Cited by 896Advanced Glycation End Products researchCell Adhesion Molecules ResearchNitric Oxide and Endothelin Effects

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.

Open access

Schmidt, A M, Hori, O, Chen, J X, Li, J F, Crandall, J, Zhang, J, Cao, R, Yan, S D, Brett, J, Stern, D·1995·Journal of Clinical Investigation

DOI 10.1172/jci118175PMC PMC185762

Open this paper in CoChat — free account Open PDF

Abstract

Vascular cell adhesion molecule-1 (VCAM-1), an inducible cell-cell recognition protein on the endothelial cell surface (EC), has been associated with early stages of atherosclerosis. In view of the accelerated vascular disease observed in patients with diabetes, and the enhanced expression of VCAM-1 in diabetic rabbits, we examined whether irreversible advanced glycation endproducts (AGEs), could mediate VCAM-1 expression by interacting with their endothelial cell receptor (receptor for AGE, RAGE). Exposure of cultured human ECs to AGEs induced expression of VCAM-1, increased adhesivity of the monolayer for Molt-4 cells, and was associated with increased levels of VCAM-1 transcripts. The inhibitory effect of anti-RAGE IgG, a truncated form of the receptor (soluble RAGE) or N-acetylcysteine on VCAM-1 expression indicated that AGE-RAGE-induced oxidant stress was central to VCAM-1 induction. Electrophoretic mobility shift assays on nuclear extracts from AGE-treated ECs showed induction of specific DNA binding activity for NF-kB in the VCAM-1 promoter, which was blocked by anti-RAGE IgG or N-acetylcysteine. Soluble VCAM-1 antigen was elevated in human diabetic plasma. These data are consistent with the hypothesis that AGE-RAGE interaction induces expression of VCAM-1 which can prime diabetic vasculature for enhanced interaction with circulating monocytes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci118175

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,460
Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.
Jaffe, E. A., Nachman, R., Becker, C. G., & Minick, C. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107470 · Cited by 7,146
Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells
Schreiber, E. H., Matthias, P., Müller, M. M., & Schaffner, W. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.15.6419 · Cited by 4,179
Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1.
Schreck, R., RIEBER, P., & Baeuerle, P. A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07761.x · Cited by 3,793
Role of Oxidative Stress in Development of Complications in Diabetes
Baynes, J. (1991) · Diabetes · doi:10.2337/diab.40.4.405 · Cited by 3,791
Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications
Flier, J. S., Underhill, L. H., Brownlee, M., Cerami, A., & Vlassara, H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805193182007 · Cited by 2,512
Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis
Cybulsky, M. I., & Gimbrone, M. A. (1991) · Science · doi:10.1126/science.1990440 · Cited by 1,710
Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.
Neeper, M. P., Schmidt, A. M., Brett, J., Yan, S. D., Wang, F., Pan, Y., Elliston, K. O., Stern, D., & SHAW, A. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42138-2 · Cited by 1,545
Self-citation
Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins
Yan, S. D., Schmidt, A. M., Anderson, G. M., Zhang, J., Brett, J., Zou, Y., Pinsky, D. J., & Stern, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36966-1 · Cited by 1,305
Self-citation
Cytokines and endothelial cell biology
Pober, J. S., & Cotran, R. S. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.427 · Cited by 1,251

Show all 43 references

Sorted by citations

Items 301–400 of 893

Receptor for Advanced Glycation Endproducts Mediates Neutrophil Migration across Intestinal Epithelium
Zen, K., Chen, C. X.-J., Chen, Y.-T., Wilton, R., & Liu, Y. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2483 · Cited by 78
Increased glycated albumin and decreased esRAGE levels are related to angiographic severity and extent of coronary artery disease in patients with type 2 diabetes
Lu, L., Pu, L. J., Zhang, Q., Wang, L. J., Kang, S., Zhang, R., Chen, Q., Wang, J. G., Caterina, R. D., & Shen, W. F. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.12.045 · Cited by 77
Interaction between Advanced Glycation End Products Formation and Vascular Responses in Femoral and Coronary Arteries from Exercised Diabetic Rats
Delbin, M. A., Davel, A. P., Couto, G. K., de Araújo, G. G., Rossoni, L. V., Antunes, E., & Zanesco, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0053318 · Cited by 75
“Furthermore, earliest studies have shown an up-regulation of AGEs/RAGE signaling pathway in isolated endothelial cells, but not in RAGE protein expression [69,70].”
Background
Potential role of oxidized lipids and lipoproteins in antioxidant defense
Parthasarathy, S., Santanam, N., Ramachandran, S., & Meilhac, O. (2000) · Free Radical Research · doi:10.1080/10715760000301381 · Cited by 76
Genetics of Diabetic Retinopathy, a Leading Cause of Irreversible Blindness in the Industrialized World
Bhatwadekar, A. D., Shughoury, A., Belamkar, A. V., & Ciulla, T. A. (2021) · Genes · doi:10.3390/genes12081200 · Cited by 81
Oxidant Stress, Immune Dysregulation, and Vascular Function in Type I Diabetes
Nicolls, M. R., HASKINS, K. M., & Flores, S. C. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1631 · Cited by 76
“Glucose plays a central role in increasing oxidant burden via accumulation of advanced glycation end (AGE) products and AGE-receptor-mediated activation of vascular NADPH oxidase (35, 94, 114).”
Multiple structural states of S100A12: A key to its functional diversity
Moroz, O. V., Dodson, G. G., Wilson, K. S., Lukanidin, E. M., & Bronstein, I. B. (2003) · Microscopy Research and Technique · doi:10.1002/jemt.10300 · Cited by 75
“For example, as a result of such interactions, endothelial cells increase expression of cytokines and growth factors (Schmidt et al., 1994, 1995; Wautier et al., 1996).”
Background
Do Advanced Glycation End Products and Its Receptor Play a Role in Pathophysiology of Hypertension?
Mishra, M., & Prasad, K. (2017) · International Journal of Angiology · doi:10.1055/s-0037-1598183 · Cited by 75
Dissecting the Crosstalk between Endothelial Mitochondrial Damage, Vascular Inflammation, and Neurodegeneration in Cerebral Amyloid Angiopathy and Alzheimer’s Disease
Parodi‐Rullán, R. M., Javadov, S. A., & Fossati, S. (2021) · Cells · doi:10.3390/cells10112903 · Cited by 75
“Other promoters of inflammation include the vascular endothelial growth factors (VEGFs) [147], which are able to stimulate the expression of CAMs through NFκB [148].”
BackgroundInfluential
Effect of diabetes and aminoguanidine therapy on renal advanced glycation end-product binding
Youssef, S., Nguyen, D. T., Soulis, T., Panagiotopoulos, S., Jerums, G., & Cooper, M. E. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.055003907.x · Cited by 74
Anti-Inflammatory Effects of the Advanced Glycation End Product Inhibitor LR-90 in Human Monocytes
Figarola, J. L., Shanmugam, N., Natarajan, R. D., & Rahbar, S. (2007) · Diabetes · doi:10.2337/db06-0936 · Cited by 73
“Although we did not study the expression of other genes known to be involved directly in the binding of monocytes to endothelial cells such as 2-integrins, E and P-selectins, ICAM-1 (intercellular adhesion molecule-1), PECAM-1 (platelet/endothelial cell adhesion molecule-1), and other chemokines and related adhesion m…”
Background
Update on the management of diabetic polyneuropathies
Stevens, M. J., & Shakher, J. (2011) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s11324 · Cited by 82
“Elevated intracellular glucose also stimulates formation of diacylglycerol, which leads to the activation of protein kinase C (PKC).(53,54) The role of PKC is better defined in the pathogenesis of diabetic retinopathy and although the mechanism of its involvement in neuronal damage is unclear and debated, it probably…”
Argpyrimidine-modified Heat Shock Protein 27 in human non-small cell lung cancer: A possible mechanism for evasion of apoptosis
van Heijst, J. W. J., Niessen, H. W. M., Musters, R. J. P., van Hinsbergh, V. W. M., Hoekman, K., & Schalkwijk, C. G. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.10.042 · Cited by 72
Glycated Serum Albumin and AGE Receptors
Vetter, S. W. (2015) · Advances in clinical chemistry · doi:10.1016/bs.acc.2015.07.005 · Cited by 73
The role of immune and inflammatory processes in the development of macrovascular disease in diabetes
Lopes-Virella, M. F. (2003) · Frontiers in bioscience · doi:10.2741/1141 · Cited by 71
“Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule1 (VCAM-1) in cultured human endothelial cells and in mice.”
BackgroundInfluential
Advanced Glycation End Products (AGEs) Induce Apoptosis via a Novel Pathway
Mahali, S. K., Raviprakash, N., Raghavendra, P. B., & Manna, S. K. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.279190 · Cited by 70
Advanced glycation end products and diabetic retinopathy
Sharma, Y., Saxena, S., Mishra, A., Saxena, A., & Natu, S. M. (2012) · Journal of ocular biology, diseases, and informatics · doi:10.1007/s12177-013-9104-7 · Cited by 69
“Serum AGEs measured by ELISA were found co-related with diabetic retinopathy in NIDDM patients without renal dysfunction [93], though some studies have reported no correlation between AGE levels and retinopathy in diabetic patients [94].”
Background
Abundance matters: role of albumin in diabetes, a proteomics perspective
Bhat, S., Jagadeeshaprasad, M. G., Venkatasubramani, V., & Kulkarni, M. J. (2017) · Expert Review of Proteomics · doi:10.1080/14789450.2017.1352473 · Cited by 70
“The interaction of GA with RAGE causes oxidative stress and thereby activation of transcription factors like nuclear factor-κB (NF-κB), which further leads to increased vascular permeability in the endothelial cells via activation pro-inflammatory signaling [68].”
