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The syndecan family of proteoglycans. Novel receptors mediating internalization of atherogenic lipoproteins in vitro.
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Proteoglycans act independently in the hepatic clearance of triglyceride-rich remnants.
“coupled with numerous cell culture studies by other groups over the years (13–19, 21), argue for independent action of proteoglycans in the hepatic clearance of triglyceride-rich remnants.”
From Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice (2009) · cites this paper as [13]
The Direct internalization versus ligand transfer section reports that syndecan-mediated lipoprotein catabolism occurred without a detectable role for LRP in the authors’ cell-culture system. The Discussion says syndecans might contribute to LDL receptor-independent catabolism in vivo, but describes their role in hepatic clearance of chylomicron remnants as speculation, not an established finding. (LLM, conf=0.86)
Experimental — accuracy not yet measuredSince membrane proteoglycans undergo clustering and constitutive endocytosis, lipoproteins bound to the proteoglycans could piggy-back into the cell.
“Since membrane proteoglycans undergo clustering and constitutive endocytosis (4, 22, 62, 63), lipoproteins bound to the proteoglycans could “piggy-back” into the cell.”
From Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members (2007) · cites this paper as [22]
The Results and Discussion report that clustering of syndecan domains can trigger internalization of bound ligands, including LpL–lipoprotein complexes. They support the proposed route into the cell, but do not establish that this endocytosis is constitutive. (LLM, conf=0.84)
Experimental — accuracy not yet measuredClustering of syndecan may trigger internalization by endocytosis.
“Clustering of syndecan may in fact trigger internalization by endocytosis (13, 21).”
From Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice (2009) · cites this paper as [13]
Syndecans and perlecan have been shown to mediate the internalization of model remnant lipoproteins or TRL preparations enriched in LPL or apoE.
“Syndecans (13–16) and perlecan (14, 17, 18) have been shown to mediate the internalization of model remnant lipoproteins or TRL preparations enriched in LPL or apoE.”
From Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice (2009) · cites this paper as [13]
The genetic data presented here and previously, coupled with cell culture studies, argue for independent action of proteoglycans in the hepatic system.
“Thus, we believe that the genetic data presented here and previously (9), coupled with numerous cell culture studies by other groups over the years (13–19, 21), argue for independent action of proteoglycans in the hepatic”
From Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice (2009) · cites this paper as [13]
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Citations
Cites
A Receptor-Mediated Pathway for Cholesterol Homeostasis
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Metadata
- Authors
- Fuki, I. V., Kuhn, K. M., Lomazov, I. R., Rothman, V. L., Tuszynski, G. P., Iozzo, R. V., Swenson, T. L., Fisher, E. A., & Williams, K. J.
- Venue
- Journal of Clinical Investigation
- Published
- 1997-09-15
- Volume
- 100
- Issue
- 6
- Pages
- 1611-1622
- ISSN
- 0021-9738
- Cited by
- 213
- References
- 2
- Language
- en
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