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CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity.
Open accessAbstract
Clonal expansion of CD4+ T cells is a characteristic finding in patients with RA and is only infrequently found in patients with psoriatic arthritis and healthy controls. Expanded CD4+ clonotypes are present in the blood, infiltrate into the joint, and persist over years. We have not addressed the question of whether the expanded clonotypes have unique functional and phenotypic properties which may explain the preferential in vivo expansion in RA. In contrast to most CD4+ T cells, expanded clonotypes lacked the expression of the CD28 and CD7 cell surface molecules. Accordingly, the subsets of CD4+ CD28- (9.7 vs 1.7, P = 0.00002) and CD4+ CD7- T cells (21.5 vs 12.26, P = 0.018) were increased in RA patients compared with age-matched normal individuals. Despite the lack of CD28 expression, clonally expanded CD4+ T cells were not anergic but proliferated in response to immobilized anti-CD3 and could be maintained in tissue culture. In vivo expanded CD4+ T cells were autoreactive to ubiquitously distributed autoantigens. They responded in an autologous mixed lymphocyte reaction, and T cell clones isolated from selected patients proliferated to autologous peripheral blood adherent cells. These data suggest that in RA patients selected CD4+ T cells which share the CD7- CD28- phenotype escape from peripheral tolerance.
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Citations
Cites
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
Watanabe‐Fukunaga, R., Brannan, C., Copeland, N., Jenkins, N., & Nagata, S. (1992) · Nature · doi:10.1038/356314a0 · Cited by 3,153
Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
Dhein, J., Walczak, H., Bäumler, C., Debatin, K., & Krammer, P. (1995) · Nature · doi:10.1038/373438a0 · Cited by 1,814
Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
Ju, S., Panka, D., Cui, H., Ettinger, R., EI-Khatib, M., Sherr, D., Stanger, B., & Marshak-Rothstein, A. (1995) · Nature · doi:10.1038/373444a0 · Cited by 1,709
Epstein, F. H., & Harris, E. D. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005033221805 · Cited by 1,549
Brunner, T., Mogil, R. J., LaFace, D., Yoo, N. J., Mahboubi, A., Echeverri, F., Martin, S. J., Force, W. R., Lynch, D. H., Ware, C. F., et al. (1995) · Nature · doi:10.1038/373441a0 · Cited by 1,314
The Role of the CD28 Receptor During T Cell Responses to Antigen
Linsley, P. S., & Ledbetter, J. A. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.001203 · Cited by 1,298
Moskophidis, D., Lechner, F., Pircher, H., & Zinkernagel, R. M. (1993) · Nature · doi:10.1038/362758a0 · Cited by 1,240
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL
Boise, L., Minn, A. J., Noel, P. J., June, C. H., Accavitti, M. A., Lindsten, T., & Thompson, C. B. (1995) · Immunity · doi:10.1016/1074-7613(95)90161-2 · Cited by 1,219
Apoptosis And Programmed Cell Death In Immunity
Cohen, J., Duke, R. C., Fadok, V. A., & Sellins, K. S. (1992) · Annual Review of Immunology · doi:10.1146/annurev.iy.10.040192.001411 · Cited by 1,112
Lantz, O. J., & Bendelac, A. S. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.3.1097 · Cited by 1,036
Cited by
Sorted by citations
Brenchley, J. M., Karandikar, N. J., Betts, M. R., Ambrozak, D. R., Hill, B. J., Crotty, L. E., Casazza, J. P., Kuruppu, J., Migueles, S. A., Connors, M., et al. (2003) · Blood · doi:10.1182/blood-2002-07-2103 · Cited by 1,073
Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis
Lin, Y., Anzaghe, M., & Schülke, S. (2020) · Cells · doi:10.3390/cells9040880 · Cited by 1,012
Organ-specific disease provoked by systemic autoimmunity.
