CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity.

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

Watanabe‐Fukunaga, R., Brannan, C., Copeland, N., Jenkins, N., & Nagata, S. (1992) · Nature · doi:10.1038/356314a0 · Cited by 3,153

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

Dhein, J., Walczak, H., Bäumler, C., Debatin, K., & Krammer, P. (1995) · Nature · doi:10.1038/373438a0 · Cited by 1,814

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

Ju, S., Panka, D., Cui, H., Ettinger, R., EI-Khatib, M., Sherr, D., Stanger, B., & Marshak-Rothstein, A. (1995) · Nature · doi:10.1038/373444a0 · Cited by 1,709

Rheumatoid Arthritis

Epstein, F. H., & Harris, E. D. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005033221805 · Cited by 1,549

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

Brunner, T., Mogil, R. J., LaFace, D., Yoo, N. J., Mahboubi, A., Echeverri, F., Martin, S. J., Force, W. R., Lynch, D. H., Ware, C. F., et al. (1995) · Nature · doi:10.1038/373441a0 · Cited by 1,314

The Role of the CD28 Receptor During T Cell Responses to Antigen

Linsley, P. S., & Ledbetter, J. A. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.001203 · Cited by 1,298

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

Moskophidis, D., Lechner, F., Pircher, H., & Zinkernagel, R. M. (1993) · Nature · doi:10.1038/362758a0 · Cited by 1,240

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

Boise, L., Minn, A. J., Noel, P. J., June, C. H., Accavitti, M. A., Lindsten, T., & Thompson, C. B. (1995) · Immunity · doi:10.1016/1074-7613(95)90161-2 · Cited by 1,219

Apoptosis And Programmed Cell Death In Immunity

Cohen, J., Duke, R. C., Fadok, V. A., & Sellins, K. S. (1992) · Annual Review of Immunology · doi:10.1146/annurev.iy.10.040192.001411 · Cited by 1,112

An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans.

Lantz, O. J., & Bendelac, A. S. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.3.1097 · Cited by 1,036

T-Cells in Multiple Sclerosis

Severson, C., & Hafler, D. A. (2009) · Results and problems in cell differentiation · doi:10.1007/400_2009_12 · Cited by 56

The Role of T Cells in Rheumatoid Arthritis

Weyand, C. M., Bryl, E., & Goronzy, J. J. (2001) · Springer eBooks · doi:10.1007/978-94-010-0981-2_13 · Cited by 55

Pityriasis lichenoides chronica: stratification by molecular and phenotypic profile

MAGRO, C. M. J., CROWSON, A. N., MORRISON, C., & LI, J. (2007) · Human Pathology · doi:10.1016/j.humpath.2006.09.013 · Cited by 54

Chronic beryllium disease: immune‐mediated destruction with implications for organ‐specific autoimmunity

Fontenot, A. P., & Kotzin, B. L. (2003) · Tissue Antigens · doi:10.1046/j.1399-0039.2003.00160.x · Cited by 54

Distinct costimulation dependent and independent autoreactive T-cell clones in primary biliary cirrhosis

Kamihira, T., Shimoda, S., Harada, K., Kawano, A., Handa, M., Baba, E., Tsuneyama, K., Nakamura, M., Ishibashi, H., Nakanuma, Y., et al. (2003) · Gastroenterology · doi:10.1016/j.gastro.2003.07.013 · Cited by 54

T-cells in the pathogenesis of rheumatoid arthritis Villains or accomplices?

Kinne, R. W., Palombo‐Kinne, E., & Emmrich, F. (1997) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(96)00079-8 · Cited by 53

Immune Aging in Rheumatoid Arthritis

Weyand, C. M., & Goronzy, J. J. (2025) · Arthritis & Rheumatology · doi:10.1002/art.43105 · Cited by 61

Between adaptive and innate immunity: TLR4-mediated perforin production by CD28nullT-helper cells in ankylosing spondylitis

Raffeiner, B., Dejaco, C., Duftner, C., Kullich, W., Goldberger, C., Vega, S. C., Keller, M., Grubeck‐Loebenstein, B., & Schirmer, M. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1840 · Cited by 52

