Arguing for the motion: yes, RAGE is a receptor for advanced glycation endproducts
Abstract
Advanced glycation endproducts (AGEs) are an heterogenous class of compounds formed by diverse stimuli, including hyperglycemia, oxidative stress, inflammation, renal failure, and innate aging. Recent evidence suggests that dietary sources of AGE may contribute to pathology. AGEs impart diverse effects in cells; evidence strongly suggests that crosslinking of proteins by AGEs may irrevocably alter basement membrane integrity and function. In addition, the ability of AGEs to bind to cells and activate signal transduction, thereby affecting broad properties in the cellular milieu, indicates that AGEs are not innocent bystanders in the diseases of AGEing. Here, we present evidence that receptor for AGE (RAGE) is a receptor for AGEs.
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Leptin is preferentially expressed and secreted by subcutaneous adipose tissue, while adiponectin, visfatin, omentin, resistin, PAI-1, IL-8, IL-7, IL-1a, MCP-1, TGF-b, growth-related oncogene, CCL5 and MIP-1b are expressed more in abdominal fat.
“Thus, leptin is preferentially expressed and secreted by subcutaneous adipose tissue (52) , while the expression of adiponectin, visfatin, omentin, resistin, PAI-1, IL-8, IL-7, IL-1a, MCP-1, TGF-b, growth-related oncogena, CCL5 and MIP-1b is higher in abdominal fat.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [52]
Adipokine secretion profiles differ between subcutaneous and abdominal adipose tissues.
“In addition, the profile of adipokines produced is dissimilar between the subcutaneous and abdominal adipose tissues.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [52]
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He, H., Liu, Y., Zeng, H., Sun, X., Zhang, L., Zhang, X.-L., Liao, W., Zhou, X., & He, Y. (2015) · PubMed Central · Cited by 12 · see citing works
Dapagliflozin Ameliorates Neural Damage in the Heart and Kidney of Diabetic Mice
Donoiu, I., Târtea, G. C., Sfredel, V., Raicea, V. C., Țucă, A.-M., Preda, A. N., Cozma, D. C., & Vatasescu, R. G. (2023) · Biomedicines · doi:10.3390/biomedicines11123324 · Cited by 10 · see citing works
S100A8/A9-RAGE pathway and chronic airway inflammation in smoke-induced lung carcinogenesis
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Diabetes Associated Memory Impairment: Perspective on Management Strategies
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Cell and Molecular Mediators involved in damage and repair in emphysema using mouse models
Sambamurthy, N. (2014) · D-Scholarship@Pitt (University of Pittsburgh)
- Authors
- Ramasamy, R., Yan, S. F., & Schmidt, A. M.
- Affiliations
- Columbia University Irving Medical Center (US)
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2007-09
- Volume
- 51
- Issue
- 9
- Pages
- 1111-1115
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W1999723121
- Cited by
- 58
- References
- 41
- Citations by year
- 2025: 1 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 3 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 5 · 2012: 4
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- USPHS
- Juvenile Diabetes Research Foundation International
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- advanced glycation end products, receptor for advanced glycation end products, RAGE, protein cross-linking, basement membrane integrity, signal transduction, dietary AGEs, aging, hyperglycemia, oxidative stress, inflammation
- MeSH terms
- Receptor for Advanced Glycation End Products, Animals, Cattle, Humans, Lung, Lysine, Receptors, Immunologic, Signal Transduction, Glycation End Products, Advanced
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