Kouskoff, V., Korganow, A., Duchatelle, V., Degott, C., Benoist, C., & Mathis, D. (1996) · Cell · doi:10.1016/s0092-8674(00)81989-3 · Cited by 949
The immunology of rheumatoid arthritis
Weyand, C. M., & Goronzy, J. J. (2020) · Nature Immunology · doi:10.1038/s41590-020-00816-x · Cited by 835
Self-citationCD28− T cells: their role in the age-associated decline of immune function
Weng, N., Akbar, A. N., & Goronzy, J. J. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.03.013 · Cited by 630
Self-citationSpatial map of human T cell compartmentalization and maintenance over decades of life
Thome, J. J. C., Yudanin, N., Ohmura, Y., Kubota, M., Grinshpun, B., Sathaliyawala, T., Kato, T., Lerner, H., Shen, Y., & Farber, D. L. (2014) · Cell · doi:10.1016/j.cell.2014.10.026 · Cited by 587
Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes.
Liuzzo, G., Goronzy, J. J., Yang, H., Kopecky, S. L., Holmes, D. R., Frye, R. L., & Weyand, C. M. (2000) · Circulation · doi:10.1161/01.cir.101.25.2883 · Cited by 552
Self-citationAging of the Immune System. Mechanisms and Therapeutic Targets
Weyand, C. M., & Goronzy, J. J. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201602-095aw · Cited by 586
Self-citationGroh, V., Brühl, A., El-Gabalawy, H. S., Nelson, J. L., & Spies, T. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1632807100 · Cited by 507
T cell subset-specific susceptibility to aging
Czesnikiewicz-Guzik, M., Lee, W.-W., Cui, D., Hiruma, Y., Lamar, D. L., Yang, Z.-Z., Ouslander, J. G., Weyand, C. M., & Goronzy, J. J. (2008) · Clinical Immunology · doi:10.1016/j.clim.2007.12.002 · Cited by 478
Self-citationT cell homeostasis in patients with rheumatoid arthritis
Koetz, K., Bryl, E., Spickschen, K., O’Fallon, W. M., Goronzy, J. J., & Weyand, C. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.9203 · Cited by 465
Self-citationCD28 extinction in human T cells: altered functions and the program of T‐cell senescence
Vallejo, A. N. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00256.x · Cited by 446
Perturbation of the T-cell repertoire in patients with unstable angina.
Liuzzo, G., Kopecky, S. L., Frye, R. L., Fallon, W. M. O., Maseri, A., Goronzy, J. J., & Weyand, C. M. (1999) · Circulation · doi:10.1161/01.cir.100.21.2135 · Cited by 398
Self-citationPI3Kδ and PI3Kγ: partners in crime in inflammation in rheumatoid arthritis and beyond?
Rommel, C., Camps, M., & Ji, H. (2007) · Nature reviews. Immunology · doi:10.1038/nri2036 · Cited by 405
Pasceri, V., & Yeh, E. T. H. (1999) · Circulation · doi:10.1161/01.cir.100.21.2124 · Cited by 383
van Leeuwen, E. M. M., Remmerswaal, E. B. M., Vossen, M. T. M., Rowshani, A. T., Dillen, P. M. E. W., van Lier, R. A. W., & ten Berge, I. J. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1834 · Cited by 369
T cells and aging january 2002 update
Pawelec, G. (2002) · Frontiers in bioscience · doi:10.2741/a831 · Cited by 372
Inflammaging decreases adaptive and innate immune responses in mice and humans
Frasca, D., & Blomberg, B. B. (2016) · Biogerontology · doi:10.1007/s10522-015-9578-8 · Cited by 357
Pawelec, G. (1998) · Frontiers in bioscience · doi:10.2741/a266 · Cited by 357
Yang, Z., Fujii, H., Mohan, S. V., Goronzy, J. J., & Weyand, C. M. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130252 · Cited by 334
Self-citationReplicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?