Peripheral and Site‐Specific CD 4+ CD 28null T Cells from Rheumatoid Arthritis Patients Show Distinct Characteristics

Pieper, J., Johansson, S., Snir, O., Linton, L., Rieck, M., Buckner, J. H., Winqvist, O., van Vollenhoven, R., & Malmström, V. (2013) · Scandinavian Journal of Immunology · doi:10.1111/sji.12139 · Cited by 54

Clonal expansion is a characteristic feature of the B-cell repertoire of patients with rheumatoid arthritis

Itoh, K., Patki, V., Furie, R. A., Chartash, E., Jain, R. I., LANE, L. B., Asnis, S. E., & Chiorazzi, N. (1999) · Arthritis Research & Therapy · doi:10.1186/ar68 · Cited by 51

Reactive oxygen intermediate-induced pathomechanisms contribute to immunosenescence, chronic inflammation and autoimmunity

Peters, T., Weiss, J. M., Sindrilaru, A., Wang, H., Oreshkova, T., Wlaschek, M., Maity, P., Reimann, J., & Scharffetter‐Kochanek, K. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.07.003 · Cited by 51

CD28null pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death

Pera, A., Caserta, S., Albanese, F., Blowers, P., Morrow, G. W., Terrazzini, N., Smith, H. E., Rajkumar, C., Reus, B., Msonda, J. R., et al. (2018) · Theranostics · doi:10.7150/thno.27428 · Cited by 49

Cell Proliferation and Apoptosis in the Immune System in the Elderly

Ginaldi, L., Martinis, M. D., D’Ostilio, A., Marini, L., Loreto, M. F., Corsi, M. P., & Quaglino, D. (2000) · Immunologic Research · doi:10.1385/ir:21:1:31 · Cited by 48

Aging, cytomegalovirus (CMV) and influenza vaccine responses

Frasca, D., & Blomberg, B. B. (2016) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1105413 · Cited by 46

Active Crohn's Disease Patients Show a Distinctive Expansion of Circulating Memory CD4+CD45RO+CD28null T Cells

De Tena, J. G., Manzano, L., Leal, J. C., Antonio, E. S., Sualdea, V., & Álvarez-Mon, M. (2004) · Journal of Clinical Immunology · doi:10.1023/b:joci.0000019784.20191.7f · Cited by 59

CTLA‐4IG suppresses reactive oxygen species by preventing synovial adherent cell–induced inactivation of rap1, a ras family GTPASE mediator of oxidative stress in rheumatoid arthritis T cells

Remans, P. H. J., Wijbrandts, C. A., Sanders, M. E., Toes, R. E. M., Breedveld, F. C., Tak, P. P., van Laar, J. M., & Reedquist, K. A. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22139 · Cited by 43

T Cells in Autoimmunity-Associated Cardiovascular Diseases

Muallem, D. R., Burma, A. M., Kitakule, M. M., Luo, Y., & Mehta, N. N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.588776 · Cited by 47

Apoptosis in rheumatoid arthritis: friend or foe

Liu, H., & Pope, R. M. (2004) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2004.04.010 · Cited by 46

Subclinical Reactivation of Cytomegalovirus Drives CD4+CD28null T-Cell Expansion and Impaired Immune Response to Pneumococcal Vaccination in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

Chanouzas, D., Sagmeister, M. S., Faustini, S. E., Nightingale, P., Richter, A. G., Ferro, C. J., Morgan, M. D., Moss, P. A. H., & Harper, L. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy493 · Cited by 45

CD28null CD4 T-cell expansions in autoimmune disease suggest a link with cytomegalovirus infection

Bano, A., Pera, A., Almoukayed, A., Clarke, T. H. S., Kirmani, S., Davies, K. A., & Kern, F. (2019) · F1000Research · doi:10.12688/f1000research.17119.1 · Cited by 47

Different distribution of CD4 and CD8 T cells in synovial membrane and peripheral blood of rheumatoid arthritis and osteoarthritis patients.

