The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero
Open accessAbstract
As the immune system develops, T cells are selected or regulated to become tolerant of self antigens and reactive against foreign antigens. In mice, the induction of such tolerance is thought to be attributable to the deletion of self-reactive cells. Here, we show that the human fetal immune system takes advantage of an additional mechanism: the generation of regulatory T cells (T regs ) that suppress fetal immune responses. We find that substantial numbers of maternal cells cross the placenta to reside in fetal lymph nodes, inducing the development of CD4+CD25 high FoxP3+ T regs that suppress fetal antimaternal immunity and persist at least until early adulthood. These findings reveal a form of antigen-specific tolerance in humans, induced in utero and probably active in regulating immune responses after birth.
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Citations
Cites
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Cited by
Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774
Overview of the immune response
Chaplin, D. D. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.12.980 · Cited by 2,235
Preterm labor: One syndrome, many causes
Romero, R., Dey, S. K., & Fisher, S. J. (2014) · Science · doi:10.1126/science.1251816 · Cited by 1,984
REVIEW ARTICLE: The Immune System in Pregnancy: A Unique Complexity
Mor, G., & Cardenas, I. (2010) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2010.00836.x · Cited by 1,431
Human T cell development, localization, and function throughout life
Kumar, B. V., Connors, T. J., & Farber, D. L. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.007 · Cited by 1,257
Metadata
- Authors
- Mold, J. E., Michaëlsson, J., Burt, T. D., Muench, M. O., Beckerman, K. P., Busch, M. P., Lee, T.-H., Nixon, D. F., & McCune, J. M.
- Venue
- Science
- Published
- 2008-12-05
- Volume
- 322
- Issue
- 5907
- Pages
- 1562-1565
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2072066004
- Cited by
- 836
- References
- 23
- FWCI
- 19.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Mold, J. E., Michaëlsson, J., Burt, T. D., Muench, M. O., Beckerman, K. P., Busch, M. P., Lee, T.-H., Nixon, D. F., & McCune, J. M. (2008). Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero. Science. https://doi.org/10.1126/science.1164511
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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