Background
High Sensitivity C-reactive Protein: An Emerging Role in Cardiovascular Risk Assessment
Benzaquen, L. R., Yu, H., & Rifai, N. (2002) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360290795556 · Cited by 68
The Potential Role of Curcumin in Modulating the Master Antioxidant Pathway in Diabetic Hypoxia-Induced Complications
Ghareghomi, S., Rahban, M., Moosavi‐Movahedi, Z., Habibi-Rezaei, M., Saso, L., & Moosavi‐Movahedi, A. A. (2021) · Molecules · doi:10.3390/molecules26247658 · Cited by 68
Lycopene supplementation reduces TNF-α via RAGE in the kidney of obese rats
Pierine, D. T., Navarro, M. E. L., Minatel, I. O., Luvizotto, R. D. A. M., do Nascimento, A. F., Ferreira, A. L. A., Yeum, K., & Corrêa, C. R. (2014) · Nutrition and Diabetes · doi:10.1038/nutd.2014.39 · Cited by 68
Quantification of Carbamylated LDL in Human Sera by a New Sandwich ELISA
Apostolov, E. O., Shah, S. V., Ok, E., & Basnakian, A. G. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2004.044032 · Cited by 68
“Several chemically modified forms of LDL have been reported since the 1970s: acLDL (21, 45), gLDL ( 46 , 47), oxLDL (20, 41), and cLDL (8, 11, 27).”
Background
Relationship of Soluble RAGE and RAGE Ligands HMGB1 and EN-RAGE to Endothelial Dysfunction in Type 1 and Type 2 Diabetes Mellitus
Škrha, J., Kalousová, M., Švarcová, J., Muravská, A., Kvasnička, J., Landová, L., Zima, T., & Škrha, J. (2012) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0031-1283161 · Cited by 68
Advanced glycation end products increase, through a protein kinase C-dependent pathway, vascular endothelial growth factor expression in retinal endothelial cells
Mamputu, J., & Renier, G. (2002) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(01)00229-x · Cited by 68
Exploring the causal relationships between type 2 diabetes and neurological disorders using a Mendelian randomization strategy
Wei, Y., Xu, S., Wu, Z., Zhang, M., Bao, M., & He, B. (2024) · Medicine · doi:10.1097/md.0000000000040412 · Cited by 68
Cardiovascular protective effect of polysaccharide from Ophiopogon japonicus in diabetic rats
Zhang, J., Fan, S., Mao, Y., Ji, Y., Jin, L., Lü, J., & Chen, X. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.09.069 · Cited by 67
Self-citation
The influence of short‐term diabetes mellitus and insulin therapy on alveolar bone loss in rats
Holzhausen, M., Garcia, D. F., Pepato, M. T., & Marcantônio, É. (2004) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2004.00723.x · Cited by 67
Amadori-modified glycated albumin predominantly induces E-selectin expression on human umbilical vein endothelial cells through NADPH oxidase activation
Higai, K., Shimamura, A., & Matsumoto, K. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.12.008 · Cited by 67
Inhibition of human endothelial cell nitric oxide synthesis by advanced glycation end-products but not glucose: relevance to diabetes
Xu, B., Ji, Y. H., Kang, Y., Cao, Y., & Ferro, A. (2005) · Clinical Science · doi:10.1042/cs20050183 · Cited by 66
Porphyromonas gingivalis ‐derived outer membrane vesicles promote calcification of vascular smooth muscle cells through ERK 1/2‐ RUNX 2
Yang, W., Guo, B., Jia, W., & Jia, Y. X. (2016) · FEBS Open Bio · doi:10.1002/2211-5463.12151 · Cited by 67
Diabetic vascular dysfunction: Links to glucose‐induced reductive stress and VEGF
Tilton, R. G. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10092 · Cited by 65
“…by stimulating expression of target genes such as heme oxygenase, vascular cell adhesion molecule 1 (VCAM-1), procoagulant tissue factor, endothelin-1, macrophage colony-stimulating factor, TNF- , IL-1 , PDGF, IGF-1, and RAGE itself (Schmidt et al., 1995; references cited in Yeh et al., 2001).”
Glucose and Blood Pressure-Dependent Pathways–The Progression of Diabetic Kidney Disease
Patel, D. M., Bose, M., & Cooper, M. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062218 · Cited by 65
“RAGE appears to have a major role in immune and inflammatory responses [217,218].”
Background
Glycation, carbonyl stress and AGEs inhibitors: a patent review
Jahan, H., & Choudhary, M. I. (2015) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2015.1076394 · Cited by 66
A review of therapies for diabetic macular oedema and rationale for combination therapy
Amoaku, W. M. K., Saker, S., & Stewart, E. A. (2015) · Eye · doi:10.1038/eye.2015.110 · Cited by 63
Diabète sucré, stress oxydant et produits de glycation avancée
Bonnefont‐Rousselot, D., Beaudeux, J., Thérond, P., Peynet, J., Legrand, A., & Delattre, J. (2004) · Annales Pharmaceutiques Françaises · doi:10.1016/s0003-4509(04)94297-6 · Cited by 63
Beneficial effects of a novel RAGE inhibitor on early diabetic retinopathy and tactile allodynia.
