The effects of non-insulin-dependent diabetes mellitus on the kinetics of onset of insulin action in hepatic and extrahepatic tissues
Open accessAbstract
The mechanism(s) of insulin resistance in non-insulin-dependent diabetes mellitus remains ill defined. The current studies sought to determine whether non-insulin-dependent diabetes mellitus is associated with (a) a delay in the rate of onset of insulin action, (b) impaired hepatic and extrahepatic kinetic responses to insulin, and (c) an alteration in the contribution of gluconeogenesis to hepatic glucose release. To answer these questions, glucose disappearance, glucose release, and the rate of incorporation of 14CO2 into glucose were measured during 0.5 and 1.0 mU/kg-1 per min-1 insulin infusions while glucose was clamped at approximately 95 mg/dl in diabetic and nondiabetic subjects. The absolute rate of disappearance was lower (P < 0.05) and the rate of increase slower (P < 0.05) in diabetic than nondiabetic subjects during both insulin infusions. In contrast, the rate of suppression of glucose release in response to a change in insulin did not differ in the diabetic and nondiabetic subjects during either the low (slope 30-240 min:0.02 +/- 0.01 vs 0.02 +/- 0.01) or high (0.02 +/- 0.00 vs 0.02 +/- 0.00) insulin infusions. However, the hepatic response to insulin was not entirely normal in the diabetic subjects. Both glucose release and the proportion of systemic glucose being derived from 14CO2 (an index of gluconeogenesis) was inappropriately high for the prevailing insulin concentration in the diabetic subjects. Thus non-insulin-dependent diabetes mellitus slows the rate-limiting step in insulin action in muscle but not liver and alters the relative contribution of gluconeogenesis and glycogenolysis to hepatic glucose release.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
When age-, gender-, and weight-matched groups have been compared, hepatic insulin resistance has frequently been reported to be comparable.
“but when age-, gender-, and weight-matched groups have been compared, hepatic insulin resistance has frequently been reported to be comparable.[27][28][29][30][31][32]”
From Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. (2008) · cites this paper as [28]
In other studies, S-free insulin concentrations have been comparable between type 2 diabetic patients and normal subjects.
“In other studies, S-free insulin concentrations have been comparable between type 2 diabetic patients and normal subjects.28,30 -32”
From Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. (2008) · cites this paper as [28]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A peroxidase-coupled method for the colorimetric determination of serum triglycerides.
McGowan, M. W., Artiss, J. D., Strandbergh, D. R., & Zak, B. (1983) · Clinical Chemistry · doi:10.1093/clinchem/29.3.538 · Cited by 1,298 · see citing works
Assessment of insulin sensitivity in vivo.
Bergman, R., Finegood, D., & Ader, M. (1985) · Endocrine reviews · doi:10.1210/edrv-6-1-45 · Cited by 1,215 · see citing works
DeFronzo, R. A., Gunnarsson, R., Björkman, O., Olsson, M., & Wahren, J. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111938 · Cited by 1,167 · see citing works
Measurement of Size and Turnover Rate of Body Glucose Pool by the Isotope Dilution Method
Steele, R., Wall, J. S., de Bodo, R. C., & Altszuler, N. (1956) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1956.187.1.15 · Cited by 816 · see citing works
Groop, L. C., Bonadonna, R. C., DelPrato, S., Ratheiser, K., Zyck, K., Ferrannini, E., & DeFronzo, R. A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114142 · Cited by 812 · see citing works
Magnusson, I., Rothman, D. L., Katz, L. D., Shulman, R. G., & Shulman, G. I. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115997 · Cited by 757 · see citing works
Dose-response characteristics for effects of insulin on production and utilization of glucose in man
Rizza, R. A., Mandarino, L. J., & Gerich, J. E. (1981) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1981.240.6.e630 · Cited by 703 · see citing works
Kolterman, O., Gray, R. S., Griffin, J., BURSTEIN, P. J., Insel, J. R., Scarlett, J. A., & Olefsky, J. M. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110350 · Cited by 629 · see citing works
Finegood, D. T., Bergman, R. N., & Vranić, M. (1987) · Diabetes · doi:10.2337/diab.36.8.914 · Cited by 546 · see citing works
ON THE HORMONAL REGULATION OF CARBOHYDRATE METABOLISM; STUDIES WITH C14 GLUCOSE.
