The DOI matches its OpenAlex record; 1 of the 1 references it cites were found in a registry or an index.
Mature CD8+ T lymphocyte response to viral infection during fetal life
Open accessAbstract
Immunization of newborns against viral infections may be hampered by ineffective CD8(+) T cell responses. To characterize the function of CD8(+) T lymphocytes in early life, we studied newborns with congenital human cytomegalovirus (HCMV) infection. We demonstrate that HCMV infection in utero leads to the expansion and the differentiation of mature HCMV-specific CD8(+) T cells, which have similar characteristics to those detected in adults. High frequencies of HCMV-specific CD8(+) T cells were detected by ex vivo tetramer staining as early as after 28 weeks of gestation. During the acute phase of infection, these cells had an early differentiation phenotype (CD28(-)CD27(+)CD45RO(+), perforin(low)), and they acquired a late differentiation phenotype (CD28(-)CD27(-)CD45RA(+), perforin(high)) during the course of the infection. The differentiated cells showed potent perforin-dependent cytolytic activity and produced antiviral cytokines. The finding of a mature and functional CD8(+) T cell response to HCMV suggests that the machinery required to prime such responses is in place during fetal life and could be used to immunize newborns against viral pathogens.
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Cites
HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function
Appay, V., Nixon, D. F., Donahoe, S. M., Gillespie, G. M. A., Dong, T., King, A., Ogg, G. S., Spiegel, H. M. L., Conlon, C., Spina, C. A., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.1.63 · Cited by 871
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Cited by
Human memory T cells: generation, compartmentalization and homeostasis
Farber, D. L., Yudanin, N. A., & Restifo, N. P. (2014) · Nature Reviews Immunology · doi:10.1038/nri3567 · Cited by 897
Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero
Mold, J. E., Michaëlsson, J., Burt, T. D., Muench, M. O., Beckerman, K. P., Busch, M. P., Lee, T.-H., Nixon, D. F., & McCune, J. M. (2008) · Science · doi:10.1126/science.1164511 · Cited by 836
Human CD8+ T-cell differentiation in response to viruses
van Lier, R. A. W., ten Berge, I. J. M., & Gamadia, L. E. (2003) · Nature Reviews Immunology · doi:10.1038/nri1254 · Cited by 297
Unique aspects of the perinatal immune system
Zhang, X., Zhivaki, D., & Lo-Man, R. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.54 · Cited by 276
Marques, A. H., O'Connor, T. G., Roth, C., Susser, E., & Bjørke-Monsen, A.-L. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00120 · Cited by 226
Metadata
- Authors
- Marchant, A., Appay, V., van der Sande, M. A. B., Dulphy, N., Liesnard, C., Kidd, M., Kaye, S., Ojuola, O. O., Gillespie, G. M. A., Cuero, A. L. V., Cerundolo, V., Callan, M. F. C., McAdam, K. P. W. J., Rowland‐Jones, S., Donner, C., McMichael, A. J., & Whittle, H. C.
- Venue
- Journal of Clinical Investigation
- Publisher
- American Society for Clinical Investigation
- Published
- 2003-06-01
- Volume
- 111
- Issue
- 11
- Pages
- 1747-1755
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2129472676
- Cited by
- 269
- References
- 1
- FWCI
- 10.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Marchant, A., Appay, V., van der Sande, M. A. B., Dulphy, N., Liesnard, C., Kidd, M., Kaye, S., Ojuola, O. O., Gillespie, G. M. A., Cuero, A. L. V., Cerundolo, V., Callan, M. F. C., McAdam, K. P. W. J., Rowland‐Jones, S., Donner, C., McMichael, A. J., & Whittle, H. C. (2003). Mature CD8+ T lymphocyte response to viral infection during fetal life. Journal of Clinical Investigation. https://doi.org/10.1172/jci17470
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
