The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults.
Open accessAbstract
In hypercholesterolemic rabbits, oral L-arginine (the substrate for endothelium derived nitric oxide) attenuates endothelial dysfunction and atheroma formation, but the effect in hypercholesterolemic humans is unknown. Using high resolution external ultrasound, we studied arterial physiology in 27 hypercholesterolemic subjects aged 29+/-5 (19-40) years, with known endothelial dysfunction and LDL-cholesterol levels of 238+/-43 mg/dl. Each subject was studied before and after 4 wk of L-arginine (7 grams x 3/day) or placebo powder, with 4 wk washout, in a randomized double-blind crossover study. Brachial artery diameter was measured at rest, during increased flow (causing endothelium-dependent dilation, EDD) and after sublingual glyceryl trinitrate (causing endothelium-independent dilation). After oral L-arginine, plasma L-arginine levels rose from 115+/-103 to 231+/-125 micromol/liter (P<0.001), and EDD improved from 1.7+/-1.3 to 5.6+/-3.0% (P<0.001). In contrast there was no significant change in response to glyceryl trinitrate. After placebo there were no changes in endothelium-dependent or independent vascular responses. Lipid levels were unchanged after L-arginine and placebo. Dietary supplementation with L-arginine significantly improves EDD in hypercholesterolemic young adults, and this may impact favorably on the atherogenic process.
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Cites
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742
Self-citationClose Relation of Endothelial Function in the Human Coronary and Peripheral Circulations
Anderson, T. J., Uehata, A., Gerhard, M. D., Meredith, I. T., Knab, S., Delagrange, D., Lieberman, E. H., Ganz, P., Creager, M. A., Yeung, A. C., et al. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00327-4 · Cited by 2,033 · cited 2×
“The brachial artery dilation to flow using this technique can be blocked by infusion of N -monomethyl l -arginine (L-NMMA) (17), a specific antagonist for NO synthase, and responses correlate with invasive tests of coronary endothelial function (18).”
MethodHypercholesterolemia increases endothelial superoxide anion production.
Ohara, Y., Peterson, T. E., & Harrison, D. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116491 · Cited by 1,765
Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.
Stamler, J. S., Jaraki, O., Osborne, J., Simon, D. I., Keaney, J., Vita, J., Singel, D., Valeri, C. R., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7674 · Cited by 1,238
L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits.
Rossitch, E., Alexander, E., Black, P. M., & Cooke, J. P. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115132 · Cited by 161
Cited by
Endothelial Function and Dysfunction: Testing and Clinical Relevance
Deanfield, J. E., Halcox, J. P., & Rabelink, T. J. (2007) · Circulation · doi:10.1161/circulationaha.106.652859 · Cited by 2,710
Rees, D. C., Williams, T. N., & Gladwin, M. T. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61029-x · Cited by 2,504
Arginine metabolism and nutrition in growth, health and disease
Wu, G., Bazer, F. W., Davis, T. A., Kim, S. W., Li, P., Marc Rhoads, J., Carey Satterfield, M., Smith, S. B., Spencer, T. E., & Yin, Y. (2009) · Amino Acids · doi:10.1007/s00726-008-0210-y · Cited by 1,362
Böger, R. H., Bode-Böger, S. M., Szuba, A., Tsao, P. S., Chan, J. R., Tangphao, O., Blaschke, T. F., & Cooke, J. P. (1998) · Circulation · doi:10.1161/01.cir.98.18.1842 · Cited by 1,181
The Central Role of Endothelial Dysfunction in Cardiorenal Syndrome
Zhang, J., Bottiglieri, T., & McCullough, P. A. (2017) · Cardiorenal Medicine · doi:10.1159/000452283 · Cited by 1,080
Metadata
- Authors
- Clarkson, P., Adams, M. R., Powe, A. J., Donald, A. E., McCredie, R., Robinson, J., McCarthy, S. N., Keech, A., Celermajer, D. S., & Deanfield, J. E.
- Venue
- Journal of Clinical Investigation
- Published
- 1996-04-15
- Volume
- 97
- Issue
- 8
- Pages
- 1989-1994
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2022574364
- Cited by
- 412
- References
- 6
- FWCI
- 19.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. https://app.cochat.ai/papers/10.1172/jci118632
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- Clarkson, P., Adams, M. R., Powe, A. J., Donald, A. E., McCredie, R., Robinson, J., McCarthy, S. N., Keech, A., Celermajer, D. S., & Deanfield, J. E. (1996). Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. Journal of Clinical Investigation. https://doi.org/10.1172/jci118632
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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