Cited by 482Rheumatoid Arthritis Research and TherapiesT-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

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CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity.

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Schmidt, D, Goronzy, J J, Weyand, C M·1996·Journal of Clinical Investigation

DOI 10.1172/jci118638PMC PMC507276

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Abstract

Clonal expansion of CD4+ T cells is a characteristic finding in patients with RA and is only infrequently found in patients with psoriatic arthritis and healthy controls. Expanded CD4+ clonotypes are present in the blood, infiltrate into the joint, and persist over years. We have not addressed the question of whether the expanded clonotypes have unique functional and phenotypic properties which may explain the preferential in vivo expansion in RA. In contrast to most CD4+ T cells, expanded clonotypes lacked the expression of the CD28 and CD7 cell surface molecules. Accordingly, the subsets of CD4+ CD28- (9.7 vs 1.7, P = 0.00002) and CD4+ CD7- T cells (21.5 vs 12.26, P = 0.018) were increased in RA patients compared with age-matched normal individuals. Despite the lack of CD28 expression, clonally expanded CD4+ T cells were not anergic but proliferated in response to immobilized anti-CD3 and could be maintained in tissue culture. In vivo expanded CD4+ T cells were autoreactive to ubiquitously distributed autoantigens. They responded in an autologous mixed lymphocyte reaction, and T cell clones isolated from selected patients proliferated to autologous peripheral blood adherent cells. These data suggest that in RA patients selected CD4+ T cells which share the CD7- CD28- phenotype escape from peripheral tolerance.

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Authors: Schmidt, D., Goronzy, J. J., & Weyand, C. M.
Affiliations: Mayo Clinic (US)
ORCID: Goronzy, J J
Weyand, C M
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1996-05-01
Volume: 97
Issue: 9
Pages: 2027-2037
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci118638
PMC: PMC507276
OpenAlex: W1982865105
Cited by: 482
References: 43
Citations by year: 2026: 3 · 2025: 11 · 2024: 10 · 2023: 5 · 2022: 13 · 2021: 15 · 2020: 12 · 2019: 15 · 2018: 10 · 2017: 18 · 2016: 7 · 2015: 20 · 2014: 12 · 2013: 23 · 2012: 11
FWCI: 18.26
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Arthritis Foundation
Mayo Foundation for Medical Education and Research
National Institutes of Health
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR041974, R01 AR 41974, R01AR042527, R01AR42527)
Topics: Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: rheumatoid arthritis, CD4+ T cells, clonal expansion, CD28, CD7, autoreactivity, peripheral tolerance, T cell anergy, autoantigens, mixed lymphocyte reaction, T cell proliferation, psoriatic arthritis
MeSH terms: Arthritis, Rheumatoid, Autoantigens, Base Sequence, Clone Cells, Humans, Lymphocyte Activation, Molecular Sequence Data, CD4-Positive T-Lymphocytes, Immunophenotyping, T-Lymphocyte Subsets, CD28 Antigens, Antigens, CD7

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CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity.

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