Li, G., Tang, J., Du, Y., Lee, C. A., & Kern, T. S. (2011) · PubMed Central · Cited by 63
Oxidative stress in cardiovascular disease
Parthasarathy, S., Merchant, N., Penumetcha, M., & Santanam, N. (2001) · Journal of Nuclear Cardiology · doi:10.1067/mnc.2001.114150 · Cited by 63
Diabetes Alters Activation and Repression of Pro- and Anti-Inflammatory Signaling Pathways in the Vasculature
Marco, E. D., Gray, S. P., & Jandeleit-Dahm, K. A. M. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00068 · Cited by 63
Dietary AGEs and ALEs and risk to human health by their interaction with the receptor for advanced glycation endproducts (RAGE) – an introduction
Thornalley, P. J. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700017 · Cited by 62
Cell oxidant stress delivery and cell dysfunction onset in type 2 diabetes
Kassab, A., & Piwowar, A. (2012) · Biochimie · doi:10.1016/j.biochi.2012.01.020 · Cited by 65
Pathophysiology and Medical Treatment of Carotid Artery Stenosis
Prasad, K. (2015) · International Journal of Angiology · doi:10.1055/s-0035-1554911 · Cited by 66
Function of NADPH Oxidases in Diabetic Nephropathy and Development of Nox Inhibitors
Lee, S. R., An, E. J., Kim, J., & Bae, Y. S. (2019) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2019.188 · Cited by 64
Receptors for proteins modified by advanced glycation endproducts (AGE)—their functional role in atherosclerosis
Sano, H., Nagai, R., Matsumoto, K., & Horiuchi, S. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(99)00011-1 · Cited by 61
AGE-BSA decreases ABCG1 expression and reduces macrophage cholesterol efflux to HDL
Isoda, K., Folco, E. J. E., Shimizu, K., & Libby, P. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.07.023 · Cited by 61
Endogenous secretory RAGE but not soluble RAGE is associated with carotid atherosclerosis in type 1 diabetes patients
Katakami, N., Matsuhisa, M., Kaneto, H., Matsuoka, T., Sakamoto, K., Yasuda, T., & Yamasaki, Y. (2008) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2008.031 · Cited by 61
Interaction of Diabetes and Hypertension on Determinants of Endothelial Adhesiveness
Tsao, P. S., Niebauer, J., Buitrago, R., Lin, P. S., Wang, B., Cooke, J. P., Chen, Y. I., & Reaven, G. M. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.6.947 · Cited by 61
Vascular Cell Adhesion Molecule-1 Augments Adenovirus-Mediated Gene Transfer
Chu, Y., Heistad, D. D., Cybulsky, M. I., & Davidson, B. L. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.2.238 · Cited by 61
Aminoguanidine has an anti-atherogenic effect in the cholesterol-fed rabbit
Panagiotopoulos, S., O’Brien, R. C., Bucala, R., Cooper, M. E., & Jerums, G. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(97)00192-5 · Cited by 61
“and platelet-derived growth factor release [10], induce the expression of vascular cell-adhesion molecule-1 in vivo [11] and in cultured human endothelial cells [12] and covalently trap low-density lipoprotein (LDL) [13].”
Background
The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1
van Eupen, M. G. A., Schram, M. T., Colhoun, H. M., Hanssen, N. M. J., Niessen, H. W. M., Tarnow, L., Parving, H. H., Rossing, P., Stehouwer, C. D. A., & Schalkwijk, C. G. (2013) · Diabetologia · doi:10.1007/s00125-013-2919-8 · Cited by 60
“This is consistent with experiments that demonstrated that AGEs are able to induce the expression of sVCAM-1 [28, 29].”
Result
Association between endogenous secretory RAGE, inflammatory markers and arterial stiffness
Choi, K. M., Yoo, H. J., Kim, H. Y., Lee, K. W., Seo, J. A., Kim, S. G., Kim, N. H., Choi, D. S., & Baik, S. H. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2007.10.047 · Cited by 63
“AGE–RAGE induces expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human EC [30].”