Effros, R. B., & Pawelec, G. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01079-7 · Cited by 337
Yen, J., Moore, B. E., Nakajima, T. E., Scholl, D., Schaid, D. J., Weyand, C. M., & Goronzy, J. J. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.10.1159 · Cited by 335
Self-citationFunctional Study of CD4+CD25+ Regulatory T Cells in Health and Autoimmune Hepatitis
Longhi, M. S., Hussain, M. J., Mitry, R. R., Arora, S. K., Mieli‐Vergani, G., Vergani, D., & Ma, Y. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4484 · Cited by 323
Goronzy, J. J., & Weyand, C. M. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0970-0 · Cited by 292
Self-citationExpansion of unusual CD4+ T cells in severe rheumatoid arthritis
Martens, P. B., Goronzy, J. J., Schaid, D. J., & Weyand, C. M. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400615 · Cited by 290
Self-citationRuchatz, H., Leung, B. P. L., Wei, X., McInnes, I. B., & Liew, F. Y. (1998) · PubMed · Cited by 290
The role of T cells in the immunopathogenesis of rheumatoid arthritis. New perspectives
Fox, D. A. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400403 · Cited by 289
Perturbation of the T cell repertoire in rheumatoid arthritis
Wagner, U. G., Koetz, K., Weyand, C. M., & Goronzy, J. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14447 · Cited by 278
Self-citationDown-Regulation of CD28 Expression by TNF-α
Bryl, E., Vallejo, A. N., Weyand, C. M., & Goronzy, J. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3231 · Cited by 264
Self-citationInflammation: A pivotal link between autoimmune diseases and atherosclerosis
Abou‐Raya, A., & Abou‐Raya, S. (2006) · Autoimmunity Reviews · doi:10.1016/j.autrev.2005.12.006 · Cited by 268
Recent Advances in Understanding the Pathogenesis of Rheumatoid Arthritis: New Treatment Strategies
Mueller, A., Payandeh, Z., Mohammadkhani, N., Mubarak, S. M. H., Zakeri, A., Bahrami, A. A., Brockmueller, A., & Shakibaei, M. (2021) · Cells · doi:10.3390/cells10113017 · Cited by 283
Spaulding, C., Guo, W., & Effros, R. B. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00033-9 · Cited by 258
CD4+CD28− T Lymphocytes Contribute to Early Atherosclerotic Damage in Rheumatoid Arthritis Patients
Gerli, R., Schillaci, G., Giordano, A., Bartoloni, E., Bistoni, O., Vaudo, G., Marchesi, S., Pirro, M., Ragni, F., Shoenfeld, Y., et al. (2004) · Circulation · doi:10.1161/01.cir.0000131450.66017.b3 · Cited by 254
Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis
Yamada, H., Nakashima, Y., Okazaki, K., Mawatari, T., Fukushi, J.-I., Kaibara, N., Hori, A., Iwamoto, Y., & Yoshikai, Y. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.080341 · Cited by 251
CD4+CD28– costimulation-independent T cells in multiple sclerosis
Markovic‐Plese, S., Cortese, I. C. M., Wandinger, K., McFarland, H. F., & Martinꝉ, R. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12516 · Cited by 243
Chemin, K., Gerstner, C., & Malmström, V. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00353 · Cited by 243
Recio-Mayoral, A., Mason, J. C., Kaski, J. C., Rubens, M. B., Harari, O. A., & Camici, P. G. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp205 · Cited by 235
Cutting Edge: CD7 Delivers a Pro-Apoptotic Signal During Galectin-1-Induced T Cell Death
Pace, K. E., Hahn, H. P., Pang, M., Nguyen, J. T., & Baum, L. G. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.5.2331 · Cited by 231
Vallejo, A. N., Weyand, C. M., & Goronzy, J. J. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.01.002 · Cited by 223
Self-citationVasculitic Peripheral Ulcerative Keratitis
Messmer, E. S. B. M., & Foster, C. S. (1999) · Survey of Ophthalmology · doi:10.1016/s0039-6257(98)00051-4 · Cited by 223
Ruchatz, H., Leung, B. P. L., Wei, X., McInnes, I. B., & Liew, F. Y. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.11.5654 · Cited by 218
Schönland, S. O., Lopez, C., Widmann, T., Zimmer, J., Bryl, E., Goronzy, J. J., & Weyand, C. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2233561100 · Cited by 216
