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Trisomy 21-driven metabolite alterations are linked to cellular injuries in Down syndrome

Liu, J., Chen, S., Huang, G., Wen, P., Zhou, X., & Wu, Y. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05127-0 · Cited by 4

Reduced REST Expression in Neural Progenitor Cells, Adult Cortex, and Impaired REST Nuclear Translocation in the Prefrontal Cortex of Ts1Cje Mouse Model of Down Syndrome

Lim, C.-T., Lam, X.-J., Crystal, A.-A., Huang, T., Jusoh, N., Cheah, P.-S., & Ling, K. (2024) · Neurochemical Journal · doi:10.1134/s1819712424010148 · Cited by 5

Application of brain organoids in neurodevelopmental disorders

Zhao, C., Qi, Y., Xia, L., Zhu, T., & Xia, K. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152405 · Cited by 3

Mid-gestational cell-type-specific transcriptomic signatures in the prefrontal and superior temporal cortex in Down syndrome

Niu, R., Xue, L., Tian, X., Huangfu, L., Chen, L., Zhai, C.-Y., Wang, S., Zhao, Y., Gan, Z., Qin, H.-Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66109-9 · Cited by 3

Pluripotent stem cells-based neural organoids for modelling human brain development and diseases

Tong, L., Tian, P., Wang, R., Niu, S., Wang, R., Ye, Y., Wu, Y., Zhang, W., Wang, Y., Foggetti, A., et al. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01515-6 · Cited by 3

A Novel Acetylcholine Nanosensor for Single Vesicle Storage and Sub‐Quantal Exocytosis in Living Neurons and Organoids

Zhu, W., Zhang, Y., Yu, H., Wang, D., Zhang, X., Du, X., Wu, S., Li, B., Zhang, Y., Xin, H., et al. (2026) · Angewandte Chemie International Edition · doi:10.1002/anie.202520854 · Cited by 4

The sodium channel SCN2A regulates cortical excitatory and inhibitory neurogenesis

Uy, J. A., Dargaei, Z., Geahchan, S., Botler, L., Pan, Y., Brown, C. O., Howe, J., Scherer, S. W., Bains, J. S., & Singh, K. K. (2026) · Nature Communications · doi:10.1038/s41467-026-75751-w · Cited by 2

Exploring perspectives of Dscam for cognitive deficits: a review of multifunction for regulating neural wiring in homeostasis

Xiong, Y., Li, L., & Zhang, X. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1575348 · Cited by 4

Brain organoids and genome editing: A new era in understanding human brain development and disorders

Zhou, M., Cao, Y., Yue, K., Wu, W., Xie, Y., Hu, D., Zhao, J., Xu, F., Guo, J., Li, Z., et al. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01546 · Cited by 3

Cellularity Defects Are Not Ubiquitous in the Brains of Fetuses With Down Syndrome

Emili, M., Stagni, F., Bonasoni, M., Guidi, S., & Bartesaghi, R. (2024) · Developmental Neurobiology · doi:10.1002/dneu.22953 · Cited by 3

Deciphering Neuronal Deficit and Protein Profile Changes in Human Brain Organoids from Patients with Creatine Transporter DeficiencyPreprint

Broca-Brisson, L., Harati, R., Disdier, C., Mózner, O., Gaston-Breton, R., Maïza, A., Costa, N., Guyot, A.-C., Sarkadi, B., Apáti, Á., et al. (2023) · eLife · doi:10.7554/elife.88459.1 · Cited by 3

Neural Organoids Protect Engineered Heart Tissues From Glucolipotoxicity by Transferring Versican in a Co‐Culture System

Bai, B., Li, J., Wang, Z., Yang, Y., He, J., Chen, G., Zhang, Y., Qi, Y., Wan, Z., Cai, L., et al. (2025) · Cell Proliferation · doi:10.1111/cpr.70070 · Cited by 2

Pharmacological Inhibition of p-21 Activated Kinase (PAK) Restores Impaired Neurite Outgrowth and Remodeling in a Cellular Model of Down Syndrome

Barraza, N., Pérez-Núñez, R., Gaete‐Ramírez, B., Barrios-Garrido, A., Arriagada, C., Poksay, K. S., John, V., Barnier, J., Cárdenas, A. M., & Caviedes, P. A. (2023) · Neurotoxicity Research · doi:10.1007/s12640-023-00638-3 · Cited by 2

Integration of Magnetic-Field-Directed Self-Assembly-Based Cell Culture and Biosensing Platform for Improving hPSCs-Derived Neurons and Quantitative Detection of Neurotransmitter

Zhang, Y., Cao, F., Xu, M., Li, X., Tao, M., Wu, S., Xu, W. F., Liu, Y., & Zhu, W. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c14213 · Cited by 2

Perspectives in the investigation of Cockayne syndrome group B neurological disease: the utility of patient-derived brain organoid models

Wang, X., Zheng, R., Сергеевна, Д. М., Wang, L., Shen, Y., & Lin, Z. (2024) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2300712 · Cited by 2

Modeling Down syndrome neurodevelopment with isogenic cerebral organoidsPreprint

Czerminski, J. T., King, O. D., & Lawrence, J. B. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.25.493459 · Cited by 2

The lncRNA Snhg11 is required for synaptic function, neurogenesis and memory and is downregulated in the dentate gyrus of Down syndrome mouse modelsPreprint

Sierra, C., Sabariego-Navarro, M., Fernández‐Blanco, Á., & Dierssen, M. (2022) · Research Square · doi:10.21203/rs.3.rs-2014117/v1 · Cited by 2

Spatiotemporal expression of Rest in the brain of Ts1Cje mouse model of Down syndromePreprint

Lim, C.-T., Lam, X.-J., Crystal, A.-A., Huang, T., Jusoh, N., Cheah, P.-S., & Ling, K. (2023) · Research Square · doi:10.21203/rs.3.rs-2492451/v1 · Cited by 2

Modeling Down Syndrome Cortical Neurogenesis in Human Cerebral Organoids

Davis, C. J. (2019) · Figshare · doi:10.25417/uic.12481619

Amyloid precursor protein mediates deficits in corticogenesis in Down syndrome cortical organoidsPreprint

Rakowiecki, K., Patel, D., Cofresi, L. A., & Lazarov, O. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.26.666926

Alzheimer’s disease like neuropathology in Down syndrome cortical organoids

Zhao, H., & Haddad, G. G. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1050432 · Cited by 12

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

Sharma, V., Chhawari, H., Joshi, P., Nehra, S., & Singhal, N. (2025) · Journal of Visualized Experiments · doi:10.3791/67382 · Cited by 1

Generation of Urine-Derived Induced Pluripotent Stem Cells and Cerebral Organoids for Modeling Down Syndrome

Silva, A. L. T. E., Yokota-Moreno, B. Y., Sertie, A. L., & Zampieri, B. L. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10497-8 · Cited by 17