The DOI matches its Crossref record; 166 of the 166 references it cites were found in a registry or an index.
Molecular pathways that drive diabetic kidney disease
Open accessAbstract
Kidney disease is a major driver of mortality among patients with diabetes and diabetic kidney disease (DKD) is responsible for close to half of all chronic kidney disease cases. DKD usually develops in a genetically susceptible individual as a result of poor metabolic (glycemic) control. Molecular and genetic studies indicate the key role of podocytes and endothelial cells in driving albuminuria and early kidney disease in diabetes. Proximal tubule changes show a strong association with the glomerular filtration rate. Hyperglycemia represents a key cellular stress in the kidney by altering cellular metabolism in endothelial cells and podocytes and by imposing an excess workload requiring energy and oxygen for proximal tubule cells. Changes in metabolism induce early adaptive cellular hypertrophy and reorganization of the actin cytoskeleton. Later, mitochondrial defects contribute to increased oxidative stress and activation of inflammatory pathways, causing progressive kidney function decline and fibrosis. Blockade of the renin-angiotensin system or the sodium-glucose cotransporter is associated with cellular protection and slowing kidney function decline. Newly identified molecular pathways could provide the basis for the development of much-needed novel therapeutics.
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Cites
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“The addition of finerenone also led to a reduction of albuminuria in the ARTS-DN study (163) and decreased progression of kidney disease and improved cardiovascular outcomes in the FIDELIO-DKD and FIGARO-DKD studies (161, 164).”
The molecular machinery of regulated cell death
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“GLP1 receptor agonists lower albuminuria, but their effect on composite renal outcome is not yet available (168).”
Cited by
Diabetes and its complications: molecular mechanisms, prevention and treatment
Zhao, L., Yuan, J., Yang, Q., Ma, J., Yang, F., Zou, Y., Liu, K., & Liu, F. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02401-w · Cited by 80
Insights into the molecular underpinning of type 2 diabetes complications
Singh, A., Bocher, O., & Zeggini, E. (2025) · Human Molecular Genetics · doi:10.1093/hmg/ddae203 · Cited by 10
Metadata
- Authors
- Mohandes, S., Doke, T., Hu, H., Mukhi, D., Dhillon, P., & Susztak, K.
- Venue
- Journal of Clinical Investigation
- Published
- 2023-02-15
- Volume
- 133
- Issue
- 4
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- OpenAlex
- W4320709875
- Cited by
- 341
- References
- 166
- FWCI
- 56.10
- Type
- journal article
- Language
- en
- Open access
- gold
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- Mohandes, S., Doke, T., Hu, H., Mukhi, D., Dhillon, P., & Susztak, K. (2023). Molecular pathways that drive diabetic kidney disease. Journal of Clinical Investigation. https://doi.org/10.1172/jci165654
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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