The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Role of nitric oxide in obesity-induced beta cell disease.
Open accessAbstract
Here we report that free fatty acid-induced suppression of insulin output in prediabetic Zucker diabetic fatty (ZDF) rats is mediated by NO. When normal islets were cultured in 2 mM FFA, NO production and basal insulin secretion increased slightly. In cultured prediabetic ZDF islets, FFA induced a fourfold greater rise in NO, upregulated mRNA of inducible nitric oxide synthase (iNOS), and reduced insulin output; both nicotinamide and aminoguanidine, which lower NO, prevented the FFA-mediated increase in iNOS mRNA, reduced NO, and minimized the loss of insulin secretion. In vivo nicotinamide or aminoguanidine treatment of prediabetic ZDF rats prevented the iNOS expression in islets and decreased beta cell dysfunction while blocking beta cell destruction and hyperglycemia. We conclude that NO-lowering agents prevent adipogenic diabetes in obese rats.
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Cites
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Self-citationLeptin receptor missense mutation in the fatty Zucker rat
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Cited by
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Triglyceride accumulation protects against fatty acid-induced lipotoxicity
Listenberger, L. L., Han, X., Lewis, S. E., Cases, S., Farese, R. V., Ory, D. S., & Schaffer, J. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630588100 · Cited by 2,075
Inflammation, Oxidative Stress, and Obesity
Fernández-Sánchez, A., Madrigal-Santillán, E., Bautista, M., Esquivel-Soto, J., Morales-González, Á., Esquivel-Chirino, C., Durante-Montiel, I., Sánchez-Rivera, G., Valadez-Vega, C., & Morales-González, J. A. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12053117 · Cited by 1,527
Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes
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Lipotoxic heart disease in obese rats: Implications for human obesity
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Metadata
- Authors
- Shimabukuro, M., Ohneda, M., Lee, Y., & Unger, R. H.
- Venue
- Journal of Clinical Investigation
- Published
- 1997-07-15
- Volume
- 100
- Issue
- 2
- Pages
- 290-295
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2072031497
- Cited by
- 288
- References
- 35
- FWCI
- 11.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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