Cited by 529Growth Hormone and Insulin-like Growth FactorsCytokine Signaling Pathways and InteractionsAutoimmune and Inflammatory Disorders Research

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation.

Open access

De Benedetti, F, Alonzi, T, Moretta, A, Lazzaro, D, Costa, P, Poli, V, Martini, A, Ciliberto, G, Fattori, E·1997·Journal of Clinical Investigation

DOI 10.1172/jci119207PMC PMC507846

Open this paper in CoChat — free account Open PDF

Abstract

Stunted growth is a major complication of chronic inflammation and recurrent infections in children. Systemic juvenile rheumatoid arthritis is a chronic inflammatory disorder characterized by markedly elevated circulating levels of IL-6 and stunted growth. In this study we found that NSE/hIL-6 transgenic mouse lines expressing high levels of circulating IL-6 since early after birth presented a reduced growth rate that led to mice 50-70% the size of nontransgenic littermates. Administration of a monoclonal antibody to the murine IL-6 receptor partially reverted the growth defect. In NSE/hIL-6 transgenic mice, circulating IGF-I levels were significantly lower than those of nontransgenic littermates; on the contrary, the distribution of growth hormone pituitary cells, as well as circulating growth hormone levels, were normal. Treatment of nontransgenic mice of the same strain with IL-6 resulted in a significant decrease in IGF-I levels. Moreover, in patients with systemic juvenile rheumatoid arthritis, circulating IL-6 levels were negatively correlated with IGF-I levels. Our findings suggest that IL-6-mediated decrease in IGF-I production represents a major mechanism by which chronic inflammation affects growth.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci119207

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*
Jones, J. I. W., & Clemmons, D. R. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-1-3 · Cited by 4,488
The acute phase response
Baumann, H., & Gauldie, J. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90137-6 · Cited by 2,907
Role of insulin-like growth factors in embryonic and postnatal growth
Baker, J., Liu, J.-P., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80085-6 · Cited by 2,463
Insulin-like growth factors and their binding proteins: biological actions
Jones, J. I. (1995) · Endocrine Reviews · doi:10.1210/er.16.1.3 · Cited by 2,060
Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.
Campbell, I. L., Abraham, C. R., Masliah, E., Kemper, P., Inglis, J. D., Oldstone, M. B., & Mucke, L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10061 · Cited by 1,006
The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain
Lazzaro, D., Price, M., Felice, M. D., & Lauro, R. D. (1991) · Development · doi:10.1242/dev.113.4.1093 · Cited by 902
Self-citation
Enhand secretion of tumour necrosis factor-alpha, IL-6, and IL-1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease
REINECKER, H.-C., STEFFEN, M., Witthoeft, T., Pflüger, I., Schreiber, S., MacDermott, R. P., & Raedler, A. (1993) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1993.tb05997.x · Cited by 855
Current proposed revision of JRA Criteria. JRA Criteria Subcommittee of the Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Section of The Arthritis Foundation.
Brewer, E. J., Bass, J., Baum, J., Cassidy, J. T., Fink, C., Jacobs, J. W. G., Hanson, V., Levinson, J. E., SCHALLER, J. G., & Stillman, J. S. (1977) · PubMed · Cited by 631
Defective inflammatory response in interleukin 6-deficient mice.
