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The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping

Rommens, Johanna M., Iannuzzi, Michael C., Kerem, Bat-Sheva, Drumm, Mitchell L., Melmer, Georg, Dean, Michael, Rozmahel, Richard, Cole, Jeffery L., Kennedy, Dara, Hidaka, Noriko, Zsiga, Martha, Buchwald, Manuel, Tsui, Lap-Chee, Riordan, John R., Collins, Francis S.·1989·Science
DOI 10.1126/science.2772657
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Abstract

An understanding of the basic defect in the inherited disorder cystic fibrosis requires cloning of the cystic fibrosis gene and definition of its protein product. In the absence of direct functional information, chromosomal map position is a guide for locating the gene. Chromosome walking and jumping and complementary DNA hybridization were used to isolate DNA sequences, encompassing more than 500,000 base pairs, from the cystic fibrosis region on the long arm of human chromosome 7. Several transcribed sequences and conserved segments were identified in this cloned region. One of these corresponds to the cystic fibrosis gene and spans approximately 250,000 base pairs of genomic DNA.

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Metadata

Authors
Rommens, J. M., Iannuzzi, M. C., Kerem, B.-S., Drumm, M. L., Melmer, G., Dean, M., Rozmahel, R., Cole, J. L., Kennedy, D., Hidaka, N., Zsiga, M., Buchwald, M., Tsui, L.-C., Riordan, J. R., & Collins, F. S.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1989-09-08
Volume
245
Issue
4922
Pages
1059-1065
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.2772657
OpenAlex
W1969697265
Cited by
3,253
References
5
FWCI
294.67
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping. https://app.cochat.ai/papers/10.1126/science.2772657
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Rommens, J. M., Iannuzzi, M. C., Kerem, B.-S., Drumm, M. L., Melmer, G., Dean, M., Rozmahel, R., Cole, J. L., Kennedy, D., Hidaka, N., Zsiga, M., Buchwald, M., Tsui, L.-C., Riordan, J. R., & Collins, F. S. (1989). Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping. Science. https://doi.org/10.1126/science.2772657

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