Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis

Sow, Fatoumata B; Florence, William C; Satoskar, Abhay R; Schlesinger, Larry S; Zwilling, Bruce S; Lafuse, William P

doi:10.1189/jlb.0407216

Cited by 229Iron Metabolism and DisordersTuberculosis Research and EpidemiologyAntimicrobial Peptides and Activities

Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis

Sow, Fatoumata B, Florence, William C, Satoskar, Abhay R, Schlesinger, Larry S, Zwilling, Bruce S, Lafuse, William P·2007·Journal of Leukocyte Biology

DOI 10.1189/jlb.0407216

Open this paper in CoChat — free account

Abstract

Hepcidin is an antimicrobial peptide produced by the liver in response to inflammatory stimuli and iron overload. Hepcidin regulates iron homeostasis by mediating the degradation of the iron export protein ferroportin 1, thereby inhibiting iron absorption from the small intestine and release of iron from macrophages. Here, we examined the expression of hepcidin in macrophages infected with the intracellular pathogens Mycobacterium avium and Mycobacterium tuberculosis. Stimulation of the mouse RAW264.7 macrophage cell line and mouse bone marrow-derived macrophages with mycobacteria and IFN-γ synergistically induced high levels of hepcidin mRNA and protein. Similar results were obtained using the human THP-1 monocytic cell line. Stimulation of macrophages with the inflammatory cytokines IL-6 and IL-β did not induce hepcidin mRNA expression. Iron loading inhibited hepcidin mRNA expression induced by IFN-γ and M. avium, and iron chelation increased hepcidin mRNA expression. Intracellular protein levels and secretion of hepcidin were determined by a competitive chemiluminescence ELISA. Stimulation of RAW264.7 cells with IFN-γ and M. tuberculosis induced intracellular expression and secretion of hepcidin. Furthermore, confocal microscopy analyses showed that hepcidin localized to the mycobacteria-containing phagosomes. As hepcidin has been shown to possess direct antimicrobial activity, we investigated its activity against M. tuberculosis. We found that hepcidin inhibited M. tuberculosis growth in vitro and caused structural damage to the mycobacteria. In summary, our data show for the first time that hepcidin localizes to the phagosome of infected, IFN-γ-activated cells and has antimycobacterial activity.

Integrity signals

Registry

Crossref · 10.1189/jlb.0407216

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

M. tuberculosis can stimulate hepcidin formation in macrophages and subvert ferroportin-mediated iron excess, ensuring iron retention within the macrophage.
“However, M. tuberculosis can also stimulate the formation of hepcidin in MΦs and subvert the stimulation of ferroportin-mediated iron excess and ensure iron retention within the MO (197).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [197]
Very high concentrations of hepcidin have been shown to inhibit M. tuberculosis growth in vitro.
“Similarly, very high concentrations of hepcidin have been shown to inhibit M. tuberculosis growth in vitro [32], but it is unknown whether these concentrations are relevant to in vivo infections.”
From Hepcidin and Host Defense against Infectious Diseases (2015) · cites this paper as [32]
The detrimental effect of hepcidin in intracellular infections has been demonstrated convincingly in vitro.
“This effect has been demonstrated convincingly in vitro”
From Hepcidin and Host Defense against Infectious Diseases (2015) · cites this paper as [32]
Hepcidin induces iron accumulation in macrophages.
“hepcidin induces iron accumulation in macrophages”
From Hepcidin and Host Defense against Infectious Diseases (2015) · cites this paper as [32]
Hepcidin may be detrimental in host defense against pathogens that occupy the intracellular niche.
“may be detrimental in defense against pathogens that occupy this intracellular niche”
From Hepcidin and Host Defense against Infectious Diseases (2015) · cites this paper as [32]

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803 · see citing works
NITRIC OXIDE AND MACROPHAGE FUNCTION
MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,184 · see citing works
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650 · cited 8× · see citing works
“Hepcidin is produced rapidly by the liver in mice in response to inflammatory stimuli, LPS, Freund adjuvant, and turpentine [29, 32, 33, 40].”
BackgroundInfluential
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.
Flynn, J. L., Chan, J., Triebold, K. J., Dalton, D. K., Stewart, T. A., & Bloom, B. R. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.6.2249 · Cited by 2,468 · see citing works
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168 · see citing works
Disseminated tuberculosis in interferon gamma gene-disrupted mice.
Cooper, A. M., Dalton, D. K., Stewart, T. A., Griffin, J. P., Russell, D. G., & Orme, I. M. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.6.2243 · Cited by 1,987 · see citing works
A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload
Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., & Loréal, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008923200 · Cited by 1,697 · see citing works
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
Ganz, T. (2003) · Blood · doi:10.1182/blood-2003-03-0672 · Cited by 1,544 · see citing works
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages
Schnappinger, D., Ehrt, S., Voskuil, M. I., Liu, Y., Mangan, J. A., Monahan, I. M., Dolganov, G., Efron, B., Butcher, P. D., Nathan, C., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030846 · Cited by 1,420 · see citing works
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
Nemeth, E., Valore, E. V., Territo, M., Schiller, G., Lichtenstein, A., & Ganz, T. (2003) · Blood · doi:10.1182/blood-2002-10-3235 · Cited by 1,417 · see citing works
LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
Krause, A., Neitz, S., Mägert, H.-J., Schulz, A., Forssmann, W.-G., Schulz-Knappe, P., & Adermann, K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01920-7 · Cited by 1,324 · see citing works
The role of cationic antimicrobial peptides in innate host defences
Hancock, R. E. W., & Diamond, G. (2000) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01823-0 · Cited by 1,233 · see citing works
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 ( USF2 ) knockout mice
Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A., & Vaulont, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151179498 · Cited by 1,233 · see citing works
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215686 · Cited by 1,214 · see citing works
Immunology of tuberculosis.
Flynn, J., & Chan, J. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.93 · Cited by 1,144 · see citing works
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
Nicolas, G., Bennoun, M., Porteu, A., Mativet, S., Beaumont, C., Grandchamp, B., Sirito, M., Sawadogo, M., Kahn, A., & Vaulont, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072632499 · Cited by 880 · see citing works
Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease
Weinstein, D. A., Roy, C. N., Fleming, M. D., Loda, M. F., Wolfsdorf, J. I., & Andrews, N. C. (2002) · Blood · doi:10.1182/blood-2002-04-1260 · Cited by 632 · see citing works
Macrophage phagocytosis of virulent but not attenuated strains of Mycobacterium tuberculosis is mediated by mannose receptors in addition to complement receptors
Schlesinger, L. S. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.7.2920 · Cited by 618 · see citing works
Self-citation
Regulation of hepcidin transcription by interleukin-1 and interleukin-6
Lee, P. L., Peng, H., Gelbart, T., Wang, L., & Beutler, E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409808102 · Cited by 542 · see citing works
Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells
Crichton, R. R., Wilmet, S., Legssyer, R., & Ward, R. J. (2002) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(02)00461-0 · Cited by 494 · see citing works
Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin
Knutson, M. D., Oukka, M., Koss, L. M., Aydemir, F., & Wessling-Resnick, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409409102 · Cited by 479 · see citing works
Cytokine Activation Leads to Acidification and Increases Maturation of Mycobacterium avium -Containing Phagosomes in Murine Macrophages
Schaible, U. E., Sturgill-Koszycki, S., Schlesinger, P. H., & Russell, D. G. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.3.1290 · Cited by 402 · see citing works
TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens
Peyssonnaux, C., Zinkernagel, A. S., Datta, V., Lauth, X., Johnson, R. S., & Nizet, V. (2006) · Blood · doi:10.1182/blood-2005-06-2259 · Cited by 379 · see citing works
Effects of cytokines on mycobacterial phagosome maturation
Via, L. E., Fratti, R. A., McFalone, M., Pagán-Ramos, E., Deretic, D., & Deretic, V. P. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.7.897 · Cited by 354 · see citing works
Hepcidin, A New Iron Regulatory Peptide
Nicolas, G., Viatte, L., Bennoun, M., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2002.0573 · Cited by 348 · see citing works
Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients
Timm, J., Post, F. A., Bekker, L., Walther, G. B., Wainwright, H., Manganelli, R., Chan, W.-T., Tsenova, L., Gold, B., Smith, I., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436197100 · Cited by 278 · see citing works
Hepcidin: A putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease
Fleming, R. E., & Sly, W. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161296298 · Cited by 273 · see citing works
Iron Acquisition and Metabolism by Mycobacteria
Voss, J. J. D., Rutter, K., Schroeder, B. G., & Barry, C. E. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.15.4443-4451.1999 · Cited by 268 · see citing works
The Mycobacterium tuberculosis IdeR is a dual functional regulator that controls transcription of genes involved in iron acquisition, iron storage and survival in macrophages
Gold, B., Rodríguez, G. M., Marras, S. A. E., Pentecost, M., & Smith, I. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02684.x · Cited by 261 · see citing works
Effect of hepcidin on intestinal iron absorption in mice
Laftah, A. H., Ramesh, B., Simpson, R. J., Solanky, N., Bahram, S., Schümann, K., Debnam, E. S., & Srai, S. K. S. (2004) · Blood · doi:10.1182/blood-2003-03-0953 · Cited by 217 · see citing works
The Effect of the Host’s Iron Status on Tuberculosis
Boelaert, J. R., Vandecasteele, S. J., Appelberg, R., & Gordeuk, V. R. (2007) · The Journal of Infectious Diseases · doi:10.1086/518040 · Cited by 217 · see citing works
Association of Pulmonary Tuberculosis with Increased Dietary Iron
Gangaidzo, I. T., Moyo, V. M., Mvundura, E., Aggrey, G., Murphree, N. L., Khumalo, H., Saungweme, T., Kasvosve, I., Gomo, Z. A. R., Rouault, T., et al. (2001) · The Journal of Infectious Diseases · doi:10.1086/323203 · Cited by 191 · see citing works
The many faces of host responses to tuberculosis
Collins, H., & Kaufmann, S. H. E. (2001) · Immunology · doi:10.1046/j.1365-2567.2001.01236.x · Cited by 181 · see citing works
Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages
Liu, X.-B., Nguyen, N.-B., Marquess, K. D., Yang, F., & Haile, D. J. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.04.006 · Cited by 177 · see citing works
Central role of transcription factor NF‐IL6 for cytokine and iron‐mediated regulation of murine inducible nitric oxide synthase expression
Dlaska, M., & Weiss, G. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.10.6171 · Cited by 176 · see citing works
Regulation of transferrin receptor expression and ferritin content in human mononuclear phagocytes. Coordinate upregulation by iron transferrin and downregulation by interferon gamma.
Byrd, T. F., & Horwitz, M. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116318 · Cited by 149 · see citing works
Hepcidin expression and iron transport in alveolar macrophages
Nguyen, N.-B., Callaghan, K. D., Ghio, A. J., Haile, D. J., & Yang, F. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00484.2005 · Cited by 143 · see citing works
Iron and Mycobacterium tuberculosis infection
Lounis, N., Truffot-Pernot, C., Grosset, J., Gordeuk, V. R., & Boelaert, J. R. (2001) · Journal of Clinical Virology · doi:10.1016/s1386-6532(00)00136-0 · Cited by 142 · see citing works
Inhibition of iron transport across human intestinal epithelial cells by hepcidin
Yamaji, S., Sharp, P., Ramesh, B., & Srai, S. K. (2004) · Blood · doi:10.1182/blood-2004-03-0829 · Cited by 139 · see citing works
Intraphagosomal Mycobacterium tuberculosis Acquires Iron from Both Extracellular Transferrin and Intracellular Iron Pools
Olakanmi, O., Schlesinger, L. S., Ahmed, A., & Britigan, B. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209768200 · Cited by 122 · see citing works
Self-citation
An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice
Roy, C. N., Custodio, Á. O., de Graaf, J., Schneider, S., Akpan, I. J., Montross, L. K., Sánchez, M., Gaudino, A., Hentze, M. W., Andrews, N. C., et al. (2004) · Nature Genetics · doi:10.1038/ng1350 · Cited by 120 · see citing works
Differential iron transport into phagosomes isolated from the RAW264.7 macrophage cell lines transfected with Nramp1Gly169 or Nramp1Asp169
Kuhn, D. E., Baker, B. D., Lafuse, W. P., & Zwilling, B. S. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.1.113 · Cited by 113 · see citing works
Self-citation
Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption
Anderson, G. J., Frazer, D. M., Wilkins, S. J., Becker, E. M., Millard, K. N., Murphy, T. L., McKie, A. T., & Vulpe, C. D. (2002) · Biochemical Society Transactions · doi:10.1042/bst0300724 · Cited by 100 · see citing works
Regulation of iron metabolism in murine J774 macrophages: role of nitric oxide-dependent and -independent pathways following activation with gamma interferon and lipopolysaccharide.
Mulero, V., & Brock, J. H. (1999) · Blood · doi:10.1182/blood.v94.7.2383.419k20_2383_2389 · Cited by 86 · see citing works
Gamma-interferon modulates human monocyte/macrophage transferrin receptor expression
Taetle, R., & Honeysett, J. M. (1988) · Blood · doi:10.1182/blood.v71.6.1590.1590 · Cited by 79 · see citing works
Surfactant Protein D Inhibition of Human Macrophage Uptake of Mycobacterium tuberculosis Is Independent of Bacterial Agglutination1
Ferguson, J., Voelker, D., Ufnar, J., Dawson, A. J., & Schlesinger, L. (2002) · Journal of Immunology · doi:10.4049/jimmunol.168.3.1309 · Cited by 55 · see citing works
Self-citation
The Nature of Extracellular Iron Influences Iron Acquisition by Mycobacterium tuberculosis Residing within Human Macrophages
Olakanmi, O., Schlesinger, L., Ahmed, A., & Britigan, B. (2004) · Infection and Immunity · doi:10.1128/iai.72.4.2022-2028.2004 · Cited by 48 · see citing works
Self-citation
Receptor‐Mediated Recognition ofMycobacterium tuberculosisby Host Cells
Fenton, M. J., Riley, L. W., & Schlesinger, L. S. (2004) · Wiley eBooks · doi:10.1128/9781555817657.ch25 · Cited by 43 · see citing works
Self-citation
Infection withMycobacterium aviumDifferentially Regulates the Expression of Iron Transport Protein mRNA in Murine Peritoneal Macrophages
Zhong, W., Lafuse, W. P., & Zwilling, B. S. (2001) · Infection and Immunity · doi:10.1128/iai.69.11.6618-6624.2001 · Cited by 35 · see citing works
Self-citation

Flagged first, then by citations

2 of the 52 references couldn’t be matched to a known paper.

Sorted by citations

Systemic Iron Homeostasis
Ganz, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00008.2013 · Cited by 1,122 · see citing works
Macrophage defense mechanisms against intracellular bacteria
Weiss, G., & Schaible, U. E. (2015) · Immunological Reviews · doi:10.1111/imr.12266 · Cited by 989 · see citing works
Mycobacterium tuberculosis: success through dormancy
Gengenbacher, M., & Kaufmann, S. H. E. (2012) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2012.00331.x · Cited by 698 · see citing works
Iron Homeostasis and the Inflammatory Response
Wessling-Resnick, M. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104804 · Cited by 480 · see citing works
Impact of vitamin D on immune function: lessons learned from genome-wide analysis
Chun, R. F., Liu, P. T., Modlin, R. L., Adams, J. S., & Hewison, M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00151 · Cited by 401 · see citing works
The struggle for iron - a metal at the host-pathogen interface: Iron at the host-pathogen interface
Nairz, M., Schroll, A., Sonnweber, T., & Weiss, G. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01529.x · Cited by 398 · see citing works
Suppression of iron-regulatory hepcidin by vitamin D
Bacchetta, J., Zaritsky, J. J., Sea, J. L., Chun, R. F., Lisse, T. S., Zavala, K., Nayak, A., Wesseling-Perry, K., Westerman, M., Hollis, B. W., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013040355 · Cited by 350 · see citing works
The Role of Macrophages in Staphylococcus aureus Infection
Pidwill, G. R., Gibson, J. F., Cole, J., Renshaw, S. A., & Foster, S. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.620339 · Cited by 341 · see citing works
Iron metabolism in the anemia of chronic disease
Weiss, G. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.08.006 · Cited by 322 · see citing works
Autocrine formation of hepcidin induces iron retention in human monocytes
Theurl, I., Theurl, M., Seifert, M., Mair, S., Nairz, M., Rumpold, H., Zoller, H., Bellmann-Weiler, R., Niederegger, H., Talasz, H., et al. (2008) · Blood · doi:10.1182/blood-2007-05-090019 · Cited by 275 · see citing works
Sequestration and scavenging of iron in infection
Parrow, N. L., Fleming, R. E., & Minnick, M. F. (2013) · Infection and Immunity · doi:10.1128/iai.00602-13 · Cited by 261 · see citing works
Hepcidin in Human Iron Disorders: Diagnostic Implications
Kroot, J. J., Tjalsma, H., Fleming, R. E., & Swinkels, D. W. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2009.140053 · Cited by 246 · see citing works
Molecular Mechanisms of Hepcidin Regulation: Implications for the Anemia of CKD
Babitt, J. L., & Lin, H. Y.-F. (2010) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2009.12.030 · Cited by 236 · see citing works
Iron depletion limits intracellular bacterial growth in macrophages
Paradkar, P. N., De Domenico, I., Durchfort, N., Zohn, I., Kaplan, J., & Ward, D. M. (2008) · Blood · doi:10.1182/blood-2007-12-126854 · Cited by 216 · see citing works
Hepcidin and Host Defense against Infectious Diseases
Michels, K., Nemeth, E., Ganz, T., & Mehrad, B. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1004998 · Cited by 205 · see citing works
Human macrophage host defense against Mycobacterium tuberculosis
Liu, P. T., & Modlin, R. L. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.05.014 · Cited by 199 · see citing works
Hepcidin Regulation of Iron Transport
Collins, J. F., Wessling‐Resnick, M., & Knutson, M. D. (2008) · Journal of Nutrition · doi:10.3945/jn.108.096347 · Cited by 199 · see citing works
Iron regulation and erythropoiesis
Nemeth, E. (2008) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3282f73335 · Cited by 175 · see citing works
A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia
Guida, C., Altamura, S., Klein, F. A., Galy, B., Boutros, M., Ulmer, A. J., Hentze, M. W., & Muckenthaler, M. U. (2015) · Blood · doi:10.1182/blood-2014-08-595256 · Cited by 173 · see citing works
Bioactivity studies of rainbow trout (Oncorhynchus mykiss) interleukin-6: Effects on macrophage growth and antimicrobial peptide gene expression
Costa, M. M., Maehr, T., Díaz‐Rosales, P., Secombes, C. J., & Wang, T. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.05.027 · Cited by 171 · see citing works
Early clearance of M ycobacterium tuberculosis : a new frontier in prevention
Verrall, A. J., Netea, M. G., Alisjahbana, B., Hill, P. C., & van Crevel, R. (2013) · Immunology · doi:10.1111/imm.12223 · Cited by 156 · see citing works
Interferon‐γ limits the availability of iron for intramacrophage Salmonella typhimurium
Nairz, M., Fritsche, G., Brunner, P., Talasz, H., Hantke, K., & Weiss, G. (2008) · European Journal of Immunology · doi:10.1002/eji.200738056 · Cited by 151 · see citing works
Iron and the immune system
Ward, R. J., Crichton, R. R., Taylor, D. L., Corte, L., Srai, S. K., & Dexter, D. T. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0479-3 · Cited by 146 · see citing works
Molecular mechanisms of normal iron homeostasis
Zhang, A.-S., & Enns, C. A. (2009) · Hematology · doi:10.1182/asheducation-2009.1.207 · Cited by 145 · see citing works
Cottonseed protein concentrate (CPC) suppresses immune function in different intestinal segments of hybrid grouper ♀Epinephelus fuscoguttatus×♂Epinephelus lanceolatu via TLR-2/MyD88 signaling pathways
Yin, B., Liu, H., Tan, B., Dong, X., Chi, S., Yang, Q., Zhang, S., & Chen, L. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.07.038 · Cited by 145 · see citing works
Hepcidin, the iron watcher
Viatte, L., & Vaulont, S. (2009) · Biochimie · doi:10.1016/j.biochi.2009.06.012 · Cited by 134 · see citing works
Iron and innate antimicrobial immunity-depriving the pathogen, defending the host
Nairz, M., Dichtl, S., Schroll, A., Haschka, D., Tymoszuk, P., Theurl, I., & Weiss, G. (2018) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2018.03.007 · Cited by 123 · see citing works
Iron: An Essential Element of Cancer Metabolism
Hsu, M. Y., Mina, E., Roetto, A., & Porporato, P. E. (2020) · Cells · doi:10.3390/cells9122591 · Cited by 116 · see citing works
Mobilization of Stored Iron in Mammals: A Review
Linder, M. C. (2013) · Nutrients · doi:10.3390/nu5104022 · Cited by 111 · see citing works
Mycobacterium tuberculosis cell-wall and antimicrobial peptides: a mission impossible?
Jacobo-Delgado, Y. M., Rodríguez-Carlos, A., Serrano, C. J., & Rivas-Santiago, B. T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1194923 · Cited by 95 · see citing works
Antimicrobial activity of human hepcidin 20 and 25 against clinically relevant bacterial strains: effect of copper and acidic pH
Maisetta, G., Petruzzelli, R., Brancatisano, F. L., Esin, S., Vitali, A., Campa, M., & Batoni, G. (2010) · Peptides · doi:10.1016/j.peptides.2010.08.007 · Cited by 91 · see citing works
Interleukin-1β (IL-1β) transcriptionally activates hepcidin by inducing CCAAT enhancer-binding protein δ (C/EBPδ) expression in hepatocytes
Kanamori, Y., Murakami, M., Sugiyama, M., Hashimoto, O., Matsui, T., & Funaba, M. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.770974 · Cited by 91 · see citing works
Multiple Hepcidins in a Teleost Fish, Dicentrarchus labrax: Different Hepcidins for Different Roles
Neves, J. V., Caldas, C., Vieira, I. H., Ramos, M. F., & Rodrigues, P. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501153 · Cited by 89 · see citing works
Role of STAT1, NF-κB, and C/EBPβ in the macrophage transcriptional regulation of hepcidin by mycobacterial infection and IFN-γ
Sow, F. B., Alvarez, G. R., Gross, R. P., Satoskar, A. R., Schlesinger, L. S., Zwilling, B. S., & Lafuse, W. P. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1208719 · Cited by 83 · see citing works
Self-citation
Understanding How Minerals Contribute to Optimal Immune Function
Ştefanache, A., Lungu, I. I., Butnariu, I.-A., Călin, G., Guțu, C., Marcu, C., Grierosu, C., Goroftei, E. R. B., Duceac, L.-D., Dabija, M. G., et al. (2023) · Journal of Immunology Research · doi:10.1155/2023/3355733 · Cited by 91 · see citing works
Mycobacteria–host interactions in human bronchiolar airway organoids
Iakobachvili, N., Leon‐Icaza, S. A., Knoops, K., Sachs, N., Mazères, S., Siméone, R., Peixoto, A., Bernard, C., Murris‐Espin, M., Mazières, J., et al. (2021) · Molecular Microbiology · doi:10.1111/mmi.14824 · Cited by 76 · see citing works
Infection-induced changes in expression of antibacterial and cytokine genes in the gill epithelial cells of Atlantic cod, Gadus morhua during incubation with bacterial pathogens
Caipang, C. M. A., Lazado, C. C., Brinchmann, M. F., & Kiron, V. (2010) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2010.04.009 · Cited by 78 · see citing works
Identification of centrarchid hepcidins and evidence that 17β-estradiol disrupts constitutive expression of hepcidin-1 and inducible expression of hepcidin-2 in largemouth bass (Micropterus salmoides)
Robertson, L. S., Iwanowicz, L. R., & Marranca, J. M. (2009) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2009.03.023 · Cited by 78 · see citing works
Identification, cloning and expression analysis of a hepcidin cDNA of the Atlantic cod (Gadus morhua L.)
Solstad, T., LARSEN, A., Seppola, M., & JORGENSEN, T. (2008) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2008.05.013 · Cited by 77 · see citing works
Leishmania-Mediated Inhibition of Iron Export Promotes Parasite Replication in Macrophages
Ben-Othman, R., Flannery, A. R., Miguel, D. C., Ward, D. M., Kaplan, J., & Andrews, N. W. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003901 · Cited by 76 · see citing works
Decreased outer membrane permeability protects mycobacteria from killing by ubiquitin‐derived peptides
Purdy, G. E., Niederweis, M., & Russell, D. G. (2009) · Molecular Microbiology · doi:10.1111/j.1365-2958.2009.06801.x · Cited by 75 · see citing works
Mycobacterium tuberculosis Requires Phosphate-Responsive Gene Regulation To Resist Host Immunity
Tischler, A. D., Leistikow, R. L., Kirksey, M., Voskuil, M. I., & McKinney, J. D. (2012) · Infection and Immunity · doi:10.1128/iai.01136-12 · Cited by 68 · see citing works
Host Antimicrobial Peptides: The Promise of New Treatment Strategies against Tuberculosis
Arranz‐Trullén, J., Lu, L., Pulido, D., Bhakta, S., & Boix, E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01499 · Cited by 77 · see citing works
Two Human Host Defense Ribonucleases against Mycobacteria, the Eosinophil Cationic Protein (RNase 3) and RNase 7
Pulido, D., Torrent, M., Andreu, D., Nogués, M. V., & Boix, E. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00428-13 · Cited by 75 · see citing works
Therapeutic potential of hepcidin − the master regulator of iron metabolism
Vyoral, D., & Petrák, J. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.11.010 · Cited by 79 · see citing works
Iron Metabolism in the Tumor Microenvironment: Contributions of Innate Immune Cells
Liang, W. P., & Ferrara, N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.626812 · Cited by 74 · see citing works
The iron export protein ferroportin 1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial-containing phagosome
Van Zandt, K. E., Sow, F. B., Florence, W. C., Zwilling, B. S., Satoskar, A. R., Schlesinger, L. S., & Lafuse, W. P. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1107781 · Cited by 74 · see citing works
Self-citation
Hepcidin: Homeostasis and Diseases Related to Iron Metabolism
Reichert, C. O., da Cunha, J., Levy, D., Maselli, L. M. F., Bydlowski, S. P., & Spada, C. (2017) · Acta Haematologica · doi:10.1159/000471838 · Cited by 74 · see citing works
Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metabolism and Increases Susceptibility to Mycobacterium tuberculosis Infection
Reddy, V. P., Chinta, K. C., Saini, V., Glasgow, J. N., Hull, T. D., Traylor, A., Rey-Stolle, F., Soares, M. P., Madansein, R., Rahman, M. A., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00860 · Cited by 67 · see citing works
Role of Ferroportin in Macrophage-Mediated Immunity
Johnson, E. E., Sandgren, A., Cherayil, B. J., Murray, M., & Wessling-Resnick, M. (2010) · Infection and Immunity · doi:10.1128/iai.00498-10 · Cited by 68 · see citing works
Antiviral function of tilapia hepcidin 1–5 and its modulation of immune-related gene expressions against infectious pancreatic necrosis virus (IPNV) in Chinook salmon embryo (CHSE)-214 cells
Rajanbabu, V., & Chen, J. (2010) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2010.09.005 · Cited by 66 · see citing works
Vitamin D: Immuno-modulation and tuberculosis treatment
Selvaraj, P., Harishankar, M., & Kolloli, A. (2015) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2014-0386 · Cited by 66 · see citing works
Mycobacterium tuberculosis components stimulate production of the antimicrobial peptide hepcidin
Sow, F. B., Nandakumar, S., Velu, V., Kellar, K. L., Schlesinger, L. S., Amara, R. R., Lafuse, W. P., Shinnick, T. M., & Sable, S. B. (2011) · Tuberculosis · doi:10.1016/j.tube.2011.03.003 · Cited by 64 · see citing works
Self-citation
Insights into the Antimicrobial Properties of Hepcidins: Advantages and Drawbacks as Potential Therapeutic Agents
Lombardi, L., Maisetta, G., Batoni, G., & Tavanti, A. (2015) · Molecules · doi:10.3390/molecules20046319 · Cited by 64 · see citing works
Hepcidin expression in human airway epithelial cells is regulated by interferon-γ
Frazier, M. D., Mamo, L. B., Ghio, A. J., & Turi, J. L. (2011) · Respiratory Research · doi:10.1186/1465-9921-12-100 · Cited by 64 · see citing works
Therapeutic Advances in Regulating the Hepcidin/Ferroportin Axis
Hawula, Z. J., Wallace, D. F., Subramaniam, V. N., & Rishi, G. (2019) · Pharmaceuticals · doi:10.3390/ph12040170 · Cited by 62 · see citing works
Antimicrobial Peptides in Innate Immunity against Mycobacteria
Shin, D., & Jo, E. (2011) · Immune Network · doi:10.4110/in.2011.11.5.245 · Cited by 61 · see citing works
Neisseria gonorrhoeae modulates iron-limiting innate immune defenses in macrophages
Zughaier, S. M., Kandler, J. L., & Shafer, W. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087688 · Cited by 59 · see citing works
Immunological differences in intestine and rectum of Atlantic cod (Gadus morhua L.)
Inami, M., Taverne-Thiele, A. J., Schrøder, M. B., Kiron, V., & Rombout, J. H. W. M. (2009) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2009.03.007 · Cited by 60 · see citing works
Interferon gamma upregulates frataxin and corrects the functional deficits in a Friedreich ataxia model
Tomassini, B., Arcuri, G., Fortuni, S., Sandi, C., Ezzatizadeh, V., Casali, C., Condò, I., Malisan, F., Al‐Mahdawi, S., Pook, M. A., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds110 · Cited by 60 · see citing works
Interaction between antimicrobial peptides and mycobacteria
Gutsmann, T. (2016) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2016.01.031 · Cited by 61 · see citing works
Immune oxysterols: Role in mycobacterial infection and inflammation
Bah, S. Y., Dickinson, P., Forster, T., Kampmann, B., & Ghazal, P. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.04.015 · Cited by 59 · see citing works
Relationship Between Blood Concentrations of Hepcidin and Anemia Severity, Mycobacterial Burden, and Mortality Among Patients With HIV-Associated Tuberculosis
Kerkhoff, A. D., Meintjes, G., Burton, R., Vogt, M., Wood, R., & Lawn, S. D. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv364 · Cited by 57 · see citing works
Iron acquisition, assimilation and regulation in mycobacteria
Banerjee, S., Farhana, A., Ehtesham, N. Z., & Hasnain, S. E. (2011) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2011.02.016 · Cited by 57 · see citing works
A Functional Slow Recycling Pathway of Transferrin is Required for Growth of Chlamydia
Ouellette, S. P., & Carabeo, R. A. (2010) · Frontiers in Microbiology · doi:10.3389/fmicb.2010.00112 · Cited by 55 · see citing works
Iron in intracellular infection: to provide or to deprive?
Silva-Gomes, S., Vale-Costa, S., Appelberg, R., & Gomes, M. S. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00096 · Cited by 51 · see citing works
Hepcidin, iron, and bacterial infection
Barton, J. C., & Acton, R. T. (2019) · Vitamins and hormones · doi:10.1016/bs.vh.2019.01.011 · Cited by 53 · see citing works
Iron Regulator Hepcidin Exhibits Antiviral Activity against Hepatitis C Virus
Liu, H., Trinh, T. L., Dong, H., Keith, R., Nelson, D. R., & Liu, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046631 · Cited by 53 · see citing works
Oncostatin M is a potent inducer of hepcidin, the iron regulatory hormone
Chung, B., Verdier, F., Matak, P., Deschemin, J., Mayeux, P., & Vaulont, S. (2010) · The FASEB Journal · doi:10.1096/fj.09-152561 · Cited by 51 · see citing works
The Role of Iron in Alcohol-Mediated Hepatocarcinogenesis
Mueller, S., & Rausch, V. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-09614-8_6 · Cited by 51 · see citing works
Identification and characterization of a hepcidin from half-smooth tongue sole Cynoglossus semilaevis
Wang, Y., Liu, X., Ma, L., Yu, Y. P., Yu, H., Mohammed, S., Chu, G., Mu, L., & Zhang, Q. (2012) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2012.04.011 · Cited by 50 · see citing works
Erythrocytes: Central Actors in Multiple Scenes of Atherosclerosis
Turpin, C., Catan, A., Meilhac, O., Bourdon, E., Canonne‐Hergaux, F., & Rondeau, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115843 · Cited by 51 · see citing works
Antimicrobial and immune-modulatory effects of vitamin D provide promising antibiotics-independent approaches to tackle bacterial infections – lessons learnt from a literature survey
Golpour, A., Bereswill, S., & Heimesaat, M. M. (2019) · European Journal of Microbiology and Immunology · doi:10.1556/1886.2019.00014 · Cited by 50 · see citing works
Hepcidin expression by human monocytes in response to adhesion and pro-inflammatory cytokines
Zhang, X., & Rovin, B. H. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2010.08.005 · Cited by 49 · see citing works
Anti-tubercular peptides: A quest of future therapeutic weapon to combat tuberculosis
Khusro, A., Aarti, C., & Agastian, P. (2016) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/j.apjtm.2016.09.005 · Cited by 47 · see citing works
Bacterial cell wall constituents induce hepcidin expression in macrophages through MyD88 signaling
Layoun, A., & Santos, M. M. (2012) · Inflammation · doi:10.1007/s10753-012-9463-4 · Cited by 44 · see citing works
Increased expression of host iron-binding proteins precedes iron accumulation and calcification of primary lung lesions in experimental tuberculosis in the guinea pig
Basaraba, R. J., Bielefeldt‐Ohmann, H., Eschelbach, E. K., Reisenhauer, C., Tolnay, A.-E., Taraba, L. C., Shanley, C. A., Smith, E. A., Bedwell, C. L., Chlipala, E. A., et al. (2007) · Tuberculosis · doi:10.1016/j.tube.2007.09.002 · Cited by 44 · see citing works
Psychological stress induces hypoferremia through the IL-6–hepcidin axis in rats
Zhao, M., Chen, J., Wang, W., Wang, L., Ma, L., Shen, H., & Li, M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.05.166 · Cited by 46 · see citing works
Antimicrobial Peptides as Potential Anti-Tubercular Leads: A Concise Review
Oliveira, G. S., Costa, R. P., Gomes, P. A. C., Gomes, M. S., Silva, T., & Teixeira, C. A. S. (2021) · Pharmaceuticals · doi:10.3390/ph14040323 · Cited by 44 · see citing works
pH‐dependent disruption of E scherichia coli ATCC 25922 and model membranes by the human antimicrobial peptides hepcidin 20 and 25
Maisetta, G., Vitali, A., Scorciapino, M. A., Rinaldi, A. C., Petruzzelli, R., Brancatisano, F. L., Esin, S., Stringaro, A., Colone, M., Luzi, C., et al. (2013) · FEBS Journal · doi:10.1111/febs.12288 · Cited by 43 · see citing works
Effect of hepcidin antagonists on anemia during inflammatory disorders
Sagar, P., Angmo, S., Sandhir, R., Rishi, V., Yadav, H., & Singhal, N. K. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107877 · Cited by 43 · see citing works
Mesenchymal Stromal Cells: an Antimicrobial and Host-Directed Therapy for Complex Infectious Diseases
Shaw, T. D., Krasnodembskaya, A. D., Schroeder, G. N., Zumla, A. I., Maeurer, M. J., & O’Kane, C. M. (2021) · Clinical Microbiology Reviews · doi:10.1128/cmr.00064-21 · Cited by 42 · see citing works
Characterization and bioactivity of hepcidin-2 in zebrafish: Dependence of antibacterial activity upon disulfide bridges
Lin, W., Liu, S., Hu, L., & Zhang, S. (2014) · Peptides · doi:10.1016/j.peptides.2014.04.014 · Cited by 41 · see citing works
Serum hepcidin concentrations and type 2 diabetes
Aregbesola, A. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i7.978 · Cited by 41 · see citing works
Hepcidin is a Potential Regulator of Iron Status in Chronic Kidney Disease
Tsuchiya, K., & Nitta, K. (2012) · Therapeutic Apheresis and Dialysis · doi:10.1111/1744-9987.12001 · Cited by 41 · see citing works
Iron Supplementation Therapy, A Friend and Foe of Mycobacterial Infections?
Agoro, R., & Mura, C. (2019) · Pharmaceuticals · doi:10.3390/ph12020075 · Cited by 41 · see citing works
Resistance to Antimicrobial Peptides in Vibrios
Destoumieux‐Garzón, D., Duperthuy, M., Vanhove, A. S., Schmitt, P., & Wai, S. N. (2014) · Antibiotics · doi:10.3390/antibiotics3040540 · Cited by 39 · see citing works
Inverse relationship of serum hepcidin levels with CD4 cell counts in HIV-infected patients selected from an Indonesian prospective cohort study
Wisaksana, R., de Mast, Q., Alisjahbana, B., Jusuf, H., Sudjana, P., Indrati, A. R., Sumantri, R., Swinkels, D., van Crevel, R., & van der Ven, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079904 · Cited by 35 · see citing works
Hepcidin in Trauma: Linking Injury, Inflammation, and Anemia
Sihler, K. C., Raghavendran, K., Westerman, M. E., Ye, W., & Napolitano, L. M. (2010) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3181f066d5 · Cited by 37 · see citing works
Hypoxia enhances H2O2-mediated upregulation of hepcidin: Evidence for NOX4-mediated iron regulation
da Silva, I. P., Rausch, V., Peccerella, T., Millonig, G., Seitz, H. K., & Mueller, S. (2018) · Redox Biology · doi:10.1016/j.redox.2018.02.005 · Cited by 35 · see citing works
The iron link between malaria and invasive non-typhoid Salmonella infections
van Santen, S., de Mast, Q., Swinkels, D. W., & van der Ven, A. J. A. M. (2013) · Trends in Parasitology · doi:10.1016/j.pt.2013.03.006 · Cited by 33 · see citing works
Current Insights into the Chemistry and Antitubercular Potential of Benzimidazole and Imidazole Derivatives
Parwani, D., Bhattacharya, S., Rathore, A., Mallick, C., Asati, V., Agarwal, S., Rajoriya, V., Das, R., & Kashaw, S. K. (2020) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557520666201102094401 · Cited by 35 · see citing works
Lysosomal ubiquitin and the demise of Mycobacterium tuberculosis
Purdy, G. E., & Russell, D. G. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01039.x · Cited by 35 · see citing works
Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent
Wu, X., Yung, L.-M., Cheng, W.-H., Yu, P. B., Babitt, J. L., Lin, H. Y., & Xia, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044622 · Cited by 34 · see citing works
Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi
Koening, C. L., Miller, J. C., Nelson, J. M., Ward, D. M., Kushner, J. P., Bockenstedt, L. K., Weis, J. J., Kaplan, J., & Domenico, I. D. (2009) · Blood · doi:10.1182/blood-2009-03-209577 · Cited by 32 · see citing works
Iron and Microbial Growth
Symeonidis, A. S., & Marangos, M. N. (2012) · InTech eBooks · doi:10.5772/34760 · Cited by 33 · see citing works
Design, synthesis and structure-activity relationship study of wollamide B; a new potential anti TB agent
Asfaw, H., Laqua, K., Walkowska, A. M., Cunningham, F., Martínez, M. S., Cuevas-Zurita, J. C., Ballell, L., & Imming, P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176088 · Cited by 32 · see citing works
Mycobacteria-induced anaemia revisited: A molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin
Rodrigues, P. N., Gomes, S. S., Neves, J. V., Gomes-Pereira, S., Correia-Neves, M., Nunes-Alves, C., Stolte, J., Sanchez, M., Appelberg, R., Muckenthaler, M. U., et al. (2011) · Immunobiology · doi:10.1016/j.imbio.2011.04.004 · Cited by 31 · see citing works
Oncostatin M and leukemia inhibitory factor increase hepcidin expression in hepatoma cell lines
Kanda, J., Uchiyama, T., Tomosugi, N., Higuchi, M., Uchiyama, T., & Kawabata, H. (2009) · International Journal of Hematology · doi:10.1007/s12185-009-0443-x · Cited by 31 · see citing works
IL-1 beta-mediated macrophage-hepatocyte crosstalk upregulates hepcidin under physiological low oxygen levels
da Silva, I. P., Peccerella, T., Mueller, S., & Rausch, V. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101209 · Cited by 31 · see citing works

Expression and localization of hepcidin in macrophages:
Zwilling, B. S., & Lafuse, W. P. (2015)
Self-citation
Hepcidin is synergistically induced in mouse macrophages by mycobacteria and IFN-γ, and is present in the mycobacterial phagosome (B166)
Sow, F. B., Schlesinger, L. S., Satoskar, A. R., Zwilling, B. S., & Lafuse, W. P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.supp.b166
Self-citation
Role of Hepcidin in the Innate Immune Response to Mycobacterium tuberculosis
Sow, F. B., Sable, S. B., Plikaytis, B. B., Lafuse, W. P., & Shinnick, T. M. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.2_supplement.556 · Cited by 3 · see citing works
Self-citation
Expression and regulation of the iron regulatory hormone and antimicrobial peptide hepcidin in mycobacteria-infected mice and macrophages
Sow, F. B. (2007) · OhioLink ETD Center (Ohio Library and Information Network)
Self-citation
Role of STAT1, NF-κB, and C/EBPβ in the macrophage transcriptional regulation of hepcidin by mycobacterial infection and IFN-γ
Sow, F. B., Alvarez, G. R., Gross, R. P., Satoskar, A. R., Schlesinger, L. S., Zwilling, B. S., & Lafuse, W. P. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1208719 · Cited by 83 · see citing works
Self-citation

Authors: Sow, F. B., Florence, W. C., Satoskar, A. R., Schlesinger, L. S., Zwilling, B. S., & Lafuse, W. P.
Affiliations: The Ohio State University (US)
Corresponding author: Lafuse, William P
ORCID: Sow, Fatoumata B
Satoskar, Abhay R
Schlesinger, Larry S
Lafuse, William P
Venue: Journal of Leukocyte Biology
Publisher: Oxford University Press (OUP)
Published: 2007-07-03
Volume: 82
Issue: 4
Pages: 934-945
ISSN: 0741-5400 (ISSN-L)
1938-3673
DOI: 10.1189/jlb.0407216
OpenAlex: W2107072141
Cited by: 229
References: 52
Citations by year: 2026: 6 · 2025: 7 · 2024: 10 · 2023: 6 · 2022: 12 · 2021: 19 · 2020: 7 · 2019: 12 · 2018: 9 · 2017: 14 · 2016: 10 · 2015: 17 · 2014: 12 · 2013: 18 · 2012: 13
FWCI: 9.16
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Journal of Leukocyte Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (RO1DK-57667)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Keywords: hepcidin, macrophages, tuberculosis, Mycobacterium tuberculosis, Mycobacterium avium, iron homeostasis, ferroportin 1, interferon-gamma, antimicrobial activity, phagosome, host defense, iron chelation, iron loading
MeSH terms: Animals, Cell Line, Gene Expression Regulation, Homeostasis, Humans, Immunity, Innate, Interferon-gamma, Intestinal Absorption, Iron, Iron Chelating Agents, Liver, Mycobacterium avium, Mycobacterium tuberculosis, Phagosomes, RNA, Messenger, Tuberculosis, Iron Overload, Antimicrobial Cationic Peptides, Mice, Hepcidins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks