The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Nitric oxide synthesis in the lung. Regulation by oxygen through a kinetic mechanism.
Open accessAbstract
In this study, we show that oxygen regulates nitric oxide (NO) levels through effects on NO synthase (NOS) enzyme kinetics. Initially, NO synthesis in the static lung was measured in bronchiolar gases during an expiratory breath-hold in normal individuals. NO accumulated exponentially to a plateau, indicating balance between NO production and consumption in the lung. Detection of NO2-, NO3-, and S-nitrosothiols in lung epithelial lining fluids confirmed NO consumption by chemical reactions in the lung. Interestingly, alveolar gas NO (estimated from bronchiolar gases at end-expiration) was near zero, suggesting NO in exhaled gases is not derived from circulatory/systemic sources. Dynamic NO levels during tidal breathing in different airway regions (mouth, trachea, bronchus, and bronchiole) were similar. However, in individuals breathing varying levels of inspired oxygen, dynamic NO levels were notably dependent on O2 concentration in the hypoxic range (KmO2 190 microM). Purified NOS type II enzyme activity in vitro was similarly dependent on molecular oxygen levels (KmO2 135 microM), revealing a means by which oxygen concentration affects NO levels in vivo. Based upon these results, we propose that NOS II is a mediator of the vascular response to oxygen in the lung, because its KmO2 allows generation of NO in proportion to the inspired oxygen concentration throughout the physiologic range.
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Citations
Cites
The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678
Nitric oxide as a secretory product of mammalian cells
Nathan, C. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.12.1381691 · Cited by 4,350
Biochemistry of nitric oxide and its redox-activated forms
Stamler, J. S., Singel, D. J., & Loscalzo, J. (1992) · Science · doi:10.1126/science.1281928 · Cited by 2,744
Schmidt, H. H. H. W., & Walter, U. (1994) · Cell · doi:10.1016/0092-8674(94)90267-4 · Cited by 1,476
Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution
Rennard, S. I., Basset, G., Lecossier, D., O'Donnell, K. M., Pinkston, P., Martin, P. G., & Crystal, R. G. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.60.2.532 · Cited by 1,131
Blood Flow Regulation by S -Nitrosohemoglobin in the Physiological Oxygen Gradient
Stamler, J. S., Jia, L., Eu, J. P., McMahon, T. J., Demchenko, I. T., Bonaventura, J., Gernert, K., & Piantadosi, C. A. (1997) · Science · doi:10.1126/science.276.5321.2034 · Cited by 1,050
Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans
Gustafsson, L. E., Leone, A. M., Persson, M. G., Wiklund, N. P., & Moncada, S. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91268-h · Cited by 964
Measurement of nitric oxide in biological models
Archer, S. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.2.8440411 · Cited by 926
The biology of nitrogen oxides in the airways
Gaston, B., Drazen, J. M., Loscalzo, J., & Stamler, J. S. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.149.2.7508323 · Cited by 918 · cited 1×
“Three NOSs (types I, II, and III) have been identified in the human lung (9, 10).”
BackgroundNitric Oxide Synthase in Human and Rat Lung: Immunocytochemical and Histochemical Localization
Kobzik, L., Bredt, D. S., Lowenstein, C. J., Drazen, J., Gaston, B., Sugarbaker, D., & Stamler, J. S. (1993) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/9.4.371 · Cited by 810
Cited by
(2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200406-710st · Cited by 3,203
Physiology of Nitric Oxide in Skeletal Muscle
Stamler, J. S., & Meissner, G. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.209 · Cited by 1,080
Mammalian nitric oxide synthases
Stuehr, D. J. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00016-x · Cited by 996
Self-citation(1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.6.ats8-99 · Cited by 771
Shiva, S., Huang, Z., Grubina, R., Sun, J., Ringwood, L. A., MacArthur, P. H., Xu, X., Murphy, E., Darley-Usmar, V. M., & Gladwin, M. T. (2007) · Circulation Research · doi:10.1161/01.res.0000260171.52224.6b · Cited by 599
Metadata
- Authors
- Dweik, R. A., Laskowski, D., Abu-Soud, H. M., Kaneko, F., Hutte, R., Stuehr, D. J., & Erzurum, S. C.
- Venue
- Journal of Clinical Investigation
- Published
- 1998-02-01
- Volume
- 101
- Issue
- 3
- Pages
- 660-666
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1997030028
- Cited by
- 311
- References
- 45
- FWCI
- 13.45
- Type
- journal article
- Language
- en
- Open access
- green
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- Dweik, R. A., Laskowski, D., Abu-Soud, H. M., Kaneko, F., Hutte, R., Stuehr, D. J., & Erzurum, S. C. (1998). Nitric oxide synthesis in the lung. Regulation by oxygen through a kinetic mechanism. Journal of Clinical Investigation. https://doi.org/10.1172/jci1378
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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