Cited by 149Iron Metabolism and DisordersNeurological diseases and metabolismTrace Elements in Health

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Regulation of transferrin receptor expression and ferritin content in human mononuclear phagocytes. Coordinate upregulation by iron transferrin and downregulation by interferon gamma.

Open access

Byrd, T F, Horwitz, M A·1993·Journal of Clinical Investigation

Open this paper in CoChat — free account Open PDF

Abstract

We have investigated the regulation of key human iron binding proteins in mononuclear phagocytes by IFN gamma and iron transferrin. In a previous study, we demonstrated that IFN gamma downregulates the expression on human monocytes of transferrin receptors, the major source of iron for the cell. In the present study, we show that IFN gamma also downregulates the intracellular concentration of ferritin, the major iron storage protein in the cell. By radioimmunoassay, the mean ferritin content of nonactivated monocytes was 361 +/- 107 fg/monocyte (mean +/- SEM) whereas the mean ferritin content of IFN gamma-activated monocytes was 64 +/- 13 fg/monocyte, an 82% reduction with activation (P < 0.01, t test). Consistent with its downregulating effect on these iron proteins, IFN gamma treatment also results in decreased iron incorporation. IFN gamma-activated monocytes incorporated 33% less iron from 59Fe-transferrin than nonactivated monocytes (P < 0.05, t test). Gel filtration chromatography revealed that incorporated iron is located primarily in ferritin in both nonactivated and IFN gamma-activated monocytes. Ferritin in IFN gamma-activated monocytes is saturated with approximately three times as much 59Fe as ferritin in nonactivated monocytes. We have also explored the effect of iron transferrin on transferrin receptor expression and intracellular ferritin content in human monocytes. We have found that iron transferrin markedly upregulates both transferrin receptor expression and intracellular ferritin content in both nonactivated (2.3- and 1.3-fold, respectively) and IFN gamma-activated (3.4- and 2.9-fold, respectively) monocytes. This study demonstrates that transferrin receptor expression and intracellular ferritin content in human monocytes is unidirectionally and coordinately upregulated by iron transferrin and unidirectionally and coordinately downregulated by IFN gamma.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci116318

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Interleukin-1
Dinarello, C. A. (1984) · Clinical Infectious Diseases · doi:10.1093/clinids/6.1.51 · Cited by 1,647
Cachectin: More Than a Tumor Necrosis Factor
Epstein, F. H., Beutler, B., & Cerami, A. (1987) · New England Journal of Medicine · doi:10.1056/nejm198702123160705 · Cited by 1,423
Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome
Lähdevirta, J., Maury, C. P. J., Teppo, A., & Repo, H. (1988) · The American Journal of Medicine · doi:10.1016/0002-9343(88)90576-1 · Cited by 717
Iron-Responsive Elements: Regulatory RNA Sequences That Control mRNA Levels and Translation
Casey, J. L., Hentze, M. W., Koeller, D. M., Caughman, S. W., Rouault, T. A., Klausner, R. D., & Harford, J. B. (1988) · Science · doi:10.1126/science.2452485 · Cited by 709
Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5′ untranslated region of ferritin heavy- and light-subunit mRNAs.
Leibold, E. A., & Munro, H. N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.7.2171 · Cited by 671
Legionnaires' Disease Bacterium (Legionella pneumophila) Multiplies Intracellularly in Human Monocytes
Horwitz, M. A., & Silverstein, S. C. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109874 · Cited by 639
Self-citation
A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA
Müllner, E. W., Neupert, B., & Kühn, L. C. (1989) · Cell · doi:10.1016/0092-8674(89)90851-9 · Cited by 497
Perspectives in Iron Metabolism
Finch, C. A., & Huebers, H. A. (1982) · New England Journal of Medicine · doi:10.1056/nejm198206243062504 · Cited by 390
Low molecular weight intracellular iron transport compounds
Jacobs, A. J. (1977) · Blood · doi:10.1182/blood.v50.3.433.433 · Cited by 386
Oxidation-Reduction and the Molecular Mechanism of a Regulatory RNA-Protein Interaction
Hentze, M. W., Rouault, T. A., Harford, J. B., & Klausner, R. D. (1989) · Science · doi:10.1126/science.2711187 · Cited by 377

Show all 43 references

Research works printed but not linked: 1

Methods in Enzymology: Peptide Growth Factors. Part B. 1987. Edited by D. Barnes, D., and D. A. Sirbasku, editors. Academic Press Inc. Harcourt Brace Jovanovich, New York. p. 274.

