Cited by 196Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and TreatmentSelenium in Biological Systems

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Type 2 iodothyronine deiodinase is highly expressed in human thyroid.

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Salvatore, D, Tu, H, Harney, J W, Larsen, P R·1996·Journal of Clinical Investigation

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Abstract

Type 2 iodothyronine deiodinase (D2) is a recently cloned selenodeiodinase thought to provide intracellular 3,5,3' triiodothyronine (T3) to a restricted group of tissues. We report here the presence of D2 mRNA in human thyroid at levels 50-150-fold higher than in placenta. Surprisingly, while type 1 deiodinase (D1) is known to be present in human thyroid, D2 has not been evaluated previously. D2 mRNA was especially high in thyroids from Graves' patients and in follicular adenomas. Stimulated thyroids had higher D2 to D1 mRNA ratios than normal or multinodular glands suggesting differential regulation of D1 and D2 expression. Microsomes from normal, Graves', and TSH-stimulated thyroids contained low Km D2 activity resistant to propylthiouracil (1 mM) or to inactivation by N-bromoacetyl T3, agents which block or inactivate D1. At 2 nM thyroxine (T4), 100 times the physiological-free T4 levels, 60-80% of T4 to T3 conversion in stimulated, but only 27% of that in normal thyroids, is catalyzed by D2. We conclude that intrathyroidal T4 to T3 conversion by D2 may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves' disease, toxic adenomas, and, perhaps, iodine deficiency.

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Authors: Salvatore, D., Tu, H., Harney, J. W., & Larsen, P. R.
Affiliations: Brigham and Women's Hospital (US)
Corresponding author: Larsen, P R
ORCID: Salvatore, D
Tu, H
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1996-08-15
Volume: 98
Issue: 4
Pages: 962-968
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci118880
PMC: PMC507511
OpenAlex: W2011717087
Cited by: 196
References: 42
Citations by year: 2026: 1 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 6
FWCI: 7.79
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK36256, R01DK036256, T32DK007529, DK-07529)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
Keywords: type 2 deiodinase, type 1 iodothyronine deiodinase, thyroid gland, triiodothyronine, T4 to T3 conversion, Graves' disease, follicular adenoma, multinodular goiter, TSH stimulation, propylthiouracil, iodine deficiency, thyroid hormone metabolism
MeSH terms: Enzyme Inhibitors, Humans, Iodide Peroxidase, Isoenzymes, Kinetics, Microsomes, Placenta, Propylthiouracil, RNA, Messenger, Thyroid Gland, Thyroxine, Triiodothyronine, Gene Expression

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Type 2 iodothyronine deiodinase is highly expressed in human thyroid.

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