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Diminished brain glucose metabolism is a significant determinant for falling rates of systemic glucose utilization during sleep in normal humans.
Open accessAbstract
Systemic glucose utilization declines during sleep in man. We tested the hypothesis that this decline in utilization is largely accounted for by reduced brain glucose metabolism. 10 normal subjects underwent internal jugular and radial artery cannulation to determine cerebral blood flow by N2O equilibrium technique and to quantitate cross-brain glucose and oxygen differences before and every 3 h during sleep. Sleep stage was graded by continuous electroencephalogram, and systemic glucose turnover was estimated by isotope dilution. Brain glucose metabolism fell from 33.6 +/- 2.2 mumol/100 g per min (mean +/- SE) before sleep (2300 h) to a mean nadir of 24.3 +/- 1.1 mumol/100 g per min at 0300 h during sleep (P = 0.001). Corresponding rates of systemic glucose utilization fell from 13.2 +/- 0.8 to 11.0 +/- 0.5 mumol/kg per min (P = 0.003). Diminished brain glucose metabolism was the product of a reduced arteriovenous glucose difference, 0.643 +/- 0.024 to 0.546 +/- 0.020 mmol/liter (P = 0.002), and cerebral blood flow, 50.3 +/- 2.8 to 44.6 +/- 1.4 cc/100 g per min (P = 0.021). Brain oxygen metabolism fell commensurately from 153.4 +/- 11.8 to 128.0 +/- 8.4 mumol/100 g per min (P = 0.045). The observed reduction in brain metabolism occurred independent of stage of central nervous system electrical activity (electroencephalographic data), and was more closely linked to duration of sleep. We conclude that a decline in brain glucose metabolism is a significant determinant of falling rates of systemic glucose utilization during sleep.
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“Aerobic glycolysis (AG), i.e., non-oxidative metabolism of glucose despite the presence of abundant oxygen, accounts for 10–12% of glucose used by the adult human brain.”
From Aerobic glycolysis in the human brain is associated with development and neotenous gene expression (2014) · cites this paper as Boyle et al., 1994
Experimental — accuracy not yet measuredIn the citing paper
“SWS, which is particularly abundant at the beginning of the sleep period, has been shown to result in a 30–40% decrease in cerebral glucose metabolism relative to waking or rapid eye movement (REM) sleep [12].”
From Sleep and metabolic function (2012) · cites this paper as [12]
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“In adult studies, cerebral glucose utilization declines (7) and plasma glucose rises (8) in N3 sleep.”
From Sleep architecture and glucose and insulin homeostasis in obese adolescents (2011) · cites this paper as [8]
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Cites
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772
Hobson, J. A. (1969) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(69)90021-2 · Cited by 5,215
Kety, S. S., & Schmidt, C. F. (1948) · Journal of Clinical Investigation · doi:10.1172/jci101994 · Cited by 2,058
Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity
Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C. (1988) · Science · doi:10.1126/science.3260686 · Cited by 1,796
Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber.
Ravussin, E., Lillioja, S., Anderson, T. E., Christin, L., & Bogardus, C. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112749 · Cited by 1,166
An Introduction to the Study of Experimental Medicine
Bernard, C., Wolf, S., & Greene, H. C. (2018) · Routledge eBooks · doi:10.4324/9781351320764-1 · Cited by 937
Growth hormone secretion during sleep
Takahashi, Y., KIPNIS, D. M., & Daughaday, W. H. (1968) · Journal of Clinical Investigation · doi:10.1172/jci105893 · Cited by 799
Brain metabolism: a perspective from the blood-brain barrier
Pardridge, W. M. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.4.1481 · Cited by 745
A Sensitive Double Antibody Immunoassay for Human Growth Hormone in Plasma
Schalch, P., & PARKER, M. L. (1964) · Nature · doi:10.1038/2031141a0 · Cited by 635
Determination of Free and Total Insulin and C-Peptide in Insulin-treated Diabetics
Kuzuya, H., BLIX, P. M., Horwitz, D. L., Steiner, D. F., & Rubenstein, A. H. (1977) · Diabetes · doi:10.2337/diab.26.1.22 · Cited by 603
Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues
Hue, L., & Rider, M. H. (1987) · Biochemical Journal · doi:10.1042/bj2450313 · Cited by 421
Cerebral arteriovenous oxygen difference as an estimate of cerebral blood flow in comatose patients
ROBERTSON, C. S., Narayan, R. K., Gokaslan, Z. L., Pahwa, R., Grossman, R. G., Caram, P., & Allen, E. (1989) · Journal of neurosurgery · doi:10.3171/jns.1989.70.2.0222 · Cited by 385
The concept of coupling blood flow to brain function: Revision required?
Lou, H. C., Edvinsson, L. I., & MacKenzie, E. T. (1987) · Annals of Neurology · doi:10.1002/ana.410220302 · Cited by 304
Maquet, P., Dive, D., Salmon, E., Sadzot, B., Franco, G., Poirrier, R., von Frenckell, R., & Franck, G. (1990) · Brain Research · doi:10.1016/0006-8993(90)91099-3 · Cited by 292
Firth, R. G., Bell, P. M., Marsh, H. W., Hansen, I., & Rizza, R. A. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112467 · Cited by 284
Regional cerebral glucose metabolic rate in human sleep assessed by positron emission tomography
Buchsbaum, M. S., Gillin, J. C., Wu, J. C., Hazlett, E. A., Sicotte, N. L., Dupont, R. M., & Bunney, W. E. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90021-0 · Cited by 280
Cerebral O2 metabolism and cerebral blood flow in humans during deep and rapid-eye-movement sleep
Madsen, P. L., Schmidt, J. F., Wildschiødtz, G., Friberg, L., Holm, S., Vorstrup, S., & Lassen, N. A. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.70.6.2597 · Cited by 254
Pathogenesis of the Dawn Phenomenon in Patients with Insulin-Dependent Diabetes Mellitus
Campbell, P. J., Bolli, G. B., Cryer, P. E., & Gerich, J. E. (1985) · New England Journal of Medicine · doi:10.1056/nejm198506063122302 · Cited by 218
An Introduction to the Study of Experimental Medicine
(1950) · JAMA · doi:10.1001/jama.1950.02910390073029 · Cited by 205
Mangold, R., Sokoloff, L., Conner, E. H., Kleinerman, J. I., Therman, P.-O. G., & Kety, S. S. (1955) · Journal of Clinical Investigation · doi:10.1172/jci103158 · Cited by 195
Role of Brain in Counterregulation of Insulin-Induced Hypoglycemia in Dogs
Biggers, D. W., Myers, S. R., Neal, D. W., Stinson, R. L., Cooper, N. B., Jaspan, J. B., Williams, P. E., Cherrington, A. D., & Frizzell, R. T. (1989) · Diabetes · doi:10.2337/diab.38.1.7 · Cited by 192
Human cerebral blood flow during sleep and waking.
Townsend, R. E., Prinz, P. N., & Obrist, W. D. (1973) · Journal of Applied Physiology · doi:10.1152/jappl.1973.35.5.620 · Cited by 187
Human Regional Cerebral Blood Flow during Rapid-Eye-Movement Sleep
Madsen, P. L., Holm, S., Vorstrup, S., Friberg, L., Lassen, N. A., & Wildschiødtz, G. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.94 · Cited by 163
Oxygen Consumption Rate and Electroencephalographic Stage of Sleep
Brebbia, D. R., & Altshuler, K. Z. (1965) · Science · doi:10.1126/science.150.3703.1621 · Cited by 162
Local cerebral glucose utilization in non-rapid eye movement sleep
Kennedy, C., Gillin, J. C., Mendelson, W. B., Suda, S., Miyaoka, M., Ito, M., Nakamura, R., Storch, F. I., Pettigrew, K. D., Mishkin, M., et al. (1982) · Nature · doi:10.1038/297325a0 · Cited by 144
Normal Values in Clinical Medicine
(1950) · JAMA · doi:10.1001/jama.1950.02910320076033 · Cited by 142
Normal Values in Clinical Medicine
&NA; (1950) · Southern Medical Journal · doi:10.1097/00007611-195007000-00025 · Cited by 128
(1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-100-1-171_2 · Cited by 127
Regional cerebral glucose metabolism in man during wakefulness, sleep, and dreaming
Heiss, W., Pawlik, G., Herholz, K., Wagner, R. L., & Wienhard, K. (1985) · Brain Research · doi:10.1016/0006-8993(85)91537-9 · Cited by 126
Fructose-2,6-P2, chemistry and biological function
Uyeda, K., Furuya, E., Richards, C. S., & Yokoyama, M. (1982) · Molecular and Cellular Biochemistry · doi:10.1007/bf00227610 · Cited by 113
Cortical unit activity in sleep and waking
Hobson, J. A., & McCarley, R. W. (1971) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(71)90271-9 · Cited by 113
Normal human sleep: Regional cerebral hemodynamics
Sakai, F., Meyer, J. S., Karacan, I., Derman, S., & Yamamoto, M. (1980) · Annals of Neurology · doi:10.1002/ana.410070514 · Cited by 108
Insulin, glucagon, and catecholamines in prevention of hypoglycemia during fasting
Boyle, P. J., SHAH, S. D., & Cryer, P. E. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.256.5.e651 · Cited by 83
Self-citationEnsinck, J. W. (1983) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-68866-9_10 · Cited by 72
Underestimation of hepatic glucose production by radioactive and stable tracers
Argoud, G., Schade, D. S., & Eaton, R. P. (1987) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1987.252.5.e606 · Cited by 72
TANAKA, K., Nicholson, W. E., & Orth, D. N. (1978) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-46-6-883 · Cited by 65
Brain metabolism and blood flow during sleep
FRANZINI, C. (1992) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1992.tb00002.x · Cited by 62
Clore, J. N., Nestler, J. E., & Blackard, W. G. (1989) · Diabetes · doi:10.2337/diab.38.3.285 · Cited by 62
Validity of internal jugular blood for study of cerebral blood flow and metabolism
Lassen, N. A., & Lane, M. H. (1961) · Journal of Applied Physiology · doi:10.1152/jappl.1961.16.2.313 · Cited by 59
Godine, J. E. (1984) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62429-x · Cited by 56
Role of Liver in Glucose Homeostasis
Sherwin, R. S. (1980) · Diabetes Care · doi:10.2337/diacare.3.2.261 · Cited by 55
Cardiac output during human sleep.
Miller, J. C., & Horvath, S. M. (1976) · PubMed · Cited by 53
McMahon, M., Marsh, H. M., & Rizza, R. A. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-68-3-647 · Cited by 53
Direct muscarinic cholinergic inhibition of hepatic glucose production in humans.
Boyle, P. J., Liggett, S. B., SHAH, S. D., & Cryer, P. E. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113617 · Cited by 36
Self-citationCerebral blood flow and metabolism in sleep
Sawaya, R. A., & Ingvar, D. H. (1989) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1989.tb03915.x · Cited by 35
Boyle, P. J., Avogaro, A., Smith, I., SHAH, S. D., Cryer, P. E., & Santiago, J. V. (1992) · Diabetologia · doi:10.1007/bf00401205 · Cited by 27
Self-citation
Research works printed but not linked: 2
- Ashmore, J., and D. Morgan. 1967. Metabolic effects ofadrenal glucocor- ticoid hormones. In The Adrenal Cortex. A. B. Eisenstein, editor. Little, Brown and Company, Boston. pp. 249-267.
- Siesjo, B. K. 1978. Utilization of substrates of brain tissues. In Brain Energy Metabolism. Wiley, NY. pp. 1-20.
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Spiegel, K., Knutson, K., Leproult, R., Tasali, E., & Cauter, E. V. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00660.2005 · Cited by 1,175
Raichle, M. E. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.01.008 · Cited by 1,111
Brain Glucose Metabolism: Integration of Energetics with Function
Dienel, G. A. (2018) · Physiological Reviews · doi:10.1152/physrev.00062.2017 · Cited by 911
Regional aerobic glycolysis in the human brain
Vaishnavi, S. N., Vlassenko, A. G., Rundle, M. M., Snyder, A. Z., Mintun, M. A., & Raichle, M. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010459107 · Cited by 738
Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation
Cauter, E. V., Polonsky, K. S., & Scheen, A. J. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.5.0317 · Cited by 632
Metadata
- Authors
- Boyle, P. J., Scott, J. C., Krentz, A. J., Nagy, R. J., Comstock, E., & Hoffman, C.
- Affiliations
- University of New Mexico (US)
- ORCID
- Krentz, A J
- Venue
- Journal of Clinical Investigation
- Published
- 1994-02-01
- Volume
- 93
- Issue
- 2
- Pages
- 529-535
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC293874
- OpenAlex
- W2168937351
- Cited by
- 202
- References
- 47
- Citations by year
- 2026: 1 · 2025: 11 · 2024: 10 · 2023: 4 · 2022: 7 · 2021: 11 · 2020: 10 · 2019: 5 · 2018: 10 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 17 · 2013: 11 · 2012: 13
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- National Center for Research Resources (5 M01 RR00997-15, M01RR000997)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- brain glucose metabolism, sleep, cerebral blood flow, cerebral oxygen consumption, arteriovenous glucose difference, sleep stages, glucose turnover, sleep duration
- MeSH terms
- Activity Cycles, Adult, Analysis of Variance, Blood Glucose, Brain, C-Peptide, Cerebrovascular Circulation, Electroencephalography, Female, Glucagon, Glucose, Humans, Insulin, Male, Oxygen Consumption, Reference Values, Regional Blood Flow, Sleep, Sleep Stages, Growth Hormone
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