The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Neutrophil-dependent acute lung injury. Requirement for P-selectin (GMP-140).
Open accessAbstract
Rapid translocation of P-selectin (GMP-140) from cytoplasmic granules to the cell membrane of endothelial cells promotes adhesive interactions with neutrophils which, when activated, damage the endothelium. The role of P-selectin in lung vascular endothelial injury in rats after systemic activation of complement by intravenous infusion of cobra venom factor has been assessed. Within 5-10 min after cobra venom factor infusion, the pulmonary vasculature demonstrated immunohistochemical expression of an epitope that reacts with anti-human P-selectin. Monoclonal antibody to human P-selectin blocked in vitro adherence of rat or human platelets (activated with thrombin) to neutrophils and was demonstrated to react with thrombin-activated rat platelets. The antibody did not react with rat neutrophils. In vivo, the antibody had strongly protective effects against cobra venom factor-induced pulmonary vascular injury as determined by permeability changes and hemorrhage. In parallel, lung myeloperoxidase content was greatly reduced and, by transmission electron microscopy, there was markedly diminished adherence of neutrophils to the pulmonary vascular endothelium and much diminished injury of endothelial cells, as defined by hemorrhage. These data indicate that anti-human P-selectin reacts with a pulmonary vascular antigen in rats and that this antigen is essential for the full expression of lung injury.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
Butcher, E. C. (1991) · Cell · doi:10.1016/0092-8674(91)90279-8 · Cited by 2,761
Lawrence, M. B., & Springer, T. A. (1991) · Cell · doi:10.1016/0092-8674(91)90393-d · Cited by 2,129
Bevilacqua, M. P., Stengelin, S., Gimbrone, M. A., & Seed, B. (1989) · Science · doi:10.1126/science.2466335 · Cited by 2,005
LEUKOCYTE ADHESION DEFICIENCY: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins
Anderson, D. C., & Springer, T. A. (1987) · Annual Review of Medicine · doi:10.1146/annurev.me.38.020187.001135 · Cited by 1,148
Rapid neutrophil adhesion to activated endothelium mediated by GMP-140
Geng, J.-G., Bevilacquat, M. P., Moore, K. L., Mclntyre, T. M., Prescott, S. M., Kim, J. M., Bliss, G. A., Zimmerman, G. A., & McEver, R. P. (1990) · Nature · doi:10.1038/343757a0 · Cited by 956
von Andrian, U. H., Chambers, J. D., McEvoy, L. M., Bargatze, R. F., Arfors, K. E., & Butcher, E. C. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7538 · Cited by 953
Stenberg, P. E., McEver, R. P., Shuman, M. A., Jacques, Y. V., & Bainton, D. F. (1985) · The Journal of cell biology · doi:10.1083/jcb.101.3.880 · Cited by 871
Lorant, D. E., Patel, K. D., McIntyre, T. M., McEver, R. P., Prescott, S. M., & Zimmerman, G. A. (1991) · The Journal of cell biology · doi:10.1083/jcb.115.1.223 · Cited by 576
Picker, L. J., Warnock, R. A., Burns, A. R., Doerschuk, C. M., Berg, E. L., & Butchert, E. C. (1991) · Cell · doi:10.1016/0092-8674(91)90438-5 · Cited by 570
Till, G. O., Johnson, K. J., Kunkel, R., & Ward, P. A. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110548 · Cited by 549
Self-citation
Cited by
Adhesion molecules and inflammatory injury
Albelda, S. M., Smith, C. W., & Ward, P. A. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.8.8181668 · Cited by 1,015
Self-citationC5a-induced expression of P-selectin in endothelial cells.
Foreman, K. E., Vaporciyan, A. A., Bonish, B. K., Jones, M. L., Johnson, K. J., Glovsky, M. M., Eddy, S. M., & Ward, P. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117430 · Cited by 473
Self-citationOkada, Y., Copeland, B. R., Mori, E., Tung, M. M., Thomas, W. S., & del Zoppo, G. J. (1994) · Stroke · doi:10.1161/01.str.25.1.202 · Cited by 435
Zingarelli, B., Salzman, A. L., & Szabó, C. (1998) · Circulation Research · doi:10.1161/01.res.83.1.85 · Cited by 334
Ebnet, K., & Vestweber, D. (1999) · Histochemistry and Cell Biology · doi:10.1007/s004180050387 · Cited by 278
Metadata
- Authors
- Mulligan, M. S., Polley, M. J., Bayer, R. J., Nunn, M. F., Paulson, J. C., & Ward, P. A.
- Venue
- Journal of Clinical Investigation
- Published
- 1992-10-01
- Volume
- 90
- Issue
- 4
- Pages
- 1600-1607
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1974913500
- Cited by
- 381
- References
- 32
- FWCI
- 16.89
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Neutrophil-dependent acute lung injury. Requirement for P-selectin (GMP-140). https://app.cochat.ai/papers/10.1172/jci116029
- The paper
- Mulligan, M. S., Polley, M. J., Bayer, R. J., Nunn, M. F., Paulson, J. C., & Ward, P. A. (1992). Neutrophil-dependent acute lung injury. Requirement for P-selectin (GMP-140). Journal of Clinical Investigation. https://doi.org/10.1172/jci116029
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