Background
Relation Between Serum 3-Deoxyglucosone and Development of Diabetic Microangiopathy
Kusunoki, H., Miyata, S., Ohara, T., Liu, B.-F., Uriuhara, A., Kojima, H., Suzuki, K., Miyazaki, H., Yamashita, Y., Inaba, K., et al. (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1889 · Cited by 59
Pathogenic Molecular Mechanisms in Periodontitis and Peri-Implantitis: Role of Advanced Glycation End Products
Plemmenos, G., & Piperi, C. (2022) · Life · doi:10.3390/life12020218 · Cited by 59
“Cultured human endothelial cells and murine vasculature Increased VCAM-1 production [68]”
Background
The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: a complementary concept to Mendelian genetics
Krzywanski, D. M., Moellering, D. R., Fetterman, J. L., Dunham‐Snary, K. J., Sammy, M. J., & Ballinger, S. W. (2011) · Laboratory Investigation · doi:10.1038/labinvest.2011.95 · Cited by 60
RAGE: A journey from the complications of diabetes to disorders of the nervous system – striking a fine balance between injury and repair
Rong, L., Gooch, C. L., Szabolcs, M., Herold, K. C., Lalla, E., Hays, A. P., Yan, S. F., Yan, S. S. D., & Schmidt, A. M. (2005) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2005-00322 · Cited by 58
Self-citation
Accelerated atherosclerosis, dyslipidemia, and oxidative stress in end-stage renal disease
Mathur, S., Devaraj, S., & Jialal, I. (2002) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200203000-00003 · Cited by 59
Association of A1C with cardiovascular disease and metabolic syndrome in Asian Indians with normal glucose tolerance
Dilley, J., Ganesan, A., Deepa, R., Deepa, M., Sharada, G., Williams, O. D., & Mohan, V. (2007) · Diabetes Care · doi:10.2337/dc06-2414 · Cited by 58
Arguing for the motion: yes, RAGE is a receptor for advanced glycation endproducts
Ramasamy, R., Yan, S. F., & Schmidt, A. M. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700008 · Cited by 58
High fructose-induced metabolic changes enhance inflammation in human dendritic cells
Jaiswal, N., Agrawal, S., & Agrawal, A. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13299 · Cited by 61
Long-term exposure to high glucose up-regulates VCAM-induced endothelial cell adhesiveness to PBMC
Esposito, C., Fasoli, G., Plati, A., Bellotti, N., Conte, M. M., Cornacchia, F., Foschi, A., Mazzullo, T., Semeraro, L., & Canton, A. D. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.0590051842.x · Cited by 58
Lipoprotein Autoantibodies
Virella, G., & Lopes-Virella, M. F. (2003) · Clinical and Vaccine Immunology · doi:10.1128/cdli.10.4.499-505.2003 · Cited by 58
Potential effects of flavonoids on the etiology of vascular disease
Schramm, D. D., & German, J. B. (1998) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(98)00051-5 · Cited by 58
The dual face of endogenous α-aminoketones: Pro-oxidizing metabolic weapons
Bechara, E. J. H., Dutra, F., Cardoso, V. E. S., Sartori, A., Olympio, K. P. K., Penatti, C. A. A., Adhikari, A., & Assunção, N. A. (2007) · Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology · doi:10.1016/j.cbpc.2006.07.004 · Cited by 57
“, 1994), and the regulation of cellular adhesion (Vlassara et al., 1995; Schmidt et al., 1995).”
Background
Endothelial dysfunctions: common denominators in vascular disease
Caterina, R. D. (2000) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200011000-00007 · Cited by 57
Advanced Glycation End Products (AGE) Potently Induce Autophagy through Activation of RAF Protein Kinase and Nuclear Factor κB (NF-κB)
Verma, N., & Manna, S. K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.667576 · Cited by 57
“AGE are known to interact with their specific receptors, RAGE (receptors for AGE), which results in cell signaling that induces various ailments like retinopathy, neuropathy, nephropathy, and atherosclerosis (5, 6).”
Background
Receptor for advanced glycation endproduct (RAGE)–mediated nuclear factor‐κB activation in vasculitic neuropathy
Haslbeck, K.-M., Bierhaus, A., Erwin, S., Kirchner, A., Nawroth, P. P., Schlötzer, U., Neundörfer, B., & Heuß, D. F. (2004) · Muscle & Nerve · doi:10.1002/mus.20039 · Cited by 56
Persistent Elevation and Metabolic Dependence of Circulating E-Selectin after Delivery in Women with Gestational Diabetes Mellitus
Kautzky‐Willer, A., Fasching, P., Jilma, B., Waldhäusl, W. K., & Wagner, O. F. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4419 · Cited by 57
“Although cVCAM-1 was not directly related to glucose metabolism in GDM or NIDDM, additional metabolic aberrations as increased formation of advanced glycosylation end products may add to its increase (27).”
Background
The Effect of Hormonal Replacement Therapy on the Vascular Reactivity and Endothelial Function of Healthy Individuals and Individuals with Type 2 Diabetes1
Lim, S. C., Caballero, A. E., Arora, S., Smakowski, P., Bashoff, E. M., Brown, F. M., LoGerfo, F. W., Horton, E. S., & Veves, A. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.11.6160 · Cited by 57
Endothelial cell adhesion molecule and PMNL response to inflammatory stimuli and AGE-modified fibronectin
Sengoelge, G., Födinger, M., Skoupy, S., Ferrara, I., Zangerle, C., Rogy, M. A., Hörl, W. H., Sunder–Plassmann, G., & Menzel, J. E. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00157.x · Cited by 57
“The concentration of albumin (500 m g/ml) in our study was higher than that used by Schmidt et al [32].”
