Circadian Rhythms in Drinking Behavior and Locomotor Activity of Rats Are Eliminated by Hypothalamic Lesions
Open accessAbstract
Bilateral electrolytic lesions in the suprachiasmatic nuclei permanently eliminated nocturnal and circadian rhythms in drinking behavior and locomotor activity of albino rats. The generation of 24-hr behavioral rhythms and the entrainment of these rhythms to the light-dark cycle of environmental illumination may be coordinated by neurons in the suprachiasmatic region of the rat brain. Destruction of the medial preoptic area had no effect on 24-hr drinking rhythms.
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In rodents, lesions of the suprachiasmatic nucleus abolish or attenuate daily rhythms in locomotor activity, body temperature, blood pressure, and heart rate, showing that these rhythms are endogenous rather than resulting from daily changes in behavior or environment.
“In rodents, lesions of the SCN abolish or attenuate daily rhythms in locomotor activity, body temperature, BP, and HR (22)(23)(24), showing that these rhythms are endogenous rather than resulting from daily changes in behavior or environment.”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [23]
The suprachiasmatic nucleus functions as the primary central circadian oscillator in mammals.
“The SCN functions as the primary central circadian oscillators in mammals (Stephan and Zucker, 1972; Moore and Eichler, 1972).”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Stephan and Zucker, 1972
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- Authors
- Stephan, F. K., & Zucker, I.
- Affiliations
- University of California, Berkeley (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1972-06
- Volume
- 69
- Issue
- 6
- Pages
- 1583-1586
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC426753
- OpenAlex
- W1986608768
- Cited by
- 2,039
- References
- 8
- Citations by year
- 2026: 29 · 2025: 29 · 2024: 53 · 2023: 65 · 2022: 67 · 2021: 79 · 2020: 68 · 2019: 64 · 2018: 73 · 2017: 82 · 2016: 53 · 2015: 63 · 2014: 91 · 2013: 68 · 2012: 62
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian rhythm, drinking behavior, locomotor activity, suprachiasmatic nucleus, hypothalamic lesions, electrolytic lesions, light-dark cycle entrainment, medial preoptic area, rats
- MeSH terms
- Animals, Behavior, Animal, Blindness, Castration, Circadian Rhythm, Drinking Behavior, Female, Hypothalamus, Motor Activity, Optic Chiasm, Stereotaxic Techniques, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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