Sorted by citations

Macrophage defense mechanisms against intracellular bacteria
Weiss, G., & Schaible, U. E. (2015) · Immunological Reviews · doi:10.1111/imr.12266 · Cited by 989
Iron and microbial infection
Schaible, U. E., & Kaufmann, S. H. E. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1046 · Cited by 945
Iron Homeostasis and the Inflammatory Response
Wessling-Resnick, M. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104804 · Cited by 480
Mechanisms of Therapeutic Activity for Gallium
Bernstein, L. R. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01383-8 · Cited by 458
Legionella PneumophilaPathogenesis: A Fateful Journey from Amoebae to Macrophages
Swanson, M. S., & Hammer, B. K. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.567 · Cited by 402
Iron at the interface of immunity and infection
Nairz, M., Haschka, D., Demetz, E., & Weiss, G. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00152 · Cited by 325
“…promote efficient iron storage within macrophages/monocytes by increasing the expression of ferritin, both at the transcriptional and posttranscriptional level (Byrd and Horwitz, 1993; Weiss et al., 1997a; Mulero and Brock, 1999; Arosio and Levi, 2002; Tilg et al., 2002; Ludwiczek et al., 2003).”
Background
Iron metabolism in the anemia of chronic disease
Weiss, G. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.08.006 · Cited by 322
Iron and immunity: a double-edged sword.
Weiss, G. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.0320s1070.x · Cited by 317
Iron in innate immunity: starve the invaders
Ganz, T. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.01.011 · Cited by 284
Pathogenesis and treatment of anaemia of chronic disease
Weiß, G. (2002) · Blood Reviews · doi:10.1054/blre.2002.0193 · Cited by 276
Iron metabolism and the innate immune response to infection
Johnson, E. E., & Wessling-Resnick, M. (2012) · Microbes and Infection · doi:10.1016/j.micinf.2011.10.001 · Cited by 253
“Activation of phagocytes via PRRs and the Th1 cell-derived cytokine interferon-γ results in decreased expression of transferrin receptors and enhanced expression of the natural resistance associated macrophage protein-1 (Nramp1) and ferroportin [36-39].”
Background
Macrophages in resistance to candidiasis
Vázquez‐Torres, A., & Balish, E. (1997) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.61.2.170-192.1997 · Cited by 233
Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis
Sow, F. B., Florence, W. C., Satoskar, A. R., Schlesinger, L. S., Zwilling, B. S., & Lafuse, W. P. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0407216 · Cited by 229
Exochelins of Mycobacterium tuberculosis remove iron from human iron-binding proteins and donate iron to mycobactins in the M. tuberculosis cell wall.
Gobin, J., & Horwitz, M. A. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.4.1527 · Cited by 209
Self-citation
Correction of the Iron Overload Defect in β-2-Microglobulin Knockout Mice by Lactoferrin Abolishes Their Increased Susceptibility to Tuberculosis
Schaible, U. E., Collins, H. L., Priem, F., & Kaufmann, S. H. E. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020897 · Cited by 198
Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease
Theurl, I., Mattle, V., Seifert, M., Mariani, M., Marth, C., & Weiss, G. (2006) · Blood · doi:10.1182/blood-2005-08-3364 · Cited by 188
Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis
Kahnert, A., Seiler, P. J., Stein, M., Bandermann, S., Hahnke, K., Mollenkopf, H., & Kaufmann, S. H. E. (2006) · European Journal of Immunology · doi:10.1002/eji.200535496 · Cited by 190
Role of IL-10 for induction of anemia during inflammation
Tilg, H., Ulmer, H., Kaser, A., & Weiss, G. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.2204 · Cited by 181
Iron acquisition by Mycobacterium tuberculosis: isolation and characterization of a family of iron-binding exochelins.