Pawłowska, J., Mikosik, A., Soroczynska-Cybula, M., Jóźwik, A., Łuczkiewicz, P., Mazurkiewicz, S., Lorczyński, A., Witkowski, J. M., & Bryl, E. (2010) · Folia Histochemica et Cytobiologica · doi:10.2478/v10042-009-0117-9 · Cited by 45

T-Cell Aging-Associated Phenotypes in Autoimmune Disease

Zhao, T. V., Sato, Y., Goronzy, J. J., & Weyand, C. M. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.867950 · Cited by 50

T cell aging as a risk factor for autoimmunity

Liu, Q., Zheng, Y., Goronzy, J. J., & Weyand, C. M. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102947 · Cited by 48

Enriched Cd141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis

Canavan, M., Walsh, A. M., Bhargava, V., Wade, S. M., McGarry, T., Marzaioli, V., Moran, B., Biniecka, M., Convery, H., Wade, S. C., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.95228 · Cited by 42

ZAP70, too little, too much can lead to autoimmunity*

Ashouri, J. F., Lo, W., Nguyen, T. T. T., Shen, L., & Weiss, A. (2021) · Immunological Reviews · doi:10.1111/imr.13058 · Cited by 47

A Novel T Cell Cytokine Stimulates Interleukin-6 in Human Osteoblastic Cells

Rifas, L., & Avioli, L. V. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.7.1096 · Cited by 44

Monoclonal T-Cell Dyscrasia of Undetermined Significance Associated With Recalcitrant Erythroderma

Gniadecki, R., & Lukowsky, A. (2005) · Archives of Dermatology · doi:10.1001/archderm.141.3.361 · Cited by 44

Polyfunctional KLRG-1+CD57+ Senescent CD4+ T Cells Infiltrate Tumors and Are Expanded in Peripheral Blood From Breast Cancer Patients

Ramello, M. C., Núñez, N. G., Tosello, J., Bossio, S., Canale, F. P., Abrate, C., Ponce, N. E., del Castillo, A., Ledesma, M., Viel, S., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.713132 · Cited by 46

Functional Killer Ig-Like Receptors on Human Memory CD4+ T Cells Specific for Cytomegalovirus

van Bergen, J., Kooy-Winkelaar, E. M. C., van Dongen, H., van Gaalen, F. A., Thompson, A., Huizinga, T. W. J., Feltkamp, M. C. W., Toes, R. E. M., & Koning, F. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0800455 · Cited by 43

Proteomic Analysis of the Inflamed Intestinal Mucosa Reveals Distinctive Immune Response Profiles in Crohn’s Disease and Ulcerative Colitis

Berndt, U., Bartsch, S., Philipsen, L., Danese, S., Wiedenmann, B., Dignass, A. U., Hämmerle, M., & Sturm, A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.295 · Cited by 40

Defective CD8+CD28− regulatory T cell suppressor function in rheumatoid arthritis is restored by tumour necrosis factor inhibitor therapy

Ceeraz, S., Hall, C. L., Choy, E., Spencer, J., & Corrigall, V. (2013) · Clinical & Experimental Immunology · doi:10.1111/cei.12161 · Cited by 41

The power of the third dimension

Weyand, C. M., Kang, Y. M., Kurtin, P. J., & Goronzy, J. J. (2003) · Current Opinion in Rheumatology · doi:10.1097/00002281-200305000-00013 · Cited by 41

Targeted gene disruption of murine CD7

Bonilla, F. A. (1997) · International Immunology · doi:10.1093/intimm/9.12.1875 · Cited by 41

Rheumatoid synovial CD4+ T cells exhibit a reduced capacity to differentiate into IL-4-producing T-helper-2 effector cells

Davis, L. S., Cush, J. J., Schulze‐Koops, H., & Lipsky, P. E. (2000) · Arthritis Research & Therapy · doi:10.1186/ar140 · Cited by 41

HLA Polymorphisms and T Cells in Rheumatoid Arthritis

Weyand, C. M., & Goronzy, J. J. (1999) · International Reviews of Immunology · doi:10.3109/08830189909043018 · Cited by 41

The impact of CD4+CD28null T-lymphocytes on atrial fibrillation and mortality in patients with chronic heart failure

