, M. J., Hevener, A. L., Lancaster, G. I., & Febbraio, M. A. (2006) · Endocrinology · doi:10.1210/en.2005-1074 · Cited by 87 · see citing works
Thyfault, J. P., Cree, M. G., Zheng, D., Zwetsloot, J. J., Tapscott, E. B., Koves, T. R., Ilkayeva, O., Wolfe, R. R., Muoio, D. M., & Dohm, G. L. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00311.2006 · Cited by 87 · see citing works
Devries, M. C., Lowther, S. A., Glover, A. W., Hamadeh, M. J., & Tarnopolsky, M. A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00510.2007 · Cited by 87 · see citing works
Spiegelhalter, C., Tosch, V., Hentsch, D., Koch, M., Kessler, P., Schwab, Y., & Laporte, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009014 · Cited by 83 · see citing works
Hatch, G. M., Smith, A. J., Xu, F. Y., Hall, A. M., & Bernlohr, D. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200130-jlr200 · Cited by 83 · see citing works
Sarbassov, D. D., Jones, L. G., & Peterson, C. A. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.13.0036 · Cited by 82 · see citing works
Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor
Rapizzi, E., Taddei, M. L., Fiaschi, T., Donati, C., Bruni, P., & Chiarugi, P. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0106-3 · Cited by 81 · see citing works
Intramuscular fatty acid metabolism in contracting and non‐contracting human skeletal muscle
Sacchetti, M., Saltin, B., Osada, T., & van Hall, G. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013912 · Cited by 81 · see citing works
Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance
Röhl, M., Pasparakis, M., Baudler, S., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200418712 · Cited by 81 · see citing works
Kim, H. J., Lee, J. S., & Kim, C. K. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-004-1214-2 · Cited by 79 · see citing works
Malenfant, P., Tremblay, A., Doucet, É., Imbeault, P., Simoneau, J., & Joanisse, D. R. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.4.e632 · Cited by 78 · see citing works
Watt, M. J., Heigenhauser, G. J. F., & Spriet, L. L. (2002) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00301.x · Cited by 77 · see citing works
Holloway, G. P., Jain, S., Bézaire, V., Han, X. X., Glatz, J. F. C., Luiken, J. J. F. P., Harper, M., & Bonen, A. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.91021.2008 · Cited by 77 · see citing works
Aas, V., Kase, E. T., Solberg, R., Jensen, J., & Rustan, A. C. (2004) · Diabetologia · doi:10.1007/s00125-004-1465-9 · Cited by 76 · see citing works
Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation
Kaiser, C., & James, S. R. (2004) · BMC Biology · doi:10.1186/1741-7007-2-23 · Cited by 74 · see citing works
Wensaas, A. J., Rustan, A. C., Just, M., Berge, R. K., Drevon, C. A., & Gaster, M. (2009) · Diabetes · doi:10.2337/db08-1043 · Cited by 73 · see citing works
Effects of epinephrine on lipid metabolism in resting skeletal muscle
Peters, S. J., Dyck, D. J., Bonen, A., & Spriet, L. L. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.2.e300 · Cited by 72 · see citing works
Deficiency of the Mitochondrial Electron Transport Chain in Muscle Does Not Cause Insulin Resistance
Han, D.-H., Hancock, C. R., Jung, S. R., Higashida, K., Kim, S. H., & Holloszy, J. O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019739 · Cited by 71 · see citing works
Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts
Gangoiti, P., Bernacchioni, C., Donati, C., Cencetti, F., Ouro, A., Gómez‐Muñoz, A., & Bruni, P. (2011) · Biochimie · doi:10.1016/j.biochi.2011.09.009 · Cited by 71 · see citing works
Pleiotropic effects of sphingolipids in skeletal muscle
Bruni, P., & Donati, C. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8236-6 · Cited by 68 · see citing works
Bourron, O., Daval, M., Hainault, I., Hajduch, É., Servant, J. M., Gautier, J. F., Ferré, P., & Foufelle, F. (2009) · Diabetologia · doi:10.1007/s00125-009-1639-6 · Cited by 66 · see citing works
