The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Specific Acceptance of Cardiac Allograft After Treatment with Antibodies to ICAM-1 and LFA-1
Abstract
An indefinite survival of cardiac allografts between fully incompatible mice strains was observed when monoclonal antibodies (MAbs) to intercellular adhesion molecule-1 (ICAM-1) and leukocyte function-associated antigen-1 (LFA-1) were simultaneously administered after the transplantation for 6 days. Mice with long-term surviving cardiac allografts accepted skin grafts from the donor-strain but rejected skin grafts from a third-party strain. Because MAbs to ICAM-1 or LFA-1 alone were insufficient for prolonged tolerance, the two MAbs probably acted synergistically to induce specific unresponsiveness. Thus, ICAM-1—LFA-1 adhesion participates in the induction of allograft rejection and MAbs may be useful as therapeutic agents.
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Citations
Cites
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
Cited by
Schwartz, R. H. (1992) · Cell · doi:10.1016/s0092-8674(05)80055-8 · Cited by 1,293
"Infectious" Transplantation Tolerance
Qin, S., Cobbold, S. P., Pope, H., Elliott, J., Kioussis, D., Davies, J., & Waldmann, H. (1993) · Science · doi:10.1126/science.8094901 · Cited by 871
Intercellular adhesion molecule-1
van de Stolpe, A., & van der Saag, P. T. (1996) · Journal of Molecular Medicine · doi:10.1007/bf00202069 · Cited by 802
Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses
Gramaglia, I., Weinberg, A. D., Lemon, M., & Croft, M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.12.6510 · Cited by 527
Participation in Normal Immune Responses of a Metastasis-Inducing Splice Variant of CD44
Arch, R., Wirth, K., Hofmann, M., Ponta, H., Matzku, S., Herrlich, P., & Zöller, M. (1992) · Science · doi:10.1126/science.1496383 · Cited by 403
Metadata
- Authors
- Isobe, M., Yagita, H., Okumura, K., & Ihara, A.
- Venue
- Science
- Published
- 1992-02-28
- Volume
- 255
- Issue
- 5048
- Pages
- 1125-1127
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2028146382
- Cited by
- 715
- References
- 1
- FWCI
- 86.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Isobe, M., Yagita, H., Okumura, K., & Ihara, A. (1992). Specific Acceptance of Cardiac Allograft After Treatment with Antibodies to ICAM-1 and LFA-1. Science. https://doi.org/10.1126/science.1347662
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
