Serum levels of leptin and proinflammatory cytokines in patients with advanced-stage cancer at different sites
Abstract
Leptin is a recently identified hormone produced by the adipocyte ob gene which acts as a negative feedback signal critical to the normal control of food intake and body weight. A number of proinflammatory cytokines, such as interleukin (IL) 1alpha, IL-6, tumor necrosis factor (TNF) alpha and interferon (IFN) gamma, have been proposed as mediators of cancer cachexia. These data suggest that abnormalities in leptin production/release or in its feedback mechanism play a role in cancer patients. To elucidate this we studied the relationship between total serum leptin and serum cytokines IL-1alpha, IL-6, TNFalpha as well as the production of leptin and cytokines by peripheral blood mononuclear cells (PBMC) isolated from cancer patients. Sixteen advanced cancer patients (mainly stage IV) with tumors at different sites were included in the study. The serum levels of leptin in cancer patients were significantly lower than those of healthy individuals at all times (7 a.m., noon, 3 p.m.). No significant differences were found in circadian rhythm between patients and controls. Serum levels of IL-1alpha, IL-6, and TNFalpha were significantly higher in cancer patients than in healthy individuals. An inverse correlation between serum levels of leptin and IL-6 was found in cancer patients. The production in culture of leptin by unstimulated PBMCs and those stimulated by phytohemagglutinin M or by phorbol myristate acetate isolated from cancer patients was very low; no differences were obse…
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Proinflammatory cytokines TNF-α, IL-6, and IFN-γ drive catabolic signaling associated with cachexia.
“Proinflammatory cytokines, such as TNF-α, IL-6, and IFN-γ, drive catabolic signaling associated with cachexia”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Mantovani et al., 2000
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- Authors
- Mantovani, G., Macciò, A., Mura, L., Massa, E., Mudu, M. C., Mulas, C., Lusso, M. R., Madeddu, C., & Dessì, A.
- Affiliations
- University of Cagliari (IT)
- Venue
- Journal of Molecular Medicine
- Published
- 2000-10-18
- Volume
- 78
- Issue
- 10
- Pages
- 554-561
- ISSN
- 0946-2716 (ISSN-L)
- 1432-1440
- OpenAlex
- W2124360707
- Cited by
- 232
- References
- 54
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 14 · 2019: 7 · 2018: 10 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 6 · 2013: 11 · 2012: 10
- FWCI
- 8.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- leptin, inflammatory cytokines, advanced cancer, cancer cachexia, interleukin-6, interleukin-1 alpha, TNF-α, interferon-gamma, peripheral blood mononuclear cells, circadian rhythm, serum cytokine levels, tumor location
- MeSH terms
- Adult, Aged, Anorexia, Cachexia, Female, Humans, Leukocytes, Mononuclear, Lymphocyte Activation, Male, Middle Aged, Neoplasms, Syndrome, Body Mass Index, Cytokines, Matched-Pair Analysis, Leptin
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