Fattori, E., Cappelletti, M., Costa, P., Sellitto, C., Cantoni, L., Carelli, M., Faggioni, R., Fantuzzi, G., Ghezzi, P., & Poli, V (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.4.1243 · Cited by 525
Self-citation
On a Form of Chronic Joint Disease in Children
Still, G., & Garrod, A. E. (1897) · Journal of the Royal Society of Medicine · doi:10.1177/095952879708000106 · Cited by 435

Flagged first, then by citations

Show all 48 references

Sorted by citations

Items 101–200 of 525

Role for interleukin-6 in structural joint damage and systemic bone loss in rheumatoid arthritis
Goff, B. L., Blanchard, F., Berthelot, J., Heymann, D., & Maugars, Y. (2010) · Joint Bone Spine · doi:10.1016/j.jbspin.2010.03.002 · Cited by 91
Puberty in Chronically Diseased Patients
Simon, D. (2002) · Hormone Research in Paediatrics · doi:10.1159/000058102 · Cited by 89
The mother-offspring dyad and the immune system
La, H. (2000) · Acta Paediatrica · doi:10.1111/j.1651-2227.2000.tb01325.x · Cited by 87
Growth Failure and Nutrition Considerations in Chronic Childhood Wasting Diseases
Kyle, U. G., Shekerdemian, L. S., & Coss‐Bu, J. A. (2014) · Nutrition in Clinical Practice · doi:10.1177/0884533614555234 · Cited by 88
Growth problems in children with IBD
Sanderson, I. R. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.102 · Cited by 92
Relation of cord serum levels of growth hormone, insulin-like growth factors, insulin-like growth factor binding proteins, leptin, and interleukin-6 with birth weight, birth length, and head circumference in term and preterm neonates
Lo, H., Tsao, L., Hsu, W., Chen, H.-N., Yu, W.-K., & Chi, C. (2002) · Nutrition · doi:10.1016/s0899-9007(01)00811-5 · Cited by 87
New insights in systemic juvenile idiopathic arthritis--from pathophysiology to treatment
Frosch, M., & Roth, J. (2007) · Rheumatology · doi:10.1093/rheumatology/kem271 · Cited by 87
Association of C-reactive protein and muscle strength in the English Longitudinal Study of Ageing
Hamer, M., & Molloy, G. J. (2009) · AGE · doi:10.1007/s11357-009-9097-0 · Cited by 91
The hormetic and hermetic role of IL-6
Forcina, L., Franceschi, C., & Musarò, A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101697 · Cited by 85
Systemic effects of IL-6 blockade in rheumatoid arthritis beyond the joints
Jarlborg, M., & Gabay, C. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155742 · Cited by 90
Cytokine actions in growth disorders associated with pediatric chronic inflammatory diseases (Review)
MacRae, V. E., Wong, S. C., Farquharson, C., & Ahmed, S. F. (2006) · International Journal of Molecular Medicine · doi:10.3892/ijmm.18.6.1011 · Cited by 86
Inflammation is a modulator of the insulin-like growth factor (IGF)/IGF-binding protein system inducing reduced bioactivity of IGFs in cystic fibrosis
Street, M. E., Ziveri, M. A., Spaggiari, C., Viani, I., Volta, C., Grzincich, G. L., Virdis, R., & Bernasconi, S. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.02064 · Cited by 82
A Review of Activity Indices and End Points for Clinical Trials in Children with Crohnʼs Disease
Griffiths, A. M., Otley, A. R., Hyams, J. S., Quiros, A. R., Grand, R. J., Bousvaros, A., Feagan, B. G., & Ferry, G. (2005) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200502000-00013 · Cited by 83
Normal and Aberrant Growth
Cooke, D. W., DiVall, S. A., & Radovick, S. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00024-9 · Cited by 85
Growth failure and intestinal inflammation
Ballinger, A. (2001) · QJM · doi:10.1093/qjmed/94.3.121 · Cited by 83
Impact of Disease and Treatments on Growth and Puberty of Pediatric Patients with Inflammatory Bowel Disease
Ezri, J., Marques-Vidal, P. M., & Nydegger, A. (2012) · Digestion · doi:10.1159/000336766 · Cited by 82
Juvenile rheumatoid arthritis
Schneider, R., & Passo, M. H. (2002) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(02)00016-9 · Cited by 80
Inflammatory bowel disease
Griffiths, A. M. (1998) · Nutrition · doi:10.1016/s0899-9007(98)00085-9 · Cited by 82
Reduced serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in adults with inflammatory bowel disease
Katsanos, K. H., Tsatsoulis, A. A., Christodoulou, D. K., Challa, A. S., Katsaraki, A., & Tsianos, E. V. (2001) · Growth Hormone & IGF Research · doi:10.1054/ghir.2001.0248 · Cited by 81
Catch‐Up Growth During Tocilizumab Therapy for Systemic Juvenile Idiopathic Arthritis: Results From a Phase III Trial
Benedetti, F. D., Brunner, H. I., Ruperto, N., Schneider, R., Xavier, R. M., Allen, R. C., Brown, D. E., Chaitow, J., Pardeo, M., Espada, G., et al. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38984 · Cited by 81
Self-citation
Recombinant human growth hormone treatment in pediatric burn patients and its role during the hepatic acute phase response
Jeschke, M. G., Barrow, R. E., & Herndon, D. N. (2000) · Critical Care Medicine · doi:10.1097/00003246-200005000-00053 · Cited by 80
Inflammatory cytokines and the GH/IGF‐I axis: novel actions on bone growth
Pass, C., MacRae, V. E., Ahmed, S. F., & Farquharson, C. (2009) · Cell Biochemistry and Function · doi:10.1002/cbf.1551 · Cited by 76
Skeletal muscle growth in young rats is inhibited by chronic exposure to IL-6 but preserved by concurrent voluntary endurance exercise
Bodell, P. W., Kodesh, E., Haddad, F., Zaldivar, F. P., Cooper, D. M., & Adams, G. R. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90831.2008 · Cited by 78
Nutrition Support for Pediatric Patients With Inflammatory Bowel Disease: A Clinical Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
Kleinman, R. E., Baldassano, R. N., Caplan, A., Griffiths, A. M., Heyman, M. B., Issenman, R. M., & Lake, A. M. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200407000-00005 · Cited by 78
Growth Factors, Nutrient Signaling, and Cardiovascular Aging
Fontana, L., Vinciguerra, M., & Longo, V. D. (2012) · Circulation Research · doi:10.1161/circresaha.111.246470 · Cited by 76
Suppressors of cytokine signaling: Relevance to gastrointestinal function and disease
Greenhalgh, C. J., Miller, M. E., Hilton, D. J., & Lund, P. K. (2002) · Gastroenterology · doi:10.1053/gast.2002.37068 · Cited by 75
The role of growth hormone and insulin-like growth factors in the immune system
van Buul-Offers, S. C., & Kooijman, R. (1998) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050237 · Cited by 75
Final adult height of children with inflammatory bowel disease is predicted by parental height and patient minimum height Z-score
Lee, J. J., Escher, J. C., Shuman, M. J., Forbes, P. W., Delemarre, L. C., Harr, B. W., Kruijer, M. J. P., Moret, M., Allende‐Richter, S., & Grand, R. J. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21214 · Cited by 73
Adult height in patients with early onset of Crohn's disease
Alemzadeh, N., Rekers-Mombarg, L. T. M., Mearin, M. L., Wit, J. M., Lamers, C. B. H. W., & van Hogezand, R. A. (2002) · Gut · doi:10.1136/gut.51.1.26 · Cited by 73
Energy balance, viral burden, insulin-like growth factor-1, interleukin-6 and growth impairment in children infected with human immunodeficiency virus
Johann‐Liang, R., O'Neill, L., Cervia, J. S., Haller, I., Giunta, Y., Licholai, T., & Noel, G. J. (2000) · AIDS · doi:10.1097/00002030-200004140-00007 · Cited by 73
Expression of Epidermal Growth Factor in Transgenic Mice Causes Growth Retardation
Chan, S. Y., & Wong, R. W.-C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004189200 · Cited by 74
Growth Factors in Inflammatory Bowel Disease
Theiss, A. L., Fruchtman, S., & Lund, P. K. (2004) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200411000-00021 · Cited by 72
The pathophysiology of the growth plate in juvenile idiopathic arthritis
MacRae, V. E., Farquharson, C., & Ahmed, S. F. (2005) · Rheumatology · doi:10.1093/rheumatology/kei091 · Cited by 72
Inflammatory Diseases and Growth: Effects on the GH–IGF Axis and on Growth Plate
Cirillo, F., Lazzeroni, P., Sartori, C., & Street, M. E. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091878 · Cited by 72
Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice
Pelosi, L., Berardinelli, M. G., Forcina, L., Spelta, E., Rizzuto, E., Nicoletti, C., Camilli, C., Testa, E., Catizone, A., Benedetti, F. D., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv323 · Cited by 72
Muscle contractures in patients with cerebral palsy and acquired brain injury are associated with extracellular matrix expansion, pro‐inflammatory gene expression, and reduced rRNA synthesis
von Walden, F., Gantelius, S., Liu, C., Borgström, H., Björk, L., Gremark, O., Stål, P., Nader, G. A., & Pontén, E. (2018) · Muscle & Nerve · doi:10.1002/mus.26130 · Cited by 71
Growth Hormone Increases Final Height in Patients with Juvenile Idiopathic Arthritis: Data from a Randomized Controlled Study
Bechtold, S. M., Ripperger, P., Pozza, R. D., Bonfig, W., Häfner, R., Michels, H., & Schwarz, H. P. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0544 · Cited by 70
From bench to bedside and back again: translational research in autoinflammation
Holzinger, D., Kessel, C., Omenetti, A., & Gattorno, M. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.79 · Cited by 69
Growth Abnormalities in Children with Type 1 Diabetes, Juvenile Chronic Arthritis, and Asthma
Giannini, C., Mohn, A., & Chiarelli, F. (2014) · International Journal of Endocrinology · doi:10.1155/2014/265954 · Cited by 75
An evolving perspective about the origins of childhood undernutrition and nutritional interventions that includes the gut microbiome
Ahmed, T., Auble, D., Berkley, J. A., Black, R. E., Ahern, P. P., Hossain, M., Hsieh, A. T., Ireen, S., Arabi, M., & Gordon, J. I. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12487 · Cited by 71
The Insulin-Like Growth Factor System and Markers of Inflammation in Adult Patients with Inflammatory Bowel Disease
Eivindson, M., Nielsen, J. N., Grønbæk, H., Flyvbjerg, A., & Hey, H. (2005) · Hormone Research in Paediatrics · doi:10.1159/000087190 · Cited by 69
Age-associated Differences in Cardiovascular Inflammatory Gene Induction during Endotoxic Stress
Saitō, H., & Papaconstantinou, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103740200 · Cited by 69
Systemic juvenile idiopathic arthritis: New insights into pathogenesis and cytokine directed therapies
Pardeo, M., Bracaglia, C., & De Benedetti, F. (2017) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2018.02.002 · Cited by 60
Targeting the interleukin‐6 receptor: A new treatment for systemic juvenile idiopathic arthritis?
Benedetti, F. D., & Martini, A. (2005) · Arthritis & Rheumatism · doi:10.1002/art.20946 · Cited by 66
Self-citation
Serum insulin-like growth factor-I, iron, C-reactive protein, and serum amyloid A for prediction of outcome in dogs with pyometra
Jitpean, S., Holst, B. S., Höglund, O. V., Pettersson, A., Olsson, U., Strage, E. M., Södersten, F., & Hagman, R. (2014) · Theriogenology · doi:10.1016/j.theriogenology.2014.02.014 · Cited by 66
Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat
Hidalgo, J., Florit, S., Giralt, M., Ferrer, B., Keller, C., & Pilegaard, H. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.09.002 · Cited by 66
IGF-1 and IGFBP-3 gene variants influence on serum levels and prostate cancer risk in African-Americans
Hernandez, W., Grenade, C., Santos, E. R., Bonilla, C., Ahaghotu, C. A., & Kittles, R. A. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm190 · Cited by 65
Low Bone Mass in Subjects on a Long-term Raw Vegetarian Diet
Fontana, L., Shew, J., Holloszy, J. O., & Villareal, D. T. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.6.684 · Cited by 64
Receptor Subunit-specific Action of Oncostatin M in Hepatic Cells and Its Modulation by Leukemia Inhibitory Factor
Wang, Y., Robledo, O., Kinzie, E., Blanchard, F., Richards, C. D., Miyajima, A., & Baumann, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002296200 · Cited by 63
Increased Circulating Levels of Interleukin-6 Affect the Redox Balance in Skeletal Muscle
Forcina, L., Miano, C., Scicchitano, B. M., Rizzuto, E., Berardinelli, M. G., Benedetti, F. D., Pelosi, L., & Musarò, A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3018584 · Cited by 63
Tocilizumab: Therapy and safety management
Pham, T., Claudepierre, P., Constantin, A., Bandt, M. D., Fautrel, B., Gossec, L., Gottenberg, J., Goupille, P., Guillaume, S., HACHULLA, E., et al. (2010) · Joint Bone Spine · doi:10.1016/s1297-319x(10)70001-4 · Cited by 60
Up-Regulation of MicroRNA-190b Plays a Role for Decreased IGF-1 That Induces Insulin Resistance in Human Hepatocellular Carcinoma
Hung, T., Ho, C., Liu, Y., Lee, J.-L., Liao, Y.-R., Wu, Y., Ho, M., Chen, C., Lai, H., & Lee, P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089446 · Cited by 60
Sex differences in statural growth impairment in Crohnʼs disease: Role of IGF-1
Gupta, N., Lustig, R. H., Kohn, M. A., McCracken, M. F., & Vittinghoff, E. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21617 · Cited by 62
Induction of Suppressors of Cytokine Signaling by the Trichothecene Deoxynivalenol in the Mouse
Amuzie, C. J., Shinozuka, J., & Pestka, J. J. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp150 · Cited by 59
Effects of insulin-like growth factor 1 in preventing acute coronary syndromes: The PRIME study
Ruidavets, J., Luc, G., Machez, E., Genoux, A., Kee, F., Arveiler, D., Morange, P., Woodside, J. V., Amouyel, P., EVANS, A. E., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.05.034 · Cited by 59
Reciprocal Association of Plasma IGF-1 and Interleukin-6 Levels With Cardiometabolic Risk Factors in Nondiabetic Subjects
Succurro, E., Andreozzi, F., Sciaqua, A., Hribal, M. L., Perticone, F., & Sesti, G. (2008) · Diabetes Care · doi:10.2337/dc08-0553 · Cited by 58
From hormones to immunity: the physiology of immunology
Kelley, K. W. (2003) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.10.003 · Cited by 58
Local insulin-like growth factor I prevents sepsis-induced muscle atrophy
Nystrom, G. J., Pruznak, A. M., Huber, D. S., Frost, R. A., & Lang, C. H. (2009) · Metabolism · doi:10.1016/j.metabol.2009.01.015 · Cited by 58
Juvenile Idiopathic Arthritis
Petty, R. E., Laxer, R. M., & Wedderburn, L. R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-24145-8.00015-6 · Cited by 58
Impaired Growth Plate Chondrogenesis in Children with Chronic Illnesses
Luca, F. D. (2006) · Pediatric Research · doi:10.1203/01.pdr.0000214966.60416.1b · Cited by 59
Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-α, and IL-1β
Zhao, Y., Xiao, X., Frank, S. J., Lin, H. Y., & Xia, Y. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00652.2013 · Cited by 56
Interleukin-6 in juvenile idiopathic arthritis
Akioka, S. (2019) · Modern Rheumatology · doi:10.1080/14397595.2019.1574697 · Cited by 55
Effect of electrical muscle stimulation on prevention of ICU acquired muscle weakness and facilitating weaning from mechanical ventilation
Abu-Khaber, H. A., Abouelela, A., & Abdelkarim, E. M. (2013) · Alexandria Journal of Medicine · doi:10.1016/j.ajme.2013.03.011 · Cited by 56
Interleukin-6 in Traumatic Brain Injury: A Janus-Faced Player in Damage and Repair
Ciryam, P., Gerzanich, V., & Simard, J. M. (2023) · Journal of Neurotrauma · doi:10.1089/neu.2023.0135 · Cited by 55
Efficacy, safety and tolerability of tocilizumab in patients with systemic juvenile idiopathic arthritis
Yokota, S., Tanaka, T., & Kishimoto, T. (2012) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x12455960 · Cited by 55
Growth Retardation in Early-Onset Inflammatory Bowel Disease: Should We Monitor and Treat These Patients Differently?
Griffiths, A. M. (2009) · Digestive Diseases · doi:10.1159/000228581 · Cited by 55
Regulation of insulin-like growth factor-I and of insulin-like growth factor binding protein-1, -3 and -4 in cocultures of rat hepatocytes and Kupffer cells by interleukin-6
Lelbach, A., Scharf, J., & Ramadori, G. P. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00170-2 · Cited by 55
Role of Interleukin-6 in Growth Failure: An Animal Model
Benedetti, F. D., Meazza, C., & Martini, A. (2002) · Hormone Research in Paediatrics · doi:10.1159/000064757 · Cited by 54
Self-citation
Growth abnormalities in children and adolescents with juvenile idiopathic arthritis
Bechtold, S. M., & Simon, D. (2014) · Rheumatology International · doi:10.1007/s00296-014-3022-2 · Cited by 54
The independent role of inflammation in physical frailty among older adults with mild cognitive impairment and mild-to-moderate Alzheimer's disease
Tay, L. B. G., Lim, W. S., Chan, M. Y., Ye, R. J., & Chong, M. S. (2015) · The journal of nutrition health & aging · doi:10.1007/s12603-015-0617-6 · Cited by 57
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Metabolic and Respiratory Effects of Growth Hormone in Children With Cystic Fibrosis
Schnabel, D., Grasemann, C., Staab, D., Wollmann, H. A., Ratjen, F. A., & for the German Cystic Fibrosis Growth Hormone Study Group (2007) · PEDIATRICS · doi:10.1542/peds.2006-2783 · Cited by 51
Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1
Forsblad‐d’Elia, H., Mattsson, L., Ohlsson, C., Nordborg, E., & Carlsten, H. (2003) · Arthritis Research & Therapy · doi:10.1186/ar761 · Cited by 52
IL-6-overexpression brings about growth impairment potentially through a GH receptor defect
Lieskovská, J., Guo, D., & Derman, E. (2002) · Growth Hormone & IGF Research · doi:10.1016/s1096-6374(02)00079-5 · Cited by 52
Growth and long‐term lung function in cystic fibrosis: A longitudinal study of patients diagnosed by neonatal screening
Assael, B. M., Casazza, G., Iansa, P., Volpi, S., & Milani, S. (2009) · Pediatric Pulmonology · doi:10.1002/ppul.21001 · Cited by 51
GH Therapy in Juvenile Chronic Arthritis: Results of a Two-Year Controlled Study on Growth and Bone
Bechtold, S. M., Ripperger, P., Mühlbayer, D., Truckenbrodt, H., Häfner, R., Butenandt, O., & Schwarz, H. P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8083 · Cited by 51
Differentiating size-dependent responses of juvenile pink salmon (Oncorhynchus gorbuscha) to sea lice (Lepeophtheirus salmonis) infections
Sutherland, B. J. G., Jantzen, S. G., Sanderson, D. S., Koop, B. F., & Jones, S. R. M. (2011) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2011.04.001 · Cited by 50
Growth impairment in IL-6-overexpressing transgenic mice is associated with induction of SOCS3 mRNA
Lieskovská, J., Guo, D., & Derman, E. (2003) · Growth Hormone & IGF Research · doi:10.1016/s1096-6374(02)00135-1 · Cited by 52
Cytokine balance and cytokine-driven natural killer cell dysfunction in systemic juvenile idiopathic arthritis
Avau, A., Put, K., Wouters, C. H., & Matthys, P. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.05.005 · Cited by 49
Interleukin-6 inhibits early differentiation of ATDC5 chondrogenic progenitor cells
Nakajima, S., Naruto, T., Miyamae, T., Imagawa, T., Mori, M., Nishimaki, S., & Yokota, S. (2009) · Cytokine · doi:10.1016/j.cyto.2009.05.002 · Cited by 49
Interleukin-6 with Its Soluble Receptor Enhances the Expression of Insulin-Like Growth Factor-I in Osteoblasts1
Franchimont, N., Gangji, V., Durant, D., & CANALIS, E. M. (1997) · Endocrinology · doi:10.1210/endo.138.12.5559 · Cited by 49
Effects of improved water, sanitation, and hygiene and improved complementary feeding on environmental enteric dysfunction in children in rural Zimbabwe: A cluster-randomized controlled trial
Gough, E. K., Moulton, L. H., Mutasa, K., Ntozini, R., Stoltzfus, R. J., Majo, F. D., Smith, L. E., Panić, G., Giallourou, N., Jamell, M., et al. (2020) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007963 · Cited by 51
High‐dose azathioprine in children with inflammatory bowel disease
Fuentes, D., Torrente, F., Keady, S., Thirrupathy, K., Thomson, M. A., Walker-Smith, J. A., MURCH, S. H., & Heuschkel, R. B. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01540.x · Cited by 48
Mouse as a Model of Growth Retardation in Cystic Fibrosis
Rosenberg, L. A., SCHLUCHTER, M. D., Parlow, A. F., & Drumm, M. L. (2006) · Pediatric Research · doi:10.1203/01.pdr.0000196720.25938.be · Cited by 47
In Vivo Neutralization of Human IL-6 (hIL-6) Achieved by Immunization of hIL-6-Transgenic Mice with a hIL-6 Receptor Antagonist1
de Benedetti, F., Pignatti, P., Vivarelli, M., Meazza, C., Ciliberto, G., Savino, R., & Martini, A. (2001) · Journal of Immunology · doi:10.4049/jimmunol.166.7.4334 · Cited by 49
Self-citation
Inhibitory effects of IL‐6 on IGF‐1 activity in skeletal myoblasts could be mediated by the activation of SOCS‐3
Al‐Shanti, N., & Stewart, C. E. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23420 · Cited by 47
Update on the pathogenesis and treatment of systemic onset juvenile rheumatoid arthritis
Adams, A. B., & Lehman, T. J. A. (2005) · Current Opinion in Rheumatology · doi:10.1097/01.bor.0000169363.69066.d0 · Cited by 46
Enteral Nutrition in the Management of Crohn's Disease
Griffiths, A. M. (2005) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/01486071050290s4s108 · Cited by 45
Increased postnatal concentrations of pro-inflammatory cytokines are associated with reduced IGF-I levels and retinopathy of prematurity
Hellgren, G., Löfqvist, C., Pupp, I. H., Gram, M., Smith, L. E. H., Ley, D., & Hellström, A. (2017) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2017.11.006 · Cited by 45
Beneficial synergistic interactions of TNF-α and IL-6 in C2 skeletal myoblasts—Potential cross-talk with IGF system
Al‐Shanti, N., Saini, A. S., Faulkner, S. H., & Stewart, C. E. (2008) · Growth Factors · doi:10.1080/08977190802025024 · Cited by 45
Brain-derived neurotrophic factor, insulin like growth factor-1 and inflammatory cytokine responses to continuous and intermittent exercise in patients with type 1 diabetes
Żebrowska, A., Hall, B., Maszczyk, A., Banaś, R., & Urban, J. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.08.018 · Cited by 44
Paediatric exercise immunology: Health and clinical applications
Timmons, B. W. (2026) · PubMed · doi:10.22029/eir.2005.1619 · Cited by 44
Inflammation: the driver of poor outcomes among children with severe acute malnutrition?
Sturgeon, J. P., Njunge, J. M., Bourke, C. D., Gonzales, G. B., Robertson, R. C., Bwakura‐Dangarembizi, M., Berkley, J. A., Kelly, P. M., & Prendergast, A. J. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad030 · Cited by 43
IGF-I Increases Interferon-γ and IL-6 mRNA Expression and Protein Production in Neonatal Mononuclear Cells
Tu, W., Cheung, P., & Lau, Y. (1999) · Pediatric Research · doi:10.1203/00006450-199912000-00019 · Cited by 43
Transcriptional Modulation of Intestinal Innate Defense/Inflammation Genes by Preterm Infant Microbiota in a Humanized Gnotobiotic Mouse Model
Lu, L., Yu, Y., Guo, Y., Wang, Y., Chang, E. B., & Claud, E. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124504 · Cited by 42
An update of the role of nutritional therapy in the management of Crohn’s disease
Alhagamhmad, M. H., Day, A. S., Lemberg, D. A., & Leach, S. T. (2012) · Journal of Gastroenterology · doi:10.1007/s00535-012-0617-9 · Cited by 42
Inhibition of IGF-I–related intracellular signaling pathways by proinflammatory cytokines in growth plate chondrocytes
Choukair, D., Hügel, U., Sander, A., Uhlmann, L., & Tönshoff, B. (2014) · Pediatric Research · doi:10.1038/pr.2014.84 · Cited by 43
Changes and relationships of IGFS and IGFBPS and cytokines in coeliac disease at diagnosis and on gluten‐free diet
Street, M. E., Volta, C., Ziveri, M. A., Zanacca, C., Banchini, G., Viani, I., Rossi, M., Virdis, R., & Bernasconi, S. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02992.x · Cited by 42
The Anti‐Inflammatory Effects of Enteral Nutrition
Sanderson, I. R., & Croft, N. M. (2005) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/01486071050290s4s134 · Cited by 42
Interleukin-6 Release by Cultured Peripheral Blood Mononuclear Cells Inversely Correlates with Height Velocity, Bone Age, Insulin-like Growth Factor-I, and Insulin-like Growth Factor Binding Protein-3 Serum Levels in Children with Perinatal HIV-1 Infection
de Martino, M., Galli, L., Chiarelli, F., Verrotti, A., Rossi, M. E., Bindi, G., Galluzzi, F., Salti, R., & VIERUCCI, A. (2000) · Clinical Immunology · doi:10.1006/clim.2000.4838 · Cited by 42
Impact of Inflammatory Bowel Disease upon Growth in Children and Adolescents
Moeeni, V., & Day, A. S. (2011) · ISRN Pediatrics · doi:10.5402/2011/365712 · Cited by 41

Authors: De Benedetti, F., Alonzi, T., Moretta, A., Lazzaro, D., Costa, P., Poli, V, Martini, A., Ciliberto, G., & Fattori, E.
Affiliations: Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani (IT)
University of Pavia (IT)
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
ORCID: Alonzi, T
Moretta, A
Poli, V
Martini, A
Ciliberto, G
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1997-02-15
Volume: 99
Issue: 4
Pages: 643-650
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci119207
PMC: PMC507846
OpenAlex: W1972763246
Cited by: 529
References: 48
Citations by year: 2026: 12 · 2025: 10 · 2024: 8 · 2023: 8 · 2022: 6 · 2021: 9 · 2020: 11 · 2019: 24 · 2018: 23 · 2017: 17 · 2016: 10 · 2015: 31 · 2014: 26 · 2013: 25 · 2012: 24
FWCI: 9.97
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
Keywords: interleukin-6, insulin-like growth factor I, growth arrest, chronic inflammation, systemic juvenile idiopathic arthritis, growth retardation, growth hormone, transgenic mice, child growth
MeSH terms: Adolescent, Animals, Arthritis, Juvenile, Blood Glucose, Child, Child, Preschool, Chronic Disease, Disease Models, Animal, Eating, Growth Disorders, Humans, Insulin-Like Growth Factor I, Mice, Inbred C57BL, Mice, Transgenic, Phosphopyruvate Hydratase, Pituitary Gland, Interleukin-6, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks