The DOI matches its Crossref record; 29 of the 30 references it cites were found in a registry or an index.
Mechanism of plasma cholesteryl ester transfer in hypertriglyceridemia.
Open accessAbstract
Plasma net cholesteryl ester (CE) transfer and optimum cho- lesteryl ester transfer protein (CETP) activity were determined in primary hypertriglyceridemic (a = 11) and normolipidemic (a = 15) individuals.The hypertriglyceridemic group demon- strated threefold greater net CE transfer leading to enhanced accumulation of CE in VLDL.This increased net transfer was not accompanied by a change in CETP activity.In normolipide- mia, but not in hypertriglyceridemia, net CE transfer correlated with VLDL triglyceride (r = 0.92, P < 0.001).In contrast, net CE transfer in hypertriglyceridemia, but not in normolipide- mia, correlated with CETP activity (r = 0.73, P < 0.01).Correc- tion of hypertriglyceridemia with bezafibrate reduced net CE transfer towards normal and restored the correlation with VLDL triglyceride (r = 0.90, P < 0.005) while suppressing the correlation with CETP activity.That net CE transfer depends on VLDL concentration was confirmed by an increase ofnet CE transfer in normolipidemic plasma supplemented with purified VLDL.Supplementation of purified CETP to normolipidemic plasma did not stimulate net CE transfer.In contrast, net CE transfer was enhanced by addition of CETP to both plasma supplemented with VLDL and hypertriglyceridemic plasma.Thus, in normal subjects, VLDL concentration determines the rate of net CE transfer.CETP becomes rate limiting as VLDL concentration increases, i.e, in hypertriglyceridemia. (J.Clin.Invest.1991.88:2059-2066.)Key words: cholesteryl ester transfer protein * very low density lipoprotein -high density lipoprotein -cardiovascular disease * reverse cholesterol trans- port MO.Bezafibrate (2-[4-[2-[(4-chlorobenzoyl)amino]-ethyl]phenoxy]-2methylpropanoic acid) was obtained from Boehringer Mannheim (for- merly MCP Pharmaceuticals), Livingstone, Scotland. Cholesteryl Ester Transfer in Hypertriglyceridemia 2059
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Hepatic lipase and cholesterol ester transfer protein contribute to the remodeling processes; whether hepatic lipase or cholesterol ester transfer protein has the predominant effect on the size and density of LDL and HDL particles depends on the triglyceride content of very low-density lipoproteins (VLDL) (27,28).”
From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [27]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Incidence of Coronary Heart Disease and Lipoprotein Cholesterol Levels
Castelli, W. P. (1986) · JAMA · doi:10.1001/jama.256.20.2835 · Cited by 2,512
Castelli, W. P., Doyle, J. T., Gordon, T., Hames, C. G., Hjortland, M. C., Hulley, S. B., Kagan, A., & Zukel, W. J. (1977) · Circulation · doi:10.1161/01.cir.55.5.767 · Cited by 1,492
Inazu, A., Brown, M. L., Hesler, C. B., Agellon, L. B., Koizumi, J., Takata, K., Maruhama, Y., Mabuchi, H., & Tall, A. R. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011013231803 · Cited by 862
Gidez, L. I., Miller, G. J., Burstein, M., Slagle, S., & Eder, H. (1982) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38059-7 · Cited by 757
PLASMA LIPID TRANSFER PROTEINS
Tall, A. R. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.001315 · Cited by 639
Brown, M. L., Inazu, A., Hesler, C. B., Agellon, L. B., Mann, C., Whitlock, M. E., Marcel, Y. L., Milne, R. W., Koizumi, J., Mabuchi, H., et al. (1989) · Nature · doi:10.1038/342448a0 · Cited by 470
Self-citationPlasma lipid transfer proteins.
Tall, A. R. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38819-2 · Cited by 377
Agellon, L. B., Walsh, A., Hayek, T., Moulin, P., Jiang, X., Shelanski, S. A., Breslow, J. L., & Tall, A. R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99088-5 · Cited by 297
Gordon, D. J., Knoke, J. D., Probstfield, J. L., Superko, H. R., & Tyroler, H. A. (1986) · Circulation · doi:10.1161/01.cir.74.6.1217 · Cited by 289
Cited by
Sorted by citations
Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism
Staels, B., Dallongeville, J., Auwerx, J., Schoonjans, K., Leitersdorf, E., & Fruchart, J.-C. (1998) · Circulation · doi:10.1161/01.cir.98.19.2088 · Cited by 1,786
Molecular physiology of reverse cholesterol transport.
Fielding, C. J., & Fielding, P. E. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39898-9 · Cited by 1,448
Plasma cholesteryl ester transfer protein
Tall, A. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)36957-1 · Cited by 953
Metabolic origins and clinical significance of LDL heterogeneity
Berneis, K. K., & Krauss, R. M. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r200004-jlr200 · Cited by 896
“limiting for the transfer of triglyceride from VLDL to HDL in hypertriglyceridemia, but not normotriglyceridemia (108).”
BackgroundEvaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline
Berglund, L., Brunzell, J. D., Goldberg, A. C., Goldberg, I. J., Sacks, F., Murad, M. H., & Stalenhoef, A. F. H. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3213 · Cited by 887
Metadata
- Authors
- Mann, C. J., Yen, F. T., Grant, A. M., & Bihain, B. E.
- Affiliations
- Louisiana State University (US)
- ORCID
- Yen, F T
- Venue
- Journal of Clinical Investigation
- Published
- 1991-12-01
- Volume
- 88
- Issue
- 6
- Pages
- 2059-2066
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2114689977
- Cited by
- 339
- References
- 30
- Citations by year
- 2024: 5 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 10 · 2013: 1 · 2012: 2
- FWCI
- 17.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01hl025596-15)
- National Heart, Lung, and Blood Institute (HL255-96)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Keywords
- cholesteryl ester transfer, cholesteryl ester transfer protein, hypertriglyceridemia, VLDL, VLDL triglycerides, reverse cholesterol transport, CETP activity, bezafibrate, lipoprotein metabolism, rate-determining step
- MeSH terms
- Adult, Bezafibrate, Biological Transport, Carrier Proteins, Cholesterol Esters, Glycoproteins, Humans, Lipoproteins, HDL, Lipoproteins, LDL, Lipoproteins, VLDL, Triglycerides, Hypertriglyceridemia, Cholesterol Ester Transfer Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
