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Cited by 522

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes.

Open access
Calver, A, Collier, J, Vallance, P·1992·Journal of Clinical Investigation
DOI 10.1172/jci116149
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Abstract

Patients with insulin-dependent diabetes mellitus have an increased mortality and morbidity due to vascular complications. Nitric oxide from the vascular endothelium contributes to the control of normal vascular tone, and endothelial dysfunction has been implicated in the pathogenesis of diabetic vascular disease. In this study we have examined basal and stimulated nitric oxide-mediated vasodilatation in insulin-dependent diabetics and age- and sex-matched healthy controls. Drugs were infused locally into the brachial artery and forearm blood flow measured using venous occlusion plethysmography. Noradrenaline and NG-monomethyl-L-arginine produced similar reductions in resting forearm blood flow in healthy controls. However, in the diabetics, NG-monomethyl-L-arginine was significantly less effective than noradrenaline. Comparing between groups, the response to NG-monomethyl-L-arginine was also significantly less in the diabetics compared with the healthy controls. The response to sodium nitroprusside was significantly less in the diabetics compared with the healthy controls, whereas the responses to both acetylcholine and verapamil were the same in the two groups. The results provide evidence for an abnormality of basal nitric oxide-mediated dilatation in the forearm arterial bed of patients with insulin-dependent diabetes mellitus, and suggest that the vascular smooth muscle is less sensitive to nitric oxide.

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Metadata

Authors
Calver, A., Collier, J., & Vallance, P.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1992-12-01
Volume
90
Issue
6
Pages
2548-2554
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci116149
OpenAlex
W2025445144
Cited by
522
References
46
FWCI
11.98
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes. https://app.cochat.ai/papers/10.1172/jci116149
The paper
Calver, A., Collier, J., & Vallance, P. (1992). Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes. Journal of Clinical Investigation. https://doi.org/10.1172/jci116149

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.