Sulzgruber, P., Koller, L., Winter, M., Richter, B., Blum, S., Korpak, M., Hülsmann, M., Goliasch, G., Wojta, J., & Niessner, A. (2016) · Thrombosis and Haemostasis · doi:10.1160/th16-07-0531 · Cited by 40

Autoreactivity of Peripheral Helper T Cells in the Joints of Rheumatoid Arthritis

Sakuragi, T., Yamada, H., Haraguchi, A., Kai, K., Fukushi, J., Ikemura, S., Akasaki, Y., Fujiwara, T., Tsushima, H., Tsutsui, T., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2000783 · Cited by 39

Age as a risk factor in vasculitis

Gloor, A. D., Berry, G. J., Goronzy, J. J., & Weyand, C. M. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00911-1 · Cited by 44

Multiple Mechanisms Support Oligoclonal T Cell Expansion in Rheumatoid Synovitis

Rittner, H. L., Zettl, A., Jendro, M. C., Bartz‐Bazzanella, P., Goronzy, J. J., & Weyand, C. M. (1997) · Molecular Medicine · doi:10.1007/bf03401692 · Cited by 40

Accelerated Atherosclerosis in Rheumatoid Arthritis: Mechanisms and Treatment

Reiss, A. B., Silverman, A., Khalfan, M., Vernice, N. A., Kasselman, L. J., Carsons, S. E., & Leon, J. D. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190430113212 · Cited by 38

The tetraspanin CD9 is preferentially expressed on the human CD4+CD45RA+ naive T cell population and is involved in T cell activation

Kobayashi, H., Hosono, O., Iwata, S., Kawasaki, H., Kuwana, M., Tanaka, H., Dang, N. H., & Morimoto, C. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02494.x · Cited by 38

Leukemic T cells are specifically enriched in a unique CD3dimCD7low subpopulation of CD4+ T cells in acute‐type adult T‐cell leukemia

Tian, Y., Kobayashi, S., Ohno, N., Isobe, M., Tsuda, M., Zaike, Y., Watanabe, N., Tani, K., Tojo, A., & Uchimaru, K. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01833.x · Cited by 39

Neopterin, CD4+CD28− lymphocytes and the extent and severity of coronary artery disease

Alber, H. F., Duftner, C., Wanitschek, M. M., Dörler, J., Schirmer, M., Suessenbacher, A., Frick, M., Dichtl, W., Pachinger, O. M., & Weidinger, F. F. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.03.010 · Cited by 37

Preferential type 1 chemokine receptors and cytokine production of CD28− T cells in ankylosing spondylitis

Duftner, C., Dejaco, C., Kullich, W., Klauser, A. S., Goldberger, C., Falkenbach, A., & Schirmer, M. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.042085 · Cited by 37

Precocious Atherosclerosis in Rheumatoid Arthritis

Gerli, R., Sherer, Y., Bartoloni, E., Vaudo, G., Moscatelli, S., & Shoenfeld, Y. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1422.038 · Cited by 37

TCRβ spectratyping in RA: evidence of clonal expansions in peripheral blood lymphocytes

Hall, F. C., Thomson, K. J., Procter, J., McMichael, A. J., & Wordsworth, B. P. (1998) · Annals of the Rheumatic Diseases · doi:10.1136/ard.57.5.319 · Cited by 37

Involvement of CD4+,CD57+ T cells in the disease activity of rheumatoid arthritis

Maeda, T., Yamada, H., Nagamine, R., Shuto, T., Nakashima, Y., Hirata, G., & Iwamoto, Y. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10133 · Cited by 37

Reply

Griffiths, D. J., & Venables, P. J. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199911)42:11 · Cited by 1

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis

Ashouri, J. F., Hsu, L., Yu, S., Rychkov, D., Chen, Y., Cheng, D. A., Sirota, M., Hansen, E., Lattanza, L. L., Zikherman, J., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1904271116 · Cited by 35

Rosuvastatin induces apoptosis in CD4+CD28null T cells in patients with acute coronary syndromes

Link, A., Selejan, S., Hewera, L., Walter, F. G., Nickenig, G., & Böhm, M. (2010) · Clinical Research in Cardiology · doi:10.1007/s00392-010-0225-8 · Cited by 36

Age-Related Changes in Major Lymphocyte Subsets in Cynomolgus Monkeys.

Nam, K., Akari, H., Terao, K., ITAGAKI, S.-I., & Yoshikawa, Y. (1998) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.47.159 · Cited by 36

Chronic Inflammatory Autoimmune Disorders and Atherosclerosis

ABOURAYA, S., Abou‐Raya, A., Naim, A., & Abuelkheir, H. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1381.007 · Cited by 36

Ex Vivo Homeostatic Proliferation of CD4+ T Cells in Rheumatoid Arthritis Is Dysregulated and Driven by Membrane-Anchored TNFα

Wagner, U. G., Pierer, M., Wahle, M., Moritz, F., Kaltenhäuser, S., & Häntzschel, H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.4.2825 · Cited by 35

Stem cell aging and autoimmunity in rheumatoid arthritis

Weyand, C. M., & Goronzy, J. J. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.07.006 · Cited by 35

Adaptive immunity and atherosclerosis: aging at its crossroads

Snijckers, R., & Foks, A. C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1350471 · Cited by 40

Metabolic checkpoints in rheumatoid arthritis

Weyand, C. M., & Goronzy, J. J. (2024) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2024.152586 · Cited by 38

Latent Cytomegalovirus Infection in Rheumatoid Arthritis and Increased Frequencies of Cytolytic LIR‐1+CD8+ T Cells

Rothe, K., Quandt, D., Schubert, K. A., Rossol, M., Klingner, M., Jasinski‐Bergner, S., Scholz, R., Seliger, B., Pierer, M., Baerwald, C., et al. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39331 · Cited by 34

Unusual CD4+CD28−T Cells and Their Pathogenic Role in Chronic Inflammatory Disorders

Lee, G. H., & Lee, W. (2016) · Immune Network · doi:10.4110/in.2016.16.6.322 · Cited by 35

Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells

Wanjalla, C. N., McDonnell, W. J., Ram, R., Chopra, A., Gangula, R., Leary, S., Mashayekhi, M., Simmons, J. D., Warren, C. M., Bailin, S. S., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100205 · Cited by 34

Synoviocyte Stimulation by the LFA-1–Intercellular Adhesion Molecule-2–Ezrin–Akt Pathway in Rheumatoid Arthritis

Singh, K., Colmegna, I., He, X., Weyand, C. M., & Goronzy, J. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1971 · Cited by 34

Genetics of rheumatoid arthritis: Is there a pattern predicting extraarticular manifestations?

Turesson, C., Weyand, C. M., & Matteson, E. L. (2004) · Arthritis Care & Research · doi:10.1002/art.20693 · Cited by 34

CAR-Based Therapy for Autoimmune Diseases: A Novel Powerful Option

Műzes, G., & Sípos, F. (2023) · Cells · doi:10.3390/cells12111534 · Cited by 39

Role of immune system, apoptosis and angiogenesis in pathogenesis of rheumatoid arthritis and joint destruction, a systematic review.

Dhaouadi, T., Sfar, I., Abelmoula, L., Jendoubi-Ayed, S., Aouadi, H., Abdallah, T. B., Ayed, K., Zouari, R., & Gorgi, Y. L. (2007) · PubMed · Cited by 32

The CD3 versus CD7 Plot in Multicolor Flow Cytometry Reflects Progression of Disease Stage in Patients Infected with HTLV-I

Kobayashi, S., Tian, Y., Ohno, N., Yuji, K., Ishigaki, T., Isobe, M., Tsuda, M., Oyaizu, N., Watanabe, E., Watanabe, N., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053728 · Cited by 32

T Cell Costimulatory and Coinhibitory Pathways in Vascular Inflammatory Diseases

Lichtman, A. H. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00018 · Cited by 32

CD4+CD28null T Lymphocytes are Associated with the Development of Atrial Fibrillation after Elective Cardiac Surgery

Sulzgruber, P., Thaler, B., Koller, L., Baumgartner, J., Pilz, A., Steininger, M., Schnaubelt, S., Fleck, T., Laufer, G., Steinlechner, B., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-28046-0 · Cited by 30

Mass spectrometry-based proteomic exploration of the small urinary extracellular vesicles in ANCA-associated vasculitis in comparison with total urine

Přikryl, P., Satrapová, V., Frýdlová, J., Hrušková, Z., Zima, T., Tesař, V., & Vokurka, M. (2020) · Journal of Proteomics · doi:10.1016/j.jprot.2020.104067 · Cited by 31

The host cellular immune response to cytomegalovirus targets the endothelium and is associated with increased arterial stiffness in ANCA-associated vasculitis

Chanouzas, D., Sagmeister, M. S., Dyall, L., Sharp, P., Powley, L., Johal, S., Bowen, J., Nightingale, P., Ferro, C. J., Morgan, M. D., et al. (2018) · Arthritis Research & Therapy · doi:10.1186/s13075-018-1695-8 · Cited by 31

Rationale and Design of the ARREST Trial Investigating Mesenchymal Stem Cells in the Treatment of Small Abdominal Aortic Aneurysm

Wang, S. K., Green, L. A., Gutwein, A. R., Drucker, N. A., Motaganahalli, R. L., Fajardo, A. C., Babbey, C. M., & Murphy, M. P. (2017) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2017.08.044 · Cited by 30

Activation signal transduction by β1 integrin in T cells from patients with systemic lupus erythematosus

Nakayamada, S., Saito, K., Nakano, K., & Tanaka, Y. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22581 · Cited by 30

Cytomegalovirus driven immunosenescence—An immune phenotype with or without clinical impact?

Söderberg‐Nauclér, C., Fornara, O., & Rahbar, A. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.06.005 · Cited by 30

Atherosclerosis and connective tissue diseases

Meyer, O. (2001) · Joint Bone Spine · doi:10.1016/s1297-319x(01)00330-x · Cited by 30

Distinct aging profiles of CD8+ T cells in blood versus gastrointestinal mucosal compartments

Dock, J., Ramirez, C. M., Hultin, L. E., Hausner, M. A., Hultin, P. M., Elliott, J. E., Yang, O. O., Anton, P. A., Jamieson, B. D., & Effros, R. B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182498 · Cited by 29

CD28 expression in sentinel node biopsies from breast cancer patients in comparison with CD3-ζ chain expression

Schüle, J. M., Bergkvist, L., Håkansson, L., Gustafsson, B., & Håkansson, A. (2004) · Journal of Translational Medicine · doi:10.1186/1479-5876-2-45 · Cited by 29

Expansion of CD4+CD28− T cells producing high levels of interferon-γ in peripheral blood of patients with multiple sclerosis

Miyazaki, Y., Iwabuchi, K., Kikuchi, S., Fukazawa, T., Niino, M., Hirotani, M., Sasaki, H., & Onoé, K. (2008) · Multiple Sclerosis Journal · doi:10.1177/1352458508092809 · Cited by 30

Association of Circulating Fractalkine (CX3CL1) and CX3CR1+CD4+ T Cells with Common Carotid Artery Intima-Media Thickness in Patients with Chronic Kidney Disease

Yadav, A. K., Lal, A., & Jha, V. (2011) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.8722 · Cited by 28

Interleukin-15 selectively expands CD57+CD28−CD4+ T cells, which are increased in active rheumatoid arthritis

Yamada, H., Kaibara, N., Okano, S., Maeda, T., Shuto, T., Nakashima, Y., Okazaki, K., & Iwamoto, Y. (2007) · Clinical Immunology · doi:10.1016/j.clim.2007.06.001 · Cited by 28

CD28−CD8+ T cells do not contain unique clonotypes and are therefore dispensable

Weinberger, B., Welzl, K., Herndler‐Brandstetter, D., Parson, W., & Grubeck‐Loebenstein, B. (2009) · Immunology Letters · doi:10.1016/j.imlet.2009.08.008 · Cited by 26

Asthma and the Risk of Rheumatoid Arthritis: An Insight into the Heterogeneity and Phenotypes of Asthma

Rolfes, M., Juhn, Y. J., Wi, C., & Sheen, Y. H. (2017) · Tuberculosis & respiratory diseases · doi:10.4046/trd.2017.80.2.113 · Cited by 27

Usefulness of flow cytometry in the diagnosis of mycosis fungoides

Oshtory, S., Apisarnthanarax, N., Gilliam, A. C., Cooper, K. D., & Meyerson, H. J. (2007) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2007.01.017 · Cited by 27

Cooperation between 4-1BB and ICOS in the Immune Response to Influenza Virus Revealed by Studies of CD28/ICOS-Deficient Mice

Vidric, M., Suh, W., Dianzani, U., Mak, T. W., & Watts, T. H. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.11.7288 · Cited by 27

Expansion of T-Cell Receptor ζ dim Effector T Cells in Acute Coronary Syndromes

Ammirati, E., Vermi, A.-C., Cianflone, D., Banfi, M., Foglieni, C., Godino, C., Airoldi, F., Ferri, L., Gorman, C., Manfredi, A. A., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.174144 · Cited by 26

Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models

Orvain, C., Cauvet, A., Prudent, A., Guignabert, C., Thuillet, R., Ottaviani, M., Tu, L., Duhalde, F., Nicco, C., Batteux, F., et al. (2022) · Arthritis Research & Therapy · doi:10.1186/s13075-021-02709-2 · Cited by 26

Autoimmune enteropathy with a CD8+ CD7-T-cell small bowel intraepithelial lymphocytosis: case report and literature review

Bishu, S., Arsenescu, V., Lee, E. Y., Vargas, H. D., de Villiers, W. J. S., & Arsenescu, R. I. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-131 · Cited by 26

Novel Mechanisms of Action of the Biologicals in Rheumatic Diseases

Chighizola, C. B., Favalli, E. G., & Meroni, P. L. (2013) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-013-8359-x · Cited by 26

The CD4+CD28null and the regulatory CD4+CD25High T-cell phenotypes in patients with ulcerative colitis during active and quiescent disease, and following colectomy

Yokoyama, Y., Fukunaga, K., Ikeuchi, H., Kamikozuru, K., Hida, N., Ohda, Y., Iimuro, M., Yoshida, K., Kikuyama, R., Kato, K., et al. (2011) · Cytokine · doi:10.1016/j.cyto.2011.06.021 · Cited by 26

Influence of NKG2D Genetic Variants on Response to Anti-TNF Agents in Patients with Rheumatoid Arthritis

Iwaszko, M., Świerkot, J., Kolossa, K., Jeka, S., Wiland, P., & Bogunia‐Kubik, K. (2018) · Genes · doi:10.3390/genes9020064 · Cited by 26

Therapy with infliximab decreases the CD4+CD28? T cell compartment in peripheral blood in patients with rheumatoid arthritis

Pawlik, A., Ostanek, L., Brzosko, I., Brzosko, M., Masiuk, M., Machaliński, B., & Gawronska-Szklarz, B. (2003) · Rheumatology International · doi:10.1007/s00296-003-0374-4 · Cited by 26

The Immunosuppressive Effect of Methotrexate in Active Rheumatoid Arthritis Patients vs. its Stimulatory Effect in Nonactive Patients, as Indicated by Cytometric Measurements of CD4 + T Cell Subpopulations

Herman, S., Zurgil, N., Langevitz, P., Ehrenfeld, M., & Deutsch, M. (2004) · Immunological Investigations · doi:10.1081/imm-120039865 · Cited by 26

Antigen-presenting cells in rheumatoid arthritis

Thomas, R. (1998) · Springer Seminars in Immunopathology · doi:10.1007/bf00831999 · Cited by 26

The application of a monoclonal antibody to CD62L on paraffin‐embedded tissue samples in the assessment of the cutaneous T‐cell infiltrates

MAGRO, C. M. J., Sachdeva, M. P., CROWSON, A. N., Barusevicius, A., Baran, P. N., & Kovatich, A. J. (2004) · Journal of Cutaneous Pathology · doi:10.1111/j.0303-6987.2005.00259.x · Cited by 25

CD4+CD28null cells are an independent predictor of mortality in patients with heart failure

Koller, L., Richter, B., Goliasch, G., Blum, S., Korpak, M., Zorn, G., Brekalo, M., Maurer, G., Wojta, J., Pacher, R., et al. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.08.008 · Cited by 25

Characterisation of the immune response to type I collagen in scleroderma

Warrington, K. J., Nair, U., Carbone, L. D., Kang, A. H., & Postlethwaite, A. E. (2006) · Arthritis Research & Therapy · doi:10.1186/ar2025 · Cited by 25

Detecting single-nucleotide polymorphism by single-nucleotide polymorphism interactions in rheumatoid arthritis using a two-step approach with machine learning and a Bayesian threshold least absolute shrinkage and selection operator (LASSO) model

González-Recio, Ó., de Maturana, E. L., Vega, A. T., Engelman, C. D., & Broman, K. W. (2009) · BMC Proceedings · doi:10.1186/1753-6561-3-s7-s63 · Cited by 25

Type 1 and type 2 immune responses in children: their relevance in juvenile arthritis

Wedderburn, L. R., & Woo, P. M. (1999) · Springer Seminars in Immunopathology · doi:10.1007/bf00812262 · Cited by 26

The Induction of Apoptosis by Methotrexate in Activated Lymphocytes as Indicated by Fluorescence Hyperpolarization: a Possible Model for Predicting Methotrexate Therapy for Rheumatoid Arthritis Patients

Herman, S., Zurgil, N., Langevitz, P., Ehrenfeld, M., & Deutsch, M. (2003) · Cell Structure and Function · doi:10.1247/csf.28.113 · Cited by 25

CD28null T cells in aging and diseases: From biology to assessment and intervention

Guan, Y., Cao, M., Wu, X., Yan, J., Hao, Y., & Zhang, C. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111807 · Cited by 27

Phenotypic characterization of autoreactive T cells in multiple sclerosis

Ratts, R. B., Karandikar, N. J., Hussain, R. Z., Choy, J., Northrop, S. C., Lovett‐Racke, A. E., & Racke, M. K. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.06.010 · Cited by 24

Role of GADD45β in the regulation of synovial fluid T cell apoptosis in rheumatoid arthritis

Du, F., Wang, L. L., Zhang, Y., Jiang, W., Sheng, H., Cao, Q., Wu, J., Shen, B., Shen, T.-W., Zhang, J. Z., et al. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.03.523 · Cited by 24

Reduced T-cell repertoire restrictions in abatacept-treated rheumatoid arthritis patients

Imberti, L., Scarsi, M., Zanotti, C., Chiarini, M., Bertoli, D., Tincani, A., & Airó, P. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-014-0363-2 · Cited by 24

T Cells Are Expanded in Rheumatoid Arthritis and Are Characterized by Autoreactivity

Schmidt, D., Goronzy, J. J., & Wey, C. M. (2016)

The expansion of CD4+CD28- T cells in patients with rheumatoid arthritis

Pawlik, A., Ostanek, L., Brzosko, I., Brzosko, M., Masiuk, M., Machaliński, B., & Gawronska-Szklarz, B. (2003) · Arthritis Research & Therapy · doi:10.1186/ar766 · Cited by 127

Association of Interferon I signaling with CD4 T cell clonal expansion in rheumatoid arthritis

Nguyen, P., Apel, H., Braune, L., Hagemann, T., Rothe, K., & Wagner, U. G. (2025) · German Medical Science (German Research Foundation) · doi:10.3205/25rhk035

CD4 + CD8αlow T Cell Clonal Expansion Dependent on Costimulation in Patients With Rheumatoid Arthritis

Beck, F., Nguyen, P., Hoffmann, A., Loyal, L., Thiel, A., Melzer, M., Apel, H., Pierer, M., Krasselt, M., Seifert, O., et al. (2024) · Arthritis & Rheumatology · doi:10.1002/art.42960 · Cited by 9

Detection of bacterial DNA in joint samples from patients with undifferentiated arthritis and reactive arthritis, using polymerase chain reaction with universal 16S ribosomal RNA primers

Wilbrink, B., van der Heijden, I. M., Schouls, L. M., van Embden, J. D. A., Hazes, J. M. W., Breedveld, F. C., & Tak, P. P. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199803)41:3 · Cited by 125