Virus-induced airway hyperresponsiveness in guinea pigs is related to a deficiency in nitric oxide.
Open accessAbstract
Intratracheal inoculation of parainfluenza type 3 virus to guinea pigs induces a marked increase in airway responsiveness in vivo and in vitro. In spontaneously breathing anesthetized guinea pigs inhalation of an aerosol containing the nitric oxide (NO) precursor L-arginine (2.0 mM) completely prevented the virus-induced airway hyperresponsiveness to histamine. In addition, perfusion of L-arginine (200 microM) or the direct NO-donor S-nitroso-N-acetyl-penicillamine (SNAP, 1 microM) through the lumen of tracheal tubes from infected animals prevented the increase in airway responsiveness to histamine or the cholinoceptor agonist methacholine. The NO synthase inhibitor N omega-nitro-L-arginine methyl ester (L-NAME, 120 microM) did not further increase the virus-induced airway hyperresponsiveness. In additional experiments, NO was measured with an Iso-NO nitric oxide meter and sensor. Stimulation of control tissues in vitro with histamine (10(-3) M) resulted in a contraction with a simultaneous release of NO (44.5 +/- 5.4 nM). The release of NO was markedly reduced by 75% (P < 0.01, 11.4 +/- 3.1 nM) in tracheas from virus-infected animals that demonstrated enhanced contractile responses. Preincubation of tissues from virus-treated guinea pigs with L-arginine (200 microM) completely prevented the enhanced contraction and simultaneously returned the NO production to control values (51.2 +/- 3.4 nM). An NO deficiency might be causally related to the development of airway hyperresponsiveness after a viral respiratory infection.
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- Authors
- Folkerts, G., van der Linde, H. J., & Nijkamp, F. P.
- Affiliations
- Utrecht University (NL)
- ORCID
- Folkerts, G
- Venue
- Journal of Clinical Investigation
- Published
- 1995-01-01
- Volume
- 95
- Issue
- 1
- Pages
- 26-30
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC295362
- OpenAlex
- W1996060907
- Cited by
- 104
- References
- 35
- Citations by year
- 2023: 1 · 2016: 3 · 2015: 2 · 2014: 1
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- airway hyperresponsiveness, nitric oxide deficiency, parainfluenza virus type 3, respiratory viral infections, L-arginine, nitric oxide synthase, histamine-induced contraction, methacholine, tracheal smooth muscle, guinea pig
- MeSH terms
- Animals, Arginine, Guinea Pigs, Histamine, Hypersensitivity, Muscle Contraction, Nitric Oxide, Parainfluenza Virus 3, Human, Penicillamine, Respiratory System, Trachea, Vasodilator Agents, Bronchoconstriction, NG-Nitroarginine Methyl Ester, S-Nitroso-N-Acetylpenicillamine, In Vitro Techniques
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