DeBodo, R. C., Steele, R., ALTSZULER, N., Dunn, A., & Bishop, J. (1963) · PubMed · Cited by 532 · see citing works
Predominant Role of Gluconeogenesis in Increased Hepatic Glucose Production in NIDDM
Consoli, A., Nurjhan, N., Capani, F., & Gerich, J. E. (1989) · Diabetes · doi:10.2337/diab.38.5.550 · Cited by 406 · see citing works
Bogardus, C., Lillioja, S., Howard, B. V., Reaven, G. M., & Mott, D. M. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111533 · Cited by 397 · see citing works
The disposal of an oral glucose load in patients with non-insulin-dependent diabetes
Ferrannini, E., Simonson, D. C., Katz, L. D., Reichard, G., Bevilacqua, S., Barrett, E. J., Olsson, M., & DeFronzo, R. A. (1988) · Metabolism · doi:10.1016/0026-0495(88)90033-9 · Cited by 305 · see citing works
Insulin transport across capillaries is rate limiting for insulin action in dogs.
Yang, Y. J., Hope, I. D., Ader, M., & Bergman, R. N. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114339 · Cited by 303 · see citing works
Facilitative glucose transporters: regulatory mechanisms and dysregulation in diabetes.
Kahn, B. B. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115724 · Cited by 286 · see citing works
Firth, R. G., Bell, P. M., Marsh, H. W., Hansen, I., & Rizza, R. A. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112467 · Cited by 280 · see citing works
Campbell, P. J., Mandarino, L. J., & Gerich, J. E. (1988) · Metabolism · doi:10.1016/0026-0495(88)90023-6 · Cited by 226 · see citing works
Initial splanchnic extraction of ingested glucose in normal man
Radziuk, J., McDonald, T. J., Rubenstein, D., & Dupre, J. (1978) · Metabolism · doi:10.1016/0026-0495(78)90003-3 · Cited by 207 · see citing works
Prager, R., Wallace, P., & Olefsky, J. M. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112599 · Cited by 204 · see citing works
Elias, H. (1949) · American Journal of Anatomy · doi:10.1002/aja.1000850303 · Cited by 196 · see citing works
Jenssen, T. G., Nurjhan, N., Consoli, A., & Gerich, J. E. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114735 · Cited by 162 · see citing works
Calles-Escandon, J., & Robbins, D. C. (1987) · Diabetes · doi:10.2337/diab.36.10.1167 · Cited by 154 · see citing works
Castillo, C., Bogardus, C., Bergman, R. N., Thuillez, P., & Lillioja, S. (1994) · Journal of Clinical Investigation · doi:10.1172/jci116932 · Cited by 154 · see citing works
Jansson, P., Fowelin, J., von Schenck, H., Smith, U., & Lönnroth, P. (1993) · Diabetes · doi:10.2337/diab.42.10.1469 · Cited by 129 · see citing works
Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM
Consoli, A., Nurjhan, N., Capani, F., et al. (1989) · Diabetes · doi:10.2337/diabetes.38.5.550 · Cited by 126 · see citing works
Determination of gluconeogenesis in vivo with 14C-labeled substrates
Katz, J. (1985) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1985.248.4.r391 · Cited by 119 · see citing works
Practical Closed-Loop Insulin Delivery
White, N. H., SKOR, D., & SANTIAGO, J. V. (1982) · Annals of Internal Medicine · doi:10.7326/0003-4819-97-2-210 · Cited by 109 · see citing works
Firth, R. G., Bell, P. M., & Rizza, R. A. (1987) · Metabolism · doi:10.1016/0026-0495(87)90031-x · Cited by 101 · see citing works
INSULIN RECEPTORS IN HUMAN ENDOTHELIAL CELLS: IDENTIFICATION AND CHARACTERIZATION1
