The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Transit time of leukocytes rolling through venules controls cytokine-induced inflammatory cell recruitment in vivo.
Open accessAbstract
Leukocyte recruitment requires leukocyte rolling, activation, firm adhesion, and transmigration. Injection of the proinflammatory cytokine TNF-alpha induces expression of E-selectin, interleukin-8, and other adhesion molecules and chemoattractants on the endothelial surface. TNF-alpha- treated CD18 null mouse cremaster muscle venules show increased leukocyte rolling velocity and reduced leukocyte recruitment efficiency. Leukocyte recruitment in CD18 null but not wild-type mice is significantly blocked by an mAb to E-selectin. To understand this overlap between adhesion events previously considered separate, we introduce a quantitative analysis of the efficiency of induction of rolling, conversion of rolling to adhesion, and of adhesion to transmigration. We find that CD18 and E-selectin cooperate to control the time a leukocyte needs to roll through an inflamed area and to convert rolling to firm adhesion. Leukocyte rolling time, defined as the time it takes for a rolling leukocyte to pass through a defined length of a vessel segment, emerges as a unifying parameter determining the efficiency of inducing firm adhesion, which is a rate-limiting step controlling leukocyte recruitment in inflammation. We conclude that leukocytes integrate chemoattractant signals while rolling along the endothelial surface until they reach a critical level of activation and become firmly adherent.
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Traffic Signals on Endothelium for Lymphocyte Recirculation and Leukocyte Emigration
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Cited by
Getting to the site of inflammation: the leukocyte adhesion cascade updated
Ley, K., Laudanna, C., Cybulsky, M. I., & Nourshargh, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2156 · Cited by 4,354
Self-citationSelectins: initiators of leucocyte adhesion and signalling at the vascular wall
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Metadata
- Authors
- Jung, U., Norman, K. E., Scharffetter-Kochanek, K., Beaudet, A. L., & Ley, K.
- Venue
- Journal of Clinical Investigation
- Published
- 1998-10-15
- Volume
- 102
- Issue
- 8
- Pages
- 1526-1533
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1971444570
- Cited by
- 275
- References
- 33
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Transit time of leukocytes rolling through venules controls cytokine-induced inflammatory cell recruitment in vivo. https://app.cochat.ai/papers/10.1172/jci119893
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- Jung, U., Norman, K. E., Scharffetter-Kochanek, K., Beaudet, A. L., & Ley, K. (1998). Transit time of leukocytes rolling through venules controls cytokine-induced inflammatory cell recruitment in vivo. Journal of Clinical Investigation. https://doi.org/10.1172/jci119893
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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