The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Impaired diurnal adrenal rhythmicity restored by constant infusion of corticotropin-releasing hormone in corticotropin-releasing hormone-deficient mice.
Open accessAbstract
The normal pattern of daily glucocorticoid production in mammals requires circadian modulation of hypothalamicpituitary-adrenal axis activity. To assess both the factors responsible for imparting this diurnal profile and its physiologic importance, we have exploited corticotropin-releasing hormone (CRH)-deficient mice generated by homologous recombination in embryonic stem cells. CRH-deficient mice have lost normal circadian variations in plasma ACTH and glucocorticoid while maintaining normal circadian locomotor activity. Constant peripheral infusion of CRH produced marked diurnal excursions of plasma glucocorticoid, indicating that CRH acts in part as a permissive factor for other circadian modulators of adrenocortical activity. The presence of atrophic adrenals in CRH-deficient mice without an overt deficit in basal plasma ACTH concentration suggests that the diurnal increase in ACTH is essential to maintain normal adrenal function.
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“CRH KO mice also demonstrate this sexual dichotomy in response to stress, indicating a mechanism independent of CRH (12, 38).”
From Interleukin-6 is an essential, corticotropin-releasing hormone-independent stimulator of the adrenal axis during immune system activation (2000) · cites this paper as [38]
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Cites
Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965
Stephan, F. K., & Zucker, I. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.6.1583 · Cited by 2,039
Nemeroff, C. B., Widerlöv, E., Bissette, G., Walléus, H., Karlsson, I., Eklund, K., Kilts, C. D., Loosen, P. T., & Vale, W. (1984) · Science · doi:10.1126/science.6334362 · Cited by 1,485
Vaughan, J. M., Donaldson, C. J., Bittencourt, J. C., Perrin, M. H., Lewis, K., Sutton, S. W., Chan, R. K. W., Turnbull, A. V., Lovejoy, D. A., RIVIER, C. L., et al. (1995) · Nature · doi:10.1038/378287a0 · Cited by 1,479
Dunn, A. J., & Berridge, C. W. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90012-d · Cited by 1,352
Corticosteroid inhibition of acth secretion
KELLER-WOOD, M. E., & DALLMAN, M. F. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-1-1 · Cited by 1,219
Regulation of ACTH Secretion: Variations on a Theme of B
DALLMAN, M. F., AKANA, S. F., CASCIO, C. S., DARLINGTON, D. N., JACOBSON, L., & LEVIN, N. (1987) · Proceedings of the 1986 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571143-2.50010-1 · Cited by 655
Self-citationCorticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need
Muglia, L., Jacobson, L., Dikkes, P., & Majzoub, J. A. (1995) · Nature · doi:10.1038/373427a0 · Cited by 524
Self-citationModulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep
Van Cauter, E., Blackman, J. D., Roland, D., Spire, J. P., Refetoff, S., & Polonsky, K. S. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115396 · Cited by 448
Food and Water Restriction Shifts Corticosterone, Temperature, Activity and Brain Amine Periodicity
Krieger, D. T. (1974) · Endocrinology · doi:10.1210/endo-95-5-1195 · Cited by 382
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(2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80049-5 · Cited by 1
Molecular Pathology of Corticotroph Function
Clark, A., & Swords, F. M. (2001) · KARGER eBooks · doi:10.1159/000060866 · Cited by 1
Gaston, L. S., & Majzoub, J. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99899-4.00013-5 · Cited by 1
Self-citationThe Role of Oxytocin in the Stress and Anxiety Response.
Mantella, R. C. (2005) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 1
Physiological functions of the adrenocortical circadian clock
Leliavski, A. (2014) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-4675
Multifactorial regulation of the corticotroph axis: animal models
Karalis, K. P. (2003) · Endocrine updates · doi:10.1007/978-1-4615-0501-3_3
Jacobson, L., Ansari, T., Potts, J., & McGuinness, O. P. (2016)
Self-citationGaston, L. S., Jorgensen, B. C., Friedman, H. R., Sherman, M. S., & Majzoub, J. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.30.651350
Self-citationRegulation and Actions of Corticotropin‐Releasing Hormone
Weninger, S. C., & Majzoub, J. A. (2000) · Comprehensive physiology · doi:10.1002/j.2040-4603.2000.tb01511.x
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Metadata
- Authors
- Muglia, L. J., Jacobson, L., Weninger, S. C., Luedke, C. E., Bae, D. S., Jeong, K. H., & Majzoub, J. A.
- Affiliations
- Boston Children's Hospital (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Majzoub, J A
- Venue
- Journal of Clinical Investigation
- Published
- 1997-06-15
- Volume
- 99
- Issue
- 12
- Pages
- 2923-2929
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC508144
- OpenAlex
- W1992866860
- Cited by
- 115
- References
- 47
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 5 · 2014: 6 · 2013: 2 · 2012: 1
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health (1p30hd033688-01)
- Pfizer Pharmaceuticals
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 33688)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- corticotropin-releasing factor, circadian rhythm, hypothalamic-pituitary-adrenal axis, ACTH, adrenal atrophy, adrenocortical function, glucocorticoid synthesis
- MeSH terms
- Adrenal Cortex, Adrenocorticotropic Hormone, Animals, Blood Glucose, Circadian Rhythm, Corticosterone, Corticotropin-Releasing Hormone, Female, Glucocorticoids, Insulin, Light, Male, Mice, Inbred C57BL, Motor Activity, Photoperiod, Mice, Knockout, Mice
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