Bar, R. S., Hoak, J. C., & Peacock, M. L. (1978) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-47-3-699 · Cited by 96 · see citing works
Puhakainen, I., Koivisto, V. A., & Yki‐Järvinen, H. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.3.1517368 · Cited by 86 · see citing works
In vivo evidence for hepatic autoregulation during FFA-stimulated gluconeogenesis in normal humans
Clore, J. N., Glickman, P. S., Nestler, J. E., & Blackard, W. G. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.261.4.e425 · Cited by 85 · see citing works
Postprandial Hyperglycemia in Patients with Noninsulin-dependent Diabetes Mellitus
Firth, R. G., Bell, P. M., Marsh, H. W., & RIZZA, R. A. (1986) · Cited by 75 · see citing works
Role of hepatic nerves in response of liver to intraportal glucose delivery in dogs
Adkins-Marshall, B. A., Pagliassotti, M. J., Asher, J. R., Connolly, C. C., Neal, D. W., Williams, P. E., Myers, S. R., Hendrick, G. K., Adkins, R. B., & Cherrington, A. D. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.5.e679 · Cited by 71 · see citing works
Effects of Basal Insulin Supplementation on Disposition of Mixed Meal in Obese Patients With NIDDM
McMahon, M., Marsh, H. W., & Rizza, R. A. (1989) · Diabetes · doi:10.2337/diab.38.3.291 · Cited by 71 · see citing works
Poulin, R. A., Steil, G. M., Moore, D. M., Ader, M., & Bergman, R. N. (1994) · Diabetes · doi:10.2337/diab.43.2.180 · Cited by 65 · see citing works
Quantitation of measurement error with Optimal Segments: basis for adaptive time course smoothing
Bradley, D. C., Steil, G. M., & Bergman, R. N. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.264.6.e902 · Cited by 64 · see citing works
Nielsen, O. H., Schmitz, O., Bak, J. F., & Beck‐Nielsen, H. (1987) · Diabetologia · doi:10.1007/bf00274790 · Cited by 62 · see citing works
Puhakainen, I., & Yki‐Järvinen, H. (1993) · Diabetes · doi:10.2337/diab.42.12.1694 · Cited by 62 · see citing works
Effects of insulin at two dose levels on gluconeogenesis from alanine in fasting man
Chiasson, J. L., Atkinson, R. L., Cherrington, A. D., Keller, U. B., SINCLAIR-SMITH, B. C., LACY, W. W., & LILJENQUIST, J. E. (1980) · Metabolism · doi:10.1016/0026-0495(80)90119-5 · Cited by 57 · see citing works
Mechanism of growth hormone-induced postprandial carbohydrate intolerance in humans
Butler, P. C., Kryshak, E. J., & Rizza, R. A. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.260.4.e513 · Cited by 51 · see citing works
Insulin inhibition of overnight glucose production and gluconeogenesis from lactate in NIDDM
Yki‐Järvinen, H., Helve, E., Sane, T., Nurjhan, N., & Taskinen, M. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.256.6.e732 · Cited by 37 · see citing works
Butler, P. C., Caumo, A., Zerman, A., O’Brien, P. C., Cobelli, C., & Rizza, R. A. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.264.4.e548 · Cited by 35 · see citing works
Katz, H., Butler, P. C., Homan, M., Zerman, A., Caumo, A., Cobelli, C., & Rizza, R. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.264.4.e561 · Cited by 33 · see citing works
Butler, P. C., Kryshak, E. J., Schwenk, W. F., Haymond, M. W., & Rizza, R. A. (1990) · Diabetes · doi:10.2337/diab.39.2.217 · Cited by 32 · see citing works
Pathways of carbon flux in gluconeogenesis.
