Cerebral glucose utilization during sleep-wake cycle in man determined by positron emission tomography and [18F]2-fluoro-2-deoxy-d-glucose method
Abstract
Using the [18F]fluorodeoxyglucose method and positron emission tomography, we studied cerebral glucose utilization during sleep and wakefulness in 11 young normal subjects. Each of them was studied at least thrice: during wakefulness, slow wave sleep (SWS) and rapid eye movement sleep (REMS), at 1 week intervals. Four stage 3-4 SWS and 4 REMS fulfilled the steady state conditions of the model. The control population consisted of 9 normal age-matched subjects studied twice during wakefulness at, at least, 1 week intervals. Under these conditions, the average difference between the first and the second cerebral glucose metabolic rates (CMRGlu was: -7.91 +/- 15.46%, which does not differ significantly from zero (P = 0.13). During SWS, a significant decrease in CMRGlu was observed as compared to wakefulness (mean difference: -43.80 +/- 14.10%, P less than 0.01). All brain regions were equally affected but thalamic nuclei had significantly lower glucose utilization than the average cortex. During REMS, the CMRGlu were as high as during wakefulness (mean difference: 4.30 +/- 7.40%, P = 0.35). The metabolic pattern during REMS appeared more heterogeneous than at wake. An activation of left temporal and occipital areas is suggested. It is hypothetized that energy requirements for maintaining membrane polarity are reduced during SWS because of a decreased rate of synaptic events. During REMS, cerebral glucose utilization is similar to that of wakefulness, presumably because of reactivated neurotransmission and increased need for ion gradients maintenance.
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In adult studies, cerebral glucose utilization declines in N3 sleep.
“In adult studies, cerebral glucose utilization declines (7) and plasma glucose rises (8) in N3 sleep.”
From Sleep architecture and glucose and insulin homeostasis in obese adolescents (2011) · cites this paper as [7]
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- Authors
- Maquet, P., Dive, D., Salmon, E., Sadzot, B., Franco, G., Poirrier, R., von Frenckell, R., & Franck, G.
- Affiliations
- University of Liège (BE)
- Corresponding author
- Franck, Georges
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1990-04
- Volume
- 513
- Issue
- 1
- Pages
- 136-143
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2070003298
- Cited by
- 292
- References
- 46
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 6 · 2020: 11 · 2019: 7 · 2018: 14 · 2017: 8 · 2016: 10 · 2015: 7 · 2014: 10 · 2013: 12 · 2012: 17
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- ORBi (University of Liège) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- brain glucose metabolism, sleep-wake cycle, slow-wave sleep, REM sleep, glucose metabolic rate, thalamus, brain energy metabolism, synaptic activity, membrane potential, neurotransmission
- MeSH terms
- Adult, Brain, Deoxy Sugars, Deoxyglucose, Female, Humans, Male, Sleep, Tomography, Emission-Computed, Wakefulness, Fluorodeoxyglucose F18
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