The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitis.
Open accessAbstract
The aim of this study was to determine whether tumor necrosis factor-alpha (TNFalpha) and receptors for TNFalpha are expressed in the exocrine pancreas, and whether pancreatic acinar cells release and respond to TNFalpha. Reverse transcription PCR, immunoprecipitation, and Western blot analysis demonstrated the presence of TNFalpha and 55- and 75-kD TNFalpha receptors in pancreas from control rats, rats with experimental pancreatitis induced by supramaximal doses of cerulein, and in isolated pancreatic acini. Immunohistochemistry showed TNFalpha presence in pancreatic acinar cells. ELISA and bioassay measurements of TNFalpha indicated its release from pancreatic acinar cells during incubation in primary culture. Acinar cells responded to TNFalpha. TNFalpha potentiated NF-kappaB translocation into the nucleus and stimulated apoptosis in isolated acini while not affecting LDH release. In vivo studies demonstrated that neutralization of TNFalpha with an antibody produced a mild improvement in the parameters of cerulein-induced pancreatitis. However, TNFalpha neutralization greatly inhibited apoptosis in a modification of the cerulein model of pancreatitis which is associated with a high percentage of apoptotic cell death. The results indicate that pancreatic acinar cells produce, release, and respond to TNFalpha. This cytokine regulates apoptosis in both isolated pancreatic acini and experimental pancreatitis.
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Cites
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Cited by
Pathophysiology of acute pancreatitis
Bhatia, M., Wong, F. L., Cao, Y., Lau, H. Y., Huang, J., Puneet, P., & Chevali, L. (2005) · Pancreatology · doi:10.1159/000085265 · Cited by 544
Regeneration and Repair of the Exocrine Pancreas
Murtaugh, L. C., & Keefe, M. D. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071727 · Cited by 197
Pathobiology of Alcoholic Pancreatitis
Pandol, S. J., & Raraty, M. (2007) · Pancreatology · doi:10.1159/000104235 · Cited by 84
Self-citation
Metadata
- Authors
- Gukovskaya, A. S., Gukovsky, I., Zaninovic, V, Song, M., Sandoval, D., Gukovsky, S., & Pandol, S. J.
- Venue
- Journal of Clinical Investigation
- Published
- 1997-10-01
- Volume
- 100
- Issue
- 7
- Pages
- 1853-1862
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2081935849
- Cited by
- 384
- References
- 48
- FWCI
- 9.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gukovskaya, A. S., Gukovsky, I., Zaninovic, V, Song, M., Sandoval, D., Gukovsky, S., & Pandol, S. J. (1997). Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitis. Journal of Clinical Investigation. https://doi.org/10.1172/jci119714
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
