The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty.
Open accessAbstract
Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for vascular smooth muscle cells (SMC) in vitro, but its activities in vivo remain largely undefined. We infused recombinant PDGF-BB (0.01-0.30 mg/kg per d i.v.) into rats subjected to carotid injury. PDGF-BB produced a small increase (two- to threefold) in medial SMC proliferation. More importantly, PDGF-BB greatly increased (20-fold) the intimal thickening and the migration of SMC from the media to the intima during the first 7 d after injury. These data provide support for the hypothesis that PDGF, and perhaps other platelet factors, might play an important role in the movement of mesenchymal cells into zones of injury undergoing repair.
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Cites
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Self-citationTwo Different Subunits Associate to Create Isoform-Specific Platelet-derived Growth Factor Receptors
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Self-citationTwo Classes of PDGF Receptor Eecognize Different Isoforms of PDGF
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Cited by
Alexander, M. R., & Owens, G. K. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142315 · Cited by 773
Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo
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Lillis, A. P., Van Duyn, L. B., Murphy-Ullrich, J. E., & Strickland, D. K. (2008) · Physiological Reviews · doi:10.1152/physrev.00033.2007 · Cited by 669
Egr-1-Induced Endothelial Gene Expression: A Common Theme in Vascular Injury
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Self-citationRapamycin inhibits vascular smooth muscle cell migration.
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Metadata
- Authors
- Jawien, A., Bowen-Pope, D. F., Lindner, V, Schwartz, S. M., & Clowes, A. W.
- Venue
- Journal of Clinical Investigation
- Published
- 1992-02-01
- Volume
- 89
- Issue
- 2
- Pages
- 507-511
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2063277519
- Cited by
- 674
- References
- 26
- FWCI
- 13.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty. https://app.cochat.ai/papers/10.1172/jci115613
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- Jawien, A., Bowen-Pope, D. F., Lindner, V, Schwartz, S. M., & Clowes, A. W. (1992). Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty. Journal of Clinical Investigation. https://doi.org/10.1172/jci115613
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