Jt, B. (1982) · PubMed · Cited by 31 · see citing works
Ciaraldi, T. P., Molina, J. M., & Olefsky, J. M. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-4-876 · Cited by 28 · see citing works
Delayed Onset of Insulin Activation of the Insulin Receptor Kinase In Vivo in Human Skeletal Muscle
Freidenberg, G. R., Suter, S., Henry, R. R., Nolan, J. J., Reichart, D. R., & Olefsky, J. M. (1994) · Diabetes · doi:10.2337/diab.43.1.118 · Cited by 26 · see citing works
Puhakainen, I., & Yki-Jarvinen, H. (1993) · Diabetes · doi:10.2337/diabetes.42.12.1694 · Cited by 23 · see citing works
Poulin, R. A., Steil, G. M., Moore, D. M., et al. (1994) · Diabetes · doi:10.2337/diabetes.43.2.180 · Cited by 21 · see citing works
Effects of basal insulin supplementation on disposition of mixed meal in obese patients with NIDDM
McMahon, M. M., Marsh, H. M., & Rizza, R. A. (1989) · Diabetes · doi:10.2337/diabetes.38.3.291 · Cited by 20 · see citing works
Self-citationRestricted passage of insulin across capillary endothelium in perfused rat adipose tissue
Chernick, S. S., GARDINER, R. J., & Scow, R. O. (1987) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1987.253.5.e475 · Cited by 19 · see citing works
Clore, J. N., & Blackard, W. G. (1994) · Diabetes · doi:10.2337/diab.43.2.256 · Cited by 18 · see citing works
Butler, P. C., Kryshak, E. J., Schwenk, W. F., et al. (1990) · Diabetes · doi:10.2337/diabetes.39.2.217 · Cited by 14 · see citing works
Butler, P. C., Kryshak, E. J., & RIZZA, R. A. (1991) · Cited by 13 · see citing works
Delayed onset of insulin activation of the insulin receptor kinase in vivo in human skeletal muscle
Freidenberg, G. R., Suter, S., Henry, R. R., et al. (1994) · Diabetes · doi:10.2337/diabetes.43.1.118 · Cited by 13 · see citing works
Clore, J. N., & Blackard, W. G. (1994) · Diabetes · doi:10.2337/diabetes.43.2.256 · Cited by 7 · see citing works
Bryer‐Ash, M. (1993) · Diabetes · doi:10.2337/diab.42.10.1528 · Cited by 3 · see citing works
Bryer‐Ash, M. (1993) · Diabetes · doi:10.2337/diabetes.42.10.1528 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Kotronen, A., Juurinen, L., Tiikkainen, M., Vehkavaara, S., & Yki–Järvinen, H. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.021 · Cited by 339 · see citing works
Barrett, E. J., Eggleston, E. M., Inyard, A. C., Wang, H., Li, G., Chai, W., & Liu, Z. (2009) · Diabetologia · doi:10.1007/s00125-009-1313-z · Cited by 323 · see citing works
Basu, A., Basu, R., Shah, P. J., Vella, A. V., Johnson, C. M., Nair, K. S., Jensen, M. D., Schwenk, W. F., & Rizza, R. A. (2000) · Diabetes · doi:10.2337/diabetes.49.2.272 · Cited by 203 · see citing works
Reduced synthesis of muscle proteins in chronic renal failure
Adey, D., Kumar, R., McCarthy, J. T., & Nair, K. S. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.2.e219 · Cited by 159 · see citing works
Synthesis rate of muscle proteins, muscle functions, and amino acid kinetics in type 2 diabetes.
Halvatsiotis, P., Short, K., Bigelow, M., & Nair, K. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2395 · Cited by 148 · see citing works
Non-esterified fatty acids and the liver: why is insulin secreted into the portal vein?
