Cited by 352Pancreatic function and diabetesDiabetes Treatment and ManagementLipid metabolism and biosynthesis

The DOI matches its Crossref record; 28 of the 29 references it cites were found in a registry or an index.

The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation.

Open access

Stein, D T, Stevenson, B E, Chester, M W, Basit, M, Daniels, M B, Turley, S D, McGarry, J D·1997·Journal of Clinical Investigation

DOI 10.1172/jci119546PMC PMC508203

Open this paper in CoChat — free account Open PDF

Abstract

Lowering of the elevated plasma FFA concentration in 18- 24-h fasted rats with nicotinic acid (NA) caused complete ablation of subsequent glucose-stimulated insulin secretion (GSIS). Although the effect of NA was reversed when the fasting level of total FFA was maintained by coinfusion of soybean oil or lard oil (plus heparin), the more saturated animal fat proved to be far more potent in enhancing GSIS. We therefore examined the influence of individual fatty acids on insulin secretion in the perfused rat pancreas. When present in the perfusion fluid at 0.5 mM (in the context of 1% albumin), the fold stimulation of insulin release from the fasted pancreas in response to 12.5 mM glucose was as follows: octanoate (C8:0), 3.4; linoleate (C18:2 cis/cis), 5.3; oleate (C18:1 cis), 9.4; palmitate (C16:0), 16. 2; and stearate (C18:0), 21.0. The equivalent value for palmitoleate (C16:1 cis) was 3.1. A cis--> trans switch of the double bond in the C16:1 and C18:1 fatty acids had only a modest, if any, impact on their potency. A similar profile emerged with regard to basal insulin secretion (3 mM glucose). When a subset of these fatty acids was tested in pancreases from fed animals, the same rank order of effectiveness at both basal and stimulatory levels of glucose was seen. The findings reaffirm the essentiality of an elevated plasma FFA concentration for GSIS in the fasted rat. They also show, however, that the insulinotropic effect of individual fatty acids spans a remarkably broad range, increasing and decreasing dramatically with chain length and degree of unsaturation, respectively. Thus, for any given level of glucose, insulin secretion will be influenced greatly not only by the combined concentration of all circulating (unbound) FFA, but also by the makeup of this FFA pool. Both factors will likely be important considerations in understanding the complex interplay between the nature of dietary fat and whole body insulin, glucose, and lipid dynamics.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci119546

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Dietary influences on serum lipids and lipoproteins.
Grundy, S. M., & Denke, M. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42625-2 · Cited by 1,044
Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.
Lee, Y., Hirose, H., Ohneda, M., Johnson, J. H., McGarry, J., & Unger, R. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.10878 · Cited by 832
Self-citation
Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion.
Prentki, M., Vischer, S., Glennon, M. C., Regazzi, R., Deeney, J. T., & Corkey, B. E. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42624-5 · Cited by 442
Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat.
Stein, D. T., Esser, V., Stevenson, B. E., Lane, K. E., Whiteside, J. H., Daniels, M. B., Chen, S., & McGarry, J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118727 · Cited by 371
Self-citation
Unbound free fatty acid levels in human serum.
Richieri, G. V., & Kleinfeld, A. M. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39899-0 · Cited by 320
Effects of a 48-h Fat Infusion on Insulin Secretion and Glucose Utilization
Boden, G., Chen, X., Rosner, J., & Barton, M. (1995) · Diabetes · doi:10.2337/diab.44.10.1239 · Cited by 271
Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans
Zhou, Y. P. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.80.5.1584 · Cited by 243
Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects
Paolisso, G., Gambardella, A., Amato, L., Tortoriello, R., D'Amore, A., Varricchio, M., & D'Onofrio, F. (1995) · Diabetologia · doi:10.1007/bf00401761 · Cited by 217
Relationship of dietary saturated fatty acids and body habitus to serum insulin concentrations: the Normative Aging Study
Parker, D., Weiss, S. T., Troisi, R. J., Cassano, P. A., Vokonas, P., & Landsberg, L. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.2.129 · Cited by 212
Rapid separation of neutral lipids, free fatty acids and polar lipids using prepacked silica sep‐Pak columns
Hamilton, J. G. C., & Comai, K. (1988) · Lipids · doi:10.1007/bf02535281 · Cited by 208

Show all 29 references

Sorted by citations

Items 201–300 of 352

Palmitate-induced changes in protein expression of insulin secreting INS-1E cells
Hovsepyan, M., Sargsyan, E., & Bergsten, P. (2010) · Journal of Proteomics · doi:10.1016/j.jprot.2010.01.012 · Cited by 20
Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma.
Kawai, T., Hirose, H., Seto, Y., Fujita, H., Fujita, H., Ukeda, K., & Saruta, T. (2002) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(01)00367-9 · Cited by 22
Secretion of Insulin in Response to Diet and Hormones
Elizabeth Mann 1, M. S. 2. (2020) · doi:10.3998/panc.2020.16 · Cited by 22
Differential modulation of L-type calcium channel subunits by oleate
Tian, Y., Corkey, R. F., Yaney, G. C., Goforth, P. B., Satin, L. S., & de Vargas, L. M. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90237.2008 · Cited by 20
Erucic acid inhibits growth performance and disrupts intestinal structural integrity of on-growing grass carp (Ctenopharyngodon idella)
Gan, L., Wu, P., Feng, L., Jiang, W., Liu, Y., Jiang, J., Kuang, S., Tang, L., & Zhou, X. (2019) · Aquaculture · doi:10.1016/j.aquaculture.2019.734437 · Cited by 19
Chronic Effects of Different Non-esterified Fatty Acids on Pancreatic Islets of Rats
Wang, Y., Wang, P., & Takashi, K. (2006) · Endocrine · doi:10.1385/endo:29:1:169 · Cited by 19
The Natural PPAR Agonist Linoleic Acid Stimulated Insulin Release in the Rat Pancreas
Lai, M.-C., Teng, T., & Yang, C. (2013) · Journal of Veterinary Medical Science · doi:10.1292/jvms.13-0189 · Cited by 19
Free fatty acid kinetics during long‐term treatment with pioglitazone added to sulfonylurea or metformin in Type 2 diabetes
Roden, M., Mariz, S., Brazzale, A. R., & Pacini, G. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.02040.x · Cited by 19
Role of Protein Kinase C Isoenzymes in Fatty Acid Stimulation of Insulin Secretion
Littman, E. D., Pitchumoni, S., Garfinkel, M. R., & Opara, E. C. (2000) · Pancreas · doi:10.1097/00006676-200004000-00006 · Cited by 19
Fatty acids and beta-cell function
Björklund, A., Yaney, G. C., McGarry, J., & Weir, G. C. (1997) · Diabetologia · doi:10.1007/bf03168182 · Cited by 19
Self-citation
Changes in food intake, metabolic parameters and insulin resistance are induced by an isoenergetic, medium-chain fatty acid diet and are associated with modifications in insulin signalling in isolated rat pancreatic islets
Marçal, A. C., Camporez, J. P., de Lima, T. M., Cintra, D. E., Akamine, E. H., Ribeiro, L. M., Almeida, F. N., Zanuto, R., Curi, R., Boldrini, S., et al. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512004576 · Cited by 18
Identification of early biological changes in palmitate-treated isolated human islets
Sargsyan, E., Cen, J., Roomp, K., Schneider, R., & Bergsten, P. (2018) · BMC Genomics · doi:10.1186/s12864-018-5008-z · Cited by 18
Quantitative Mapping of Triacylglycerol Chain Length and Saturation Using Broadband CARS Microscopy
Paul, A., Wang, Y., Brännmark, C., Kumar, S., Bonn, M., & Parekh, S. H. (2019) · Biophysical Journal · doi:10.1016/j.bpj.2019.04.036 · Cited by 18
Effects of Lipid Structure Changed by Interesterification on Melting Property and Lipemia
Wang, T., Wang, X., & Wang, X. (2016) · Lipids · doi:10.1007/s11745-016-4184-3 · Cited by 17
Oleic acid increases the transcriptional activity of FoxO1 by promoting its nuclear translocation and β-catenin binding in pancreatic β-cells
Jazurek, M., Janikiewicz, J., Dobrzyń, P., Dziewulska, A., Koziński, K., & Dobrzyń, A. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.06.018 · Cited by 18
High-Fat Feeding During Gestation and Nursing Period have Differential Effects on the Insulin Secretory Capacity in Offspring from Normal Wistar Rats
Dyrskog, S., Gregersen, S., & Hermansen, K. (2005) · The Review of Diabetic Studies · doi:10.1900/rds.2005.2.136 · Cited by 16
Massive Augmentation of Stimulated Insulin Secretion Induced by Fatty Acid–Free BSA in Rat Pancreatic Islets
Straub, S. G., & Sharp, G. W. G. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3152 · Cited by 17
Invited review: Moving from dietary fat to fatty acids—New insights into how fatty acids affect digestibility, metabolism, and performance in dairy cows
Lock, A. L., Neto, J. M. D. S., & de Souza, J. (2025) · Journal of Dairy Science · doi:10.3168/jds.2025-27040 · Cited by 16
Physiology and Therapeutics of the Free Fatty Acid Receptor GPR40
Huang, H., Dai, M., & Tao, Y. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-800101-1.00003-x · Cited by 16
A Fall in Plasma Free Fatty Acid (FFA) Level Activates the Hypothalamic-Pituitary-Adrenal Axis Independent of Plasma Glucose: Evidence for Brain Sensing of Circulating FFA
Oh, Y. T., Oh, K.-S., Kang, I., & Youn, J. H. (2012) · Endocrinology · doi:10.1210/en.2012-1330 · Cited by 16
Oleic Acid Glucose-Independently Stimulates Glucagon Secretion by Increasing Cytoplasmic Ca2+via Endoplasmic Reticulum Ca2+Release and Ca2+Influx in the Rat Islet α-Cells
Fujiwara, K., Maekawa, F., Dezaki, K., Nakata, M., Yashiro, T., & Yada, T. (2007) · Endocrinology · doi:10.1210/en.2006-1156 · Cited by 17
Nutrigenómica y obesidad
Palou, A., Bonet, M. L., Picó, C., & Rodríguez, A. M. (2017) · Revista de medicina de la Universidad de Navarra · doi:10.15581/021.7462 · Cited by 16
Lipid partitioning in the pancreatic β cell: physiologic and pathophysiologic implications
Poitout, V. (2002) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-200204000-00005 · Cited by 16
Factors Affecting Insulin-Regulated Hepatic Gene Expression
Guan, H.-P., & Chen, G. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-800101-1.00006-5 · Cited by 15
The Epidemic of Type 2 Diabetes Mellitus: Its Links to Obesity, Insulin Resistance, and Lipotoxicity
Cusi, K. J. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-260-1_1 · Cited by 15
Activation of Aldehyde Dehydrogenase 2 Ameliorates Glucolipotoxicity of Pancreatic Beta Cells
Chen, S.-M., Hee, S., Chou, S.-Y., Liu, M.-W., Chen, C., Mochly‐Rosen, D., Chang, T., & Chuang, L. (2021) · Biomolecules · doi:10.3390/biom11101474 · Cited by 14
Role of Ectopic Olfactory Receptors in the Regulation of the Cardiovascular–Kidney–Metabolic Axis
Beito, M., Ashraf, S., Odogwu, D., & Harmancey, R. (2024) · Life · doi:10.3390/life14050548 · Cited by 15
Untargeted metabolomics study of mature human milk from women with and without gestational diabetes mellitus
Yao, D., Shen, C., Zhang, X., Tang, J., Yu, J., Tu, M., Panpipat, W., Chaijan, M., Zhang, H., Xu, X., et al. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.140663 · Cited by 14
Elevation in Intracellular Long-Chain Acyl-Coenzyme A Esters Lead to Reduced β-Cell Excitability via Activation of Adenosine 5′-Triphosphate-Sensitive Potassium Channels
Webster, N. J., Searle, G. J., Lam, P. P. L., Huang, Y., Riedel, M. J., Harb, G., Gaisano, H. Y., Holt, A., & Light, P. E. (2008) · Endocrinology · doi:10.1210/en.2007-1138 · Cited by 14
Intramyocellular lipids and their dynamics assessed by 1H magnetic resonance spectroscopy
Gacesa, J. P., Schick, F., Machann, J., & Grujic, N. (2017) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12346 · Cited by 13
Palmitate is not an effective fuel for pancreatic islets and amplifies insulin secretion independent of calcium release from endoplasmic reticulum
Kuok, I. T., Rountree, A. M., Jung, S., & Sweet, I. R. (2019) · Islets · doi:10.1080/19382014.2019.1601490 · Cited by 15
Saturated fat supplementation interacts with dietary forage neutral detergent fiber content during the immediate postpartum period in Holstein cows: Energy balance and metabolism
Piantoni, P., Lock, A. L., & Allen, M. S. (2015) · Journal of Dairy Science · doi:10.3168/jds.2014-8799 · Cited by 14
Dietary n-3 and n-6 fatty acids alter avian glucose metabolism
Newman, R. E., Bryden, W. L., Kirby, A. C., Storlien, L. H., & Downing, J. A. (2005) · British Poultry Science · doi:10.1080/00071660400023987 · Cited by 14
Irregular circulating insulin concentrations in type 2 diabetes mellitus: An inverse relationship between circulating free fatty acid and the disorderliness of an insulin time series in diabetic and healthy individuals
Schmitz, O., Juhl, C. B., Hollingdal, M., Veldhuis, J. D., Pørksen, N., & Pincus, S. M. (2001) · Metabolism · doi:10.1053/meta.2001.19524 · Cited by 14
Macrophages transfer [14C]‐labelled fatty acids to pancreatic islets in culture
Garcia, J. R., Curi, R., Martins, E. F., & Carpinelli, Â. R. (2001) · Cell Biochemistry and Function · doi:10.1002/cbf.887 · Cited by 14
Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling
Wing, A., Jeffery, E. C., CHURCH, C. D., Goodell, J., Saavedra-Peña, R. D. M., Saha, M., Holtrup, B., Voisin, M., Alavi, N. S., Floody, M., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115527 · Cited by 15
Interplay of fatty acids, insulin and exercise in vascular health
Anderson, K. C., Liu, J., & Liu, Z. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-024-02421-5 · Cited by 18
Islet hormones at the intersection of glucose and amino acid metabolism
White, P. J., Albrechtsen, N. J. W., & Campbell, J. E. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01100-4 · Cited by 15
Label-free CARS microscopy reveals similar triacylglycerol acyl chain length and saturation in myocellular lipid droplets of athletes and individuals with type 2 diabetes
Daemen, S., Gemmink, A., Paul, A., Billecke, N., Rieger, K., Parekh, S. H., & Hesselink, M. K. C. (2020) · Diabetologia · doi:10.1007/s00125-020-05266-6 · Cited by 13
Short-term effects of a moderate fish oil or soybean oil supplementation on postprandial glucose and insulin responses in healthy horses
Vervuert, I., Klein, S., & Coenen, M. (2009) · The Veterinary Journal · doi:10.1016/j.tvjl.2009.01.013 · Cited by 13
A dual action of saturated fatty acids on electrical activity in rat pancreatic β‐cells. Role of volume‐regulated anion channel and KATP channel currents
Best, L. C., Jarman, E., & Brown, P. D. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.200741 · Cited by 13
4 Nutrients as regulators of endocrine and neuroendocrine secretion
Best, L. C., & McLaughlin, J. T. (2004) · Topics in current genetics · doi:10.1007/978-3-540-39898-1_5 · Cited by 13
Dietary fats and diabetes mellitus: Is there a good fat?
Segal-Isaacson, C. J., Carello, E., & Wylie‐Rosett, J. (2001) · Current Diabetes Reports · doi:10.1007/s11892-001-0029-3 · Cited by 13
Insulingene expression and biosynthesis
Poitout, V., Stein, R. W., & Rhodes, C. J. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch6 · Cited by 13
Hydrolysed proteins in preterm formula: influence on plasma aminoacids, blood fatty acids and insulinaemia
Agosti, M. A., Pugni, L., Ramenghi, L. A., Mosca, F., & Marini, A. (2003) · Acta Paediatrica · doi:10.1080/08035320310018673 · Cited by 12
An adipocentric perspective of pancreatic lipotoxicity in diabetes pathogenesis
Risi, R., Vidal‐Puig, A., & Bidault, G. (2024) · Journal of Endocrinology · doi:10.1530/joe-23-0313 · Cited by 18
Circulating free fatty acids inhibit food intake in an oleate-specific manner in rats
Oh, Y. T., Oh, H. H., Nguyen, A.-K., Choi, C. S., & Youn, J. H. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.09.015 · Cited by 12
Improved metabolic control by depletion of Liver X Receptors in mice
Schuster, G. U., Johansson, L., Kietz, S., Stulnig, T. M., Parini, P., & Gustafsson, J.-Α. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.07.044 · Cited by 12
Intracellular depletion of insulin: a comparative study with palmitate, oleate and elaidate in INS-1 cells
Bollheimer, L., Kemptner, D. M., Kagerbauer, S. M., Kestler, T., Wrede, C., & Buettner, R. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1480481 · Cited by 12
Trans -palmitoleic acid, a dairy fat biomarker, stimulates insulin secretion and activates G protein-coupled receptors with a different mechanism from the cis isomer
Korkus, E., Szustak, M., Madaj, R., Chworoś, A., Drzazga, A. K., Koziołkiewicz, M., Dąbrowski, G., Czaplicki, S., Konopka, I., & Gendaszewska‐Darmach, E. (2023) · Food & Function · doi:10.1039/d2fo03412c · Cited by 11
Localized Fetomaternal Hyperglycemia: Spatial and Kinetic Definition by Positron Emission Tomography
Yao, J., Wang, C., Walsh, S. A., Hu, S., Sawatzke, A. B., Dang, D., Segar, J. L., Ponto, L. L. B., Sunderland, J. J., & Norris, A. W. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012027 · Cited by 11
The regulation of insulin secretion via phosphoinositide-specific phospholipase Cβ signaling
Hwang, H.-J., Jang, H.-J., Cocco, L., & Suh, P.-G. (2019) · Advances in Biological Regulation · doi:10.1016/j.jbior.2018.09.011 · Cited by 11
[Usefulness and controversial issues of middle-chain fatty acids consumption on lipid-protein metabolism and obesity].
Sáyago‐Ayerdi, S. G., Vaquero, M. P., Moreira, A. R. S., Bastida, S., & Sánchez-Muniz, F. J. (2008) · PubMed · Cited by 11
Secretion of Insulin in Response to Diet and Hormones
(2), E. M. (. A. M. D. B. (2016) · doi:10.3998/panc.2016.3 · Cited by 13
The Degree of Saturation of Fatty Acids in Dietary Fats Does Not Affect the Metabolic Response to Ingested Carbohydrate
Radulescu, A., Hassan, Y., Gannon, M. C., & Nuttall, F. Q. (2009) · Journal of the American College of Nutrition · doi:10.1080/07315724.2009.10719783 · Cited by 10
Marked differences in the IGF system that are associated with migration in comparable populations of Gujaratis living in Sandwell, UK, and Gujarat, India
Heald, A. H., Anderson, S. G., Vyas, A., Siddals, K. W., Patel, J. V., Yates, A. P., Bhatnagar, D., Prabhakaran, D., Hughes, E. A., Rudenski, A. S., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1871-7 · Cited by 10
Lowering of Circulating Free-Fatty Acids Levels and Reduced Expression of Leptin in White Adipose Tissue in Postobesity Status
Greco, A. V., Mingrone, G., Vettor, R., Manco, M., Rosa, G., Capristo, E., Federspil, G., Castagneto, M., & Gasbarrini, A. (2002) · Journal of Investigative Medicine · doi:10.2310/6650.2002.33435 · Cited by 9
Fentanyl inhibits glucose-stimulated insulin release from β-cells in rat pancreatic islets
Qian, T.-L., Wang, X., Liu, S., Ma, L., & Lu, Y. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.4163 · Cited by 8
Consequences of a Fat Diet in the Distribution of Minerals within Pancreatic Tissues of Rats and Rabbits
Ynsa, M. D., Minquin, R., Rajendran, R., Pinheiro, T., & Watt, F. (2012) · Microscopy and Microanalysis · doi:10.1017/s1431927612001547 · Cited by 8
Management of Type 2 Diabetes With Thiazolidinediones
Bell, D. S. H. (2004) · The Endocrinologist · doi:10.1097/01.ten.0000139039.06946.b2 · Cited by 8
NEFA-glucose comodulation model of β-cell insulin secretion in 24-h multiple-meal test
Salinari, S., BERTUZZI, A., Manco, M., & Mingrone, G. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00563.2006 · Cited by 8
Insulin Gene Expression and Biosynthesis
Poitout, V., Stein, R. W., & Rhodes, C. J. (2003) · Wiley eBooks · doi:10.1002/0470862092.d0203 · Cited by 8
Endoplasmic reticulum stress inhibition ameliorated WFS1 expression alterations and reduced pancreatic islets’ insulin secretion induced by high-fat diet in rats
Binayi, F., Fahanik‐Babaei, J., Salimi, M., Eskandari, F., Sahraei, M., Ranjbary, A. G., Ghasemi, R., Hedayati, M., Khodagholi, F., Eliassi, A., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-28329-1 · Cited by 7
Effects of dietary supplementation with omega-3 fatty acid-rich linseed on the reproductive performance of ewes in subtropical climates
Akhtar, P., Rajoriya, J. S., Singh, A. K., Ojha, B. K., Jha, A. K., Bisen, A., Bajaj, N., Ahirwar, M. K., Raje, A., Singh, A. K., et al. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1398961 · Cited by 7
Have we overlooked the importance of serine/threonine protein phosphatases in pancreatic beta-cells? Role played by protein phosphatase 2A in insulin secretion.
Parameswara, V., Sule, A. J., & Esser, V. (2005) · PubMed · Cited by 7
Metabolomic signatures of low- and high-adiposity neonates differ based on maternal BMI
Mathyk, B. A., Piccolo, B. D., Alvarado, F., Shankar, K., & O’Tierney-Ginn, P. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00356.2021 · Cited by 6
Unsaturated Oral Fat Load Test Improves Glycemia, Insulinemia and Oxidative Stress Status in Nondiabetic Subjects with Abdominal Obesity
Martínez‐Hervás, S., Navarro, I., Real, J. T., Artero, A., Peiró, M., Navarro, H. G., Carmena, R., & Ascaso, J. F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161400 · Cited by 6
Glucose Responsiveness of β-Cells Depends on Fatty Acids
Gerst, F., Singer, C., Noack, K., Graf, D., Kaiser, G., Panse, M., Kovářová, M., Schleicher, E. D., Häring, H., Drews, G., et al. (2019) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-0884-2919 · Cited by 6
Noncanonical Regulation of cAMP‐Dependent Insulin Secretion and Its Implications in Type 2 Diabetes
Ramanadham, S., TURK, J. W., & Bhatnagar, S. (2023) · Comprehensive physiology · doi:10.1002/cphy.c220031 · Cited by 11
Physiological Fatty Acid-Stimulated Insulin Secretion and Redox Signaling Versus Lipotoxicity
Ježek, P. (2025) · Antioxidants and Redox Signaling · doi:10.1089/ars.2024.0799 · Cited by 6
Biological roles and therapeutic potential of G protein-coupled receptors for free fatty acids and metabolic intermediates
Suzuki, K., & Kaneko‐Kawano, T. (2016) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.5.213 · Cited by 5
Analysis of the Bovine DLK1 Gene Polymorphism and Its Relation to Lipid Metabolism in Chinese Simmental
Wang, M., Jiang, P., Yu, X., Mi, J., Bai, Z., Zhang, X., Liu, Y., Fang, X., Yang, R., & Zhao, Z. (2020) · Animals · doi:10.3390/ani10060923 · Cited by 5
Postprandial triglyceridaemia is modulated by insulin resistance but not by grade of obesity in abdominal and morbid obese subjects
Moreno‐Pérez, B., Benito, E., Civera, M., Alabadí, B., Martínez‐Hervás, S., Peiró, M., Navarro, H. G., Piqueras, L., Sanz, M., Ascaso, J. F., et al. (2020) · International Journal of Clinical Practice · doi:10.1111/ijcp.13776 · Cited by 4
Arachidonic acid fights palmitate: new insights into fatty acid toxicity in β-cells
Ortsäter, H. (2010) · Clinical Science · doi:10.1042/cs20100521 · Cited by 5
Dietary fatty acids and insulin secretion
Mingrone, G. (2006) · Scandinavian Journal of Food & Nutrition · doi:10.1080/17482970601076354 · Cited by 5
2-Hydroxylation is a chemical switch linking fatty acids to glucose-stimulated insulin secretion
Li, H., Lin, L., Huang, X., Lü, Y., & Su, X. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107912 · Cited by 4
The Metabolic Basis of Insulin Secretion
Doliba, N. M., & Matschinsky, F. M. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-310-1_6 · Cited by 4
Modulation of avian metabolism by dietary fatty acids
Newman, R. E. (2000) · UPT. Syiah Kuala University Library (Syiah Kuala University) · Cited by 4
Satiety, weight management and foods : literature review
Salmenkallio‐Marttila, M., & Gunnarsdóttir, I. (2009) · Cited by 4
Obesity and Insulin Resistance in Childhood and Adolescence
Bergström, E., & Hernell, O. (2005) · Humana Press eBooks · doi:10.1007/978-1-59259-880-9_12 · Cited by 3
Normal β‐cell function
Natali, A., Prato, S. D., & Mari, A. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch8 · Cited by 4
Effects of a westernized lifestyle on the association between fasting serum nonesterified fatty acids and insulin secretion in Japanese men
Kamei, N., Yamane, K., Nakanishi, S., Ishida, K., Ohtaki, M., Okubo, M., & Kohno, N. (2005) · Metabolism · doi:10.1016/j.metabol.2004.12.016 · Cited by 4
Effects of the Different Dietary Fish Oil Calcium Salt on Production Performance, Blood Biochemical Parameters, Egg Quality Traits and Yolk Fatty Acid Profile in Laying Hens at Peak Production Period
Ghaderi‐Chaparabad, H., Mirghelenj, S. A., Payvastegan, S., Behroozyar, H. K., & Zadeh, A. M. (2025) · Veterinary Medicine and Science · doi:10.1002/vms3.70610 · Cited by 3
Pancreatic β Cells in Metabolic Syndrome
Hiriart, M., Velasco, M., Díaz‐García, C. M., Larqué, C., Sánchez-Soto, C., Albarado-Ibáñez, A., Chávez‐Maldonado, J. P., Toledo, A., & García-Delgado, N. (2014) · Springer eBooks · doi:10.1007/978-94-007-6686-0_27 · Cited by 3
Effects of Dietary Lipid Intake on Diabetes
Kadegowda, A. K. G., & Yu, L. (2015) · Elsevier eBooks · doi:10.1016/b978-1-78242-247-1.00006-5 · Cited by 5
Mitochondrial Function in Diabetes
Mechanick, J. I. (2006) · Nutrition and disease prevention · doi:10.1201/9781420014884.ch13 · Cited by 3
Effects of dietary fats on red blood cell membrane insulin receptor in normo- and hypercholesterolemic miniature swine
Bhathena, S. J., Berlin, E., McClure, D., & Peters, R. C. (2001) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(01)00171-1 · Cited by 3
Dietary fatty acids, insulin resistance and diabetes
Shaw, D. I., Hall, W. L., & Williams, C. M. (2006) · Elsevier eBooks · doi:10.1533/9781845691073.1.25 · Cited by 2
Dietary treatment of obesity
Lottenberg, A. M. (2006) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 7
Effects of Individual Circulating FFAs on Plasma and Hepatic FFA Epoxides, Diols, and Epoxide-Diol Ratios as Indices of Soluble Epoxide Hydrolase Activity
Oh, Y. T., Yang, J., Morisseau, C. H. P., He, Q., Hammock, B. D., & Youn, J. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310760 · Cited by 2
Metabolic Mechanisms and Diabetes Candidate Genes: Insights Gained from Genetic Engineering with Recombinant Adenoviruses
Berman, H. K., Trinh, K. Y., O'Doherty, R. M., Antinozzi, P. A., Gasa, R., & Newgard, C. B. (2000) · KARGER eBooks · doi:10.1159/000060915 · Cited by 2
In a Western Dietary Context Excess Oxidised Linoleic Acid of Dietary and Endogenous Origin by Over-Activation of PPAR Gamma so Immune and Inflammatory Pathways, and through Cardiolipin Damage, Increases Cardiovascular Risk
Brown, R. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-40458-5_29 · Cited by 1
John Denis McGarry, PhD: A Remembrance of a Master Metabolic Physiologist
Newgard, C. B. (2018) · Diabetes Care · doi:10.2337/dci18-0022 · Cited by 1
Pancreatic Beta Cells in Metabolic Syndrome
Hiriart, M., Velasco, M., Díaz‐García, C. M., Larqué, C., Sánchez-Soto, C., Albarado-Ibáñez, A., Chávez‐Maldonado, J. P., Toledo, A., & García-Delgado, N. (2014) · Springer eBooks · doi:10.1007/978-94-007-6884-0_27-2 · Cited by 1
Dietary fatty acids and insulin secretion
Mingrone, G. (2006) · Food & Nutrition Research · doi:10.3402/fnr.v50i0.1580 · Cited by 1
ÁCIDOS GRASOS EN LA DIETA DIABETES MELLITUS E INSULINO RESISTENCIA
Clara Eugenia Pérez, G., & Carlos Arturo Guerrero, F. (2006) · Revista de la Facultad de Medicina · Cited by 1
Nutritional modulation of the transcriptome in adipose, liver, and polymorphonuclear leukocytes in peripartal dairy cows
Agrawal, A. (2016) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign) · Cited by 1
Investigation of the function, pharmacology and oligomerisation of GPR40, GPR41 and GPR43
Stoddart, L. A. (2007) · Enlighten: Theses (The University of Glasgow) · Cited by 1
Biogenesis of the Rat Liver Mitochondrial Carnitine Palmitoyltransferase I
Cohen, I., Girard, J. R., & Prip‐Buus, C. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-46818-2_1 · Cited by 1
Role of insulin in the development of metabolic and reproductive malfunctions of periparturient dairy cows
Kerestes, Á. M. (2009) · Hungarian Veterinary Archive · Cited by 1

Authors: Stein, D. T., Stevenson, B. E., Chester, M. W., Basit, M., Daniels, M. B., Turley, S. D., & McGarry, J. D.
Affiliations: The University of Texas Southwestern Medical Center (US)
ORCID: McGarry, J D
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1997-07-15
Volume: 100
Issue: 2
Pages: 398-403
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci119546
PMC: PMC508203
OpenAlex: W2083278430
Cited by: 352
References: 29
Citations by year: 2026: 1 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 6 · 2019: 12 · 2018: 9 · 2017: 6 · 2016: 10 · 2015: 12 · 2014: 12 · 2013: 9 · 2012: 12
FWCI: 11.13
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK 18573)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: fatty acids, insulin secretion, glucose-stimulated insulin secretion, fatty acid chain length, degree of unsaturation, nicotinic acid, pancreatic islets, palmitate, oleate, linoleate, octanoate, stearate, palmitoleic acid, cis-trans isomerization, dietary fat, insulin resistance
MeSH terms: Animals, Dietary Fats, Fat Emulsions, Intravenous, Fatty Acids, Fatty Acids, Unsaturated, Glucose, Insulin, Male, Niacin, Pancreas, Perfusion, Soybean Oil, Rats, Sprague-Dawley, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks