The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation.
Open accessAbstract
The interaction between nitric oxide (NO) and cyclooxygenase (COX) was studied in a rabbit model of renal inflammation, the ureteral obstructed hydronephrotic kidney (HNK). Ex vivo perfusion of the HNK but not the control kidney (e.g., unobstructed contralateral kidney, CLK), led to a time-dependent release of nitrite (NO2-), a breakdown product of NO. Stimulation of the HNK with bradykinin (BK) evoked a time-dependent increase in prostaglandin E2 (PGE2) production. NG-monomethyl-L-arginine (L-NMMA), which blocks the activity of both constitutive and inducible nitric oxide synthase (cNOS and iNOS), aminoguanidine, a recently described selective iNOS inhibitor, dexamethasone, or cycloheximide abolished the release of NO2- and attenuated the exaggerated BK-induced PGE2 production. This supports the existence of iNOS and COX-2 in the HNK. In the CLK, BK elicited release of both NO2- and PGE2 but this did not augment with time. L-NMMA but not aminoguanidine, dexamethasone, or cycloheximide attenuated NO2- and PGE2 release indicative of the presence of constitutive but not inducible NOS or COX. The current study suggests that the endogenous release of NO from cNOS in the CLK activates a constitutive COX resulting in optimal PGE2 release by BK. In addition, in the HNK, NO release from iNOS activates the induced COX resulting in markedly increased release of proinflammatory prostaglandin. The broader implication of this study is that the cyclooxygenase isozymes are potential receptor targets for nitric oxide.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Nitric oxide as a secretory product of mammalian cells
Nathan, C. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.12.1381691 · Cited by 4,350
Ignarro, L. J., Lippton, H., Edwards, J. C., Baricos, W. H., Hyman, A. L., Kadowitz, P. J., & Gruetter, C. A. (1981) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32738-2 · Cited by 1,633
Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate
Marletta, M. A., Yoon, P. S., Iyengar, R., Leaf, C. D., & Wishnok, J. S. (1988) · Biochemistry · doi:10.1021/bi00424a003 · Cited by 1,600
Nitric oxide activates cyclooxygenase enzymes.
Salvemini, D., Misko, T. P., Masferrer, J. L., Seibert, K., Currie, M. G., & Needleman, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.7240 · Cited by 1,395
Self-citationRadomski, M. W., Palmer, R. M., & Moncada, S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.10043 · Cited by 1,096
The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.
Fu, J. Y., Masferrer, J. L., Seibert, K., Raz, A., & Needleman, P. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44821-6 · Cited by 944
Self-citationSelective inhibition of the inducible nitric oxide synthase by aminoguanidine
Misko, T. P., Moore, W. M., Kasten, T. P., Nickols, G. A., Corbett, J. A., Tilton, R. G., McDaniel, M. L., Williamson, J. R., & Currie, M. G. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90357-n · Cited by 721
Self-citationKatsuki, S., Arnold, W. P., Mittal, C. K., & Murad, F. (1977) · PubMed · Cited by 700
Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction
Corbett, J. A., Tilton, R. G., Chang, K., Hasan, K. S., Ido, Y., Wang, J. L., Sweetland, M. A., Lancaster, J. R., Williamson, J. R., & McDaniel, M. L. (1992) · Diabetes · doi:10.2337/diab.41.4.552 · Cited by 628
Cited by
Wink, D. A., & Mitchell, J. B. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00092-6 · Cited by 1,606
Nitric oxide: a key mediator in the early and late phase of carrageenan‐induced rat paw inflammation
Salvemini, D., Wang, Z., Wyatt, P. S., Bourdon, D. M., Marino, M. H., Manning, P. T., & Currie, M. G. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15475.x · Cited by 668
Self-citationCyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease
Singer, I. I., Kawka, D. W., Schloemann, S., Tessner, T., Riehl, T., & Stenson, W. F. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70196-9 · Cited by 455
Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors
Mollace, V., Muscoli, C., Masini, E., Cuzzocrea, S., & Salvemini, D. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.1 · Cited by 357
Self-citationSwierkosz, T. A., Mitchell, J. A., Warner, T. D., Botting, R. M., & Vane, J. R. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb13353.x · Cited by 342
Metadata
- Authors
- Salvemini, D., Seibert, K., Masferrer, J. L., Misko, T. P., Currie, M. G., & Needleman, P.
- Venue
- Journal of Clinical Investigation
- Published
- 1994-05-01
- Volume
- 93
- Issue
- 5
- Pages
- 1940-1947
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2018789478
- Cited by
- 306
- References
- 33
- FWCI
- 20.61
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation. https://app.cochat.ai/papers/10.1172/jci117185
- The paper
- Salvemini, D., Seibert, K., Masferrer, J. L., Misko, T. P., Currie, M. G., & Needleman, P. (1994). Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation. Journal of Clinical Investigation. https://doi.org/10.1172/jci117185
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
