Cited by 2,039Circadian rhythm and melatoninSleep and Wakefulness ResearchSleep and Work-Related Fatigue

Circadian Rhythms in Drinking Behavior and Locomotor Activity of Rats Are Eliminated by Hypothalamic Lesions

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Stephan, Friedrich K., Zucker, Irving·1972·Proceedings of the National Academy of Sciences

Abstract

Bilateral electrolytic lesions in the suprachiasmatic nuclei permanently eliminated nocturnal and circadian rhythms in drinking behavior and locomotor activity of albino rats. The generation of 24-hr behavioral rhythms and the entrainment of these rhythms to the light-dark cycle of environmental illumination may be coordinated by neurons in the suprachiasmatic region of the rat brain. Destruction of the medial preoptic area had no effect on 24-hr drinking rhythms.

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Crossref · 10.1073/pnas.69.6.1583

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8 of 8 references verified0 citation errors · 0 not checkable

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  • In rodents, lesions of the suprachiasmatic nucleus abolish or attenuate daily rhythms in locomotor activity, body temperature, blood pressure, and heart rate, showing that these rhythms are endogenous rather than resulting from daily changes in behavior or environment.

    “In rodents, lesions of the SCN abolish or attenuate daily rhythms in locomotor activity, body temperature, BP, and HR (22)(23)(24), showing that these rhythms are endogenous rather than resulting from daily changes in behavior or environment.”

    From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [23]

  • The suprachiasmatic nucleus functions as the primary central circadian oscillator in mammals.

    “The SCN functions as the primary central circadian oscillators in mammals (Stephan and Zucker, 1972; Moore and Eichler, 1972).”

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Authors
Stephan, F. K., & Zucker, I.
Affiliations
University of California, Berkeley (US)
Venue
Proceedings of the National Academy of Sciences
Published
1972-06
Volume
69
Issue
6
Pages
1583-1586
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1986608768
Cited by
2,039
References
8
Citations by year
2026: 29 · 2025: 29 · 2024: 53 · 2023: 65 · 2022: 67 · 2021: 79 · 2020: 68 · 2019: 64 · 2018: 73 · 2017: 82 · 2016: 53 · 2015: 63 · 2014: 91 · 2013: 68 · 2012: 62
FWCI
5.30
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
circadian rhythm, drinking behavior, locomotor activity, suprachiasmatic nucleus, hypothalamic lesions, electrolytic lesions, light-dark cycle entrainment, medial preoptic area, rats
MeSH terms
Animals, Behavior, Animal, Blindness, Castration, Circadian Rhythm, Drinking Behavior, Female, Hypothalamus, Motor Activity, Optic Chiasm, Stereotaxic Techniques, Rats

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