Aging-Dependent Reduction in Glyoxalase 1 Delays Wound Healing
Fleming, T. H., Theilen, T., Masania, J., Wunderle, M., Karimi, J., Vittas, S., Bernauer, R., Bierhaus, A., Rabbani, N., Thornalley, P. J., et al. (2013) · Gerontology · doi:10.1159/000351628 · Cited by 58
Blockade of Endogenous Cytokines Mitigates Neointimal Formation in Obese Zucker Rats
Takeda, R., Suzuki, E., Satonaka, H., Oba, S., Nishimatsu, H., Omata, M., Fujita, T., Nagai, R., & Hirata, Y. (2005) · Circulation · doi:10.1161/01.cir.0000158482.83179.db · Cited by 56
The Receptor for Advanced Glycation End Products (RAGE) Contributes to the Progression of Emphysema in Mice
Sambamurthy, N., Leme, A. S., Oury, T. D., & Shapiro, S. D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118979 · Cited by 56
“In addition AGE-RAGE signaling may up-regulate the expression of several adhesion molecules through NF-κB activation namely E-selectin, intercellular adhesion molecule-1 and vascular adhesion molecule-1 specifically on endothelial cells [50,51].”
Background
Nonoxidative protein glycation is implicated in familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation
Shibata, N., Nagai, R., Miyata, S., Jono, T., Horiuchi, S., Hirano, A., Kato, S., Sasaki, S., Asayama, K., & Kobayashi, M. (2000) · Acta Neuropathologica · doi:10.1007/s004019900173 · Cited by 56
Induction of aldose reductase in cultured human microvascular endothelial cells by advanced glycation end products
Nakamura, N., Obayashi, H., Fujii, M., Fukui, M., Yoshimori, K., Ogata, M., Hasegawa, G., Shigeta, H., Kitagawa, Y., Yoshikawa, T., et al. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00286-0 · Cited by 56
Effect of dietary advanced glycation end products on postprandial appetite, inflammation, and endothelial activation in healthy overweight individuals
Poulsen, M. W., Bak, M. J., Andersen, J. M., Monošík, R., Giraudi-Futin, A. C., Holst, J. J., Nielsen, J., Lauritzen, L., Larsen, L. H., Bügel, S., et al. (2014) · European Journal of Nutrition · doi:10.1007/s00394-013-0574-y · Cited by 55
Tissue plasminogen activator treatment of stroke in type-1 diabetes rats
Ning, R., Chopp, M., Yan, T., Zacharek, A., Zhang, C., Roberts, C., Cui, X., Lü, M., & Chen, J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.07.018 · Cited by 56
“[PubMed: 10699444] Schmidt AM, Hori O, Chen JX, Li JF, Crandall J, Zhang J, Cao R, Yan SD, Brett J, Stern D. Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice.”
BackgroundInfluentialSelf-citation
The G82S Polymorphism Promotes Glycosylation of the Receptor for Advanced Glycation End Products (RAGE) at Asparagine 81
Park, S. J., Kleffmann, T., & Hessian, P. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.241281 · Cited by 55
Natural History of Age-Related Retinal Lesions That Precede AMD in Mice Fed High or Low Glycemic Index Diets
Weikel, K., FitzGerald, P., Shang, F., Caceres, A., Bian, Q., Handa, J. T., Stitt, A. W., & Taylor, A. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8545 · Cited by 56
Lipids and the Endothelium: Bidirectional Interactions
Goldberg, I. J., & Bornfeldt, K. (2013) · Current Atherosclerosis Reports · doi:10.1007/s11883-013-0365-1 · Cited by 57
“increased levels of advanced glycation end products associated with diabetes [72], increased production of ROS through mitochondria [73] and NADPH oxidase 1 [74], aldose reductase activity [4, 7], activation of protein kinase C by hyperglycemia [75], and lack of proper insulin signaling [76, 77].”
Background
Definition of the immunogenic forms of modified human LDL recognized by human autoantibodies and by rabbit hyperimmune antibodies
Virella, G., Thorpe, S. R., Alderson, N. L., Derrick, M. B., Chassereau, C. N., Rhett, J. M., & Lopes-Virella, M. F. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400095-jlr200 · Cited by 55
“LDL, like most plasma proteins, is susceptible to AGE modification ( 12 ).”
Role of oxidized low-density lipoprotein in the atherosclerosis of uremia
Drüeke, T. B., Nguyen‐Khoa, T., Massy, Z. A., Witko‐Sarsat, V., Lacour, B., & Descamps‐Latscha, B. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.59780114.x · Cited by 55
Aminoguanidine and ramipril prevent diabetes-induced increases in protein kinase C activity in glomeruli, retina and mesenteric artery
Osicka, T. M., Yunxia, Y. U., Lee, V. W., Panagiotopoulos, S., Kemp, B. E., & Jerums, G. (2001) · Clinical Science · doi:10.1042/cs1000249 · Cited by 55
Fosinopril decreases levels of soluble vascular cell adhesion molecule-1 in borderline hypertensive type II diabetic patients with microalbuminuria
Gasic, S. (1999) · American Journal of Hypertension · doi:10.1016/s0895-7061(98)00229-5 · Cited by 55
“36 In addition, VCAM-1 is increased by advanced glycosylation end product”
Background
Vasculopathy and insulin resistance in the JCR:LA-cp rat
Richardson, M., Schmidt, A. M., Graham, S. E., Achen, B., Dereske, M., & Russell, J. C. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00012-4 · Cited by 55
Self-citation
Influence of obesity and metabolic dysfunction on the endothelial control in the coronary circulation
de Chantemèle, E. J. B., & Stepp, D. W. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.08.018 · Cited by 54
“According to these authors [94, 95] and others [96, 97] AGEs promote NADPH oxidase-derived ROS secretion through an inflammatory process involving the NF-κB and TNF-α signaling pathway, highlighting the role of inflammation in the vascular dysfunction associated with obesity.”
Background
RAGE and its ligands: a lasting memory in diabetic complications?
Yan, S.-F., Ramasamy, R., Bucciarelli, L. G., Wendt, T., Lee, L. K., Hudson, B. I., Stenr, D. M., Lalla, E., Yan, S. D., Rong, L., et al. (2004) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2004.001 · Cited by 53
Self-citation
Soluble RAGE-Modulating Drugs: State-of-the-Art and Future Perspectives for Targeting Vascular Inflammation
Lanati, N., Emanuele, E., Brondino, N., & Geroldi, D. (2010) · Current Vascular Pharmacology · doi:10.2174/157016110790226642 · Cited by 54
“The interaction of RAGE with its ligands upregulates the expression of RAGE itself as well as of proinflammatory molecules including TNF- [12], IL-6 [13], IL-1ß [14], insulin-like growth factor-1 (IGF-1) [15], vascular cell adhesion molecule-1 (VCAM-1) [16], and tissue factor (TF) [17] via activation of the transcript…”
Background
The Receptor for Advanced Glycation End Products (RAGE) Is Elevated in Women with Preeclampsia
Cooke, C. M., BROCKELSBY, J. C., Baker, P. N., & Davidge, S. T. (2003) · Hypertension in Pregnancy · doi:10.1081/prg-120021068 · Cited by 54
“For example, stimulation of the RAGE pathway increases TNFa secretion from endothelial cells (12) as well as increases the expression of VCAM-1 (30).”
Background
AGEs/RAGE in CKD: irreversible metabolic memory road toward CVD?
Koyama, H., & Nishizawà, Y. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2010.02298.x · Cited by 53
Localization of Tissue Transglutaminase in Human Carotid and Coronary Artery Atherosclerosis: Implications for Plaque Stability and Progression
Haroon, Z. A., Wannenburg, T., Gupta, M., Greenberg, C. S., Wallin, R., & Sane, D. C. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780214 · Cited by 53
“…generation of oxidant stress from smoking (Pryor et al, 1984; Tully et al, 1969), hyperlipidemia (Ohara et al, 1993), diabetes (Horie et al, 1997; Schmidt et al, 1995), and hypertension (Harrison, 1997; Scheidegger et al, 1997), as well as the health status of the endothelium, which is…”
Background
Emerging drugs for diabetic neuropathy
Tahrani, A. A., Askwith, T., & Stevens, M. J. (2010) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2010.512610 · Cited by 52
“In addition, AGE can bind to receptor of AGE (RAGE) causing the production of inflammatory cytokines, growth factors and adhesion molecules such as IL-1, IGF-1, platelet derived growth factor, TNF-a, TGF-b and vascular cell adhesion molecule-1 [34,72,75-77].”
Background
Effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy in patients with type 2 diabetes, in relation to suppression of Nɛ-carboxymethyl lysine
Kawai, T., Takei, I., Tokui, M., Funae, O., Miyamoto, K., Tabata, M., Hirata, T., Saruta, T., Shimada, A., & Itoh, H. (2009) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2008.10.005 · Cited by 52
Acute hyperglycaemia induces an inflammatory response in young patients with type 1 diabetes
Gordin, D., Forsblom, C. M., Rönnback, M., Parkkonen, M., Wadén, J., Hietala, K., & Groop, P. (2008) · Annals of Medicine · doi:10.1080/07853890802126547 · Cited by 52
The effects of hormone replacement therapy on carbohydrate metabolism and cardiovascular risk factors in surgically postmenopausal cynomolgus monkeys
Wagner, J. D., Martino, M. A., Jayo, M. J., Anthony, M. S., Clarkson, T. B., & Cefalu, W. T. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90244-9 · Cited by 51
Pathogenic Role of Modified LDL Antibodies and Immune Complexes in Atherosclerosis
Lopes-Virella, M. F., & Virella, G. (2013) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.19281 · Cited by 52
Therapeutic potential of dietary phase 2 enzyme inducers in ameliorating diseases that have an underlying inflammatory component
Juurlink, B. H. J. (2001) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y00-120 · Cited by 51
“…gastrointestinal tract (GPx-GI, (iii ) a membrane-associated GPx (GPx4) that scavenge membrane-bound phospholipid hydroperoxides as well as other organic peroxides and hydrogen peroxide, (iv) a plasma GPx (GPx3), and (v) a plasma GPx known as selenoprotein P (Ursini et al. 1995; Saito et al. 1999).”
