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Evidence for the involvement of interleukin 6 in experimental cancer cachexia.
Open accessAbstract
In this report we describe an experimental model of cachexia that fulfills the criteria of an early effect with a small tumor mass not related to the growth rate of the tumor, and progressive wasting of muscle and fat without a detectable loss of appetite. C-26.IVX is a cell line derived from murine colon-26 adenocarcinoma which retains the transplantability of the original tumor and induces true cachexia in syngeneic hosts. Evidence is presented to support a role for interleukin (IL-6) as a cachectic factor in the development of cancer cachexia in this model system. Thus, increasing levels of IL-6 in C-26.IVX-bearing mice correlate with the development of cachexia. If the primary tumors were resected, mice gained weight and the levels of IL-6 in the serum were reduced significantly. Moreover, monoclonal antibody to murine IL-6 (but not anti-tumor necrosis factor antibody) was able to significantly suppress the development of key parameters of cachexia in tumor bearing mice.
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Metadata
- Authors
- Strassmann, G., Fong, M., Kenney, J. S., & Jacob, C. O.
- Venue
- Journal of Clinical Investigation
- Published
- 1992-05-01
- Volume
- 89
- Issue
- 5
- Pages
- 1681-1684
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2126540916
- Cited by
- 658
- References
- 0
- FWCI
- 13.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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