Gobin, J., Moore, C. H., Reeve, J. R., Wong, D. K., Gibson, B. W., & Horwitz, M. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.5189 · Cited by 179
Self-citation
Interferon- γ and infectious diseases: Lessons and prospects
Casanova, J., MacMicking, J. D., & Nathan, C. (2024) · Science · doi:10.1126/science.adl2016 · Cited by 184
Antibody regulation of T-cell immunity: implications for vaccine strategies against intracellular pathogens
Igietseme, J. U., Eko, F. O., He, Q., & Black, C. M. (2004) · Expert Review of Vaccines · doi:10.1586/14760584.3.1.23 · Cited by 166
Modification of iron regulation by the inflammatory response
WEISS, G. (2005) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2004.09.001 · Cited by 161
Pathogenesis and Treatment of the Anemia of Chronic Disease
Krantz, S. B. (1994) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199405000-00009 · Cited by 157
Macrophage nutriprive antimicrobial mechanisms
Appelberg, R. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0206079 · Cited by 152
Mycobactin-mediated iron acquisition within macrophages
Luo, M., Fadeev, E. A., & Groves, J. T. (2005) · Nature Chemical Biology · doi:10.1038/nchembio717 · Cited by 141
Iron: Mammalian defense systems, mechanisms of disease, and chelation therapy approaches
Kontoghiorghes, G. J., & Weinberg, E. D. (1995) · Blood Reviews · doi:10.1016/0268-960x(95)90038-1 · Cited by 134
Role of HIF-1 and NF-κB Transcription Factors in the Modulation of Transferrin Receptor by Inflammatory and Anti-inflammatory Signals
Tacchini, L., Gammella, E., De Ponti, C., Recalcati, S., & Cairo, G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800365200 · Cited by 132
Identification of Fur, Aconitase, and Other Proteins Expressed by Mycobacterium tuberculosis under Conditions of Low and High Concentrations of Iron by Combined Two-Dimensional Gel Electrophoresis and Mass Spectrometry
Wong, D. K., Lee, B., Horwitz, M. A., & Gibson, B. W. (1999) · Infection and Immunity · doi:10.1128/iai.67.1.327-336.1999 · Cited by 136
Self-citation
Chemokine CXCL12 Induces Binding of Ferritin Heavy Chain to the Chemokine Receptor CXCR4, Alters CXCR4 Signaling, and Induces Phosphorylation and Nuclear Translocation of Ferritin Heavy Chain
Li, R., Luo, C., Mines, M. A., Zhang, J., & Fan, G.-H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607266200 · Cited by 129
Iron Storage Proteins Are Essential for the Survival and Pathogenesis of Mycobacterium tuberculosis in THP-1 Macrophages and the Guinea Pig Model of Infection
Reddy, P. V., Puri, R. V., Khera, A., & Tyagi, A. K. (2011) · Journal of Bacteriology · doi:10.1128/jb.05553-11 · Cited by 125
Iron at the Centre of Candida albicans Interactions
Fourie, R., Kuloyo, O. O., Mochochoko, B. M., Albertyn, J., & Pohl, C. H. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00185 · Cited by 118
T cell responses to Chlamydia trachomatis
Loomis, W. H. (2002) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(02)00291-6 · Cited by 124
Intraphagosomal Mycobacterium tuberculosis Acquires Iron from Both Extracellular Transferrin and Intracellular Iron Pools
Olakanmi, O., Schlesinger, L. S., Ahmed, A., & Britigan, B. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209768200 · Cited by 122
Iron and anemia of chronic disease
Weiß, G. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.055suppl.69012.x · Cited by 111
Role of iron in the pathogenesis of respiratory disease
Ali, M. K., Kim, R., Karim, R., Mayall, J., Martin, K. L., Shahandeh, A., Abbasian, F., Starkey, M. R., Loustaud-Ratti, V., Johnstone, D. M., et al. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.05.003 · Cited by 114
Anaemia of cancer: an overview of mechanisms involved in its pathogenesis
Grotto, H. Z. W. (2007) · Medical Oncology · doi:10.1007/s12032-007-9000-8 · Cited by 110
5 Iron metabolism in inflammation
Konijn, A. M. (1994) · Baillière s Clinical Haematology · doi:10.1016/s0950-3536(05)80127-1 · Cited by 108
Acute-phase proteins during inflammatory reaction by bacterial infection: Fish-model
Charlie‐Silva, I., Klein, A., Mendonça-Gomes, J. M., Prado, E. J. D. R., de Moraes, A. C., Eto, S. F., Fernandes, D. C., Fagliari, J. J., Corrêa, J. D., Lima, C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-41312-z · Cited by 106
Chlamydial Infection in Inducible Nitric Oxide Synthase Knockout Mice
Igietseme, J. U., Perry, L. L., Ananaba, G. A., Uriri, I. M., Ojior, O. O., Kumar, S. N., & Caldwell, H. D. (1998) · Infection and Immunity · doi:10.1128/iai.66.4.1282-1286.1998 · Cited by 98
Inappropriately high iron regulatory protein activity in monocytes of patients with genetic hemochromatosis
Cairo, G., Recalcati, S., Montosi, G., Castrusini, E., Conte, D., & Pietrangelo, A. (1997) · Blood · doi:10.1182/blood.v89.7.2546 · Cited by 96
Immune-mediated control of Chlamydia infection
Roan, N. R., & Starnbach, M. N. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01069.x · Cited by 96
Tumor necrosis factor alpha (TNFalpha) promotes growth of virulent Mycobacterium tuberculosis in human monocytes iron-mediated growth suppression is correlated with decreased release of TNFalpha from iron-treated infected monocytes
Byrd, T. F. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119436 · Cited by 90
Self-citation
Hereditary hemochromatosis results in decreased iron acquisition and growth by Mycobacterium tuberculosis within human macrophages
Olakanmi, O., Schlesinger, L. S., & Britigan, B. E. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0606405 · Cited by 88
Regulation of iron metabolism in murine J774 macrophages: role of nitric oxide-dependent and -independent pathways following activation with gamma interferon and lipopolysaccharide.
Mulero, V., & Brock, J. H. (1999) · Blood · doi:10.1182/blood.v94.7.2383.419k20_2383_2389 · Cited by 86
Intracellular innate resistance to bacterial pathogens
Radtke, A. L., & O’Riordan, M. X. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00795.x · Cited by 85
The iron export protein ferroportin 1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial-containing phagosome
Van Zandt, K. E., Sow, F. B., Florence, W. C., Zwilling, B. S., Satoskar, A. R., Schlesinger, L. S., & Lafuse, W. P. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1107781 · Cited by 74
The Macrophage: A Cellular Factory at the Interphase Between Iron and Immunity for the Control of Infections
Theurl, I., Fritsche, G., Ludwiczek, S., Garimorth, K., Bellmann-Weiler, R., & Weiss, G. (2005) · BioMetals · doi:10.1007/s10534-005-3710-1 · Cited by 72
Inhibition of Legionella pneumophila growth by gamma interferon in permissive A/J mouse macrophages: role of reactive oxygen species, nitric oxide, tryptophan, and iron(III)
Gebran, S. J., Yamamoto, Y., Newton, C. A., Klein, T., & Friedman, H. P. (1994) · Infection and Immunity · doi:10.1128/iai.62.8.3197-3205.1994 · Cited by 70
Transient Transgenic Expression of Gamma Interferon PromotesLegionella pneumophilaClearance in Immunocompetent Hosts
Deng, J. C., Tateda, K., Zeng, X., & Standiford, T. J. (2001) · Infection and Immunity · doi:10.1128/iai.69.10.6382-6390.2001 · Cited by 67
The IFN-Inducible Golgi- and Endoplasmic Reticulum- Associated 47-kDa GTPase IIGP Is Transiently Expressed During Listeriosis
Zerrahn, J., Schaible, U. E., Brinkmann, V., Guhlich‐Bornhof, U., & Kaufmann, S. H. E. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3428 · Cited by 62
Interferon gamma upregulates frataxin and corrects the functional deficits in a Friedreich ataxia model
Tomassini, B., Arcuri, G., Fortuni, S., Sandi, C., Ezzatizadeh, V., Casali, C., Condò, I., Malisan, F., Al‐Mahdawi, S., Pook, M. A., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds110 · Cited by 60
Chlamydia Vaccines
Igietseme, J. U., Black, C. M., & Caldwell, H. D. (2002) · BioDrugs · doi:10.2165/00063030-200216010-00003 · Cited by 58
Heme carrier protein (HCP-1) spatially interacts with the CD163 hemoglobin uptake pathway and is a target of inflammatory macrophage activation
Schaer, C. A., Vallelian, F., Imhof, A., Schoedon, G., & Schaer, D. J. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0407226 · Cited by 56
The major iron-containing protein of Legionella pneumophila is an aconitase homologous with the human iron-responsive element-binding protein
Mengaud, J., & Horwitz, M. A. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.17.5666-5676.1993 · Cited by 54
Self-citation
Maturation of theLegionella pneumophila-Containing Phagosome into a Phagolysosome within Gamma Interferon-Activated Macrophages
Šantić, M., Molmeret, M., & Kwaik, Y. A. (2005) · Infection and Immunity · doi:10.1128/iai.73.5.3166-3171.2005 · Cited by 54
Improving sensitivity and specificity of capturing and detecting targeted cancer cells with anti-biofouling polymer coated magnetic iron oxide nanoparticles
Lin, R., Li, Y., MacDonald, T. J., Wu, H. C., Provenzale, J., Peng, X., Huang, J., Wang, L., Wang, A. Y., Yang, J., et al. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.10.026 · Cited by 52
Macrophage permissiveness for Legionella pneumophila growth modulated by iron
Gebran, S. J., Newton, C. A., Yamamoto, Y., Widen, R. H., Klein, T., & Friedman, H. P. (1994) · Infection and Immunity · doi:10.1128/iai.62.2.564-568.1994 · Cited by 51
Contemporary approaches to designing and evaluating vaccines against Chlamydia
Igietseme, J. U., Eko, F. O., & Black, C. M. (2003) · Expert Review of Vaccines · doi:10.1586/14760584.2.1.129 · Cited by 51
Interferon-γ Listericidal Action Is Mediated by Novel Rab5a Functions at the Phagosomal Environment
Prada‐Delgado, A., Carrasco-Marı́n, E., Bokoch, G., & Alvarez-Domı́nguez, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101639200 · Cited by 49
The Nature of Extracellular Iron Influences Iron Acquisition byMycobacterium tuberculosisResiding within Human Macrophages
Olakanmi, O., Schlesinger, L. S., Ahmed, A., & Britigan, B. E. (2004) · Infection and Immunity · doi:10.1128/iai.72.4.2022-2028.2004 · Cited by 50
Aberrant Transferrin and Ferritin Upregulation Elicits Iron Accumulation and Oxidative Inflammaging Causing Ferroptosis and Undermines Estradiol Biosynthesis in Aging Rat Ovaries by Upregulating NF-Κb-Activated Inducible Nitric Oxide Synthase: First Demonstration of an Intricate Mechanism
Sze, S. C. W., Zhang, L., Zhang, S., Lin, K., Ng, T. B., Ng, M. L., Lee, C., Lam, J. K. W., Zhang, Z., & Yung, K. K. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012689 · Cited by 49
Pathophysiology of cancer-related anemia
Nowrousian, M. R. (2002) · Springer eBooks · doi:10.1007/978-3-7091-7658-0_3 · Cited by 46
The Role of Iron Metabolism in Lung Inflammation and Injury
Kim, J. (2012) · Journal of Allergy & Therapy · doi:10.4172/2155-6121.s4-004 · Cited by 48
Immune Control of Chlamydial Growth in the Human Epithelial Cell Line RT4 Involves Multiple Mechanisms That Include Nitric Oxide Induction, Tryptophan Catabolism and Iron Deprivation
