The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Functional significance of the platelet immune receptors GPVI and CLEC-2
Open accessAbstract
Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM). GPVI is activated by collagen in the subendothelial matrix, by fibrin and fibrinogen in the thrombus, and by a remarkable number of other ligands. CLEC-2 is activated by the transmembrane protein podoplanin, which is found outside of the vasculature and is upregulated in development, inflammation, and cancer, but there is also evidence for additional ligands. In this Review, we discuss the physiological and pathological roles of CLEC-2 and GPVI and their potential as targets in thrombosis and thrombo-inflammatory disorders (i.e., disorders in which inflammation plays a critical role in the ensuing thrombosis) relative to current antiplatelet drugs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Thrombosis as an intravascular effector of innate immunity
Engelmann, B., & Massberg, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3345 · Cited by 1,989
von Brühl, M.-L., Stark, K., Steinhart, A., Chandraratne, S., Konrad, I., Lorenz, M., Khandoga, A., Tirniceriu, A., Coletti, R., Köllnberger, M., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20112322 · Cited by 1,823
Platelet-collagen interaction: is GPVI the central receptor?
Nieswandt, B., & Watson, S. P. (2003) · Blood · doi:10.1182/blood-2002-12-3882 · Cited by 1,150
Self-citationPlatelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production
Boilard, E., Nigrovic, P. A., Larabee, K., Watts, G. F. M., Coblyn, J. S., Weinblatt, M. E., Massarotti, E. M., Remold-O’Donnell, E., Farndale, R. W., Ware, J., et al. (2010) · Science · doi:10.1126/science.1181928 · Cited by 1,085
Neutrophil extracellular traps promote deep vein thrombosis in mice
BRILL, A., FUCHS, T. A., SAVCHENKO, A. S., THOMAS, G. M., MARTINOD, K., DE MEYER, S. F., BHANDARI, A. A., & WAGNER, D. D. (2012) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04544.x · Cited by 897
Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo
Müller, F., Mutch, N. J., Schenk, W. A., Smith, S. A., Esterl, L., Spronk, H. M., Schmidbauer, S., Gahl, W. A., Morrissey, J. H., & Renné, T. (2009) · Cell · doi:10.1016/j.cell.2009.11.001 · Cited by 831
Burkhart, J. M., Vaudel, M., Gambaryan, S., Radau, S., Walter, U., Martens, L., Geiger, J., Sickmann, A., & Zahedi, R. P. (2012) · Blood · doi:10.1182/blood-2012-04-416594 · Cited by 776
T1 /podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema
Schacht, V. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg342 · Cited by 653
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
Turner, M., Joseph Mee, P., Costello, P. S., Williams, O., Price, A. A., Duddy, L. P., Furlong, M. T., Geahlen, R. L., & Tybulewicz, V. L. J. (1995) · Nature · doi:10.1038/378298a0 · Cited by 612
Schacht, V., Dadras, S. S., Johnson, L. A., Jackson, D. G., Hong, Y.-K., & Detmar, M. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62311-5 · Cited by 596
Cited by
Platelets release mitochondrial antigens in systemic lupus erythematosus
Melki, I., Allaeys, I., Tessandier, N., Lévesque, T., Cloutier, N., Laroche, A., Vernoux, N., Becker, Y., Benk-Fortin, H., Zufferey, A., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.aav5928 · Cited by 125
Eble, J. A. (2019) · Toxins · doi:10.3390/toxins11030136 · Cited by 82
Neutrophils: Linking Inflammation to Thrombosis and Unlocking New Treatment Horizons
Li, H., Shan, W., Zhao, X., & Sun, W. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051965 · Cited by 32
Metadata
- Authors
- Rayes, J., Watson, S. P., & Nieswandt, B.
- Venue
- Journal of Clinical Investigation
- Published
- 2019-01-02
- Volume
- 129
- Issue
- 1
- Pages
- 12-23
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- OpenAlex
- W2907399917
- Cited by
- 328
- References
- 135
- FWCI
- 26.59
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Functional significance of the platelet immune receptors GPVI and CLEC-2. https://app.cochat.ai/papers/10.1172/jci122955
- The paper
- Rayes, J., Watson, S. P., & Nieswandt, B. (2019). Functional significance of the platelet immune receptors GPVI and CLEC-2. Journal of Clinical Investigation. https://doi.org/10.1172/jci122955
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
