Cited by 529Growth Hormone and Insulin-like Growth FactorsCytokine Signaling Pathways and InteractionsAutoimmune and Inflammatory Disorders Research

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Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation.

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De Benedetti, F, Alonzi, T, Moretta, A, Lazzaro, D, Costa, P, Poli, V, Martini, A, Ciliberto, G, Fattori, E·1997·Journal of Clinical Investigation

DOI 10.1172/jci119207PMC PMC507846

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Abstract

Stunted growth is a major complication of chronic inflammation and recurrent infections in children. Systemic juvenile rheumatoid arthritis is a chronic inflammatory disorder characterized by markedly elevated circulating levels of IL-6 and stunted growth. In this study we found that NSE/hIL-6 transgenic mouse lines expressing high levels of circulating IL-6 since early after birth presented a reduced growth rate that led to mice 50-70% the size of nontransgenic littermates. Administration of a monoclonal antibody to the murine IL-6 receptor partially reverted the growth defect. In NSE/hIL-6 transgenic mice, circulating IGF-I levels were significantly lower than those of nontransgenic littermates; on the contrary, the distribution of growth hormone pituitary cells, as well as circulating growth hormone levels, were normal. Treatment of nontransgenic mice of the same strain with IL-6 resulted in a significant decrease in IGF-I levels. Moreover, in patients with systemic juvenile rheumatoid arthritis, circulating IL-6 levels were negatively correlated with IGF-I levels. Our findings suggest that IL-6-mediated decrease in IGF-I production represents a major mechanism by which chronic inflammation affects growth.

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Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*
Jones, J. I. W., & Clemmons, D. R. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-1-3 · Cited by 4,488
The acute phase response
Baumann, H., & Gauldie, J. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90137-6 · Cited by 2,907
Role of insulin-like growth factors in embryonic and postnatal growth
Baker, J., Liu, J.-P., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80085-6 · Cited by 2,463
Insulin-like growth factors and their binding proteins: biological actions
Jones, J. I. (1995) · Endocrine Reviews · doi:10.1210/er.16.1.3 · Cited by 2,060
Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.
Campbell, I. L., Abraham, C. R., Masliah, E., Kemper, P., Inglis, J. D., Oldstone, M. B., & Mucke, L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10061 · Cited by 1,006
The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain
Lazzaro, D., Price, M., Felice, M. D., & Lauro, R. D. (1991) · Development · doi:10.1242/dev.113.4.1093 · Cited by 902
Self-citation
Enhand secretion of tumour necrosis factor-alpha, IL-6, and IL-1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease
REINECKER, H.-C., STEFFEN, M., Witthoeft, T., Pflüger, I., Schreiber, S., MacDermott, R. P., & Raedler, A. (1993) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1993.tb05997.x · Cited by 855
Current proposed revision of JRA Criteria. JRA Criteria Subcommittee of the Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Section of The Arthritis Foundation.
Brewer, E. J., Bass, J., Baum, J., Cassidy, J. T., Fink, C., Jacobs, J. W. G., Hanson, V., Levinson, J. E., SCHALLER, J. G., & Stillman, J. S. (1977) · PubMed · Cited by 631
Defective inflammatory response in interleukin 6-deficient mice.
Fattori, E., Cappelletti, M., Costa, P., Sellitto, C., Cantoni, L., Carelli, M., Faggioni, R., Fantuzzi, G., Ghezzi, P., & Poli, V (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.4.1243 · Cited by 525
Self-citation
On a Form of Chronic Joint Disease in Children
Still, G., & Garrod, A. E. (1897) · Journal of the Royal Society of Medicine · doi:10.1177/095952879708000106 · Cited by 435

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CHRONIC ARTHRITIS IN CHILDHOOD
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Authors: De Benedetti, F., Alonzi, T., Moretta, A., Lazzaro, D., Costa, P., Poli, V, Martini, A., Ciliberto, G., & Fattori, E.
Affiliations: Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani (IT)
University of Pavia (IT)
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
ORCID: Alonzi, T
Moretta, A
Poli, V
Martini, A
Ciliberto, G
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1997-02-15
Volume: 99
Issue: 4
Pages: 643-650
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci119207
PMC: PMC507846
OpenAlex: W1972763246
Cited by: 529
References: 48
Citations by year: 2026: 12 · 2025: 10 · 2024: 8 · 2023: 8 · 2022: 6 · 2021: 9 · 2020: 11 · 2019: 24 · 2018: 23 · 2017: 17 · 2016: 10 · 2015: 31 · 2014: 26 · 2013: 25 · 2012: 24
FWCI: 9.97
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
Keywords: interleukin-6, insulin-like growth factor I, growth arrest, chronic inflammation, systemic juvenile idiopathic arthritis, growth retardation, growth hormone, transgenic mice, child growth
MeSH terms: Adolescent, Animals, Arthritis, Juvenile, Blood Glucose, Child, Child, Preschool, Chronic Disease, Disease Models, Animal, Eating, Growth Disorders, Humans, Insulin-Like Growth Factor I, Mice, Inbred C57BL, Mice, Transgenic, Phosphopyruvate Hydratase, Pituitary Gland, Interleukin-6, Mice

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Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation.

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