Cited by 58Advanced Glycation End Products researchPotato Plant ResearchGenetics, Aging, and Longevity in Model Organisms

Arguing for the motion: yes, RAGE is a receptor for advanced glycation endproducts

Ramasamy, Ravichandran, Yan, Shi Fang, Schmidt, Ann Marie·2007·Molecular Nutrition & Food Research

Abstract

Advanced glycation endproducts (AGEs) are an heterogenous class of compounds formed by diverse stimuli, including hyperglycemia, oxidative stress, inflammation, renal failure, and innate aging. Recent evidence suggests that dietary sources of AGE may contribute to pathology. AGEs impart diverse effects in cells; evidence strongly suggests that crosslinking of proteins by AGEs may irrevocably alter basement membrane integrity and function. In addition, the ability of AGEs to bind to cells and activate signal transduction, thereby affecting broad properties in the cellular milieu, indicates that AGEs are not innocent bystanders in the diseases of AGEing. Here, we present evidence that receptor for AGE (RAGE) is a receptor for AGEs.

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Crossref · 10.1002/mnfr.200700008

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41 of 41 references verified0 citation errors · 0 not checkable

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  • Leptin is preferentially expressed and secreted by subcutaneous adipose tissue, while adiponectin, visfatin, omentin, resistin, PAI-1, IL-8, IL-7, IL-1a, MCP-1, TGF-b, growth-related oncogene, CCL5 and MIP-1b are expressed more in abdominal fat.

    “Thus, leptin is preferentially expressed and secreted by subcutaneous adipose tissue (52) , while the expression of adiponectin, visfatin, omentin, resistin, PAI-1, IL-8, IL-7, IL-1a, MCP-1, TGF-b, growth-related oncogena, CCL5 and MIP-1b is higher in abdominal fat.”
  • Adipokine secretion profiles differ between subcutaneous and abdominal adipose tissues.

    “In addition, the profile of adipokines produced is dissimilar between the subcutaneous and abdominal adipose tissues.”

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Authors
Ramasamy, R., Yan, S. F., & Schmidt, A. M.
Affiliations
Columbia University Irving Medical Center (US)
Venue
Molecular Nutrition & Food Research
Publisher
Wiley
Published
2007-09
Volume
51
Issue
9
Pages
1111-1115
ISSN
  • 1613-4125 (ISSN-L)
  • 1613-4133
OpenAlex
W1999723121
Cited by
58
References
41
Citations by year
2025: 1 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 3 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 5 · 2012: 4
FWCI
0.65
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Nutrition & Food Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • USPHS
  • Juvenile Diabetes Research Foundation International
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
advanced glycation end products, receptor for advanced glycation end products, RAGE, protein cross-linking, basement membrane integrity, signal transduction, dietary AGEs, aging, hyperglycemia, oxidative stress, inflammation
MeSH terms
Receptor for Advanced Glycation End Products, Animals, Cattle, Humans, Lung, Lysine, Receptors, Immunologic, Signal Transduction, Glycation End Products, Advanced

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