Background
The Epidemiology of Diabetic Retinopathy
Klein, R. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-563-3_3 · Cited by 51
Two immunochemical assays to measure advanced glycation end-products in serum from dialysis patients
Zhang, X., Frischmann, M., Kientsch-Engel, R., Steinmann, K., Stopper, H., Niwa, T., & Pischetsrieder, M. (2005) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2005.089 · Cited by 50
“It has been shown that CML binds to the receptor for AGE (RAGE), which is expressed, for example, on human endothelial cells or macrophages (42).”
Background
Low-density lipoprotein (LDL)-induced monocyte-endothelial cell adhesion, soluble cell adhesion molecules, and autoantibodies to oxidized-LDL in chronic renal failure patients on dialysis therapy
O’Byrne, D., Devaraj, S., Islam, K. N., Collazo, R., McDonald, L., Grundy, S. M., & Jialal, I. (2001) · Metabolism · doi:10.1053/meta.2001.19486 · Cited by 50
The incidence and characteristics of silent cerebral infarction in elderly diabetic patients: association with serum-soluble adhesion molecules
Kawamura, T., Umemura, T., Kanai, A., Uno, T., Matsumae, H., Sano, T., Sakamoto, N., Sakakibara, T., Nakamura, J., & Hotta, N. (1998) · Diabetologia · doi:10.1007/s001250051007 · Cited by 50
“Such increased levels of adhesion molecules found in diabetic patients may be explained by recent reports that advanced glycation end-products, caused by hyperglycaemia [46] and increased thromboxane A2 resulting from abnormal prostaglandin metabolism [47, 48], induced the expression of ICAM-1 and VCAM-1.”
Background
Postischemic reperfusion injury and allograft arteriosclerosis
Fellström, B., Aküyrek, L. M., Backman, U., Larsson, E., Melin, J., & Zezina, L. (1998) · Transplantation Proceedings · doi:10.1016/s0041-1345(98)01412-2 · Cited by 50

Authors: Schmidt, A. M., Hori, O., Chen, J. X., Li, J. F., Crandall, J., Zhang, J., Cao, R., Yan, S. D., Brett, J., & Stern, D.
Affiliations: Columbia University Irving Medical Center (US)
Columbia University (US)
ORCID: Hori, O
Crandall, J
Zhang, J
Cao, R
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1995-09-01
Volume: 96
Issue: 3
Pages: 1395-1403
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci118175
PMC: PMC185762
OpenAlex: W2138928713
Cited by: 896
References: 43
Citations by year: 2026: 5 · 2025: 11 · 2024: 15 · 2023: 16 · 2022: 13 · 2021: 21 · 2020: 16 · 2019: 23 · 2018: 16 · 2017: 26 · 2016: 17 · 2015: 34 · 2014: 32 · 2013: 35 · 2012: 36
FWCI: 17.32
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
KU ScholarWorks (University of Kansas) (submittedVersion, other-oa)
Funders: American Heart Association
National Institutes of Health (5r01hl042833-10, 5p50hl021006-17)
U.S. Public Health Service
National Institute on Aging (AG00602)
National Heart, Lung, and Blood Institute (HL-42833, HL 21006)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: advanced glycation end products, receptor for advanced glycation end products, VCAM-1, endothelial cells, diabetes mellitus, diabetic vascular disease, oxidative stress, NF-kB, soluble RAGE, N-acetylcysteine, monocyte adhesion, atherosclerosis, soluble VCAM-1
MeSH terms: Receptor for Advanced Glycation End Products, Animals, Base Sequence, Cell Adhesion, Cell Line, Cell Nucleus, Cells, Cultured, Diabetic Angiopathies, Endothelium, Vascular, Enzyme-Linked Immunosorbent Assay, Humans, Male, Models, Biological, Molecular Sequence Data, Receptors, Immunologic, Transcription, Genetic, Umbilical Veins, Cell Adhesion Molecules, Gene Expression, Polymerase Chain Reaction, Glycation End Products, Advanced, DNA Primers, Oxidative Stress, Vascular Cell Adhesion Molecule-1, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks