The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts.
Open accessAbstract
We have hypothesized that T cell cytokines participate in the pathogenesis of graft arterial disease (GAD). This study tested the consequences of IFN-gamma deficiency on arterial and parenchymal pathology in murine cardiac allografts. Hearts from C-H-2(bm12)KhEg (bm12, H-2(bm12)) were transplanted into C57/B6 (B6, H-2(b)), wild-type, or B6 IFN-gamma-deficient (GKO) recipients after immunosuppression by treatment with anti-CD4 and anti-CD8 mAbs. In wild-type recipients, myocardial rejection peaked at 4 wk, (grade 2. 1+/-0.3 out of 4, mean+/-SEM, n = 9), and by 8-12 wk evolved coronary arteriopathy. At 12 wk, the GAD score was 1.4+/-0.3, and the parenchymal rejection grade was 1.2+/-0.3 (n = 8). In GKO recipients of bm12 allografts, myocardial rejection persisted at 12 wk (grade 2.5+/-0.3, n = 6), but no GAD developed (score: 0.0+/-0.0, n = 6, P < 0.01 vs. wild-type). Mice treated with anti-IFN-gamma mAbs showed similar results. Isografts generally showed no arterial changes. In wild-type recipients, arterial and parenchymal cells showed increased MHC class II molecules, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 compared to normal or isografted hearts. The allografts in GKO recipients showed attenuated expression of these molecules (n = 6). Thus, development of GAD, but not parenchymal rejection, requires IFN-gamma. Reduced expression of MHC antigens and leukocyte adhesion molecules may contribute to the lack of coronary arteriopathy in hearts allografted into GKO mice.
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Cited by
Gerdes, N., Sukhova, G. K., Libby, P., Reynolds, R. S., Young, J. L., & Schönbeck, U. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011022 · Cited by 506
Self-citationMühlbauer, M., Fleck, M., Schütz, C., Weiss, T., Froh, M., Blank, C., Schölmerich, J., & Hellerbrand, C. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.05.007 · Cited by 378
Libby, P., & Pober, J. S. (2001) · Immunity · doi:10.1016/s1074-7613(01)00119-4 · Cited by 375
Self-citationMarx, N., Kehrle, B., Kohlhammer, K., Grüb, M., Koenig, W., Hombach, V., Libby, P., & Plutzky, J. (2002) · Circulation Research · doi:10.1161/01.res.0000014225.20727.8f · Cited by 331
Self-citationFang, J. C., Kinlay, S., Beltrame, J., Hikiti, H., Wainstein, M., Behrendt, D., Suh, J., Frei, B., Mudge, G. H., Selwyn, A. P., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08154-0 · Cited by 293
Metadata
- Authors
- Nagano, H., Mitchell, R. N., Taylor, M. K., Hasegawa, S., Tilney, N. L., & Libby, P.
- Venue
- Journal of Clinical Investigation
- Published
- 1997-08-01
- Volume
- 100
- Issue
- 3
- Pages
- 550-557
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2059787313
- Cited by
- 275
- References
- 37
- FWCI
- 15.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nagano, H., Mitchell, R. N., Taylor, M. K., Hasegawa, S., Tilney, N. L., & Libby, P. (1997). Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts. Journal of Clinical Investigation. https://doi.org/10.1172/jci119564
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