Watt, M. J., Heigenhauser, G. J. F., & Spriet, L. L. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.034595 · Cited by 64 · see citing works
Self-citationSerra, C., Federici, M., Buongiorno, A. M., Senni, M., Morelli, S., Segratella, E., Pascuccio, M., Tiveron, C., Mattei, E., Tatangelo, L., et al. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10278 · Cited by 62 · see citing works
Adipophilin distribution and colocalisation with lipid droplets in skeletal muscle
Shaw, C. S., Sherlock, M., Stewart, P. M., & Wagenmakers, A. J. M. (2009) · Histochemistry and Cell Biology · doi:10.1007/s00418-009-0558-4 · Cited by 59 · see citing works
Exercise increases plasma levels of sphingoid base‐1 phosphates in humans
Baranowski, M., Charmas, M., Długołęcka, B., & Górski, J. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02322.x · Cited by 58 · see citing works
Badimón, L., Rodrı́guez, C., González-Díez, M., & Martínez‐González, J. (2009) · Thrombosis and Haemostasis · doi:10.1160/th08-10-0675 · Cited by 56 · see citing works
Luiken, J. J. F. P., Koonen, D. P. Y., Coumans, W. A., Pelsers, M. M. A. L., Binas, B., Bonen, A., & Glatz, J. F. C. (2003) · Lipids · doi:10.1007/s11745-003-1089-6 · Cited by 54 · see citing works
Lysophosphatidic acid regulates blood glucose by stimulating myotube and adipocyte glucose uptake
Yea, K., Kim, J. J., Lim, S., Park, H. S., Park, K. S., Suh, P., & Ryu, S. H. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0269-z · Cited by 52 · see citing works
High triacylglycerol turnover rate in human skeletal muscle
Sacchetti, M., Saltin, B., Olsen, D. B., & van Hall, G. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.075135 · Cited by 50 · see citing works
Furler, S. M., Cooney, G. J., Hegarty, B. D., Lim-Fraser, M., Kraegen, E. W., & Oakes, N. D. (2000) · Diabetes · doi:10.2337/diabetes.49.9.1427 · Cited by 50 · see citing works
Sphingosine 1-phosphate evokes calcium signals in C2C12 myoblasts via Edg3 and Edg5 receptors
Meacci, E., Cencetti, F., Formigli, L., Squecco, R., Donati, C., Tiribilli, B., Quercioli, F., Orlandini, S. Z., Francini, F., & Bruni, P. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3620349 · Cited by 48 · see citing works
Sphingolipids: the nexus between Gaucher disease and insulin resistance
Fuller, M. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-113 · Cited by 47 · see citing works
Meacci, E., Bini, F., Sassoli, C., Martinesi, M., Squecco, R., Chellini, F., Zecchi‐Orlandini, S., Francini, F., & Formigli, L. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0442-3 · Cited by 45 · see citing works
Lysophosphatidic acid mediates pleiotropic responses in skeletal muscle cells
Jean-Baptiste, G., Yang, Z., Khoury, C., & Greenwood, M. T. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.011 · Cited by 43 · see citing works
Trafficking of Dietary Fat in Lean Rats
Bessesen, D. H., Rupp, C. L., & Eckel, R. H. (1995) · Obesity Research · doi:10.1002/j.1550-8528.1995.tb00135.x · Cited by 42 · see citing works
Meacci, E., Donati, C., Cencetti, F., Romiti, E., & Bruni, P. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02039-1 · Cited by 40 · see citing works
mTOR function in skeletal muscle: a focal point for overnutrition and exercise
Rivas, D. A., Lessard, S. J., & Coffey, V. G. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-073 · Cited by 40 · see citing works
Digel, M., Staffer, S., Ehehalt, F., Stremmel, W., Ehehalt, R., & Füllekrug, J. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00079.2011 · Cited by 37 · see citing works
Effect of exercise duration on the key pathways of ceramide metabolism in rat skeletal muscles
Błachnio-Zabielska, A. U., Baranowski, M., Zabielski, P., & Górski, J. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21877 · Cited by 35 · see citing works
Shearer, J., Fueger, P. T., Rottman, J. N., Bracy, D. P., Binas, B., & Wasserman, D. H. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00287.2004 · Cited by 33 · see citing works
Jeppesen, J. F., Mogensen, M., Prats, C., Sahlin, K., Madsen, K., & Kiens, B. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m003756 · Cited by 33 · see citing works
Adipophilin protein expression in muscle – a possible protective role against insulin resistance
de Wilde, J., Smit, E., Snepvangers, F. J. M., de Wit, N. J. W., Mohren, R., Hulshof, M. F. M., & Mariman, E. C. M. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07525.x · Cited by 31 · see citing works
Dobrzyń, A., & Górski, J. (2002) · Hormone and Metabolic Research · doi:10.1055/s-2002-34793 · Cited by 31 · see citing works
Seifert, E. L., Fiehn, O., Bézaire, V., Bickel, D. R., Wohlgemuth, G., Adams, S. H., & Harper, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009834 · Cited by 30 · see citing works
Mechanisms of the lysophosphatidic acid‐induced increase in [Ca2+]iin skeletal muscle cells
Xu, Y., Tappia, P. S., Goyal, R. K., & Dhalla, N. S. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00139.x · Cited by 29 · see citing works
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Single-Cell Transcriptome Atlas of Murine Endothelial Cells
Kalucka, J. M., de Rooij, L. P. M. H., Goveia, J., Rohlenová, K., Dumas, S. J., Meta, E., Conchinha, N. V., Taverna, F., Teuwen, L.-A. M. N., Veys, K., et al. (2020) · Cell · doi:10.1016/j.cell.2020.01.015 · Cited by 1,362 · see citing works
Sugar consumption, metabolic disease and obesity: The state of the controversy
Stanhope, K. L. (2016) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2015.1084990 · Cited by 739 · see citing works
Lipids, lysosomes, and autophagy
Jaishy, B. P., & Abel, E. D. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r067520 · Cited by 229 · see citing works
Fatty acid metabolism, energy expenditure and insulin resistance in muscle.
Turner, N., Cooney, G., Kraegen, E., & Bruce, C. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0397 · Cited by 203 · see citing works
Lipotoxicity in Kidney, Heart, and Skeletal Muscle Dysfunction
Nishi, H., Higashihara, T., & Inagi, R. (2019) · Nutrients · doi:10.3390/nu11071664 · Cited by 174 · see citing works
Simvastatin Effects on Skeletal Muscle
Larsen, S., Stride, N., Hey-Mogensen, M., Hansen, C. N., Bang, L. E., Bundgaard, H., Nielsen, L. B., Helge, J. W., & Dela, F. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.09.036 · Cited by 165 · see citing works
Kemp, G. J., Ahmad, R. E., Nicolay, K., & Prompers, J. (2015) · Acta Physiologica · doi:10.1111/apha.12307 · Cited by 149 · see citing works
Skeletal muscle energy metabolism in obesity
Mengeste, A. M., Rustan, A. C., & Lund, J. (2021) · Obesity · doi:10.1002/oby.23227 · Cited by 141 · see citing works
Low‐volume high‐intensity interval training for cardiometabolic health
Sabag, A., Little, J. P., & Johnson, N. A. (2021) · The Journal of Physiology · doi:10.1113/jp281210 · Cited by 139 · see citing works
Gueugneau, M., Coudy-Gandilhon, C., Théron, L., Meunier, B., Barboiron, C., Combaret, L., Taillandier, D., Polge, C., Attaix, D., Picard, B., et al. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu086 · Cited by 137 · see citing works
Krishnan, S., & Cooper, J. A. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0638-z · Cited by 136 · see citing works
Timpani, C. A., Hayes, A., & Rybalka, E. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.08.015 · Cited by 133 · see citing works
Lipid Peroxidation in Muscle Foods: Impact on Quality, Safety and Human Health
Dragoev, S. G. (2024) · Foods · doi:10.3390/foods13050797 · Cited by 143 · see citing works
Sphingolipid Metabolism: New Insight into Ceramide-Induced Lipotoxicity in Muscle Cells
Bandet, C. L., Tan, S., Bourron, O., Stunff, H. L., & Hajduch, É. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030479 · Cited by 123 · see citing works
PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle
Mason, R. R., Mokhtar, R. A. M., Matzaris, M., Selathurai, A., Kowalski, G. M., Mokbel, N., Meikle, P. J., Bruce, C. R., & Watt, M. J. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.06.002 · Cited by 115 · see citing works
Aging-associated exacerbation in fatty degeneration and infiltration after rotator cuff tear
Gumucio, J. P., Korn, M. A., Saripalli, A. L., Flood, M. D., Phan, A. C., Roche, S. M., Lynch, E. B., Claflin, D. R., Bedi, A., & Mendias, C. L. (2013) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2013.04.011 · Cited by 109 · see citing works
Compartmentalized Acyl-CoA Metabolism in Skeletal Muscle Regulates Systemic Glucose Homeostasis
Li, L. O., Grevengoed, T. J., Paul, D. S., Ilkayeva, O., Koves, T. R., Pascual, F. L., Newgard, C. B., Muoio, D. M., & Coleman, R. (2014) · Diabetes · doi:10.2337/db13-1070 · Cited by 106 · see citing works
Lipid Accumulation in Dysferlin-Deficient Muscles
Grounds, M. D., Terrill, J. R., Radley‐Crabb, H. G., Robertson, T., Papadimitriou, J. M., Spuler, S., & Shavlakadze, T. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.02.005 · Cited by 97 · see citing works
Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis
Gumucio, J. P., Qasawa, A. H., Ferrara, P. J., Malik, A. N., Funai, K., McDonagh, B., & Mendias, C. L. (2019) · The FASEB Journal · doi:10.1096/fj.201802457rr · Cited by 96 · see citing works
Lipid droplet dynamics in skeletal muscle
Bosma, M. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.10.023 · Cited by 91 · see citing works
Goto‐Inoue, N., Yamada, K., Inagaki, A., Furuichi, Y., Ogino, S., Manabe, Y., Setou, M., & FUJII, N. L. (2013) · Scientific Reports · doi:10.1038/srep03267 · Cited by 93 · see citing works
MacPherson, R. E. K., Ramos, S. V., Vandenboom, R., Roy, B. D., & Peters, S. J. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00418.2012 · Cited by 91 · see citing works
Meta‐analysis of genome‐wide DNA methylation and integrative omics of age in human skeletal muscle
Voisin, S. A. C., Jacques, M., Landen, S., Harvey, N. R., Haupt, L. M., Griffiths, L. R., Gancheva, S., Ouni, M., Jähnert, M., Ashton, K. J., et al. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12741 · Cited by 84 · see citing works
Progress and prospects of long noncoding RNAs in lipid homeostasis
Chen, Z. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.12.003 · Cited by 83 · see citing works
Peters, S. J., Samjoo, I. A., Devries, M. C., Stevic, I., Robertshaw, H. A., & Tarnopolsky, M. A. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h2012-059 · Cited by 81 · see citing works
Mori, K. (2021) · Nutrients · doi:10.3390/nu13051538 · Cited by 79 · see citing works
Impact of Adipose Tissue and Lipids on Skeletal Muscle in Sarcopenia
Jang, S. Y., & Choi, K. M. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70000 · Cited by 81 · see citing works
Genetic diseases of the Kennedy pathways for membrane synthesis
Tavasoli, M., Lahire, S., Reid, T. R., Brodovsky, M., & McMaster, C. R. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.013529 · Cited by 74 · see citing works
Phua, W. W. T., Wong, M. X. Y., Liao, Z., & Tan, N. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051425 · Cited by 72 · see citing works
Mitochondrial involvement in skeletal muscle insulin resistance: A case of imbalanced bioenergetics
Affourtit, C. (2016) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2016.07.008 · Cited by 67 · see citing works
Role of ACSL5 in fatty acid metabolism
Luo, Q., Das, A., Oldoni, F., Wu, P., Wang, J., Luo, F., & Fang, Z. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13316 · Cited by 64 · see citing works
Intrinsic aerobic capacity impacts susceptibility to acute high-fat diet-induced hepatic steatosis
Morris, E. M., Jackman, M. R., Johnson, G. C., Cross, T.-W., Lopez, J. L., Kearney, M. L., Fletcher, J. A., Meers, G. M.-E., Koch, L. G., Britton, S. L., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00093.2014 · Cited by 65 · see citing works
Sex-based differences in hepatic and skeletal muscle triglyceride storage and metabolism.
Beaudry, K. M., & Devries, M. (2019) · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · doi:10.1139/apnm-2018-0635 · Cited by 49 · see citing works
Improvement of obesity-linked skeletal muscle insulin resistance by strength and endurance training
Meo, S. D., Iossa, S., & Venditti, P. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0186 · Cited by 62 · see citing works
Origin of breath isoprene in humans is revealed via multi-omic investigations
Sukul, P., Richter, A., Junghanß, C., Schubert, J. K., & Miekisch, W. (2023) · Communications Biology · doi:10.1038/s42003-023-05384-y · Cited by 60 · see citing works
The impact of bed rest on human skeletal muscle metabolism
Eggelbusch, M., Charlton, B. T., Bosutti, A., Ganse, B., Giakoumaki, I., Grootemaat, A. E., Hendrickse, P. W., Jaspers, Y. R. J., Kemp, S., Kerkhoff, T. J., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101372 · Cited by 57 · see citing works
Brockman, D. A., Chen, X., & Gallaher, D. D. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0478-2 · Cited by 56 · see citing works
ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle
Meex, R. C. R., Hoy, A. J., Mason, R. R., Martin, S. D., McGee, S. L., Bruce, C. R., & Watt, M. J. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00598.2014 · Cited by 54 · see citing works
The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation
Nguyen, J. H. V., Chung, J. D., Lynch, G. S., & Ryall, J. G. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00254 · Cited by 52 · see citing works
Reduced efficiency of sarcolipin-dependent respiration in myocytes from humans with severe obesity
Paran, C. W., Verkerke, A. R. P., Heden, T. D., Park, S., Zou, K., Lawson, H. A., Song, H., TURK, J. W., Houmard, J. A., & Funai, K. (2015) · Obesity · doi:10.1002/oby.21123 · Cited by 47 · see citing works
Dubin, R. L., Heymsfield, S. B., Ravussin, E., & Greenway, F. L. (2024) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15913 · Cited by 47 · see citing works
Ngo, S. T., & Steyn, F. J. (2015) · Cell Regeneration · doi:10.1186/s13619-015-0019-6 · Cited by 45 · see citing works
Brockman, D. A., Chen, X., & Gallaher, D. D. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-100 · Cited by 46 · see citing works
Thankamony, A., Capalbo, D., Marcovecchio, M., Sleigh, A., Jørgensen, S. W., Hill, N., Mooslehner, K., Yeo, G., Bluck, L., Juul, A., et al. (2014) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2013-4542 · Cited by 45 · see citing works
Fuxjager, M. J., Lee, J., Chan, T.-M., Bahn, J. H., Chew, J. G., Xiao, X. G., & Schlinger, B. A. (2016) · Molecular Endocrinology · doi:10.1210/me.2015-1270 · Cited by 43 · see citing works
Fatty Acids: Structures and Properties
Lund, J., & Rustan, A. C. (2020) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0029198 · Cited by 44 · see citing works
Role of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism
Stamatikos, A., & Paton, C. M. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00268.2013 · Cited by 44 · see citing works
LSD1 mediates metabolic reprogramming by glucocorticoids during myogenic differentiation
Anan, K., Hino, S., Shimizu, N., Sakamoto, A., Nagaoka, K., Takase, R., Kohrogi, K., Araki, H., Hino, Y., Usuki, S., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky234 · Cited by 41 · see citing works
Obesity‐induced tissue alterations resist weight loss: A mechanistic review
Guardia, L. D., & Shin, A. C. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15637 · Cited by 40 · see citing works
Bakke, S. S., Moro, C., Nikolić, N., Hessvik, N. P., Badin, P.-M., Lauvhaug, L., Fredriksson, K., Hesselink, M. K. C., Boekschoten, M. V., Kersten, S., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.07.001 · Cited by 38 · see citing works
Perilipin 5 mediated lipid droplet remodelling revealed by coherent Raman imaging
Billecke, N., Bosma, M., Rock, W., Fleißner, F., Best, G., Schrauwen, P., Kersten, S., Bonn, M., Hesselink, M. K. C., & Parekh, S. H. (2015) · Integrative Biology · doi:10.1039/c4ib00271g · Cited by 37 · see citing works
Muscle Proteomic and Transcriptomic Profiling of Healthy Aging and Metabolic Syndrome in Men
Gueugneau, M., Coudy‐Gandilhon, C., Chambon, C., Verney, J., Taillandier, D., Combaret, L., Polge, C., Walrand, S., Roche, F., Barthélemy, J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084205 · Cited by 37 · see citing works
A multi-tissue single-cell expression atlas in cattle
Han, B., Li, H., Zheng, W., Zhang, Q., Chen, A., Zhu, S., Shi, T., Wang, F., Zou, D., Yu, S., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02329-5 · Cited by 36 · see citing works
Hao, Y., Feng, Y., Yang, P., Cui, Y., Liu, J., Yang, C., & Gu, X. (2016) · Molecular Genetics and Genomics · doi:10.1007/s00438-016-1242-8 · Cited by 34 · see citing works
Conte, M., Vasuri, F., Bertaggia, E., Armani, A., Santoro, A., Bellavista, E., Degiovanni, A., D’Errico, A., Trisolino, G., Capri, M., et al. (2015) · Biogerontology · doi:10.1007/s10522-014-9549-5 · Cited by 34 · see citing works
Kramerova, I. A., Ermolova, N. V., Eskin, A., Hevener, A. L., Quehenberger, O., Armando, A. M., Haller, R. G., Romain, N., Nelson, S. F., & Spencer, M. J. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw086 · Cited by 34 · see citing works
Novel aspects of PCSK9 and lipoprotein receptors in renal disease-related dyslipidemia
Shrestha, P., van de Sluis, B., Dullaart, R. P. F., & van den Born, J. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.12.001 · Cited by 33 · see citing works
Air Pollution and Insulin Resistance: Do All Roads Lead to Rome?
Kodavanti, U. P. (2015) · Diabetes · doi:10.2337/db14-1682 · Cited by 33 · see citing works
Zhao, L., Pascual, F. L., Bacudio, L. G., Suchanek, A. L., Young, P. A., Li, L. O., Martin, S. A., Camporez, J. P., Perry, R. J., Shulman, G. I., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006790 · Cited by 32 · see citing works
Mikłosz, A., Lukaszuk, B., Baranowski, M., Górski, J., & Chabowski, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0085547 · Cited by 33 · see citing works
Melanocortin-5 Receptor: Pharmacology and Its Regulation of Energy Metabolism
Ji, L., Hong, Y., & Tao, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158727 · Cited by 31 · see citing works
Lund, J., Helle, S. A., Li, Y., Løvsletten, N. G., Stadheim, H. K., Jensen, J., Kase, E. T., Thoresen, G. H., & Rustan, A. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-35715-7 · Cited by 31 · see citing works
Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing
Wilkinson, D. J., Blanco, G. R., Dunn, W. B., Phillips, B. E., Williams, J. P., Greenhaff, P. L., Smith, K., Gallagher, I. J., & Atherton, P. J. (2020) · Aging · doi:10.18632/aging.103513 · Cited by 29 · see citing works
Tarantino, G., Costantini, S., Citro, V., Conforti, P., Capone, F., Sorice, A., & Capone, D. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-018-1754-6 · Cited by 26 · see citing works
Applications of Lipidomics to Age-Related Musculoskeletal Disorders
Mo, C.-L., Du, Y., & O'Connell, T. M. (2021) · Current Osteoporosis Reports · doi:10.1007/s11914-021-00656-0 · Cited by 17 · see citing works
T lymphocytes are not required for the development of fatty degeneration after rotator cuff tear
Gumucio, J. P., Flood, M. D., Harning, J. A., Phan, A. C., Roche, S. M., Lynch, E. B., Bedi, A., & Mendias, C. L. (2014) · Bone and Joint Research · doi:10.1302/2046-3758.39.2000294 · Cited by 21 · see citing works
Sarcopenia in MASLD—Eat to Beat Steatosis, Move to Prove Strength
Crișan, D., Avram, L., Morariu-Barb, A. M., Grapa, C. M., Hirişcău, E. I., Crăciun, R., Donca, V., & Nemeș, A. (2025) · Nutrients · doi:10.3390/nu17010178 · Cited by 20 · see citing works
Arias‐Fernández, L., Struijk, E. A., Rodríguez‐Artalejo, F., López‐García, E., & Lana, A. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.03.018 · Cited by 19 · see citing works