Self-citationMelchiorri, C., Melicòni, R., Frizziero, L., Silvestri, T., Pulsatelli, L., Mazzetti, I., Borzı̀, R. M., Uguccioni, M., & Facchini, A. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199812)41:12 · Cited by 254
Self-citationNamekawa, T., Snyder, M. R., Yen, J., Goehring, B. E., Leibson, P. J., Weyand, C. M., & Goronzy, J. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.2.1138 · Cited by 210
Self-citationVallejo, A. N., Brandes, J. C., Weyand, C. M., & Goronzy, J. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.11.6572 · Cited by 210
Self-citationGilani, S. R., Vuga, L. J., Lindell, K. O., Gibson, K. F., Xue, J., Kaminski, N., Valentine, V. G., Lindsay, E. K., George, M. P., Steele, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008959 · Cited by 203
Immunometabolism in the development of rheumatoid arthritis
Weyand, C. M., & Goronzy, J. J. (2020) · Immunological Reviews · doi:10.1111/imr.12838 · Cited by 193
Self-citationThewissen, M. M., Somers, V. A., Hellings, N., Fraussen, J., Damoiseaux, J. G. M. C., & Stinissen, P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.10.6514 · Cited by 199
Functional properties of CD4+CD28− T cells in the aging immune system
Weyand, C. M., Brandes, J. C., Schmidt, D., Fulbright, J. W., & Goronzy, J. J. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00161-9 · Cited by 201
Self-citation(2003) · doi:10.1186/ar974 · Cited by 156
Self-citationSchirmer, M., Vallejo, A. N., Weyand, C. M., & Goronzy, J. J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.2.1018 · Cited by 191
Self-citationAutoantibodies in rheumatoid arthritis: rheumatoid factors and anticitrullinated protein antibodies
Song, Y. W., & Kang, E. H. (2009) · QJM · doi:10.1093/qjmed/hcp165 · Cited by 190
Vallejo, A. N., Nestel, A. R., Schirmer, M., Weyand, C. M., & Goronzy, J. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.14.8119 · Cited by 179
Self-citationBandrés, E., Merino, J., Vázquez, B., Inogés, S., Moreno, C., Subirá, M. L., & Sánchez-Ibarrola, A. (2000) · Clinical Immunology · doi:10.1006/clim.2000.4894 · Cited by 174
Herman, S., Zurgil, N., & Deutsch, M. (2005) · Inflammation Research · doi:10.1007/s00011-005-1355-8 · Cited by 173
Gain and loss of T cell subsets in old age: age-related reshaping of the T cell repertoire.
Arnold, C. R., Wolf, J., Brunner, S., Herndler-Brandstetter, D., & Grubeck-Loebenstein, B. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9499-x · Cited by 170
Prognostic markers of radiographic progression in early rheumatoid arthritis
Goronzy, J. J., Matteson, E. L., Fulbright, J. W., Warrington, K. J., Chang‐Miller, A., Hunder, G. G., Mason, T. G., Nelson, A. M., Valente, R. M., Crowson, C. S., et al. (2004) · Arthritis & Rheumatism · doi:10.1002/art.11445 · Cited by 170
Self-citationMechanisms of Neurodegeneration and Axonal Dysfunction in Progressive Multiple Sclerosis
Correale, J., Marrodan, M., & Ysrraelit, M. C. (2019) · Biomedicines · doi:10.3390/biomedicines7010014 · Cited by 167
Clonality and longevity of CD4+CD28null T cells are associated with defects in apoptotic pathways
Vallejo, A. N., Schirmer, M., Weyand, C. M., & Goronzy, J. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6301 · Cited by 169
Self-citationT-cell aging in rheumatoid arthritis
Weyand, C. M., Yang, Z., & Goronzy, J. J. (2014) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000011 · Cited by 164
Self-citationDysregulated lymphocyte proliferation and differentiation in patients with rheumatoid arthritis
Ponchel, F., Morgan, A. W., Bingham, S. J., Quinn, M. A., Buch, M. H., Verburg, R. J., Henwood, J., Douglas, S., Masurel, A., Conaghan, P. G., et al. (2002) · Blood · doi:10.1182/blood-2002-03-0671 · Cited by 166
Analyses of immunosenescent markers in patients with autoimmune disease
Thewissen, M. M., Somers, V. A., Venken, K., Linsen, L., van Paassen, P., Geusens, P., Damoiseaux, J. G. M. C., & Stinissen, P. (2007) · Clinical Immunology · doi:10.1016/j.clim.2007.01.005 · Cited by 160
Immunosenescence, autoimmunity, and rheumatoid arthritis
Weyand, C. M., Fulbright, J. W., & Goronzy, J. J. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00090-1 · Cited by 162
Self-citationT-cell metabolism in autoimmune disease
Yang, Z., Matteson, E. L., Goronzy, J. J., & Weyand, C. M. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0542-4 · Cited by 159
Self-citationDeeks, S. G., Verdin, E. M., & McCune, J. M. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.05.004 · Cited by 169
Heat-Shock Protein 60-Reactive CD4 + CD28 null T Cells in Patients With Acute Coronary Syndromes
Zal, B., Kaski, J. C., Arno, G., Akiyu, J. P., Xu, Q., Cole, D., Whelan, M., Russell, N., Madrigal, J. A., Dodi, I. A., et al. (2004) · Circulation · doi:10.1161/01.cir.0000118476.29352.2a · Cited by 155
Autophagy in autoimmune disease
Yang, Z., Goronzy, J. J., & Weyand, C. M. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1297-8 · Cited by 159
Self-citationThe influence of ageing on the development and management of rheumatoid arthritis
Boots, A. M. H., Maier, A. B., Stinissen, P., Masson, P., Lories, R. J. U., & Keyser, F. D. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.92 · Cited by 151
Kochenderfer, J. N., Kobayashi, S., Wieder, E., Su, C., & Molldrem, J. J. (2002) · Blood · doi:10.1182/blood-2002-01-0155 · Cited by 144
Modulation of CD28 expression with anti–tumor necrosis factor α therapy in rheumatoid arthritis
Bryl, E., Vallejo, A. N., Matteson, E. L., Witkowski, J. M., Weyand, C. M., & Goronzy, J. J. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21353 · Cited by 144
Self-citation. Persistent viral infections and immune aging.
Brunner, S., Herndler-Brandstetter, D., Weinberger, B., & Grubeck-Loebenstein, B. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.003 · Cited by 143
Human Cytomegalovirus and Autoimmune Disease
Halenius, A., & Hengel, H. (2014) · BioMed Research International · doi:10.1155/2014/472978 · Cited by 145
T cells and aging (update February 1999)
Pawelec, G. (1999) · Frontiers in bioscience · doi:10.2741/pawelec · Cited by 140
Telomere dysfunction, autoimmunity and aging.
(2011) · Europe PMC (PubMed Central) · Cited by 138
Self-citationRole of CD8 T Cell Replicative Senescence in Human Aging and in HIV-mediated Immunosenescence.
Dock, J., & Effros, R. B. (2011) · Europe PMC (PubMed Central) · Cited by 137
Li, Y., Shen, Y., Hohensinner, P. J., Ju, J., Wen, Z., Goodman, S. B., Zhang, H., Goronzy, J. J., & Weyand, C. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.09.013 · Cited by 138
Self-citationRéthi, B., Fluur, C., Atlas, A., Krzyżowska, M., Mowafi, F., Grützmeier, S., Milito, A. D., Bellocco, R., Falk, K. I., Rajnavölgyi, É., et al. (2005) · AIDS · doi:10.1097/01.aids.0000189848.75699.0f · Cited by 138
Moosig, F., Csernok, E., Wang, G., & Gross, W. L. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00695.x · Cited by 138
Hug, A., Korporal, M., Schröder, I., Haas, J., Glatz, K., Storch-Hagenlocher, B., & Wildemann, B. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.1.432 · Cited by 139
CX3CR1 drives cytotoxic CD4+CD28− T cells into the brain of multiple sclerosis patients
Broux, B., Pannemans, K., Zhang, X., Markovic‐Plese, S., Broekmans, T., Eijnde, B. O., Wijmeersch, B. V., Somers, V. A., Geusens, P., van der Pol, S. M. A., et al. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.11.006 · Cited by 137
Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis
Goronzy, J. J., & Weyand, C. M. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(00)01841-x · Cited by 137
Self-citationGiles, J. T., Szklo, M., Post, W. S., Petri, M., Blumenthal, R. S., Lam, G. K., Gelber, A. C., Detrano, R., Scott, W. W., Kronmal, R. A., et al. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2641 · Cited by 137
Argyriou, A., Wadsworth, M. H., Lendvai, A., Christensen, S. M., Hensvold, A. H., Gerstner, C., van Vollenhoven, A., Kravarik, K. M., Winkler, A. R., Malmström, V., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31519-6 · Cited by 133
The Repertoire of CD4+ CD28− T Cells in Rheumatoid Arthritis
Schmidt, D., Martens, P. B., Weyand, C. M., & Goronzy, J. J. (1996) · Molecular Medicine · doi:10.1007/bf03401644 · Cited by 135
Self-citationPathogenic features of CD4+CD28– T cells in immune disorders
Broux, B., Markovic-Plese, S., Stinissen, P., & Hellings, N. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.06.003 · Cited by 131
The Janus Head of T Cell Aging – Autoimmunity and Immunodeficiency
Goronzy, J. J., Li, G., Yang, Z., & Weyand, C. M. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00131 · Cited by 135
Self-citationEconomic consequences of the progression of rheumatoid arthritis in Sweden
Kobelt, G., Eberhardt, K., J�nsson, L., & J�nsson, B. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199902)42:2 · Cited by 167
Lymphocyte Activation as a Possible Measure of Atherosclerotic Risk in Patients with Sleep Apnea
Dyugovskaya, L., Lavie, P., & Lavie, L. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1361.076 · Cited by 132
Premature Immunosenescence in Rheumatoid Arthritis and Multiple Sclerosis Patients
Thewissen, M. M., Linsen, L., Somers, V. A., Geusens, P., Raus, J., & Stinissen, P. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1361.066 · Cited by 133
CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation
Warrington, K. J., Vallejo, A. N., Weyand, C. M., & Goronzy, J. J. (2003) · Blood · doi:10.1182/blood-2002-08-2574 · Cited by 132
Self-citationKobayashi, S., Nakano, K., Watanabe, E., Ishigaki, T., Ohno, N., Yuji, K., Oyaizu, N., Asanuma, S., Yamagishi, M., Yamochi, T., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-3169 · Cited by 131
Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells
Shen, Y., Wen, Z., Li, Y., Matteson, E. L., Hong, J., Goronzy, J. J., & Weyand, C. M. (2017) · Nature Immunology · doi:10.1038/ni.3808 · Cited by 132
Self-citationDevelopments in the scientific understanding of rheumatoid arthritis
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Self-citationKim, H. Y., Yoo, T., Hwang, Y., Lee, G. H., Kim, B., Jang, J., Yu, H. T., Kim, M. C., Cho, J., Lee, C. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03130-z · Cited by 128
Heterogeneity of rheumatoid arthritis: from phenotypes to genotypes
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Self-citationThe expansion of CD4+CD28- T cells in patients with rheumatoid arthritis
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PATHOGENESIS OF RHEUMATOID ARTHRITIS
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Metadata
- Authors
- Schmidt, D., Goronzy, J. J., & Weyand, C. M.
- Affiliations
- Mayo Clinic (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1996-05-01
- Volume
- 97
- Issue
- 9
- Pages
- 2027-2037
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC507276
- OpenAlex
- W1982865105
- Cited by
- 482
- References
- 43
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 10 · 2023: 5 · 2022: 13 · 2021: 15 · 2020: 12 · 2019: 15 · 2018: 10 · 2017: 18 · 2016: 7 · 2015: 20 · 2014: 12 · 2013: 23 · 2012: 11
- FWCI
- 18.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Arthritis Foundation
- Mayo Foundation for Medical Education and Research
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR041974, R01 AR 41974, R01AR042527, R01AR42527)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- rheumatoid arthritis, CD4+ T cells, clonal expansion, CD28, CD7, autoreactivity, peripheral tolerance, T cell anergy, autoantigens, mixed lymphocyte reaction, T cell proliferation, psoriatic arthritis
- MeSH terms
- Arthritis, Rheumatoid, Autoantigens, Base Sequence, Clone Cells, Humans, Lymphocyte Activation, Molecular Sequence Data, CD4-Positive T-Lymphocytes, Immunophenotyping, T-Lymphocyte Subsets, CD28 Antigens, Antigens, CD7
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