Cited by 339Lipid metabolism and disordersCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

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Mechanism of plasma cholesteryl ester transfer in hypertriglyceridemia.

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Mann, C J, Yen, F T, Grant, A M, Bihain, B E·1991·Journal of Clinical Investigation

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Abstract

Plasma net cholesteryl ester (CE) transfer and optimum cho- lesteryl ester transfer protein (CETP) activity were determined in primary hypertriglyceridemic (a = 11) and normolipidemic (a = 15) individuals.The hypertriglyceridemic group demon- strated threefold greater net CE transfer leading to enhanced accumulation of CE in VLDL.This increased net transfer was not accompanied by a change in CETP activity.In normolipide- mia, but not in hypertriglyceridemia, net CE transfer correlated with VLDL triglyceride (r = 0.92, P < 0.001).In contrast, net CE transfer in hypertriglyceridemia, but not in normolipide- mia, correlated with CETP activity (r = 0.73, P < 0.01).Correc- tion of hypertriglyceridemia with bezafibrate reduced net CE transfer towards normal and restored the correlation with VLDL triglyceride (r = 0.90, P < 0.005) while suppressing the correlation with CETP activity.That net CE transfer depends on VLDL concentration was confirmed by an increase ofnet CE transfer in normolipidemic plasma supplemented with purified VLDL.Supplementation of purified CETP to normolipidemic plasma did not stimulate net CE transfer.In contrast, net CE transfer was enhanced by addition of CETP to both plasma supplemented with VLDL and hypertriglyceridemic plasma.Thus, in normal subjects, VLDL concentration determines the rate of net CE transfer.CETP becomes rate limiting as VLDL concentration increases, i.e, in hypertriglyceridemia. (J.Clin.Invest.1991.88:2059-2066.)Key words: cholesteryl ester transfer protein * very low density lipoprotein -high density lipoprotein -cardiovascular disease * reverse cholesterol trans- port MO.Bezafibrate (2-[4-[2-[(4-chlorobenzoyl)amino]-ethyl]phenoxy]-2methylpropanoic acid) was obtained from Boehringer Mannheim (for- merly MCP Pharmaceuticals), Livingstone, Scotland. Cholesteryl Ester Transfer in Hypertriglyceridemia 2059

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Authors: Mann, C. J., Yen, F. T., Grant, A. M., & Bihain, B. E.
Affiliations: Louisiana State University (US)
ORCID: Yen, F T
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1991-12-01
Volume: 88
Issue: 6
Pages: 2059-2066
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci115535
OpenAlex: W2114689977
Cited by: 339
References: 30
Citations by year: 2024: 5 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 10 · 2013: 1 · 2012: 2
FWCI: 17.17
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01hl025596-15)
National Heart, Lung, and Blood Institute (HL255-96)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: cholesteryl ester transfer, cholesteryl ester transfer protein, hypertriglyceridemia, VLDL, VLDL triglycerides, reverse cholesterol transport, CETP activity, bezafibrate, lipoprotein metabolism, rate-determining step
MeSH terms: Adult, Bezafibrate, Biological Transport, Carrier Proteins, Cholesterol Esters, Glycoproteins, Humans, Lipoproteins, HDL, Lipoproteins, LDL, Lipoproteins, VLDL, Triglycerides, Hypertriglyceridemia, Cholesterol Ester Transfer Proteins

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Mechanism of plasma cholesteryl ester transfer in hypertriglyceridemia.

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