The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Effects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression.
Open accessAbstract
One of the earliest events in atherosclerosis is interaction of circulating mononuclear leukocytes and the endothelium. Endothelial cell (EC) activation by cytokines results in expression of adhesion molecules and production of chemotactic factors, augmenting leukocyte adhesion and recruitment, respectively. The incidence of atherosclerosis in premenopausal women is significantly less than that observed in age-matched males with similar risk profiles. Because estrogen has gene regulatory effects, we investigated whether 17beta-estradiol (E2) can inhibit cytokine-mediated EC adhesion molecule transcriptional activation. Cultured human umbilical vein EC (estrogen receptor-positive) were propagated in gonadal hormone-free medium and were E2-pretreated for 48 h before IL-1 activation. Detected by FACS analysis, E2 strongly (60-80%) inhibited IL-1-mediated membrane E-selectin and vascular cell adhesion molecule-1 induction, and intercellular adhesion molecule-1 hyperinduction. 17alpha-estradiol (an inactive E2 stereoisomer) had no effect. This inhibition correlated with similar reductions in steady state-induced E-selectin mRNA levels, and was abrogated by the E2 antagonist ICI 164,384, demonstrating a specific, estrogen receptor-mediated effect. Nuclear run-offs confirmed suppression at the transcriptional level. The implications of these results for the cardiovascular protective role of estrogen are discussed.
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Cites
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Cited by
The Protective Effects of Estrogen on the Cardiovascular System
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Self-citation
Metadata
- Authors
- Caulin-Glaser, T., Watson, C. A., Pardi, R., & Bender, J. R.
- Venue
- Journal of Clinical Investigation
- Published
- 1996-07-01
- Volume
- 98
- Issue
- 1
- Pages
- 36-42
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2017604478
- Cited by
- 342
- References
- 45
- FWCI
- 11.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Caulin-Glaser, T., Watson, C. A., Pardi, R., & Bender, J. R. (1996). Effects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression. Journal of Clinical Investigation. https://doi.org/10.1172/jci118774
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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