Igietseme, J. U., Ananaba, G. A., CANDAL, D. H., Lyn, D., & Black, C. M. (1998) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1998.tb02332.x · Cited by 46
Gallium(III) complexes with 2-acetylpyridine-derived thiosemicarbazones: antimicrobial and cytotoxic effects and investigation on the interactions with tubulin
Lessa, J. A., Soares, M. A., dos Santos, R. G., Mendes, I. C., Salum, L. B., Daghestani, H. N., Andricopulo, A. D., Day, B. W., Vogt, A., & Beraldo, H. D. O. (2013) · BioMetals · doi:10.1007/s10534-012-9603-1 · Cited by 44
Evidence for a Role for Interleukin-17, Th17 Cells and Iron Homeostasis in Protective Immunity against Tuberculosis in Cynomolgus Macaques
Wareham, A., Tree, J. A., Marsh, P. D., Butcher, P. D., Dennis, M. J., & Sharpe, S. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088149 · Cited by 45
Cell-Autonomous Effector Mechanisms against Mycobacterium tuberculosisPreprint
MacMicking, J. D. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a018507 · Cited by 42
Mechanism and Regulation of Mycobactin Fatty Acyl-AMP Ligase FadD33
Vergnolle, O., Xu, H., & Blanchard, J. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.495549 · Cited by 42
Toll-Like Receptor Signal Adaptor Protein MyD88 Is Required for Sustained Endotoxin-Induced Acute Hypoferremic Response in Mice
Layoun, A., Huang, H., Calvé, A., & Santos, M. M. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.01.046 · Cited by 43
Established and Emerging Concepts to Treat Imbalances of Iron Homeostasis in Inflammatory Diseases
Petzer, V., Theurl, I., & Weiß, G. (2018) · Pharmaceuticals · doi:10.3390/ph11040135 · Cited by 41
Inhibitory effect of deferoxamine or macrophage activation on transformation of Paracoccidioides brasiliensis conidia ingested by macrophages: reversal by holotransferrin
Cano, L. E., Gómez, B. L., Brummer, E., Restrepo, Á., & Stevens, D. A. (1994) · Infection and Immunity · doi:10.1128/iai.62.4.1494-1496.1994 · Cited by 41
Metal complexes of lactoferrin and their effect on the intracellular multiplication of Legionella pneumophila
Goldoni, P., Sinibaldi, L., Valenti, P., & Orsi, N. (2000) · BioMetals · doi:10.1023/a:1009221616623 · Cited by 41
Co-coating of receptor-targeted drug nanocarriers with anti-phagocytic moieties enhances specific tissue uptake versus non-specific phagocytic clearance
Kim, J. P., Sinha, S., Solomon, M. A., Pérez‐Herrero, E., Hsu, J., Tsinas, Z., & Muro, S. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.08.045 · Cited by 41
Advances in Ferritin Physiology and Possible Implications in Bacterial Infection
Gehrer, C. M., Mitterstiller, A., Grubwieser, P., Meyron‐Holtz, E. G., Weiß, G., & Nairz, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054659 · Cited by 42
Decreased release of nitric oxide (NO) by alveolar macrophages after in vivo loading of rats with either iron or ethanol
Zhang, Y., Crichton, R. R., Boelaert, J. R., Jorens, P. G., Herman, A. G., Ward, R. J., Lallemand, F., & Witte, P. D. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00382-1 · Cited by 37
Post-translational Acetylation of MbtA Modulates Mycobacterial Siderophore Biosynthesis
Vergnolle, O., Xu, H., Tufariello, J. M., Favrot, L., Malek, A., Jacobs, W. R., & Blanchard, J. S. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.744532 · Cited by 36
Inhibition of Intracellular Multiplication of Human Strains ofChlamydia trachomatisby Nitric Oxide
Igietseme, J. U., Uriri, I. M., Chow, M., Abe, E., & Rank, R. G. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6335 · Cited by 35
Transient expression of transferrin receptors and localisation of iron in amoeboid microglia in postnatal rats.
Kaur, C., & Ling, E. A. (1995) · Europe PMC (PubMed Central) · Cited by 35
Disruption of normal iron homeostasis after bronchial instillation of an iron-containing particle
Ghio, A. J., Carter, J. D., Richards, J. H., Brighton, L. E., Lay, J. C., & Devlin, R. B. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.274.3.l396 · Cited by 33
Nifedipine Affects the Course of Salmonella enterica Serovar Typhimurium Infection by Modulating Macrophage Iron Homeostasis
Mair, S. M., Nairz, M., Bellmann-Weiler, R., Muehlbacher, T., Schroll, A., Theurl, I., Moser, P. L., Talasz, H., Fang, F. C., & Weiss, G. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir395 · Cited by 33
The iron regulatory hormone hepcidin inhibits expression of iron release as well as iron uptake proteins in J774 cells
Du, F., Qian, Z., Gong, Q., Zhu, Z. J., Lü, L., & Ke, Y. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.12.002 · Cited by 33
A bipartite iron-dependent transcriptional regulation of the tryptophan salvage pathway in Chlamydia trachomatis
(2019) · doi:10.7554/elife.42295 · Cited by 31
Aberrantly Low Transferrin Receptor Expression on Human Monocytes Is Associated with Nonpermissiveness forLegionella pneumophilaGrowth
Byrd, T. F., & Horwitz, M. A. (2000) · The Journal of Infectious Diseases · doi:10.1086/315390 · Cited by 31
Self-citation
Adenovirus-Mediated Human Immunodeficiency Virus-1 Nef Expression in Human Monocytes/Macrophages and Effect of Nef on Downmodulation of Fcγ Receptors and Expression of Monokines
De, S. K., Venkateshan, C. N., Seth, P. K., Gajdusek, D. C., & Gibbs, C. J. (1998) · Blood · doi:10.1182/blood.v91.6.2108 · Cited by 30
Polyvalent Cationic Metals Induce the Rate of Transferrin-independent Iron Acquisition by HL-60 Cells
Olakanmi, O., Stokes, J. B., Pathan, S., & Britigan, B. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.5.2599 · Cited by 29
Iron Deficiency and Anemia Associated with Infectious and Inflammatory Diseases
Hoffmann, A., de Souza, L. V., & Weiß, G. (2022) · Nutrition and health · doi:10.1007/978-3-031-14521-6_17 · Cited by 29
Interferon-γ mediates suppression of erythropoiesis but not reduced red cell survival following CpG-ODN administration in vivo
Thawani, N., Tam, M., Chang, K., & Stevenson, M. M. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2006.06.014 · Cited by 26
Chloroquine Inhibits Paracoccidioides brasiliensis Survival within Human Monocytes by Limiting the Availability of Intracellular Iron
Dias‐Melicio, L. A., Serezani, A. P. M., Calvi, S. A., & Soares, Â. M. V. D. C. (2006) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2006.tb03798.x · Cited by 26
Antimicrobial mechanisms of macrophages
Shiloh, M. U., & Nathan, C. (1999) · Advances in cellular and molecular biology of membranes and organelles · doi:10.1016/s1874-5172(99)80042-x · Cited by 26
Some macrophages kill Listeria monocytogenes while others do not
Fleming, S. D., & Campbell, P. A. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb00993.x · Cited by 26
Action and Reaction: Chlamydophila pneumoniae proteome alteration in a persistent infection induced by iron deficiency
Wehrl, W., Meyer, T. F., Jungblut, P. R., Müller, E., & Szczepek, A. J. (2004) · PROTEOMICS · doi:10.1002/pmic.200400917 · Cited by 25
Recombinant human erythropoietin in the treatment of anemic patients with hematological malignancies
Kasper, C. (2001) · Annals of Hematology · doi:10.1007/s002770100333 · Cited by 25
The expression of ferritin, lactoferrin, transferrin receptor and solute carrier family 11A1 in the host response to BCG-vaccination and Mycobacterium tuberculosis challenge
Thom, R. E., Elmore, M. J., Williams, A., Andrews, S. C., Drobniewski, F., Marsh, P. D., & Tree, J. A. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.03.008 · Cited by 23
The immunomicrotope of Leishmania control and persistence
Bogdan, C., Islam, N.-A.-K., Barinberg, D., Soulat, D., Schleicher, U., & Rai, B. (2024) · Trends in Parasitology · doi:10.1016/j.pt.2024.07.013 · Cited by 24
A Bioinformatics-Assisted Review on Iron Metabolism and Immune System to Identify Potential Biomarkers of Exercise Stress-Induced Immunosuppression
Bonilla, D. A., Moreno, Y., Petro, J. L., Forero, D. A., Vargas-Molina, S., Odriozola-Martínez, A., Orozco, C. A., Stout, J. R., Rawson, E. S., & Kreider, R. B. (2022) · Biomedicines · doi:10.3390/biomedicines10030724 · Cited by 26
CD4 T-cell expression of IFN-γ and IL-17 in pediatric malarial anemia
Raballah, E. O., Kempaiah, P. M., Karim, Z., Orinda, G. O., OTIENO, M. F., Perkins, D. J., & Ong’echa, J. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175864 · Cited by 22
In Vitro Interaction of Mycobacterium tuberculosis and Macrophages: Activation of Anti-mycobacterial Activity of Macrophages and Mechanisms of Anti-mycobacterial Activity
O’Brien, L. M., Roberts, B., & Andrew, P. W. (1996) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-80166-2_5 · Cited by 22
Expression and upregulation of transferrin receptors and iron uptake in the epiplexus cells of different aged rats injected with lipopolysaccharide and interferon-gamma.
Lu, J., Kaur, C., & Ling, E. (1995) · PubMed · Cited by 22
Klebsiella pneumoniae manipulates human macrophages to acquire iron
Grubwieser, P., Hilbe, R., Gehrer, C. M., Grander, M., Brigo, N., Hoffmann, A., Seifert, M., Berger, S., Theurl, I., Nairz, M., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1223113 · Cited by 21
Iron status following trauma, excluding burns
Walsh, D. S., Pattanapanyasat, K., Lamchiagdhase, P., Siritongtaworn, P., Thavichaigarn, P., Jiarakul, N., Chuntrasakul, C., Komoltri, C., Dheeradhada, C., Pearce, F. C., et al. (1996) · British journal of surgery · doi:10.1002/bjs.1800830731 · Cited by 20

Authors: Byrd, T. F., & Horwitz, M. A.
Affiliations: University of California, Los Angeles (US)
ORCID: Byrd, T F
Horwitz, M A
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1993-03-01
Volume: 91
Issue: 3
Pages: 969-976
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci116318
PMC: PMC288049
OpenAlex: W1969289450
Cited by: 149
References: 43
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 8 · 2013: 3 · 2012: 7
FWCI: 4.31
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders: American Cancer Society
National Institutes of Health (5r01ai028825-05, 5r01ai022421-08, CA16042)
National Cancer Institute (CA-16 042, P30CA016042)
National Institute of Allergy and Infectious Diseases (AI22421, AI-28825)
Jonsson Comprehensive Cancer Center
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: transferrin receptor, ferritin, monocytes, mononuclear phagocytes, interferon-gamma, iron absorption, iron metabolism, iron storage, receptor regulation
MeSH terms: Adult, Cells, Cultured, Ferritins, Humans, Interferon-gamma, Iron, Kinetics, Lymphocytes, Monocytes, Receptors, Transferrin, Recombinant Proteins, Transferrin, Down-Regulation, Up-Regulation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regulation of transferrin receptor expression and ferritin content in human mononuclear phagocytes. Coordinate upregulation by iron transferrin and downregulation by interferon gamma.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks