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Cited by 217Pancreatic function and diabetesDiabetes Treatment and ManagementDiet, Metabolism, and Disease

Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects

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Paolisso, G., Gambardella, A., Amato, L., Tortoriello, R., D'Amore, A., Varricchio, M., D'Onofrio, F.·1995·Diabetologia
DOI 10.1007/bf00401761
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Abstract

Our study investigates short- and long-term effects of infusion of non-esterified fatty acids (NEFA) on insulin secretion in healthy subjects. Twelve healthy individuals underwent a 24-h Intralipid (10% triglyceride emulsion) infusion at a rate of 0.4 ml/min with a simultaneous infusion of heparin (a bolus of 200 U followed by 0.2 U/min per kg body weight). After an overnight fast (baseline), at 6 and at 24 h of Intralipid infusion and 24 h after Intralipid discontinuation (recovery test), all subjects underwent an intravenous glucose tolerance test (iv-GTT) (25 g of glucose/min). Intralipid infusion caused a threefold rise in plasma NEFA concentrations with no difference between the 6- and the 24-h concentrations. Compared to baseline acute insulin response (AIR) (AIR = 63 +/- 8 mU/l), short-term (6-h) Intralipid infusion was associated with a significant increase in AIR (86 +/- 12 mU/l p < 0.01); in contrast, long-term (24-h) Intralipid delivery was associated with inhibition of AIR (31 +/- 5 mU/l) compared to baseline (p < 0.001) and to the 6-h (p < 0.03) triglyceride emulsion infusion. Intralipid infusion was associated with a progressive and significant decline in respiratory quotient (RQ). A positive correlation between changes in fasting plasma NEFA concentrations and AIR at the 6-h infusion (r = 0.89 p < 0.001) was found. In contrast, at the end of the Intralipid infusion period, changes in plasma NEFA concentrations and AIR were negatively correlated (r = -0.87 p < 0.001). The recovery test showed that fasting plasma NEFA concentrations, RQ and AIR had returned to baseline values. In the control study (n = 8) 0.9% NaCl infusion did not mimick the effect of Intralipid. In conclusion, our study demonstrates that short- and long-term exposures of beta cells to high plasma NEFA concentrations have opposite effects on glucose-induced insulin secretion.

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Authors
Paolisso, G., Gambardella, A., Amato, L., Tortoriello, R., D'Amore, A., Varricchio, M., & D'Onofrio, F.
Affiliations
  • University of Campania "Luigi Vanvitelli" (IT)
  • University of Naples Federico II (IT)
ORCID
Venue
Diabetologia
Publisher
Springer Science and Business Media LLC
Published
1995-11
Volume
38
Issue
11
Pages
1295-1299
ISSN
  • 0012-186X (ISSN-L)
  • 1432-0428
DOI
10.1007/bf00401761
OpenAlex
W2069971581
Cited by
217
References
20
Citations by year
2025: 2 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 2 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 8 · 2013: 11 · 2012: 6
FWCI
4.31
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Diabetologia (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
free fatty acids, insulin secretion, acute insulin response, Intralipid, beta-cell function, respiratory quotient, glucose tolerance, heparin
MeSH terms
Insulin Secretion, Adult, Blood Glucose, Fasting, Fat Emulsions, Intravenous, Fatty Acids, Nonesterified, Female, Glucose Tolerance Test, Humans, Infusions, Intravenous, Insulin, Islets of Langerhans, Male, Middle Aged, Triglycerides

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