Monoclonal antibody Y01 prevents tauopathy progression induced by lysine 280–acetylated tau in cell and mouse models
Open accessAbstract
The spatiotemporal pattern of the spread of pathologically modified tau through brain regions in Alzheimer's disease (AD) can be explained by prion-like cell-to-cell seeding and propagation of misfolded tau aggregates. Hence, to develop targeted therapeutic antibodies, it is important to identify the seeding- and propagation-competent tau species. The hexapeptide 275VQIINK280 of tau is a critical region for tau aggregation, and K280 is acetylated in various tauopathies, including AD. However, the mechanism that links tau acetylated on lysine 280 (tau-acK280) to subsequent progression to neurodegenerative disease remains unclear. Here, we demonstrate that tau-acK280 is critical for tau propagation processes including secretion, aggregation, and seeding. We developed an antibody, Y01, that specifically targets tau-acK280 and solved the crystal structure of Y01 in complex with an acK280 peptide. The structure confirmed that Y01 directly recognizes acK280 and the surrounding residues. Strikingly, upon interaction with acetylated tau aggregates, Y01 prevented tauopathy progression and increased neuronal viability in neuron cultures and in tau-Tg mice through antibody-mediated neutralization and phagocytosis, respectively. Based on our observations that tau-acK280 is a core species involved in seeding and propagation activities, the Y01 antibody that specifically recognizes acK280 represents a promising therapeutic candidate for AD and other neurodegenerative diseases associated with tauopathy.
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Tau acetylated on lysine 280 (tau-ack280) is essential for tau protein secretion, aggregation, and seeding.
“Tau acetylated on lysine 280 (tau-ack280) is essential for tau protein secretion, aggregation, and seeding”
From Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review (2024) · cites this paper as [189]
The Y01 antibody is a promising candidate for the treatment of AD and other neurodegenerative diseases associated with tauopathy.
“The Y01 antibody that specifically recognises acK280 is a promising candidate for the treatment of AD and other neurodegenerative diseases associated with tauopathy [189].”
From Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review (2024) · cites this paper as [189]
Monoclonal antibody Y01 prevents lysine 280-acetylated tau-protein-induced progression of tauopathy in cell and mouse models.
“researchers have found that the monoclonal antibody Y01 prevents the lysine 280-acetylated tau-protein-induced progression of tauopathy in cell and mouse models.”
From Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review (2024) · cites this paper as [189]
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“The Y01 antibody that specifically recognises acK280 is a promising candidate for the treatment of AD and other neurodegenerative diseases associated with tauopathy [189].”
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- Authors
- Song, H.-L., Kim, N.-Y., Park, J., Kim, M. I., Jeon, Y.-N., Lee, S.-J., Cho, K., Shim, Y.-L., Lee, K.-H., Mun, Y.-S., Song, J.-A., Kim, M.-S., Pack, C.-G., Jung, M., Jang, H., Na, D. L., Hong, M., Kim, D.-H., & Yoon, S.-Y.
- Affiliations
- Yonsei University (KR)
- Asan Medical Center (KR)
- Korea Brain Research Institute (KR)
- Samsung Medical Center (KR)
- University of Ulsan (KR)
- Corresponding author
- Hong, Minsun
- Kim, Dong-Hou
- Yoon, Seung-Yong
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2023-04-17
- Volume
- 133
- Issue
- 8
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC10104896
- OpenAlex
- W4324129007
- Cited by
- 26
- References
- 69
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 8 · 2023: 4
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Clinical Investigation (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Science, ICT, and Future Planning (2018R1A2A1A05077403,2018R1A2B6001619)
- Ministry of Health & Welfare, Republic of Korea (HI20C0654)
- Korean government (2018R1A5A2020732)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- tau acetylation, tauopathy, Alzheimer's disease, tau propagation, prion-like seeding, tau aggregation, antibody neutralization, phagocytosis, therapeutic antibodies, crystal structure
- MeSH terms
- Alzheimer Disease, Animals, Antibodies, Monoclonal, Brain, Disease Models, Animal, Lysine, tau Proteins, Neurodegenerative Diseases, Tauopathies, Mice
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