Bergman, R. N. (2000) · Diabetologia · doi:10.1007/s001250051474 · Cited by 141 · see citing works
Tissue-specific regulation of mitochondrial and cytoplasmic protein synthesis rates by insulin
Boirie, Y., Short, K. R., Ahlman, B., Charlton, M., & Nair, K. S. (2001) · Diabetes · doi:10.2337/diabetes.50.12.2652 · Cited by 137 · see citing works
The CD200 Receptor Is a Novel and Potent Regulator of Murine and Human Mast Cell Function
Cherwinski, H. M., Murphy, C. A., Joyce, B., Bigler, M., Song, Y., Zurawski, S., Moshrefi, M., Gorman, D. M., Miller, K. L., Zhang, S., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.3.1348 · Cited by 117 · see citing works
Effect of Protein Ingestion on the Glucose Appearance Rate in People with Type 2 Diabetes1
Gannon, M. C., Nuttall, J. A., Damberg, G., Gupta, V., & Nuttall, F. Q. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7263 · Cited by 105 · see citing works
Rossetti, L., Stenbit, A. E., Chen, W., Hu, M., Barzilai, N., Katz, E. B., & Charron, M. J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119711 · Cited by 93 · see citing works
Carey, P. E., Halliday, J., Snaar, J. E. M., Morris, P. G., & Taylor, R. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00471.2002 · Cited by 88 · see citing works
Regulation of endogenous glucose production after a mixed meal in type 2 diabetes
Singhal, P., Caumo, A., Carey, P. E., Cobelli, C., & Taylor, R. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00424.2001 · Cited by 80 · see citing works
Moran, A., Milla, C. E., duCret, R. P., & Nair, K. S. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1336 · Cited by 78 · see citing works
Assessment of hepatic insulin action in obese type 2 diabetic patients
Staehr, P., Hother-Nielsen, O., Levin, K., Holst, J. J., & Beck-Nielsen, H. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1363 · Cited by 74 · see citing works
Use of dicarboxylic acids in type 2 diabetes
Mingrone, G., Castagneto‐Gissey, L., & Macé, K. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04177.x · Cited by 78 · see citing works
Balasubramanian, R., Gerrard, J., Man, C. D., Firbank, M., Lane, A. P., English, P. T., Cobelli, C., & Taylor, R. (2008) · Diabetes · doi:10.2337/db07-1828 · Cited by 76 · see citing works
Schweifer, N., & Barlow, D. P. (1996) · Mammalian Genome · doi:10.1007/s003359900223 · Cited by 72 · see citing works
Radziuk, J., & Pye, S. (2002) · Diabetologia · doi:10.1007/s00125-002-0841-6 · Cited by 61 · see citing works
Nielsen, M. F., Basu, R., Wise, S., Caumo, A., Cobelli, C., & Rizza, R. A. (1998) · Diabetes · doi:10.2337/diabetes.47.11.1735 · Cited by 76 · see citing works
Rizza, R. A., Toffolo, G., & Cobelli, C. (2016) · Diabetes · doi:10.2337/db15-1166 · Cited by 42 · see citing works
The role of endothelial insulin signaling in the regulation of glucose metabolism
Kubota, T., Kubota, N., & Kadowaki, T. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9242-z · Cited by 42 · see citing works
Whole-Body Proteolysis Rate Is Elevated in HIV-Associated Insulin Resistance
Reeds, D. N., Cade, W. T., Patterson, B. W., Powderly, W. G., Klein, S., & Yarasheski, K. E. (2006) · Diabetes · doi:10.2337/db06-0255 · Cited by 30 · see citing works
Insulin resistance in non-insulin-dependent diabetes mellitus
Alzaid, A. (1996) · Acta Diabetologica · doi:10.1007/bf00569416 · Cited by 25 · see citing works
Wise, S., Nielsen, M. F., & Rizza, R. A. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.6.3971 · Cited by 26 · see citing works
Hepatic glucose production: therapeutic target in type 2 diabetes?
