The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice
Abstract
Deficiency of the membrane protein FAT/CD36 causes a marked defect in fatty acid uptake by various tissues and is genetically linked to insulin resistance in rats and humans. Here, we examined insulin responsiveness of CD36–/– mice. When fed a diet high in complex carbohydrates and low (5%) in fat, these animals cleared glucose faster than the wild-type. In vivo, uptake of 2-fluorodeoxyglucose by muscle was increased severalfold, and in vitro, insulin responsiveness of glycogenesis by the soleus was enhanced. Null mice had lower glycogen levels in muscle and liver, lower muscle triglyceride levels, and increased liver triglyceride content—all findings consistent with increased insulin-sensitivity. However, when the chow diet was switched to one high in fructose, CD36–/– mice but not wild-type mice developed marked glucose intolerance, hyperinsulinemia, and decreased muscle glucose uptake. High-fat diets impaired glucose tolerance equally in both groups, although CD36 deficiency helped moderate insulin-responsive muscle glucose oxidation. In conclusion, CD36 deficiency enhances insulin responsiveness on a high-starch, low-fat diet. It predisposes to insulin resistance induced by high fructose and partially protects from that induced by high-fat diets. In humans, CD36 deficiency may be an important factor in the metabolic adaptation to diet and in susceptibility to some forms of diet-induced pathology.
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Mechanisms for Insulin Resistance: Common Threads and Missing Links
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Lipid-induced insulin resistance: unravelling the mechanism
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The Human Obesity Gene Map: The 2005 Update
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Obesity, adiposity, and dyslipidemia: a consensus statement from the National Lipid Association
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Metadata
- Authors
- Hajri, T., Han, X. X., Bonen, A., & Abumrad, N. A.
- Venue
- Journal of Clinical Investigation
- Published
- 2002-05-15
- Volume
- 109
- Issue
- 10
- Pages
- 1381-1389
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2134283161
- Cited by
- 276
- References
- 12
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- closed
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