PRMT5 links lipid metabolism to contractile function of skeletal muscles
Kim, K. H., Jia, Z., Snyder, M. M., Chen, J., Qiu, J., Oprescu, S. N., Chen, X., Syed, S. A., Yue, F., Roseguini, B. T., et al. (2023) · EMBO Reports · doi:10.15252/embr.202357306 · Cited by 17 · see citing works
Differential Gene Expression Associated with Soybean Oil Level in the Diet of Pigs
Fanalli, S. L., da Silva, B. P. M., Gomes, J. D., de Almeida, V. V., Freitas, F. A. O., Moreira, G. C. M., Silva‐Vignato, B., Afonso, J., Reecy, J. M., Koltes, J. E., et al. (2022) · Animals · doi:10.3390/ani12131632 · Cited by 16 · see citing works
Bacquer, O. L., Combe, K., Montaurier, C., Salles, J., Giraudet, C., Patrac, V., Domingues-Faria, C., Guillet, C., Louche, K., Boirie, Y., et al. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700128 · Cited by 16 · see citing works
Espinosa, C. D., Fry, R. S., Kocher, M. E., & Stein, H. H. (2020) · Journal of Animal Science · doi:10.1093/jas/skz369 · Cited by 15 · see citing works
Sammut, M. J., Dotzert, M. S., & Melling, C. W. J. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31419 · Cited by 14 · see citing works
Skeletal Muscle ACSL Isoforms Relate to Measures of Fat Metabolism in Humans
Stierwalt, H. D., Ehrlicher, S. E., Robinson, M. M., & Newsom, S. A. (2020) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002487 · Cited by 13 · see citing works
Maretti, E., Molinari, S., Battini, R., Rustichelli, C., Truzzi, E., Iannuccelli, V., & Leo, E. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030648 · Cited by 13 · see citing works
IL-6 and epinephrine have divergent fiber type effects on intramuscular lipolysis
MacDonald, T. L., Wan, Z., Frendo‐Cumbo, S., Dyck, D. J., & Wright, D. C. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00558.2013 · Cited by 13 · see citing works
Diet and Exercise Training Influence Skeletal Muscle Long-Chain acyl-CoA Synthetases
Stierwalt, H. D., Ehrlicher, S. E., Robinson, M. M., & Newsom, S. A. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002164 · Cited by 13 · see citing works
Distinct energy requirements for human memory CD4 T‐cell homeostatic functions
Taub, D. D., Hesdorffer, C. S., Ferrucci, L., Madara, K., Schwartz, J. B., & Goetzl, E. J. (2012) · The FASEB Journal · doi:10.1096/fj.12-217620 · Cited by 13 · see citing works
Vacek, L., Dvořák, A., Bechyňská, K., Kosek, V., Elkalaf, M., Trinh, M. D., Fišerová, I., Pospíšilová, K., Slovakova, L., Vı́tek, L., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.663625 · Cited by 12 · see citing works
Characterizing skeletal muscle dysfunction in women with polycystic ovary syndrome
McDonnell, T., Cussen, L., McIlroy, M., & O’Reilly, M. (2022) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188221113140 · Cited by 13 · see citing works
Poleti, M., Regitano, L. C. D. A., Souza, G. H. M. F., César, A. S. M., Simas, R. C., Silva‐Vignato, B., Montenegro, H., Pértille, F., Balieiro, J. C. D. C., Cameron, L. C., et al. (2020) · Journal of Proteomics · doi:10.1016/j.jprot.2020.103792 · Cited by 12 · see citing works
Roberts, B. M., Deemer, S. E., Smith, D. L., Mobley, J. A., Musi, N., & Plaisance, E. P. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1041026 · Cited by 12 · see citing works
Imierska, M., Zabielski, P., Roszczyc-Owsiejczuk, K., Sokołowska, E., Pogodzińska, K., Kojta, I., & Błachnio-Zabielska, A. U. (2022) · Cells · doi:10.3390/cells11071123 · Cited by 11 · see citing works
Koh, F., Yik, V., Chin, S.-E., Kok, S., Lee, H.-B., Tong, C., Tay, P., Chean, E., Lam, Y.-E., Mah, S.-M., et al. (2024) · Nutrients · doi:10.3390/nu16244351 · Cited by 10 · see citing works
Genes and response to aerobic training
Cagnin, S., Chemello, F., & Ahmetov, I. I. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816193-7.00008-7 · Cited by 10 · see citing works
Marek, T., Amrami, K. K., Spinner, R. J., & Port, J. D. (2020) · Skeletal Radiology · doi:10.1007/s00256-020-03479-9 · Cited by 10 · see citing works
Gu, Y., Seong, D.-H., Liu, W., Wang, Z., Jeong, Y. W., Kim, J.-C., Kang, D. R., Lee, R. J. E., Koh, J., & Kim, S. H. (2024) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2024.28.6.515 · Cited by 8 · see citing works
Schilling, B. K., Baker, J. S., Komatsu, C., & Marra, K. G. (2021) · Journal of Tissue Engineering · doi:10.1177/20417314211032491 · Cited by 8 · see citing works
Metabolic and molecular regulation in skeletal muscle dysfunction and regeneration
Jin, J. B., Robinson, A., Soukup, T., Black, E., Abit, A., Hammer, S. M., Han, A., Lucas, E. A., Kim, Y., & Bae, J. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1651553 · Cited by 7 · see citing works
Sun, Y., Wang, Z., Nie, C., Xue, L., Wang, Y., Song, C., Fan, M., Qian, H., Ying, H., Li, Y., et al. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c06034 · Cited by 7 · see citing works
Lipid metabolic features of skeletal muscle in pathological and physiological conditions
Son, Y., & Paton, C. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819404-1.00018-x · Cited by 7 · see citing works
Mikłosz, A., Łukaszuk, B., Baranowski, M., Chabowski, A., & Górski, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102556 · Cited by 6 · see citing works
Screen Time and Cardiovascular Risks Among Middle-Aged Women
Ham, O. K., & Lee, B. G. (2019) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000598 · Cited by 6 · see citing works
Li, W., Zhang, Z., Berik, E., Liu, Y., Pei, W., Chen, S., Wu, W., Wang, Z., Kong, X., Long, H., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155269 · Cited by 5 · see citing works
Wu, Q., Ling, Y., Yuan, G., La, R., Xu, B., Pang, E., Lin, C., Chen, Z., Zhang, Z., Jiang, D., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-96481-x · Cited by 5 · see citing works
Knockdown of sarcolipin (SLN) impairs substrate utilization in human skeletal muscle cells
Mengeste, A. M., Katare, P. B., Dalmao‐Fernández, A., Lund, J., Bakke, H. G., Baker, D., Bartesaghi, S., Peng, X., Rustan, A. C., Thoresen, G. H., et al. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07387-0 · Cited by 5 · see citing works
Supruniuk, E., Mikłosz, A., Chabowski, A., & Łukaszuk, B. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27872 · Cited by 5 · see citing works
Zhang, X., Du, P., Wang, Z., Zhu, Y., Si, X., Chen, W., & Huang, Y. (2024) · Poultry Science · doi:10.1016/j.psj.2024.104619 · Cited by 4 · see citing works
Chronic alcohol-related myopathy: a closer look at the role of lipids
Ganjayi, M. S., Krauss, T. A., Willis, C. R. G., & Baumann, C. W. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1492405 · Cited by 4 · see citing works
Mendez‐Garcia, C., Trini, A., Browne, V., Kochansky, C. J., Pontiggia, L., & D’mello, A. P. (2019) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2018-0646 · Cited by 4 · see citing works
- Authors
- Watt, M. J., & Hoy, A. J.
- Affiliations
- Monash University (AU)
- Corresponding author
- Watt, Matthew J.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2012-06-01
- Volume
- 302
- Issue
- 11
- Pages
- E1315-E1328
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2033804400
- Cited by
- 142
- References
- 208
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 15 · 2023: 7 · 2022: 9 · 2021: 13 · 2020: 11 · 2019: 15 · 2018: 7 · 2017: 3 · 2016: 6 · 2015: 11 · 2014: 9 · 2013: 11 · 2012: 7
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- skeletal muscle lipid metabolism, fatty acid metabolism, lipolysis, de novo lipogenesis, lipid droplets, mitochondrial fatty acid oxidation, fatty acid beta-oxidation, lipid signaling, insulin action, adipose tissue lipolysis, membrane lipids
- MeSH terms
- Adaptation, Physiological, Animals, Fatty Acids, Humans, Insulin Resistance, Lipids, Triglycerides, Signal Transduction, Muscle, Skeletal, Muscle Fibers, Skeletal, Lipid Metabolism
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