Stæhr, P., Nielsen, O. H., & Beck‐Nielsen, H. (2002) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2002.00177.x · Cited by 24 · see citing works
Wise, S. D., Nielsen, M. F., Cryer, P. E., & Rizza, R. A. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.7.4976 · Cited by 26 · see citing works
Effects of Type 2 Diabetes on the Regulation of Hepatic Glucose Metabolism
Basu, A., Shah, P., Nielsen, M. F., Basu, R., & Rizza, R. A. (2004) · Journal of Investigative Medicine · doi:10.1177/108155890405200630 · Cited by 19 · see citing works
Pioglitazone Increases Whole Body Insulin Sensitivity in Obese, Insulin-Resistant Rhesus Monkeys
Tozzo, E., Bhat, G., Cheon, K., & Camacho, R. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126642 · Cited by 15 · see citing works
Schaison, G., Auclerc, M.-F., Baruchel, A., Leblanc, T. M., & Leverger, G. (2001) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/s0001-4079(19)34595-9 · Cited by 12 · see citing works
Tomita, T., Yamasaki, Y., Kubota, M., Tohdo, R., Katsura, M., IKEDA, M., Nakahara, I., Shiba, Y., Matsuhisa, M., & HORI, M. (1998) · Endocrine Journal · doi:10.1507/endocrj.45.165 · Cited by 12 · see citing works
Slower activation of insulin action in hypertension associated with obesity
Biolo, G., Toigo, G., Ciocchi, B., Situlin, R., & Guarnieri, G. (1998) · Journal of Hypertension · doi:10.1097/00004872-199816120-00011 · Cited by 11 · see citing works
Raish, M., Ahmad, A., Jan, B. L., Alkharfy, K. M., Kazi, M., Ahamad, S. R., & Ansari, M. A. (2017) · Natural Product Communications · doi:10.1177/1934578x1701200423 · Cited by 9 · see citing works
Tracer-determined glucose fluxes in health and type 2 diabetes: basal conditions
Radziuk, J., & Pye, S. (2003) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/s1521-690x(03)00038-1 · Cited by 9 · see citing works
Regulation of Insulin Transcytosis Across Endothelium in Metabolic Health and Disease
Mineo, C., & Shaul, P. W. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.321545 · Cited by 6 · see citing works
Stæhr, P., Højlund, K., Nielsen, O. H., Holst, J. J., & Beck-Nielsen, H. (2003) · Diabetic Medicine · doi:10.1046/j.1464-5491.2003.01004.x · Cited by 5 · see citing works
The Role of the Liver in Insulin Action and Resistance
Radziuk, J., & Pye, S. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-716-1_11 · Cited by 5 · see citing works
Selz, R., Jornayvaz, F. R., Tappy, L., Woringer, V., & Theintz, G. E. (2004) · Hormone Research in Paediatrics · doi:10.1159/000080070 · Cited by 4 · see citing works
Slower activation of insulin action in upper body obesity
Biolo, G., Toigo, G., & Guarnieri, G. (2001) · Metabolism · doi:10.1053/meta.2001.17726 · Cited by 3 · see citing works
The Liver, Glucose Homeostasis, and Insulin Action in Type 2 Diabetes Mellitus
Radziuk, J., & Pye, S. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-116-5_18 · Cited by 2 · see citing works
LIVER FAT IN THE METABOLIC SYNDROME AND TYPE 2 DIABETES
Kotronen, A. (2008) · Työväentutkimus Vuosikirja
Kotronen, A., Juurinen, L., Tiikkainen, M., & Vehkavaara, S. (2008)
Endogenous Glucose Production in Type 2 Diabetes: Basal and Postprandial. Role of Diurnal Rhythms
Radziuk, S. P. J. (2004) · Journal of Investigative Medicine · doi:10.1177/108155890405200632
Vanweert, F. (2023) · doi:10.26481/dis.20231117fv · Cited by 1 · see citing works
- Authors
- Turk, D., Alzaid, A., Dinneen, S., Nair, K. S., & Rizza, R.
- Affiliations
- Mayo Clinic (US)
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 1995-02-01
- Volume
- 95
- Issue
- 2
- Pages
- 755-762
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC295544
- OpenAlex
- W2028719191
- Cited by
- 45
- References
- 50
- Citations by year
- 2025: 1 · 2023: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mayo Foundation for Medical Education and Research
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 41973, DK 29953)
- National Center for Research Resources (RR-00585, M01RR000585)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 2 diabetes, insulin resistance, hepatic glucose production, gluconeogenesis, glycogenolysis, muscle glucose uptake
- MeSH terms
- Alanine, Blood Glucose, C-Peptide, Diabetes Mellitus, Type 1, Female, Gluconeogenesis, Glucose, Glycerol, Humans, Infusions, Intravenous, Insulin, Kinetics, Lactates, Liver, Male, Middle Aged, Organ Specificity, Reference Values, Glucose Clamp Technique
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
