Goronzy, Jörg J.

Understanding immunosenescence to improve responses to vaccines

Goronzy, J. J., & Weyand, C. M. (2013) · Nature Immunology

T-cell and B-cell ImmunologyImmune responses and vaccinations

Cited by 827

Diversity and clonal selection in the human T-cell repertoire

Qi, Q., Liu, Y., Cheng, Y., Glanville, J., Zhang, D., Lee, J.-Y., Olshen, R. A., Weyand, C. M., Boyd, S. D., & Goronzy, J. J. (2014) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyArtificial Immune Systems Applications

Cited by 755

HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group

High, K. P., Brennan-Ing, M., Clifford, D. B., Cohen, M. H., Currier, J., Deeks, S. G., Deren, S., Effros, R. B., Gebo, K., Goronzy, J. J., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes

HIV-related health complications and treatmentsHIV Research and Treatment

Cited by 522

Mechanisms underlying T cell ageing

Goronzy, J. J., & Weyand, C. M. (2019) · Nature Reviews Immunology

T-cell and B-cell ImmunologyTelomeres, Telomerase, and Senescence

Cited by 506

CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity.

Schmidt, D., Goronzy, J. J., & Weyand, C. M. (1996) · Journal of Clinical Investigation

Rheumatoid Arthritis Research and TherapiesT-cell and B-cell Immunology

Cited by 482

T cell subset-specific susceptibility to aging

Czesnikiewicz-Guzik, M., Lee, W.-W., Cui, D., Hiruma, Y., Lamar, D. L., Yang, Z.-Z., Ouslander, J. G., Weyand, C. M., & Goronzy, J. J. (2008) · Clinical Immunology

T-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model Organisms

Cited by 478

Successful and Maladaptive T Cell Aging

Goronzy, J. J., & Weyand, C. M. (2017) · Immunity

T-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model Organisms

Cited by 362

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

Li, G., Yu, M., Lee, W.-W., Tsang, M., Krishnan, E., Weyand, C. M., & Goronzy, J. J. (2012) · Nature Medicine

T-cell and B-cell ImmunologyProtein Tyrosine Phosphatases

Cited by 349

Immune aging and autoimmunity

Goronzy, J. J., & Weyand, C. M. (2012) · Cellular and Molecular Life Sciences

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 292

T cell development and receptor diversity during aging

Goronzy, J. J., & Weyand, C. M. (2005) · Current Opinion in Immunology

T-cell and B-cell ImmunologyHematopoietic Stem Cell Transplantation

Cited by 278

Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

Yang, Z., Shen, Y., Oishi, H., Matteson, E. L., Tian, L., Goronzy, J. J., & Weyand, C. M. (2016) · Science Translational Medicine

Rheumatoid Arthritis Research and TherapiesRedox biology and oxidative stress

Cited by 275

Epigenomics of human CD8 T cell differentiation and aging

Moskowitz, D. M., Zhang, D. W., Hu, B., Le Saux, S., Yanes, R. E., Ye, Z., Buenrostro, J. D., Weyand, C. M., Greenleaf, W. J., & Goronzy, J. J. (2017) · Science Immunology

T-cell and B-cell ImmunologyGenomics and Chromatin Dynamics

Cited by 252

T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection

Vallejo, A. N., Weyand, C. M., & Goronzy, J. J. (2004) · Trends in Molecular Medicine

T-cell and B-cell ImmunologyTelomeres, Telomerase, and Senescence

Cited by 223

Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages

Schönland, S. O., Lopez, C., Widmann, T., Zimmer, J., Bryl, E., Goronzy, J. J., & Weyand, C. M. (2003) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceRheumatoid Arthritis Research and Therapies

Cited by 216

Immunometabolism in the development of rheumatoid arthritis

Weyand, C. M., & Goronzy, J. J. (2020) · Immunological Reviews

Rheumatoid Arthritis Research and TherapiesT-cell and B-cell Immunology

Cited by 193

Telomerase insufficiency in rheumatoid arthritis

Fujii, H., Shao, L., Colmegna, I., Goronzy, J. J., & Weyand, C. M. (2009) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceRheumatoid Arthritis Research and Therapies

Cited by 172

T-cell aging in rheumatoid arthritis

Weyand, C. M., Yang, Z., & Goronzy, J. J. (2014) · Current Opinion in Rheumatology

Telomeres, Telomerase, and SenescenceT-cell and B-cell Immunology

Cited by 164

Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis.

Shao, L., Fujii, H., Colmegna, I., Oishi, H., Goronzy, J. J., & Weyand, C. M. (2009) · Journal of Experimental Medicine

DNA Repair MechanismsRheumatoid Arthritis Research and Therapies

Cited by 159

NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs

Wen, Z., Shimojima, Y., Shirai, T., Li, Y., Ju, J., Yang, Z., Tian, L., Goronzy, J. J., & Weyand, C. M. (2016) · Journal of Clinical Investigation

T-cell and B-cell ImmunologyNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 146

Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation

Wu, B., Zhao, T. V., Jin, K., Hu, Z., Abdel, M. P., Warrington, K. J., Goronzy, J. J., & Weyand, C. M. (2021) · Nature Immunology

Rheumatoid Arthritis Research and TherapiesMitochondrial Function and Pathology

Cited by 141

Expression of CD39 on activated T cells impairs their survival in older individuals

Fang, F., Yu, M., Cavanagh, M. M., Hutter Saunders, J., Qi, Q., Ye, Z., Le Saux, S., Sultan, W., Turgano, E., Dekker, C. L., et al. (2016) · Cell Reports

T-cell and B-cell ImmunologyAdenosine and Purinergic Signaling

Cited by 138

Signaling pathways in aged T cells – A reflection of T cell differentiation, cell senescence and host environment

Goronzy, J. J., Li, G., Yu, M., & Weyand, C. M. (2012) · Seminars in Immunology

T-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model Organisms

Cited by 134

Rejuvenating the immune system in rheumatoid arthritis.

Weyand, C. M., Fujii, H., Shao, L., & Goronzy, J. J. (2009) · Nature Reviews Rheumatology

Telomeres, Telomerase, and SenescenceRheumatoid Arthritis Research and Therapies

Cited by 112

Telomeres and immunological diseases of aging.

Andrews, N. P., Fujii, H., Goronzy, J. J., & Weyand, C. M. (2010) · Gerontology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 108